Model systems for regeneration: planarians

Body size-dependent energy storage causes Kleiber’s law scaling of the metabolic rate in planarians

(2019) Albert Thommen et al.   eLife

Prospectively Isolated Tetraspanin + Neoblasts Are Adult Pluripotent Stem Cells Underlying Planaria Regeneration

(2018) An Zeng et al.   CELL

EvoRegen in animals: Time to uncover deep conservation or convergence of adult stem cell evolution and regenerative processes

(2018) Alvina G. Lai et al.   DEVELOPMENTAL BIOLOGY

Critical Point in Self-Organized Tissue Growth

(2018) Daniel Aguilar-Hidalgo et al.   PHYSICAL REVIEW LETTERS

Cell type transcriptome atlas for the planarianSchmidtea mediterranea

(2018) Christopher T. Fincher et al.   SCIENCE

Cell type atlas and lineage tree of a whole complex animal by single-cell transcriptomics

(2018) Mireya Plass et al.   SCIENCE

Epigenetic analyses of planarian stem cells demonstrate conservation of bivalent histone modifications in animal stem cells

(2018) Anish Dattani et al.   GENOME RESEARCH

The genome of Schmidtea mediterranea and the evolution of core cellular mechanisms

(2018) Markus Alexander Grohme et al.   NATURE

Draft genome of Dugesia japonica provides insights into conserved regulatory elements of the brain restriction gene nou-darake in planarians

(2018) Yang An et al.   Zoological Letters

Review: The Regenerating Tail Blastema of Lizards as a Model to Study Organ Regeneration and Tumor Growth Regulation in Amniotes

(2018) Lorenzo Alibardi   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

The Cellular and Molecular Basis for Planarian Regeneration

(2018) Peter W. Reddien   CELL

PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity

(2018) Andrei Rozanski et al.   NUCLEIC ACIDS RESEARCH

Orthogonal muscle fibres have different instructive roles in planarian regeneration

(2017) M. Lucila Scimone et al.   NATURE

Convergent evolution of bilaterian nerve cords

(2017) José M. Martín-Durán et al.   NATURE

Guided self-organization and cortical plate formation in human brain organoids

(2017) Madeline A Lancaster et al.   NATURE BIOTECHNOLOGY

A tunable refractive index matching medium for live imaging cells, tissues and model organisms

(2017) Tobias Boothe et al.   eLife

Embryonic origin of adult stem cells required for tissue homeostasis and regeneration

(2017) Erin L Davies et al.   eLife

The Molecular and Cellular Choreography of Appendage Regeneration

(2016) Elly M. Tanaka   CELL

Inheritance of a Nuclear PIWI from Pluripotent Stem Cells by Somatic Descendants Ensures Differentiation by Silencing Transposons in Planarian

(2016) Norito Shibata et al.   DEVELOPMENTAL CELL

Wnt, Ptk7, and FGFRL expression gradients control trunk positional identity in planarian regeneration

(2016) Rachel Lander et al.   eLife

Two FGFRL-Wnt circuits organize the planarian anteroposterior axis

(2016) M Lucila Scimone et al.   eLife

Organoids and the genetically encoded self-assembly of embryonic stem cells

(2015) David A. Turner et al.   BIOESSAYS

Novel monoclonal antibodies to study tissue regeneration in planarians

(2015) Kelly G Ross et al.   BMC DEVELOPMENTAL BIOLOGY

A Transcriptomic-Phylogenomic Analysis of the Evolutionary Relationships of Flatworms

(2015) Bernhard Egger et al.   CURRENT BIOLOGY

A Generic and Cell-Type-Specific Wound Response Precedes Regeneration in Planarians

(2015) Omri Wurtzel et al.   DEVELOPMENTAL CELL

SmedGD 2.0: TheSchmidtea mediterraneagenome database

(2015) Sofia M.C. Robb et al.   GENESIS

Posterior Wnts Have Distinct Roles in Specification and Patterning of the Planarian Posterior Region

(2015) Miquel Sureda-Gómez et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

PlanMine – a mineable resource of planarian biology and biodiversity

(2015) Holger Brandl et al.   NUCLEIC ACIDS RESEARCH

Scaling and Regeneration of Self-Organized Patterns

(2015) Steffen Werner et al.   PHYSICAL REVIEW LETTERS

Signaling networks organizing regenerative growth of the zebrafish fin

(2015) Daniel Wehner et al.   TRENDS IN GENETICS

Set1 and MLL1/2 Target Distinct Sets of Functionally Different Genomic Loci In Vivo

