Article
Oncology
Lijie Zhou, Hongyu Li, Hongshi Cai, Wenhui Liu, Enjiu Pan, Dongsheng Yu, Shuai He
Summary: The strong invasive and metastatic abilities of oral squamous cell carcinoma in the early stage lead to poor prognosis. This study identified IGF2BP2 as a potential biomarker for oral squamous cell carcinoma based on gene coexpression network analysis. Further investigations revealed that IGF2BP2 affects the prognosis of oral squamous cell carcinoma by influencing tumor-related biological functions and pathways, as well as immune score and CD8+ T cell infiltration. Silencing IGF2BP2 can suppress the proliferation, migration, and invasion of cancer cells.
FRONTIERS IN ONCOLOGY
(2022)
Article
Otorhinolaryngology
Xiongming Zhou, Danfeng Xue, Jiaxuan Qiu
Summary: The study utilized ssGSEA and WGCNA algorithms to investigate glycolysis in OSCC, finding that glycolytic scores were significantly correlated with prognosis and identifying 5 HUB genes associated with glycolysis that could potentially serve as therapeutic targets for future OSCC treatment.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2022)
Article
Oncology
Guojin Zhou, Shoude Zhang, Mao Jin, Sunhong Hu
Summary: This study identified gene modules related to tumor stages in LSCC and explored their prognostic significance. Several genes were found to be associated with overall survival and immune cell proportions in LSCC patients, as well as differentially expressed in various tumor stages. These findings provide new insights into the progression of LSCC and the identification of prognostic genes.
Review
Oncology
Zihang Ling, Bin Cheng, Xiaoan Tao
Summary: Oral squamous cell carcinoma (OSCC) is the most common malignancy in global oral cancer, with a low survival rate due to tumor metastasis and recurrence. Epithelial-to-mesenchymal transition (EMT) plays a key role in tumor metastasis and has attracted significant attention. Further research on the role of EMT in OSCC may provide novel insights for developing strategies to combat this type of cancer.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Oncology
Yang Yang, Pengwei Ren, Xiaofeng Liu, Xiaoyan Sun, Chunfeng Zhang, Xiaojuan Du, Baocai Xing
Summary: This study found that PPP1R26 is upregulated in hepatocellular carcinoma (HCC) and is significantly associated with metastasis and poor patient survival. PPP1R26 promotes glycolysis by enhancing the splicing of PKM2 and activates epithelial-mesenchymal transition (EMT) by forming a PPP1R26-PKM2-TGIF2 complex, driving the progression of HCC.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Chukkris Heawchaiyaphum, Hironori Yoshiyama, Hisashi Iizasa, Ati Burassakarn, Zolzaya Tumurgan, Tipaya Ekalaksananan, Chamsai Pientong
Summary: This study revealed the oncogenic role of EBV in the progression of oral squamous cell carcinoma (OSCC) by inducing the Warburg effect and altering cancer stemness.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Wenli Zang, Junchao Liu, Fengxue Geng, Dongjuan Liu, Shuwei Zhang, Yuchao Li, Yaping Pan
Summary: This study found that butyrate can promote the migration and invasion of oral squamous cell carcinoma (OSCC) cells by inducing epithelial-mesenchymal transition (EMT), indicating that butyrate may contribute to the metastasis of OSCC.
Article
Genetics & Heredity
Danke Wang, Jiacheng Dai, Chen Suo, Shangzi Wang, Yuting Zhang, Xingdong Chen
Summary: This study classified ESCC patients into three subtypes based on gene expression analysis and identified differential gene expression and representative pathways for each subtype. Additionally, nine hub genes associated with survival in ESCC were discovered. These findings provide important insights into the molecular characteristics of ESCC and the identification of potential therapeutic targets.
