Pharmacokinetics and Pharmacodynamics of Key Components of a Standardized Centella asiatica Product in Cognitively Impaired Older Adults: A Phase 1, Double-Blind, Randomized Clinical Trial
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Title
Pharmacokinetics and Pharmacodynamics of Key Components of a Standardized Centella asiatica Product in Cognitively Impaired Older Adults: A Phase 1, Double-Blind, Randomized Clinical Trial
Authors
Keywords
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Journal
Antioxidants
Volume 11, Issue 2, Pages 215
Publisher
MDPI AG
Online
2022-01-24
DOI
10.3390/antiox11020215
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Note: Only part of the references are listed.- Developing a Rational, Optimized Product of Centella asiatica for Examination in Clinical Trials: Real World Challenges
- (2022) Kirsten M. Wright et al. Frontiers in Nutrition
- Prolonged Treatment with Centella asiatica Improves Memory, Reduces Amyloid-β Pathology, and Activates NRF2-Regulated Antioxidant Response Pathway in 5xFAD Mice
- (2021) Jonathan A. Zweig et al. JOURNAL OF ALZHEIMERS DISEASE
- Pharmacokinetics and metabolomics investigation of an orally modified formula of standardized Centella asiatica extract in healthy volunteers
- (2021) Phanit Songvut et al. Scientific Reports
- Caffeoylquinic acids: chemistry, biosynthesis, occurrence, analytical challenges, and bioactivity
- (2021) Armando Alcázar Magaña et al. PLANT JOURNAL
- Aducanumab for Alzheimer’s disease?
- (2021) Sebastian Walsh et al. BMJ-British Medical Journal
- Integration of mass spectral fingerprinting analysis with precursor ion (MS1) quantification for the characterisation of botanical extracts: application to extracts of Centella asiatica (L.) Urban
- (2020) Armando Alcazar Magana et al. PHYTOCHEMICAL ANALYSIS
- Therapeutic Potential of Centella asiatica and Its Triterpenes: A Review
- (2020) Boju Sun et al. Frontiers in Pharmacology
- Loss of NRF2 accelerates cognitive decline, exacerbates mitochondrial dysfunction, and is required for the cognitive enhancing effects of Centella asiatica during aging
- (2020) Jonathan A. Zweig et al. NEUROBIOLOGY OF AGING
- Safety and Pharmacokinetics of Standardized Extract of Centella asiatica (ECa 233) Capsules in Healthy Thai Volunteers: A Phase 1 Clinical Study
- (2019) Phanit Songvut et al. PLANTA MEDICA
- Improving natural product research translation: From source to clinical trial
- (2019) Barbara C. Sorkin et al. FASEB JOURNAL
- Centella Asiatica Improves Memory and Promotes Antioxidative Signaling in 5XFAD Mice
- (2019) Donald G Matthews et al. Antioxidants
- Centella asiatica increases hippocampal synaptic density and improves memory and executive function in aged mice
- (2018) Nora E. Gray et al. Brain and Behavior
- Caffeoylquinic Acids in Centella asiatica Protect against Amyloid-β Toxicity
- (2018) Nora E. Gray et al. JOURNAL OF ALZHEIMERS DISEASE
- Centella asiatica attenuates hippocampal mitochondrial dysfunction and improves memory and executive function in β-amyloid overexpressing mice
- (2018) Nora E. Gray et al. MOLECULAR AND CELLULAR NEUROSCIENCE
- Centella asiatica attenuates Aβ-induced neurodegenerative spine loss and dendritic simplification
- (2017) Nora E. Gray et al. NEUROSCIENCE LETTERS
- Centella asiatica Attenuates Mitochondrial Dysfunction and Oxidative Stress in Aβ-Exposed Hippocampal Neurons
- (2017) Nora E. Gray et al. Oxidative Medicine and Cellular Longevity
- Centella asiatica: phytochemistry and mechanisms of neuroprotection and cognitive enhancement
- (2017) Nora E. Gray et al. PHYTOCHEMISTRY REVIEWS
- Effects of Centella asiatica (L.) Urb. on cognitive function and mood related outcomes: A Systematic Review and Meta-analysis
- (2017) Panupong Puttarak et al. Scientific Reports
- Breakfast consumption induces retarded release of chlorogenic acid metabolites in humans
- (2016) D. Scherbl et al. EUROPEAN FOOD RESEARCH AND TECHNOLOGY
- Transformation of chlorogenic acids during the coffee beans roasting process
- (2016) Andrzej L. Dawidowicz et al. EUROPEAN FOOD RESEARCH AND TECHNOLOGY
- Centella asiatica modulates antioxidant and mitochondrial pathways and improves cognitive function in mice
- (2016) Nora E. Gray et al. JOURNAL OF ETHNOPHARMACOLOGY
- Stability and Degradation of Caffeoylquinic Acids under Different Storage Conditions Studied by High-Performance Liquid Chromatography with Photo Diode Array Detection and High-Performance Liquid Chromatography with Electrospray Ionization Collision-Induced Dissociation Tandem Mass Spectrometry
- (2016) Meng Xue et al. MOLECULES
- The Challenge of Reproducibility and Accuracy in Nutrition Research: Resources and Pitfalls
- (2016) Barbara C Sorkin et al. Advances in Nutrition
- Drug development in Alzheimer’s disease: the path to 2025
- (2016) Jeffrey Cummings et al. Alzheimers Research & Therapy
- Activation of the Nrf2 Cell Defense Pathway by Ancient Foods: Disease Prevention by Important Molecules and Microbes Lost from the Modern Western Diet
- (2016) Donald R. Senger et al. PLoS One
- Biopharmaceutical and pharmacokinetic characterization of asiatic acid in Centella asiatica as determined by a sensitive and robust HPLC–MS method
- (2015) Yongfang Yuan et al. JOURNAL OF ETHNOPHARMACOLOGY
- Chlorogenic acid, a polyphenol in coffee, protects neurons against glutamate neurotoxicity
- (2015) Yoshinori Mikami et al. LIFE SCIENCES
- Comparative pharmacokinetics and tissue distribution study of mono-, and di-caffeoylquinic acids isomers of Ainsliaea fragrans Champ by a fast UHPLC–MS/MS method
- (2014) Dan Su et al. FITOTERAPIA
- Melatonin Acts as Antioxidant and Improves Sleep in MS Patients
- (2014) Monika Adamczyk-Sowa et al. NEUROCHEMICAL RESEARCH
- In vivo disposition and metabolism of madecassoside, a major bioactive constituent in Centella asiatica (L.) Urb.