(2015) Elizabeth M. Duncan et al.   Cell Reports

β-Catenin-Dependent Control of Positional Information along the AP Body Axis in Planarians Involves a Teashirt Family Member

(2015) Hanna Reuter et al.   Cell Reports

Stem cells and fluid flow drive cyst formation in an invertebrate excretory organ

(2015) Hanh Thi-Kim Vu et al.   eLife

Egr-5 is a post-mitotic regulator of planarian epidermal differentiation

(2015) Kimberly C Tu et al.   eLife

Generation of cell type-specific monoclonal antibodies for the planarian and optimization of sample processing for immunolabeling

(2014) David J Forsthoefel et al.   BMC DEVELOPMENTAL BIOLOGY

Single-Cell Analysis Reveals Functionally Distinct Classes within the Planarian Stem Cell Compartment

(2014) Josien C. van Wolfswinkel et al.   Cell Stem Cell

PIWI homologs mediate Histone H4 mRNA localization to planarian chromatoid bodies

(2014) L. Rouhana et al.   DEVELOPMENT

Planarian yorkie/YAP functions to integrate adult stem cell proliferation, organ homeostasis and maintenance of axial patterning

(2014) A. Y. T. Lin et al.   DEVELOPMENT

Stem cell-dependent formation of a functional anterior regeneration pole in planarians requires Zic and Forkhead transcription factors

(2014) Matthias C. Vogg et al.   DEVELOPMENTAL BIOLOGY

Calcineurin Regulates Coordinated Outgrowth of Zebrafish Regenerating Fins

(2014) Satu Kujawski et al.   DEVELOPMENTAL CELL

Scar-free wound healing and regeneration in amphibians: Immunological influences on regenerative success

(2014) James W. Godwin et al.   DIFFERENTIATION

Organogenesis in a dish: Modeling development and disease using organoid technologies

(2014) M. A. Lancaster et al.   SCIENCE

A forkhead Transcription Factor Is Wound-Induced at the Planarian Midline and Required for Anterior Pole Regeneration

(2014) M. Lucila Scimone et al.   PLoS Genetics

zic-1 Expression in Planarian Neoblasts after Injury Controls Anterior Pole Regeneration

(2014) Constanza Vásquez-Doorman et al.   PLoS Genetics

Selective amputation of the pharynx identifies a FoxA-dependent regeneration program in planaria

(2014) Carolyn E Adler et al.   eLife

The planarian regeneration transcriptome reveals a shared but temporally shifted regulatory program between opposing head and tail scenarios

(2013) Damian Kao et al.   BMC GENOMICS

pbx is required for pole and eye regeneration in planarians

(2013) C.-C. G. Chen et al.   DEVELOPMENT

PBX/extradenticle is required to re-establish axial structures and polarity during planarian regeneration

(2013) R. A. Blassberg et al.   DEVELOPMENT

RNA interference by feeding in vitro-synthesized double-stranded RNA to planarians: Methodology and dynamics

(2013) Labib Rouhana et al.   DEVELOPMENTAL DYNAMICS

Heterochromatin protein 1 promotes self-renewal and triggers regenerative proliferation in adult stem cells

(2013) An Zeng et al.   JOURNAL OF CELL BIOLOGY

Reactivating head regrowth in a regeneration-deficient planarian species

(2013) S.-Y. Liu et al.   NATURE

The molecular logic for planarian regeneration along the anterior–posterior axis

(2013) Yoshihiko Umesono et al.   NATURE

Restoration of anterior regeneration in a planarian with limited regenerative ability

(2013) James M. Sikes et al.   NATURE

The zebrafish as a model for complex tissue regeneration

(2013) Matthew Gemberling et al.   TRENDS IN GENETICS

Muscle Cells Provide Instructions for Planarian Regeneration

(2013) Jessica N. Witchley et al.   Cell Reports

Comparative transcriptome analysis between planarian Dugesia japonica and other platyhelminth species

(2012) Osamu Nishimura et al.   BMC GENOMICS

PRMT5 and the role of symmetrical dimethylarginine in chromatoid bodies of planarian stem cells

(2012) L. Rouhana et al.   DEVELOPMENT

Amputation induces stem cell mobilization to sites of injury during planarian regeneration

(2012) O. C. Guedelhoefer et al.   DEVELOPMENT

A molecular wound response program associated with regeneration initiation in planarians

(2012) D. Wenemoser et al.   GENES & DEVELOPMENT

Planarian regeneration: a classic topic claiming new attention

(2012) Emili Saló et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Decreased neoblast progeny and increased cell death during starvation-induced planarian degrowth

