Neuroprotective effect of brain-derived neurotrophic factor mediated by autophagy through the PI3K/Akt/mTOR pathway

Neuronal injury in rat model of permanent focal cerebral ischemia is associated with activation of autophagic and lysosomal pathways

(2014) Ya-Dan Wen et al.   Autophagy

Activation of the PI3K-Akt-mTOR signaling pathway promotes necrotic cell death via suppression of autophagy

(2014) You-Tong Wu et al.   Autophagy

Induction of autophagy contributes to the neuroprotection of nicotinamide phosphoribosyltransferase in cerebral ischemia

(2012) Pei Wang et al.   Autophagy

Guidelines for the use and interpretation of assays for monitoring autophagy

(2012) Daniel J. Klionsky et al.   Autophagy

Excessive Autophagy Contributes to Neuron Death in Cerebral Ischemia

(2012) Ruoyang Shi et al.   CNS Neuroscience & Therapeutics

Rapamycin Preconditioning Attenuates Transient Focal Cerebral Ischemia/Reperfusion Injury in Mice

(2012) Lele Yin et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Autophagy in hypoxia-ischemia induced brain injury

(2012) Walter Balduini et al.   Journal of Maternal-Fetal & Neonatal Medicine

Quercetin Attenuates Cell Apoptosis in Focal Cerebral Ischemia Rat Brain Via Activation of BDNF–TrkB–PI3K/Akt Signaling Pathway

(2012) Rui-Qin Yao et al.   NEUROCHEMICAL RESEARCH

Ophiopogonin B-induced autophagy in non-small cell lung cancer cells via inhibition of the PI3K/Akt signaling pathway

(2012) MEIJUAN CHEN et al.   ONCOLOGY REPORTS

mTOR: on target for novel therapeutic strategies in the nervous system

(2012) Kenneth Maiese et al.   TRENDS IN MOLECULAR MEDICINE

Caffeine induces apoptosis by enhancement of autophagy via PI3K/Akt/mTOR/p70S6K inhibition

(2011) Shinji Saiki et al.   Autophagy

Autophagy activation is involved in neuroprotection induced by hyperbaric oxygen preconditioning against focal cerebral ischemia in rats

(2011) Wenjun Yan et al.   BRAIN RESEARCH

Activation of autophagy and Akt/CREB signaling play an equivalent role in the neuroprotective effect of rapamycin in neonatal hypoxia-ischemia

(2010) Silvia Carloni et al.   Autophagy

The promotion of neurological recovery in the rat spinal cord crushed injury model by collagen-binding BDNF

(2010) Weibang Liang et al.   BIOMATERIALS

Dual Role of 3-Methyladenine in Modulation of Autophagy via Different Temporal Patterns of Inhibition on Class I and III Phosphoinositide 3-Kinase

(2010) You-Tong Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mammalian Target of Rapamycin (mTOR) Activation Increases Axonal Growth Capacity of Injured Peripheral Nerves

(2010) Namiko Abe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neural stem cells modified to express BDNF antagonize trimethyltin-induced neurotoxicity through PI3K/Akt and MAP kinase pathways

(2010) Patrizia Casalbore et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Small molecule BDNF mimetics activate TrkB signaling and prevent neuronal degeneration in rodents

(2010) Stephen M. Massa et al.   JOURNAL OF CLINICAL INVESTIGATION

A complex interplay between Akt, TSC2 and the two mTOR complexes: Figure 1

(2009) Jingxiang Huang et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Constitutive Reactive Oxygen Species Generation from Autophagosome/Lysosome in Neuronal Oxidative Toxicity

(2009) Chisato Kubota et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neuronal release of proBDNF

(2009) Jianmin Yang et al.   NATURE NEUROSCIENCE

Mechanisms, locations, and kinetics of synaptic BDNF secretion: An update

(2009) Volkmar Leßmann et al.   NEUROSCIENCE RESEARCH

Neural stem cells improve cognition via BDNF in a transgenic model of Alzheimer disease

(2009) M. Blurton-Jones et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting the PI3K/Akt/mTOR pathway: Effective combinations and clinical considerations

(2008) J LOPICCOLO et al.   DRUG RESISTANCE UPDATES

Neuroprotection of brain-derived neurotrophic factor against hypoxic injury in vitro requires activation of extracellular signal-regulated kinase and phosphatidylinositol 3-kinase

(2007) Xiaomei Sun et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE