Preparative Production of Functionalized (N- and O-Heterocyclic) Polycyclic Aromatic Hydrocarbons by Human Cytochrome P450 3A4 in a Bioreactor

Performance metrics for sustainable catalysis in industry

(2021) Jean-Paul Lange   Nature Catalysis

Evolution and enrichment of CYP5035 in Polyporales: functionality of an understudied P450 family

(2021) Nico D. Fessner et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Natural Product Diversification by One‐Step Biocatalysis using Human P450 3A4

(2021) Nico D. Fessner et al.   ChemCatChem

Late-Stage Functionalisation of Polycyclic (N-Hetero-) Aromatic Hydrocarbons by Detoxifying CYP5035S7 Monooxygenase of the White-Rot Fungus Polyporus arcularius

(2021) Nico D. Fessner et al.   Biomolecules

Preparative‐Scale Production of Testosterone Metabolites by Human Liver Cytochrome P450 Enzyme 3A4

(2020) Nico D. Fessner et al.   ADVANCED SYNTHESIS & CATALYSIS

Cytochrome P450 Monooxygenases in Biotechnology and Synthetic Biology

(2019) Vlada B. Urlacher et al.   TRENDS IN BIOTECHNOLOGY

Energising the E-factor: The E+-factor

(2019) Florian Tieves et al.   TETRAHEDRON

P450 Monooxygenases Enable Rapid Late-Stage Diversification of Natural Products via C−H Bond Activation

(2019) Nico D. Fessner   ChemCatChem

Polycyclic Aromatic Hydrocarbons as Potential Building Blocks for Organic Solar Cells

(2019) Cyril Aumaitre et al.   CHEMICAL RECORD

Facile Synthesis of Polycyclic Aromatic Hydrocarbon (PAH)–Based Acceptors with Fine‐Tuned Optoelectronic Properties: Toward Efficient Additive‐Free Nonfullerene Organic Solar Cells

(2019) Yang Wang et al.   Advanced Energy Materials

Directed Evolution of P450 BM3 towards Functionalization of Aromatic O-Heterocycles

(2019) Gustavo de Almeida Santos et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Application of Palladium-Catalyzed C(sp2)–H Bond Arylation to the Synthesis of Polycyclic (Hetero)Aromatics

(2019) Wided Hagui et al.   Chem

Bottom-Up Synthesis of Nitrogen-Doped Polycyclic Aromatic Hydrocarbons

(2019) Junzhi Liu et al.   SYNLETT

Intercalating pyrene with polypeptide as a novel self-assembly nano-carrier for colon cancer suppression in vitro and in vivo

(2019) Pei-Ying Lo et al.   Materials Science & Engineering C-Materials for Biological Applications

Human Enzymes for Organic Synthesis

(2018) Margit Winkler et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Biocatalytic Oxidation Reactions: A Chemist's Perspective

(2018) JiaJia Dong et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Whole-Cell Cascade Biotransformations for One-Pot Multistep Organic Synthesis

(2018) Shuke Wu et al.   ChemCatChem

The Current Status of O-Heterocycles: A Synthetic and Medicinal Overview

(2018) Pankaj Kumar Singh et al.   ChemMedChem

Membrane-embedded substrate recognition by cytochrome P450 3A4

(2018) John C. Hackett   JOURNAL OF BIOLOGICAL CHEMISTRY

Anthracene-containing polymers toward high-end applications

(2018) Jonas Van Damme et al.   PROGRESS IN POLYMER SCIENCE

Synthesis, Bacteriostatic and Anticancer Activity of Novel Phenanthridines Structurally Similar to Benzo[c]phenanthridine Alkaloids

(2018) Pavel Lasák et al.   MOLECULES

Whole-cell based synthetic enzyme cascades—light and shadow of a promising technology

(2018) Florian Rudroff   CURRENT OPINION IN CHEMICAL BIOLOGY

Phenanthrenes: A Promising Group of Plant Secondary Metabolites

(2017) Barbara Tóth et al.   JOURNAL OF NATURAL PRODUCTS

Oxidation of 1-chloropyrene by human CYP1 family and CYP2A subfamily cytochrome P450 enzymes: catalytic roles of two CYP1B1 and five CYP2A13 allelic variants

(2017) Tsutomu Shimada et al.   XENOBIOTICA

Active Site Crowding of Cytochrome P450 3A4 as a Strategy To Alter Its Selectivity

