Decoding Stem Cells: An Overview on Planarian Stem Cell Heterogeneity and Lineage Progression

Reactive oxygen species rescue regeneration after silencing the MAPK–ERK signaling pathway in Schmidtea mediterranea

(2021) V. Jaenen et al.   Scientific Reports

Identification of TOR‐responsive slow‐cycling neoblasts in planarians

(2021) Alyssa M Molinaro et al.   EMBO REPORTS

Planarian stem cells specify fate yet retain potency during the cell cycle

(2021) Amelie A. Raz et al.   Cell Stem Cell

CBP/p300 homologs CBP2 and CBP3 play distinct roles in planarian stem cell function

(2021) Clara R. Stelman et al.   DEVELOPMENTAL BIOLOGY

Collagen IV differentially regulates planarian stem cell potency and lineage progression

(2021) Andy Chan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial state determines functionally divergent stem cell population in planaria

(2021) Mohamed Mohamed Haroon et al.   Stem Cell Reports

CREB-binding protein (CBP) gene family regulates planarian survival and stem cell differentiation

(2021) Susanna Fraguas et al.   DEVELOPMENTAL BIOLOGY

Identification of rare, transient post-mitotic cell states that are induced by injury and required for whole-body regeneration in Schmidtea mediterranea

(2021) Blair W. Benham-Pyle et al.   NATURE CELL BIOLOGY

Planarian stem cells sense the identity of the missing pharynx to launch its targeted regeneration

(2021) Tisha E Bohr et al.   eLife

Principles of regeneration revealed by the planarian eye

(2021) Peter W. Reddien   CURRENT OPINION IN CELL BIOLOGY

Planarian EGF repeat-containing genes megf6 and hemicentin are required to restrict the stem cell compartment

(2020) Nicole Lindsay-Mosher et al.   PLoS Genetics

Cell-type diversity and regionalized gene expression in the planarian intestine

(2020) David J Forsthoefel et al.   eLife

What is the role of PIWI family proteins in adult pluripotent stem cells? Insights from asexually reproducing animals, planarians

(2020) Makoto Kashima et al.   DEVELOPMENT GROWTH & DIFFERENTIATION

Muscle and neuronal guidepost-like cells facilitate planarian visual system regeneration

(2020) M. Lucila Scimone et al.   SCIENCE

Tnfaip2/exoc3 ‐driven lipid metabolism is essential for stem cell differentiation and organ homeostasis

(2020) Sarmistha Deb et al.   EMBO REPORTS

Muscle functions as a connective tissue and source of extracellular matrix in planarians

(2019) Lauren E. Cote et al.   Nature Communications

Model systems for regeneration: planarians

(2019) Mario Ivankovic et al.   DEVELOPMENT

Planarians recruit piRNAs for mRNA turnover in adult stem cells

(2019) Iana V. Kim et al.   GENES & DEVELOPMENT

Prospectively Isolated Tetraspanin + Neoblasts Are Adult Pluripotent Stem Cells Underlying Planaria Regeneration

(2018) An Zeng et al.   CELL

Searching for non-transposable targets of planarian nuclear PIWI in pluripotent stem cells and differentiated cells

(2018) Makoto Kashima et al.   DEVELOPMENT GROWTH & DIFFERENTIATION

Cellular, ultrastructural and molecular analyses of epidermal cell development in the planarian Schmidtea mediterranea

(2018) Li-Chun Cheng et al.   DEVELOPMENTAL BIOLOGY

A carcinogenic trigger to study the function of tumor suppressor genes in Schmidtea mediterranea

(2018) Andromeda Van Roten et al.   Disease Models & Mechanisms

Epigenetic modifications in the embryonic and induced pluripotent stem cells

(2018) Rasoul Godini et al.   GENE EXPRESSION PATTERNS

Rebuilding a planarian: from early signaling to final shape

(2018) Francesc Cebrià et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Cell type transcriptome atlas for the planarianSchmidtea mediterranea

(2018) Christopher T. Fincher et al.   SCIENCE

Cell type atlas and lineage tree of a whole complex animal by single-cell transcriptomics

(2018) Mireya Plass et al.   SCIENCE

Self-organization and progenitor targeting generate stable patterns in planarian regeneration

(2018) Kutay Deniz Atabay et al.   SCIENCE

Planarian stem cell niche, the challenge for understanding tissue regeneration

(2018) Leonardo Rossi et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Post-translational regulation of planarian regeneration

(2018) Nicholas S. Strand et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

The role of the EGFR signaling pathway in stem cell differentiation during planarian regeneration and homeostasis