FRONTIERS IN GENETICS
(2022)
Article
Immunology
Tiantian Wu, Caijin Tang, Renchuan Tao, Xiangzhi Yong, Qiaozhi Jiang, Cong Feng
Summary: The research found that PD-L1 is highly expressed in oral squamous cell carcinoma (OSCC), correlated with worse survival, and related to macrophage infiltration and EMT process. Patients with high PD-L1 expression may benefit from ICI treatment and show higher sensitivity to certain chemical drugs.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, General & Internal
Hongguo Xie, Xiaopeng Lu
Summary: The aim of this study was to investigate the role of circNFATC3 in the development of oral squamous cell carcinoma (OSCC). The levels of circNFATC3, miR-520h, and LDHA were measured and their interactions were confirmed. Functional analysis showed that knockdown of circNFATC3 inhibited glycolysis metabolism, cell proliferation, migration, and invasion, and promoted cell apoptosis in OSCC cells. LDHA was found to regulate the development of OSCC and circNFATC3 acted as a sponge for miR-520h to modulate LDHA expression. Furthermore, the absence of circNFATC3 suppressed tumor growth in mice. In conclusion, circNFATC3 promoted the progression of OSCC through the miR-520h/LDHA axis.
Article
Plant Sciences
Marcela Rodrigues de Camargo, Talita Fonseca Frazon, Kelly Karina Inacio, Fhernanda Ribeiro Smiderle, Nadia Ghinelli Amor, Thiago Jose Dionisio, Carlos Ferreira Santos, Camila Oliveira Rodini, Vanessa Soares Lara
Summary: The polysaccharides of Ganoderma lucidum have the potential to be an important ally for tongue squamous cell carcinoma treatment, as they can alter the behavior and morphology of tumor cells, as well as downregulate cancer stem cells and EMT markers.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jung Ho Han, MinJeong Kim, Hee-Jin Choi, Jung Sook Jin, Syng-Ook Lee, Sung-Jin Bae, Dongryeol Ryu, Ki-Tae Ha
Summary: The water-extracted roots of Sanguisorba officinalis L. were found to reduce lactate dehydrogenase A (LDHA) activity and improve physical performance by enhancing AMPKα and PGC-1α levels, while suppressing glycolysis. This suggests that S. officinalis may be a candidate for enhancing physical performance through inhibiting LDHA and glycolysis.
Article
Oncology
Mengmeng Fan, Makoto Arai, Akinobu Tawada, Tetsuhiro Chiba, Reo Fukushima, Katsuhiro Uzawa, Masashi Shiiba, Naoya Kato, Hideki Tanzawa, Yuichi Takiguchi
Summary: The study revealed the roles of EPSTI1 in conferring malignant characteristics to oral squamous cell carcinoma (OSCC) and lung squamous cell carcinoma (LSCC), with the gene showing oncogenic roles in OSCC and tumor-suppressive roles in LSCC. Additionally, PCR array analyses identified some genes with altered expression levels along with modified EPSTI1 expression in both OSCC and LSCC cell lines, suggesting EPSTI1 may be a therapeutic target for both types of cancer.
Article
Oncology
Tian-Tian Xu, Xiao-Wen Zeng, Xin-Hong Wang, Lu-Xi Yang, Gang Luo, Ting Yu
Summary: Our study revealed the downregulation of cystatin-B (CSTB) in oral squamous cell carcinoma (OSCC) tissues. CSTB expression was found to be associated with clinical prognosis and inhibited cell proliferation, migration, and invasion in vitro. Analysis of gene expression data and clinical information showed that lower expression levels of CSTB were correlated with poorer clinicopathological features.
FRONTIERS IN ONCOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Qian Zhang, Chunmiao Jiang, Wenhao Ren, Shaoming Li, Jingjing Zheng, Yuli Gao, Keqian Zhi, Ling Gao
Summary: The study revealed that circ-LRP6 is highly expressed in oral squamous cell carcinoma, and its downregulation can reduce the EMT and autophagy process in cells. Additionally, increased autophagy can reverse the inhibitory effect of circ-LRP6 siRNA on cell EMT.
JOURNAL OF ORAL PATHOLOGY & MEDICINE
(2021)