Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 57, Issue 41, Pages 13406-13423Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201800678
Keywords
biocatalysis; biotransformation; drug metabolites; human enzymes; pharmaceutical compounds
Categories
Funding
- Innovative Medicines Initiative Joint Undertaking project CHEM21 [8115360]
- uropean Union's Seventh Framework Programme (FP7)
- EFPIA companies
- European Union (EU) project ROBOX under the EU's Horizon 2020 Programme Research and Innovation actions H2020-LEIT BIO-2014-1 [635734]
- Austrian BMWFW
- BMVIT
- SFG
- Stand-ortagentur Tirol
- Government of Lower Austria
- ZIT through the Austrian FFG-COMET- Funding Program
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Human enzymes have been widely studied in various disciplines. The number of reactions taking place in the human body is vast, and so is the number of potential catalysts for synthesis. Herein, we focus on the application of human enzymes that catalyze chemical reactions in course of the metabolism of drugs and xenobiotics. Some of these reactions have been explored on the preparative scale. The major field of application of human enzymes is currently drug development, where they are applied for the synthesis of drug metabolites.
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