(2018) Sara Barberán et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

A lineage CLOUD for neoblasts

(2018) Thao Anh Tran et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

The true colours of the flatworm: Mechanisms of pigment biosynthesis and pigment cell lineage development in planarians

(2018) Nicole Lindsay-Mosher et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Post-transcriptional regulation in planarian stem cells

(2018) Srikar Krishna et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Planarian flatworms as a new model system for understanding the epigenetic regulation of stem cell pluripotency and differentiation

(2018) Anish Dattani et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Hippo signaling controls cell cycle and restricts cell plasticity in planarians

(2018) Nídia de Sousa et al.   PLOS BIOLOGY

Positional information specifies the site of organ regeneration and not tissue maintenance in planarians

(2018) Eric M Hill et al.   eLife

Histone Lysine and Genomic Targets of Histone Acetyltransferases in Mammals

(2018) Anne K. Voss et al.   BIOESSAYS

Epigenetic analyses of planarian stem cells demonstrate conservation of bivalent histone modifications in animal stem cells

(2018) Anish Dattani et al.   GENOME RESEARCH

Characterizing the role of SWI/SNF-related chromatin remodeling complexes in planarian regeneration and stem cell function

(2018) Toria Trost et al.   Stem Cell Research

Conservation of epigenetic regulation by the MLL3/4 tumour suppressor in planarian pluripotent stem cells

(2018) Yuliana Mihaylova et al.   Nature Communications

The Cellular and Molecular Basis for Planarian Regeneration

(2018) Peter W. Reddien   CELL

foxF-1 Controls Specification of Non-body Wall Muscle and Phagocytic Cells in Planarians

(2018) M. Lucila Scimone et al.   CURRENT BIOLOGY

SoxB1 Activity Regulates Sensory Neuron Regeneration, Maintenance, and Function in Planarians

(2018) Kelly G. Ross et al.   DEVELOPMENTAL CELL

Smed-myb-1 Specifies Early Temporal Identity during Planarian Epidermal Differentiation

(2018) Shu Jun Zhu et al.   Cell Reports

The Integrator complex regulates differential snRNA processing and fate of adult stem cells in the highly regenerative planarian Schmidtea mediterranea

(2018) David Schmidt et al.   PLoS Genetics

The pioneer factor Smed-gata456-1 is required for gut cell differentiation and maintenance in planarians

(2017) Alejandro González-Sastre et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Orthogonal muscle fibres have different instructive roles in planarian regeneration

(2017) M. Lucila Scimone et al.   NATURE

Generic wound signals initiate regeneration in missing-tissue contexts

(2017) Suthira Owlarn et al.   Nature Communications

Nervous system development and regeneration in freshwater planarians

(2017) Kelly G. Ross et al.   Wiley Interdisciplinary Reviews-Developmental Biology

The Akt signaling pathway is required for tissue maintenance and regeneration in planarians

(2016) T. Harshani Peiris et al.   BMC DEVELOPMENTAL BIOLOGY

Kat3 coactivators in somatic stem cells and cancer stem cells: biological roles, evolution, and pharmacologic manipulation

(2016) Paul D. Thomas et al.   CELL BIOLOGY AND TOXICOLOGY

The EGFR signaling pathway controls gut progenitor differentiation during planarian regeneration and homeostasis

(2016) Sara Barberán et al.   DEVELOPMENT

Essential role for the planarian intestinal GATA transcription factor in stem cells and regeneration

(2016) Natasha M. Flores et al.   DEVELOPMENTAL BIOLOGY

Inheritance of a Nuclear PIWI from Pluripotent Stem Cells by Somatic Descendants Ensures Differentiation by Silencing Transposons in Planarian

(2016) Norito Shibata et al.   DEVELOPMENTAL CELL

Egf Signaling Directs Neoblast Repopulation by Regulating Asymmetric Cell Division in Planarians

(2016) Kai Lei et al.   DEVELOPMENTAL CELL

Muscle-derived matrix metalloproteinase regulates stem cell proliferation in planarians

(2016) Caitlin B. Dingwall et al.   DEVELOPMENTAL DYNAMICS

Epigenetic control of adult stem cell function

(2016) Alexandra Avgustinova et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Neuronal sources of hedgehog modulate neurogenesis in the adult planarian brain

(2016) Ko W Currie et al.   eLife

A functional genomics screen in planarians reveals regulators of whole-brain regeneration

(2016) Rachel H Roberts-Galbraith et al.   eLife

Conserved functional antagonism of CELF and MBNL proteins controls stem cell-specific alternative splicing in planarians