(2012) Cristina González-Estévez et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Heterogeneity of planarian stem cells in the S/G2/M phase

(2012) Sören Moritz et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Hydra, a fruitful model system for 270 years

(2012) Brigitte Galliot   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

The planarian neoblast: the rambling history of its origin and some current black boxes

(2012) Jaume Baguñ   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Noggin and Noggin-Like Genes Control Dorsoventral Axis Regeneration in Planarians

(2011) M. Dolores Molina et al.   CURRENT BIOLOGY

A Bmp/Admp Regulatory Circuit Controls Maintenance and Regeneration of Dorsal-Ventral Polarity in Planarians

(2011) Michael A. Gaviño et al.   CURRENT BIOLOGY

Scaling of morphogen gradients

(2011) Danny Ben-Zvi et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

A LIM-homeobox gene is required for differentiation of Wnt-expressing cells at the posterior end of the planarian body

(2011) T. Hayashi et al.   DEVELOPMENT

Early planarian brain regeneration is independent of blastema polarity mediated by the Wnt/β-catenin pathway

(2011) Marta Iglesias et al.   DEVELOPMENTAL BIOLOGY

Stem cell-based growth, regeneration, and remodeling of the planarian intestine

(2011) David J. Forsthoefel et al.   DEVELOPMENTAL BIOLOGY

The Cellular Basis for Animal Regeneration

(2011) Elly M. Tanaka et al.   DEVELOPMENTAL CELL

De novo assembly and validation of planaria transcriptome by massive parallel sequencing and shotgun proteomics

(2011) C. Adamidi et al.   GENOME RESEARCH

Clonogenic Neoblasts Are Pluripotent Adult Stem Cells That Underlie Planarian Regeneration

(2011) D. E. Wagner et al.   SCIENCE

Polarized notum Activation at Wounds Inhibits Wnt Function to Promote Planarian Head Regeneration

(2011) C. P. Petersen et al.   SCIENCE

dlx and sp6-9 Control Optic Cup Regeneration in a Prototypic Eye

(2011) Sylvain W. Lapan et al.   PLoS Genetics

The head-regeneration transcriptome of the planarian Schmidtea mediterranea

(2011) Thomas Sandmann et al.   GENOME BIOLOGY

Evolution and regeneration of the planarian central nervous system

(2010) Yoshihiko Umesono et al.   DEVELOPMENT GROWTH & DIFFERENTIATION

Single-cell gene profiling of planarian stem cells using fluorescent activated cell sorting and its “index sorting” function for stem cell research

(2010) Tetsutaro Hayashi et al.   DEVELOPMENT GROWTH & DIFFERENTIATION

Different requirements for conserved post-transcriptional regulators in planarian regeneration and stem cell maintenance

(2010) Labib Rouhana et al.   DEVELOPMENTAL BIOLOGY

Planarian regeneration involves distinct stem cell responses to wounds and tissue absence

(2010) Danielle Wenemoser et al.   DEVELOPMENTAL BIOLOGY

Expression of secreted Wnt pathway components reveals unexpected complexity of the planarian amputation response

(2010) Kyle A. Gurley et al.   DEVELOPMENTAL BIOLOGY

A Dual Platform Approach to Transcript Discovery for the Planarian Schmidtea Mediterranea to Establish RNAseq for Stem Cell and Regeneration Biology

(2010) Martin J. Blythe et al.   PLoS One

Long-range neural and gap junction protein-mediated cues control polarity during planarian regeneration

(2009) Néstor J. Oviedo et al.   DEVELOPMENTAL BIOLOGY

A wound-induced Wnt expression program controls planarian regeneration polarity

(2009) C. P. Petersen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regeneration: Rewarding, but potentially risky

(2008) Bernhard Egger   BIRTH DEFECTS RESEARCH PART C-EMBRYO TODAY-REVIEWS

Molecular Analysis of Stem Cells and Their Descendants during Cell Turnover and Regeneration in the Planarian Schmidtea mediterranea

(2008) George T. Eisenhoffer et al.   Cell Stem Cell

Silencing of Smed- catenin1 generates radial-like hypercephalized planarians

(2008) M. Iglesias et al.   DEVELOPMENT

 -Catenin Defines Head Versus Tail Identity During Planarian Regeneration and Homeostasis

(2007) K. A. Gurley et al.   SCIENCE

Smed- catenin-1 Is Required for Anteroposterior Blastema Polarity in Planarian Regeneration

(2007) C. P. Petersen et al.   SCIENCE