Temporal Transcript Profiling Identifies a Role for Unfolded Protein Stress in Human Gut Ischemia-Reperfusion Injury

Proteomics analysis of human intestinal organoids during hypoxia and reoxygenation as a model to study ischemia-reperfusion injury

(2021) Anna M. Kip et al.   Cell Death & Disease

ER stress preconditioning ameliorates liver damage after hemorrhagic shock and reperfusion

(2021) David Obert et al.   Experimental and Therapeutic Medicine

Unfolded protein response (UPR) integrated signaling networks determine cell fate during hypoxia

(2020) Sylwia Bartoszewska et al.   CELLULAR & MOLECULAR BIOLOGY LETTERS

Mechanisms, regulation and functions of the unfolded protein response

(2020) Claudio Hetz et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Fine tuning of the unfolded protein response by ISRIB improves neuronal survival in a model of amyotrophic lateral sclerosis

(2020) Ricardo Bugallo et al.   Cell Death & Disease

Small molecule ISRIB suppresses the integrated stress response within a defined window of activation

(2019) Huib H. Rabouw et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metascape provides a biologist-oriented resource for the analysis of systems-level datasets

(2019) Yingyao Zhou et al.   Nature Communications

Preconditioning with endoplasmic reticulum stress alleviated heart ischemia/reperfusion injury via modulating IRE1/ATF6/RACK1/PERK and PGC-1α in diabetes mellitus

(2019) Bing Yan et al.   BIOMEDICINE & PHARMACOTHERAPY

Intracellular sensing of viral genomes and viral evasion

(2019) Hyun-Cheol Lee et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

ER Stress and the UPR in Shaping Intestinal Tissue Homeostasis and Immunity

(2019) Olivia I. Coleman et al.   Frontiers in Immunology

Mitochondrial function — gatekeeper of intestinal epithelial cell homeostasis

(2018) Eva Rath et al.   Nature Reviews Gastroenterology & Hepatology

Binding of ISRIB reveals a regulatory site in the nucleotide exchange factor eIF2B

(2018) Alisa F. Zyryanova et al.   SCIENCE

Coordination between Two Branches of the Unfolded Protein Response Determines Apoptotic Cell Fate

(2018) Tsun-Kai Chang et al.   MOLECULAR CELL

Acute mesenteric ischemia: guidelines of the World Society of Emergency Surgery

(2017) Miklosh Bala et al.   World Journal of Emergency Surgery

Intestinal Epithelial Cell Endoplasmic Reticulum Stress and Inflammatory Bowel Disease Pathogenesis: An Update Review

(2017) Xiaoshi Ma et al.   Frontiers in Immunology

Attenuation of PKR-like ER Kinase (PERK) Signaling Selectively Controls Endoplasmic Reticulum Stress-induced Inflammation Without Compromising Immunological Responses

(2016) Lauren N. Guthrie et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Life and death at the mucosal-luminal interface: New perspectives on human intestinal ischemia-reperfusion

(2016) Joep Grootjans et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Animal models of ischemia-reperfusion-induced intestinal injury: progress and promise for translational research

(2015) Liara M. Gonzalez et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Hypoxia-Inducible Factor-1: A Critical Player in the Survival Strategy of Stressed Cells

(2015) Shuyang Chen et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Controlling the unfolded protein response-mediated life and death decisions in cancer

(2015) Marion Maurel et al.   SEMINARS IN CANCER BIOLOGY

The small molecule ISRIB reverses the effects of eIF2α phosphorylation on translation and stress granule assembly

(2015) Carmela Sidrauski et al.   eLife

Endoplasmic Reticulum Stress-Induced Autophagy Provides Cytoprotection from Chemical Hypoxia and Oxidant Injury and Ameliorates Renal Ischemia-Reperfusion Injury

(2015) Bhavya B. Chandrika et al.   PLoS One

The role of MAPK signalling pathways in the response to endoplasmic reticulum stress

(2014) Nicola J. Darling et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

VEGF Signals through ATF6 and PERK to Promote Endothelial Cell Survival and Angiogenesis in the Absence of ER Stress

(2014) Evdoxia Karali et al.   MOLECULAR CELL

Pharmacological brake-release of mRNA translation enhances cognitive memory

(2013) Carmela Sidrauski et al.   eLife

The unfolded protein response: controlling cell fate decisions under ER stress and beyond

(2012) Claudio Hetz   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Hypoxia Inducible Factor 1-Alpha (HIF-1 Alpha) Is Induced during Reperfusion after Renal Ischemia and Is Critical for Proximal Tubule Cell Survival

(2012) Elisa Conde et al.   PLoS One

Selective Abrogation of BiP/GRP78 Blunts Activation of NF- B through the ATF6 Branch of the UPR: Involvement of C/EBP  and mTOR-Dependent Dephosphorylation of Akt

(2011) S. Nakajima et al.   MOLECULAR AND CELLULAR BIOLOGY

Paneth cells, antimicrobial peptides and maintenance of intestinal homeostasis

(2011) Charles L. Bevins et al.   NATURE REVIEWS MICROBIOLOGY

Hypoxia-inducible factor-1 alpha regulates prion protein expression to protect against neuron cell damage

(2011) Jae-Kyo Jeong et al.   NEUROBIOLOGY OF AGING

Exercise-Induced Splanchnic Hypoperfusion Results in Gut Dysfunction in Healthy Men

(2011) Kim van Wijck et al.   PLoS One

Induction of ER stress in response to oxygen-glucose deprivation of cortical cultures involves the activation of the PERK and IRE-1 pathways and of caspase-12

(2011) N Badiola et al.   Cell Death & Disease

Human Intestinal Ischemia-Reperfusion–Induced Inflammation Characterized

(2010) Joep Grootjans et al.   AMERICAN JOURNAL OF PATHOLOGY

Cardioprotection by Endoplasmic Reticulum Stress–Induced Autophagy

(2010) Goran Petrovski et al.   ANTIOXIDANTS & REDOX SIGNALING

Level of Activation of the Unfolded Protein Response Correlates With Paneth Cell Apoptosis in Human Small Intestine Exposed to Ischemia/Reperfusion

(2010) Joep Grootjans et al.   GASTROENTEROLOGY

Hypoxia: an alarm signal during intestinal inflammation

(2010) Sean P. Colgan et al.   Nature Reviews Gastroenterology & Hepatology

HSP72 Protects Cells from ER Stress-induced Apoptosis via Enhancement of IRE1α-XBP1 Signaling through a Physical Interaction

(2010) Sanjeev Gupta et al.   PLOS BIOLOGY

On the role of ischemia in the pathogenesis of IBD

(2009) Christopher B. Ibrahim et al.   INFLAMMATORY BOWEL DISEASES

ADAMTS1Is a Unique Hypoxic Early Response Gene Expressed by Endothelial Cells

(2009) Omer F. Hatipoglu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amplification efficiency: linking baseline and bias in the analysis of quantitative PCR data

(2009) J. M. Ruijter et al.   NUCLEIC ACIDS RESEARCH

Role of hypoxia-inducible factor in cell survival during myocardial ischemia–reperfusion

(2008) G Loor et al.   CELL DEATH AND DIFFERENTIATION

Transcriptional upregulation of HSP70-2 by HIF-1 in cancer cells in response to hypoxia

(2008) Wen-Jie Huang et al.   INTERNATIONAL JOURNAL OF CANCER

From endoplasmic-reticulum stress to the inflammatory response

(2008) Kezhong Zhang et al.   NATURE