(2016) Jordi Solana et al.   eLife

Two FGFRL-Wnt circuits organize the planarian anteroposterior axis

(2016) M Lucila Scimone et al.   eLife

Forkhead containing transcription factor Albino controls tetrapyrrole-based body pigmentation in planarian

(2016) Chen Wang et al.   Cell Discovery

Evolution of the EGFR pathway in Metazoa and its diversification in the planarian Schmidtea mediterranea

(2016) Sara Barberán et al.   Scientific Reports

Digital gene expression approach over multiple RNA-Seq data sets to detect neoblast transcriptional changes in Schmidtea mediterranea

(2015) Gustavo Rodríguez-Esteban et al.   BMC GENOMICS

Wnt/Notum spatial feedback inhibition controls neoblast differentiation to regulate reversible growth of the planarian brain

(2015) E. M. Hill et al.   DEVELOPMENT

Identification of HECT E3 ubiquitin ligase family genes involved in stem cell regulation and regeneration in planarians

(2015) Jordana M. Henderson et al.   DEVELOPMENTAL BIOLOGY

A Generic and Cell-Type-Specific Wound Response Precedes Regeneration in Planarians

(2015) Omri Wurtzel et al.   DEVELOPMENTAL CELL

Chromatin remodeling and bivalent histone modifications in embryonic stem cells

(2015) A. Harikumar et al.   EMBO REPORTS

Reactive Oxygen Species in Planarian Regeneration: An Upstream Necessity for Correct Patterning and Brain Formation

(2015) Nicky Pirotte et al.   Oxidative Medicine and Cellular Longevity

Set1 and MLL1/2 Target Distinct Sets of Functionally Different Genomic Loci In Vivo

(2015) Elizabeth M. Duncan et al.   Cell Reports

Stem cells and fluid flow drive cyst formation in an invertebrate excretory organ

(2015) Hanh Thi-Kim Vu et al.   eLife

A mex3 homolog is required for differentiation during planarian stem cell lineage development

(2015) Shu Jun Zhu et al.   eLife

Egr-5 is a post-mitotic regulator of planarian epidermal differentiation

(2015) Kimberly C Tu et al.   eLife

Single-Cell Analysis Reveals Functionally Distinct Classes within the Planarian Stem Cell Compartment

(2014) Josien C. van Wolfswinkel et al.   Cell Stem Cell

PIWI homologs mediate Histone H4 mRNA localization to planarian chromatoid bodies

(2014) L. Rouhana et al.   DEVELOPMENT

JNK Controls the Onset of Mitosis in Planarian Stem Cells and Triggers Apoptotic Cell Death Required for Regeneration and Remodeling

(2014) María Almuedo-Castillo et al.   PLoS Genetics

COE Loss-of-Function Analysis Reveals a Genetic Program Underlying Maintenance and Regeneration of the Nervous System in Planarians

(2014) Martis W. Cowles et al.   PLoS Genetics

Selective amputation of the pharynx identifies a FoxA-dependent regeneration program in planaria

(2014) Carolyn E Adler et al.   eLife

Neoblast Specialization in Regeneration of the Planarian Schmidtea mediterranea

(2014) M. Lucila Scimone et al.   Stem Cell Reports

Protein post-translational modifications and regulation of pluripotency in human stem cells

(2013) Yu-Chieh Wang et al.   CELL RESEARCH

Specialized progenitors and regeneration

(2013) P. W. Reddien   DEVELOPMENT

Transcription factors lhx1/5-1 and pitx are required for the maintenance and regeneration of serotonergic neurons in planarians

(2013) K. W. Currie et al.   DEVELOPMENT

A Pitx transcription factor controls the establishment and maintenance of the serotonergic lineage in planarians

(2013) M. Marz et al.   DEVELOPMENT

Genome-wide analysis of the bHLH gene family in planarians identifies factors required for adult neurogenesis and neuronal regeneration

(2013) M. W. Cowles et al.   DEVELOPMENT

Heterochromatin protein 1 promotes self-renewal and triggers regenerative proliferation in adult stem cells

(2013) An Zeng et al.   JOURNAL OF CELL BIOLOGY

Planarians as a Model to Assess In Vivo the Role of Matrix Metalloproteinase Genes during Homeostasis and Regeneration

(2013) Maria Emilia Isolani et al.   PLoS One

Muscle Cells Provide Instructions for Planarian Regeneration

(2013) Jessica N. Witchley et al.   Cell Reports

The CCR4-NOT Complex Mediates Deadenylation and Degradation of Stem Cell mRNAs and Promotes Planarian Stem Cell Differentiation

