Machilin A Inhibits Tumor Growth and Macrophage M2 Polarization Through the Reduction of Lactic Acid

How the Warburg effect supports aggressiveness and drug resistance of cancer cells?

(2018) Philippe Icard et al.   DRUG RESISTANCE UPDATES

LDHA is a direct target of miR-30d-5p and contributes to aggressive progression of gallbladder carcinoma

(2018) Yuting He et al.   MOLECULAR CARCINOGENESIS

FX11 inhibits aerobic glycolysis and growth of neuroblastoma cells

(2017) Eric J. Rellinger et al.   SURGERY

The Warburg effect and drug resistance

(2016) Bhaskar Bhattacharya et al.   BRITISH JOURNAL OF PHARMACOLOGY

The Emerging Hallmarks of Cancer Metabolism

(2016) Natalya N. Pavlova et al.   Cell Metabolism

LDHA-Associated Lactic Acid Production Blunts Tumor Immunosurveillance by T and NK Cells

(2016) Almut Brand et al.   Cell Metabolism

Metabolic plasticity underpins innate and acquired resistance to LDHA inhibition

(2016) Aaron Boudreau et al.   Nature Chemical Biology

The Regulation and Function of Lactate Dehydrogenase A: Therapeutic Potential in Brain Tumor

(2015) Cara J. Valvona et al.   BRAIN PATHOLOGY

A Lactate-Induced Response to Hypoxia

(2015) Dong Chul Lee et al.   CELL

Recent Update on Human Lactate Dehydrogenase Enzyme 5 (hLDH5) Inhibitors: A Promising Approach for Cancer Chemotherapy

(2015) Reshma Rani et al.   JOURNAL OF MEDICINAL CHEMISTRY

Expression and Efficient One-Step Chromatographic Purification of a Soluble Antagonist for Human Leukemia Inhibitory Factor Receptor in Escherichia coli

(2015) Eun-Yeong Kim et al.   JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY

Selective inhibitory effects of machilin A isolated from Machilus thunbergii on human cytochrome P450 1A and 2B6

(2015) Sun Ju Kim et al.   PHYTOMEDICINE

JQ1 suppresses tumor growth through downregulating LDHA in ovarian cancer

(2015) Haifeng Qiu et al.   Oncotarget

Structures of lactate dehydrogenase A (LDHA) in apo, ternary and inhibitor-bound forms

(2015) Subramaniapillai Kolappan et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Targeting Lactate Dehydrogenase-A Inhibits Tumorigenesis and Tumor Progression in Mouse Models of Lung Cancer and Impacts Tumor-Initiating Cells

(2014) Han Xie et al.   Cell Metabolism

Tumor-Associated Macrophages: From Mechanisms to Therapy

(2014) Roy Noy et al.   IMMUNITY

Functional polarization of tumour-associated macrophages by tumour-derived lactic acid

(2014) Oscar R. Colegio et al.   NATURE

Human Lactate Dehydrogenase A Inhibitors: A Molecular Dynamics Investigation

(2014) Yun Shi et al.   PLoS One

Structural characterization of the apo form and NADH binary complex of human lactate dehydrogenase

(2014) Sally Dempster et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Regulation of the Activity of Lactate Dehydrogenases from Four Lactic Acid Bacteria

(2013) Anna Feldman-Salit et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting lactate metabolism for cancer therapeutics

(2013) Joanne R. Doherty et al.   JOURNAL OF CLINICAL INVESTIGATION

HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations

(2013) Gregg L. Semenza   JOURNAL OF CLINICAL INVESTIGATION

Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate

(2012) Patrick S. Ward et al.   CANCER CELL

Measurement of CYP1A2 Activity: A Focus on Caffeine as a Probe

(2012) Vidya Perera et al.   CURRENT DRUG METABOLISM

Differential macrophage programming in the tumor microenvironment

(2012) Brian Ruffell et al.   TRENDS IN IMMUNOLOGY

Lactate Influx through the Endothelial Cell Monocarboxylate Transporter MCT1 Supports an NF- B/IL-8 Pathway that Drives Tumor Angiogenesis

(2011) F. Vegran et al.   CANCER RESEARCH

Tyrosine Phosphorylation of Lactate Dehydrogenase A Is Important for NADH/NAD+ Redox Homeostasis in Cancer Cells

(2011) J. Fan et al.   MOLECULAR AND CELLULAR BIOLOGY

Macrophage Diversity Enhances Tumor Progression and Metastasis

(2010) Bin-Zhi Qian et al.   CELL

Alternative Activation of Macrophages: Mechanism and Functions

(2010) Siamon Gordon et al.   IMMUNITY

Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression

(2010) A. Le et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Ganglioside GM3 inhibits VEGF/VEGFR-2-mediated angiogenesis: Direct interaction of GM3 with VEGFR-2

(2008) T.-W. Chung et al.   GLYCOBIOLOGY

Machilin A Isolated fromMyristica fragransStimulates Osteoblast Differentiation

(2008) Su-Ui Lee et al.   PLANTA MEDICA