Triple Isozyme Lactic Acid Dehydrogenase Inhibition in Fully Viable MDA-MB-231 Cells Induces Cytostatic Effects That Are Not Reversed by Exogenous Lactic Acid

LDH‐A negatively regulates dMMR in colorectal cancer

(2021) Yongjie Zhang et al.   CANCER SCIENCE

Warburg and Beyond: The Power of Mitochondrial Metabolism to Collaborate or Replace Fermentative Glycolysis in Cancer

(2020) Shamir Cassim et al.   Cancers

A population‐based comparison of treatment patterns, resource utilization, and costs by cancer stage for Ontario patients with triple‐negative breast cancer

(2020) Christine Brezden‐Masley et al.   Cancer Medicine

MUC-1 aptamer conjugated InP/ZnS quantum dots/nanohydrogel fluorescent composite for mitochondria-mediated apoptosis in MCF-7 cells

(2020) Zahra Ranjbar-Navazi et al.   Materials Science & Engineering C-Materials for Biological Applications

The oncogenic and clinical implications of lactate induced immunosuppression in the tumour microenvironment

(2020) Conall Hayes et al.   CANCER LETTERS

Reply to Beltinger: Double genetic disruption of lactate dehydrogenases A and B is required to ablate the “Warburg effect” restricting tumor growth to oxidative metabolism

(2019) Jacques Pouysségur et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Novel pharmacological effects of poly (ADP-ribose) polymerase inhibitor rucaparib on the lactate dehydrogenase pathway

(2019) Yuma Nonomiya et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Interfering cellular lactate homeostasis overcomes Taxol resistance of breast cancer cells through the microRNA-124-mediated lactate transporter (MCT1) inhibition

(2019) Lu Hou et al.   Cancer Cell International

The altered transcriptome and DNA methylation profiles of docetaxel resistance in breast cancer PDX models

(2019) Jorge Gómez-Miragaya et al.   MOLECULAR CANCER RESEARCH

Machilin A Inhibits Tumor Growth and Macrophage M2 Polarization Through the Reduction of Lactic Acid

(2019) Tae-Wook Chung et al.   Cancers

The NIR inspired nano-CuSMn(II) composites for lactate and glycolysis attenuation

(2019) Xiu-Lin Fang et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Anticancer effect of XAV939 is observed by inhibiting lactose dehydrogenase A in a 3‑dimensional culture of colorectal cancer cells

(2019) Dahee Kim et al.   Oncology Letters

Magnetic nanoparticles-based lactate dehydrogenase microreactor as a drug discovery tool for rapid screening inhibitors from natural products

(2019) Guorong Cheng et al.   TALANTA

Restricting Glycolysis Preserves T Cell Effector Functions and Augments Checkpoint Therapy

(2019) Kathrin Renner et al.   Cell Reports

LDHA Promotes Oral Squamous Cell Carcinoma Progression Through Facilitating Glycolysis and Epithelial–Mesenchymal Transition

(2019) Hongshi Cai et al.   Frontiers in Oncology

Double genetic disruption of lactate dehydrogenase A and B is required to ablate the ‘Warburg effect’ restricting tumor growth to oxidative metabolism

(2018) Maša Ždralević et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

LDH-A regulates the tumor microenvironment via HIF-signaling and modulates the immune response

(2018) Inna Serganova et al.   PLoS One

Characterization of the Saffron Derivative Crocetin as an Inhibitor of Human Lactate Dehydrogenase 5 in the Antiglycolytic Approach against Cancer

(2017) Carlotta Granchi et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Gpr132 sensing of lactate mediates tumor–macrophage interplay to promote breast cancer metastasis

(2017) Peiwen Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Modification of tumour cell metabolism modulates sensitivity to Chk1 inhibitor-induced DNA damage

(2017) Andrew J. Massey   Scientific Reports

Pharmacological or genetic inhibition of LDHA reverses tumor progression of pediatric osteosarcoma

(2016) Shan Gao et al.   BIOMEDICINE & PHARMACOTHERAPY

High expressions of LDHA and AMPK as prognostic biomarkers for breast cancer

(2016) Xiaojia Huang et al.   BREAST

LDHA-Associated Lactic Acid Production Blunts Tumor Immunosurveillance by T and NK Cells

(2016) Almut Brand et al.   Cell Metabolism

Lactate dehydrogenase downregulation mediates the inhibitory effect of diallyl trisulfide on proliferation, metastasis, and invasion in triple-negative breast cancer

(2016) Shi-Yann Cheng et al.   ENVIRONMENTAL TOXICOLOGY

Hypoxia-inducible proteins HIF1α and lactate dehydrogenase LDH5, key markers of anaerobic metabolism, relate with stem cell markers and poor post-radiotherapy outcome in bladder cancer

(2016) Michael I. Koukourakis et al.   INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

Metabolic plasticity underpins innate and acquired resistance to LDHA inhibition

(2016) Aaron Boudreau et al.   Nature Chemical Biology

Suppression of lactate dehydrogenase A compromises tumor progression by downregulation of the Warburg effect in glioblastoma

(2016) Juan Li et al.   NEUROREPORT

Synthesis of natural urolithin M6, a galloflavin mimetic, as a potential inhibitor of lactate dehydrogenase A

(2016) Sebastiano Rupiani et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Evaluation on the inhibition of pyrrol-2-yl ethanone derivatives to lactate dehydrogenase and anticancer activities

(2016) Na-Na Lu et al.   SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY

Proteomic identification of the lactate dehydrogenase A in a radioresistant prostate cancer xenograft mouse model for improving radiotherapy

(2016) Jingli Hao et al.   Oncotarget

1,2,3,4,6-Penta-O-galloylglucose within Galla Chinensis Inhibits Human LDH-A and Attenuates Cell Proliferation in MDA-MB-231 Breast Cancer Cells

(2015) Shihab Deiab et al.   Evidence-based Complementary and Alternative Medicine

Synergistic cytotoxicity of cisplatin and Taxol in overcoming Taxol resistance through the inhibition of LDHA in oral squamous cell carcinoma

(2015) LIN FENG et al.   Oncology Letters

Expression of the hypoxia-inducible monocarboxylate transporter MCT4 is increased in triple negative breast cancer and correlates independently with clinical outcome

(2014) J. Doyen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Warburg effect: molecular aspects and therapeutic possibilities

(2014) Hanh Ngo et al.   MOLECULAR BIOLOGY REPORTS