- (2013) Dan-dan Leng et al. JOURNAL OF ETHNOPHARMACOLOGY
- Tracking pathophysiological processes in Alzheimer's disease: an updated hypothetical model of dynamic biomarkers
- (2013) Clifford R Jack et al. LANCET NEUROLOGY
- Neuroprotection of Ilex latifolia and caffeoylquinic acid derivatives against excitotoxic and hypoxic damage of cultured rat cortical neurons
- (2012) Joo Youn Kim et al. ARCHIVES OF PHARMACAL RESEARCH
- Dose-dependent absorption of chlorogenic acids in the small intestine assessed by coffee consumption in ileostomists
- (2012) Thomas Erk et al. MOLECULAR NUTRITION & FOOD RESEARCH
- A liquid chromatography/electrospray ionization tandem mass spectrometric method for quantification of asiatic acid from plasma: application to pharmacokinetic study in rats
- (2012) Sreenath Nandakumar Nair et al. RAPID COMMUNICATIONS IN MASS SPECTROMETRY
- Development and validation of high-performance liquid chromatography/electrospray ionization mass spectrometry for assay of madecassoside in rat plasma and its application to pharmacokinetic study
- (2011) Wen-Jing Han et al. BIOMEDICAL CHROMATOGRAPHY
- Flavanols from green tea and phenolic acids from coffee: Critical quantitative evaluation of the pharmacokinetic data in humans after consumption of single doses of beverages
- (2011) Gary Williamson et al. MOLECULAR NUTRITION & FOOD RESEARCH
- An improved LC-MS/MS method for simultaneous determination of 1,5-dicaffeoylquinic acid and its active metabolites in human plasma and its application to a pharmacokinetic study in patients
- (2010) Jianglin Liu et al. BIOMEDICAL CHROMATOGRAPHY
- Bapineuzumab: anti-β-amyloid monoclonal antibodies for the treatment of Alzheimer’s disease
- (2010) Francesco Panza et al. Immunotherapy
- Metabolite Profiling of Hydroxycinnamate Derivatives in Plasma and Urine after the Ingestion of Coffee by Humans: Identification of Biomarkers of Coffee Consumption
- (2009) A. Stalmach et al. DRUG METABOLISM AND DISPOSITION
- In vitro and in vivo conjugation of dietary hydroxycinnamic acids by UDP-glucuronosyltransferases and sulfotransferases in humans
- (2009) Chi Chun Wong et al. JOURNAL OF NUTRITIONAL BIOCHEMISTRY
- Pentacyclic Triterpenoids from the Medicinal Herb, Centella asiatica (L.) Urban
- (2009) Jacinda James et al. MOLECULES
- Mitochondrial bioenergetic deficit precedes Alzheimer's pathology in female mouse model of Alzheimer's disease
- (2009) J. Yao et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Determination of asiatic acid in beagle dog plasma after oral administration of Centella asiatica extract by precolumn derivatization RP-HPLC
- (2008) Xiao-Chun Zheng et al. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
- Chlorogenic Acids from Green Coffee Extract are Highly Bioavailable in Humans
- (2008) Adriana Farah et al. JOURNAL OF NUTRITION
- Enhancement of Hippocampal CA3 Neuronal Dendritic Arborization by Centella asiatica (Linn) Fresh Leaf Extract Treatment in Adult Rats
- (2008) Mohandas Rao Kappettu Gadahad et al. Journal of the Chinese Medical Association
- Positive modulation of cognition and mood in the healthy elderly volunteer following the administration of Centella asiatica
- (2007) Jintanaporn Wattanathorn et al. JOURNAL OF ETHNOPHARMACOLOGY
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