(2016) Paolo Schiavini et al.   CHEMBIOCHEM

Structure–Function Studies of Naphthalene, Phenanthrene, Biphenyl, and Their Derivatives in Interaction with and Oxidation by Cytochromes P450 2A13 and 2A6

(2016) Tsutomu Shimada et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Intersection of the Roles of Cytochrome P450 Enzymes with Xenobiotic and Endogenous Substrates: Relevance to Toxicity and Drug Interactions

(2016) F. Peter Guengerich   CHEMICAL RESEARCH IN TOXICOLOGY

The medicinal chemist's toolbox for late stage functionalization of drug-like molecules

(2016) Tim Cernak et al.   CHEMICAL SOCIETY REVIEWS

Role of Enzyme Flexibility in Ligand Access and Egress to Active Site: Bias-Exchange Metadynamics Study of 1,3,7-Trimethyluric Acid in Cytochrome P450 3A4

(2016) Markéta Paloncýová et al.   Journal of Chemical Theory and Computation

Recent advances of synthesis of fluorenone and fluorene containing natural products

(2016) Yingbo Shi et al.   TETRAHEDRON

Oxidation of Acenaphthene and Acenaphthylene by Human Cytochrome P450 Enzymes

(2015) Tsutomu Shimada et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Polycyclic Aromatic Hydrocarbons: From Metabolism to Lung Cancer

(2015) Bhagavatula Moorthy et al.   TOXICOLOGICAL SCIENCES

Cytochromes P450 as promising catalysts for biotechnological application: chances and limitations

(2014) Rita Bernhardt et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Survey of Human Oxidoreductases and Cytochrome P450 Enzymes Involved in the Metabolism of Xenobiotic and Natural Chemicals

(2014) Slobodan Rendic et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Analysis of the Structural Diversity, Substitution Patterns, and Frequency of Nitrogen Heterocycles among U.S. FDA Approved Pharmaceuticals

(2014) Edon Vitaku et al.   JOURNAL OF MEDICINAL CHEMISTRY

CYP63A2, a Catalytically Versatile Fungal P450 Monooxygenase Capable of Oxidizing Higher-Molecular-Weight Polycyclic Aromatic Hydrocarbons, Alkylphenols, and Alkanes

(2013) Khajamohiddin Syed et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Cytochrome P450 Bioreactors in the Pharmaceutical Industry: Challenges and Opportunities

(2013) Carlos Martinez et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Rational engineering of the fungal P450 monooxygenase CYP5136A3 to improve its oxidizing activity toward polycyclic aromatic hydrocarbons

(2013) K. Syed et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Polycyclic aromatic hydrocarbons stimulate human CYP3A4 promoter activity via PXR

(2013) Claudia Luckert et al.   TOXICOLOGY LETTERS

Production of human cytochrome P450 2D6 drug metabolites with recombinant microbes - a comparative study

(2012) Martina Geier et al.   Biotechnology Journal

Contributions of Human Enzymes in Carcinogen Metabolism

(2012) Slobodan Rendic et al.   CHEMICAL RESEARCH IN TOXICOLOGY

New Anthracene Derivatives - Structure Elucidation and Antimicrobial Activity

(2012) Abdessamad Debbab et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Hydroxylation of non-substituted polycyclic aromatic hydrocarbons by cytochrome P450 BM3 engineered by directed evolution

(2012) Anastasia Sideri et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

A Fungal P450 (CYP5136A3) Capable of Oxidizing Polycyclic Aromatic Hydrocarbons and Endocrine Disrupting Alkylphenols: Role of Trp129 and Leu324

(2011) Khajamohiddin Syed et al.   PLoS One

Genome-to-function characterization of novel fungal P450 monooxygenases oxidizing polycyclic aromatic hydrocarbons (PAHs)

(2010) Khajamohiddin Syed et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Bioprocess scale-up: quest for the parameters to be used as criterion to move from microreactors to lab-scale

(2010) Marco P. C. Marques et al.   JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY

Rapid synthesis and zebrafish evaluation of a phenanthridine-based small molecule library

(2010) Lauren R. Donaldson et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Production of human phase 1 and 2 metabolites by whole-cell biotransformation with recombinant microbes

(2010) Andy Zöllner et al.   Bioanalysis

Synthesis and Antitumor Activities of Phenanthrene-Based Alkaloids

(2009) Songtao Li et al.   MOLECULES

Scale-up ofEscherichia coli growth and recombinant protein expression conditions from microwell to laboratory and pilot scale based on matchedkLa

(2007) R.S. Islam et al.   BIOTECHNOLOGY AND BIOENGINEERING