Discovery of structure-based small molecular inhibitor of αB-crystallin against basal-like/triple-negative breast cancer development in vitro and in vivo

αB-crystallin stimulates VEGF secretion and tumor cell migration and correlates with enhanced distant metastasis in head and neck squamous cell carcinoma

(2013) Chantal van de Schootbrugge et al.   BMC CANCER

Development of an anti-angiogenic therapeutic model combining scAAV2-delivered siRNAs and noninvasive photoacoustic imaging of tumor vasculature development

(2012) Qing Ruan et al.   CANCER LETTERS

Small heat shock proteins HSP27 (HspB1), αB-crystallin (HspB5) and HSP22 (HspB8) as regulators of cell death

(2012) Julie Acunzo et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Expression of αB-crystallin overrides the anti-apoptotic activity of XIAP

(2012) Jee Suk Lee et al.   NEURO-ONCOLOGY

Incidence and Outcome of BRCA Mutations in Unselected Patients with Triple Receptor-Negative Breast Cancer

(2011) A. M. Gonzalez-Angulo et al.   CLINICAL CANCER RESEARCH

 B-Crystallin, an Effector of Unfolded Protein Response, Confers Anti-VEGF Resistance to Breast Cancer via Maintenance of Intracrine VEGF in Endothelial Cells

(2011) Q. Ruan et al.   MOLECULAR CANCER RESEARCH

 B-crystallin: a novel VEGF chaperone

(2010) B. A. Kerr et al.   BLOOD

Solid-state NMR and SAXS studies provide a structural basis for the activation of αB-crystallin oligomers

(2010) Stefan Jehle et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Intracrine vascular endothelial growth factor signaling in survival and chemoresistance of human colorectal cancer cells

(2010) S Samuel et al.   ONCOGENE

T1N0 Triple Negative Breast Cancer: Risk of Recurrence and Adjuvant Chemotherapy

(2009) Henry G. Kaplan et al.   Breast Journal

Population Differences in Breast Cancer: Survey in Indigenous African Women Reveals Over-Representation of Triple-Negative Breast Cancer

(2009) Dezheng Huo et al.   JOURNAL OF CLINICAL ONCOLOGY

Crystal Structures of α-Crystallin Domain Dimers of αB-Crystallin and Hsp20

(2009) C. Bagnéris et al.   JOURNAL OF MOLECULAR BIOLOGY

Photoacoustic endoscopy

(2009) Joon-Mo Yang et al.   OPTICS LETTERS

Protein–protein interactions as targets for small-molecule therapeutics in cancer

(2008) Alex W. White et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

αB-crystallin: A novel marker of invasive basal-like and metaplastic breast carcinomas

(2007) Stephanie M. Sitterding et al.   Annals of Diagnostic Pathology