BACE1 Inhibition Increases Susceptibility to Oxidative Stress by Promoting Mitochondrial Damage

The Phosphorylation Status of Drp1-Ser637 by PKA in Mitochondrial Fission Modulates Mitophagy via PINK1/Parkin to Exert Multipolar Spindles Assembly during Mitosis

(2021) Huey-Jiun Ko et al.   Biomolecules

mito-QC illuminates mitophagy and mitochondrial architecture in vivo

(2016) Thomas G. McWilliams et al.   JOURNAL OF CELL BIOLOGY

Endogenous Parkin Preserves Dopaminergic Substantia Nigral Neurons following Mitochondrial DNA Mutagenic Stress

(2015) Alicia M. Pickrell et al.   NEURON

Dysregulated autophagy in the RPE is associated with increased susceptibility to oxidative stress and AMD

(2014) Sayak K Mitter et al.   Autophagy

Retinal pigment epithelial cells undergoing mitotic catastrophe are vulnerable to autophagy inhibition

(2014) S Y Lee et al.   Cell Death & Disease

Autophagy and mitochondrial alterations in human retinal pigment epithelial cells induced by ethanol: implications of 4-hydroxy-nonenal

(2014) M Flores-Bellver et al.   Cell Death & Disease

Loss of iron triggers PINK1/Parkin-independent mitophagy

(2013) George F G Allen et al.   EMBO REPORTS

Systematic Proteomic Analysis Identifies β-Site Amyloid Precursor Protein Cleaving Enzyme 2 and 1 (BACE2 and BACE1) Substrates in Pancreatic β-Cells

(2013) Ina Stützer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanisms of Mitochondrial Fission and Fusion

(2013) A. M. van der Bliek et al.   Cold Spring Harbor Perspectives in Biology

Enhanced apoptosis in retinal pigment epithelium under inflammatory stimuli and oxidative stress

(2012) Yujuan Wang et al.   APOPTOSIS

Elevated amyloid β production in senescent retinal pigment epithelium, a possible mechanism of subretinal deposition of amyloid β in age-related macular degeneration

(2012) Jiying Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Oxidative stress increases BACE1 protein levels through activation of the PKR-eIF2α pathway

(2012) François Mouton-Liger et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

β-Secretase (BACE1) inhibition causes retinal pathology by vascular dysregulation and accumulation of age pigment

(2012) Jun Cai et al.   EMBO Molecular Medicine

HIG1, a novel regulator of mitochondrial γ-secretase, maintains normal mitochondrial function

(2012) Hiroki Hayashi et al.   FASEB JOURNAL

Mitochondrial γ-secretase participates in the metabolism of mitochondria-associated amyloid precursor protein

(2010) Pavel F. Pavlov et al.   FASEB JOURNAL

The secretases: enzymes with therapeutic potential in Alzheimer disease

(2010) Bart De Strooper et al.   Nature Reviews Neurology

Association of Omi/HtrA2 with γ-secretase in mitochondria

(2010) Homira Behbahani et al.   NEUROCHEMISTRY INTERNATIONAL

Loss of PINK1 Function Promotes Mitophagy through Effects on Oxidative Stress and Mitochondrial Fission

(2009) Ruben K. Dagda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The  -Secretase Enzyme BACE in Health and Alzheimer's Disease: Regulation, Cell Biology, Function, and Therapeutic Potential

(2009) R. Vassar et al.   JOURNAL OF NEUROSCIENCE

A global view of protein expression in human cells, tissues, and organs

(2009) Fredrik Pontén et al.   Molecular Systems Biology

Selective Actions of Mitochondrial Fission/Fusion Genes on Metabolism-Secretion Coupling in Insulin-releasing Cells

(2008) Kyu-Sang Park et al.   JOURNAL OF BIOLOGICAL CHEMISTRY