Senescence in hepatic stellate cells as a mechanism of liver fibrosis reversal: a putative synergy between retinoic acid and PPAR-gamma signalings

PNPLA3 has retinyl-palmitate lipase activity in human hepatic stellate cells

(2014) Carlo Pirazzi et al.   HUMAN MOLECULAR GENETICS

Activation of adenosine receptor A2A increases HSC proliferation and inhibits death and senescence by down-regulation of p53 and Rb

(2014) Md. Kaimul Ahsan et al.   Frontiers in Pharmacology

Molecular Pathways: Current Role and Future Directions of the Retinoic Acid Pathway in Cancer Prevention and Treatment

(2013) R. M. Connolly et al.   CLINICAL CANCER RESEARCH

PNPLA3 I148M variant and hepatocellular carcinoma: A common genetic variant for a rare disease

(2013) Luca Valenti et al.   DIGESTIVE AND LIVER DISEASE

All-trans-retinoic acid ameliorates hepatic steatosis in mice by a novel transcriptional cascade

(2013) Seong Chul Kim et al.   HEPATOLOGY

Hepatic stellate cells in liver development, regeneration, and cancer

(2013) Chunyue Yin et al.   JOURNAL OF CLINICAL INVESTIGATION

Vitamin A and retinoid signaling: genomic and nongenomic effects

(2013) Ziad Al Tanoury et al.   JOURNAL OF LIPID RESEARCH

Matricellular Protein CCN1 Promotes Regression of Liver Fibrosis through Induction of Cellular Senescence in Hepatic Myofibroblasts

(2013) K.-H. Kim et al.   MOLECULAR AND CELLULAR BIOLOGY

Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome

(2013) Shin Yoshimoto et al.   NATURE

PPARγ signaling and metabolism: the good, the bad and the future

(2013) Maryam Ahmadian et al.   NATURE MEDICINE

Amplified Inhibition of Stellate Cell Activation Pathways by PPAR-γ, RAR and RXR Agonists

(2013) Efrat Sharvit et al.   PLoS One

Clearance of activated stellate cells for hepatic fibrosis regression: Molecular basis and translational potential

(2012) Desong Kong et al.   BIOMEDICINE & PHARMACOTHERAPY

Fenretinide Treatment Prevents Diet-Induced Obesity in Association With Major Alterations in Retinoid Homeostatic Gene Expression in Adipose, Liver, and Hypothalamus

(2012) G. D. Mcilroy et al.   DIABETES

Interleukin-22 induces hepatic stellate cell senescence and restricts liver fibrosis in mice

(2012) Xiaoni Kong et al.   HEPATOLOGY

Retinoic acids and hepatic stellate cells in liver disease

(2012) Young-Sun Lee et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Fibrogenic cell reversion underlies fibrosis regression in liver

(2012) S. L. Friedman   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Myofibroblasts revert to an inactive phenotype during regression of liver fibrosis

(2012) T. Kisseleva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PPARs: Fatty acid sensors controlling metabolism

(2012) Lars la Cour Poulsen et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Mechanisms of hepatic fibrogenesis

(2011) Ursula E. Lee et al.   BEST PRACTICE & RESEARCH IN CLINICAL GASTROENTEROLOGY

Hepatic metabolism of retinoids and disease associations

(2011) Yohei Shirakami et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

All-trans retinoic acid induces cellular senescence via upregulation of p16, p21, and p27

(2011) Sun-Hye Park et al.   CANCER LETTERS

Control of senescence by CXCR2 and its ligands

(2011) Juan C. Acosta et al.   CELL CYCLE

Role for PPARγ in obesity-induced hepatic steatosis as determined by hepatocyte- and macrophage-specific conditional knockouts

(2011) Eva Morán-Salvador et al.   FASEB JOURNAL

Retinoic Acid–Induced Pancreatic Stellate Cell Quiescence Reduces Paracrine Wnt–β-Catenin Signaling to Slow Tumor Progression

(2011) Fieke E.M. Froeling et al.   GASTROENTEROLOGY

Absence of hepatic stellate cell retinoid lipid droplets does not enhance hepatic fibrosis but decreases hepatic carcinogenesis

(2011) J. Kluwe et al.   GUT

Peroxisome proliferator-activated receptor gamma inhibits hepatic fibrosis in rats

(2011) Zheng Wang et al.   Hepatobiliary & Pancreatic Diseases International

Four faces of cellular senescence

(2011) Francis Rodier et al.   JOURNAL OF CELL BIOLOGY

Vitamin A and lipid metabolism: relationship between hepatic stellate cells (HSCs) and adipocytes

(2011) Patrick Sauvant et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

Senescent cells as a source of inflammatory factors for tumor progression

(2010) Albert R. Davalos et al.   CANCER AND METASTASIS REVIEWS

PPARs: diverse regulators in energy metabolism and metabolic diseases

(2010) Yong-Xu Wang   CELL RESEARCH

From carrot to clinic: an overview of the retinoic acid signaling pathway

(2010) Maria Theodosiou et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The essence of senescence

(2010) T. Kuilman et al.   GENES & DEVELOPMENT

Peroxisome proliferator-activated receptors gamma reverses hepatic nutritional fibrosis in mice and suppresses activation of hepatic stellate cells in vitro

(2010) Jun Yu et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

All-trans retinoic acid diminishes collagen production in a hepatic stellate cell line via suppression of active protein-1 and c-Jun N-terminal kinase signal

(2010) Yuan Ye et al.   Journal of Huazhong University of Science and Technology-Medical Sciences

Senescence induction therapy for the treatment of adult T-cell leukemia

(2010) Yasuhiro Maeda et al.   LEUKEMIA & LYMPHOMA

All-trans-retinoic acid ameliorates carbon tetrachloride-induced liver fibrosis in mice through modulating cytokine production

(2010) Shigeo Hisamori et al.   LIVER INTERNATIONAL

The matricellular protein CCN1 induces fibroblast senescence and restricts fibrosis in cutaneous wound healing

(2010) Joon-Il Jun et al.   NATURE CELL BIOLOGY

Biology of interleukin-22

(2010) Kerstin Wolk et al.   Seminars in Immunopathology

MeCP2 Controls an Epigenetic Pathway That Promotes Myofibroblast Transdifferentiation and Fibrosis

(2009) Jelena Mann et al.   GASTROENTEROLOGY

Adipocyte-specific Expression of Murine Resistin Is Mediated by Synergism between Peroxisome Proliferator-activated Receptor γ and CCAAT/Enhancer-binding Proteins

(2009) Takuya Tomaru et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hepatic stellate cell lipid droplets: A specialized lipid droplet for retinoid storage

(2008) William S. Blaner et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Senescence of Activated Stellate Cells Limits Liver Fibrosis

(2008) Valery Krizhanovsky et al.   CELL

Additive Inhibitory Effect of Experimentally Induced Hepatic Cirrhosis by Agonists of Peroxisome Proliferator Activator Receptor γ and Retinoic Acid Receptor

(2008) Rafael Bruck et al.   DIGESTIVE DISEASES AND SCIENCES

Hepatic Stellate Cells: Protean, Multifunctional, and Enigmatic Cells of the Liver

(2008) Scott L. Friedman   PHYSIOLOGICAL REVIEWS

Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor

(2008) Jean-Philippe Coppé et al.   PLOS BIOLOGY

Starring stellate cells in liver immunology

(2007) Florian Winau et al.   CURRENT OPINION IN IMMUNOLOGY