(2013) Jordi Solana et al.   PLoS Genetics

Genetic Regulators of a Pluripotent Adult Stem Cell System in Planarians Identified by RNAi and Clonal Analysis

(2012) Daniel E. Wagner et al.   Cell Stem Cell

An RNAi Screen Reveals Intestinal Regulators of Branching Morphogenesis, Differentiation, and Stem Cell Proliferation in Planarians

(2012) David J. Forsthoefel et al.   DEVELOPMENTAL CELL

Gene expression of pluripotency determinants is conserved between mammalian and planarian stem cells

(2012) Pinar Önal et al.   EMBO JOURNAL

Epigenetic regulation of planarian stem cells by the SET1/MLL family of histone methyltransferases

(2012) Amy Hubert et al.   Epigenetics

A molecular wound response program associated with regeneration initiation in planarians

(2012) D. Wenemoser et al.   GENES & DEVELOPMENT

The planarian neoblast: the rambling history of its origin and some current black boxes

(2012) Jaume Baguñ   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

TOR signaling regulates planarian stem cells and controls localized and organismal growth

(2012) T. H. Peiris et al.   JOURNAL OF CELL SCIENCE

Transcriptome Analysis Reveals Strain-Specific and Conserved Stemness Genes in Schmidtea mediterranea

(2012) Alissa M. Resch et al.   PLoS One

A Comparative Transcriptomic Analysis Reveals Conserved Features of Stem Cell Pluripotency in Planarians and Mammals

(2012) Roselyne M. Labbé et al.   STEM CELLS

Transcriptome Analysis of the Planarian Eye Identifies ovo as a Specific Regulator of Eye Regeneration

(2012) Sylvain W. Lapan et al.   Cell Reports

SMG-1 and mTORC1 Act Antagonistically to Regulate Response to Injury and Growth in Planarians

(2012) Cristina González-Estévez et al.   PLoS Genetics

Defining the molecular profile of planarian pluripotent stem cells using a combinatorial RNA-seq, RNA interference and irradiation approach

(2012) Jordi Solana et al.   GENOME BIOLOGY

The maintenance and regeneration of the planarian excretory system are regulated by EGFR signaling

(2011) J. C. Rink et al.   DEVELOPMENT

A regulatory program for excretory system regeneration in planarians

(2011) M. L. Scimone et al.   DEVELOPMENT

ERK signaling controls blastema cell differentiation during planarian regeneration

(2011) J. Tasaki et al.   DEVELOPMENT

Stem cell-based growth, regeneration, and remodeling of the planarian intestine

(2011) David J. Forsthoefel et al.   DEVELOPMENTAL BIOLOGY

EGFR signaling regulates cell proliferation, differentiation and morphogenesis during planarian regeneration and homeostasis

(2011) Susanna Fraguas et al.   DEVELOPMENTAL BIOLOGY

Clonogenic Neoblasts Are Pluripotent Adult Stem Cells That Underlie Planarian Regeneration

(2011) D. E. Wagner et al.   SCIENCE

dlx and sp6-9 Control Optic Cup Regeneration in a Prototypic Eye

(2011) Sylvain W. Lapan et al.   PLoS Genetics

The Mi-2-like Smed-CHD4 gene is required for stem cell differentiation in the planarian Schmidtea mediterranea

(2010) M. L. Scimone et al.   DEVELOPMENT

Single-cell gene profiling of planarian stem cells using fluorescent activated cell sorting and its “index sorting” function for stem cell research

(2010) Tetsutaro Hayashi et al.   DEVELOPMENT GROWTH & DIFFERENTIATION

Planarian regeneration involves distinct stem cell responses to wounds and tissue absence

(2010) Danielle Wenemoser et al.   DEVELOPMENTAL BIOLOGY

Smed-Evi/Wntless is required for  -catenin-dependent and -independent processes during planarian regeneration

(2009) T. Adell et al.   DEVELOPMENT

A planarian p53 homolog regulates proliferation and self-renewal in adult stem cell lineages

(2009) Bret J. Pearson et al.   DEVELOPMENT

How mitochondria produce reactive oxygen species

(2008) Michael P. Murphy   BIOCHEMICAL JOURNAL

Molecular Analysis of Stem Cells and Their Descendants during Cell Turnover and Regeneration in the Planarian Schmidtea mediterranea

(2008) George T. Eisenhoffer et al.   Cell Stem Cell