Production of human phase 1 and 2 metabolites by whole-cell biotransformation with recombinant microbes

Biotechnological Synthesis of the Designer Drug Metabolite 4'-Hydroxymethyl- -pyrrolidinohexanophenone in Fission Yeast Heterologously Expressing Human Cytochrome P450 2D6--A Versatile Alternative to Multistep Chemical Synthesis

(2013) F. T. Peters et al.   JOURNAL OF ANALYTICAL TOXICOLOGY

Optimization of the enzymatic hydrolysis and analysis of plasma conjugated γ-CEHC and sulfated long-chain carboxychromanols, metabolites of vitamin E

(2009) Helene Freiser et al.   ANALYTICAL BIOCHEMISTRY

UGT1A1 genotyping: a predictor of irinotecan-associated side effects and drug efficacy?

(2009) Christoph Schulz et al.   ANTI-CANCER DRUGS

CYP21-catalyzed production of the long-term urinary metandienone metabolite 17β-hydroxymethyl-17α-methyl-18-norandrosta-1,4,13-trien-3-one: a contribution to the fight against doping

(2009) Andy Zöllner et al.   BIOLOGICAL CHEMISTRY

Predicting Circulating Human Metabolites: How Good Are We?

(2009) Shelby Anderson et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Pharmacogenetics of Phase I and Phase II Drug Metabolism

(2009) Severine Crettol et al.   CURRENT PHARMACEUTICAL DESIGN

Isolation and Identification of Urinary Metabolites of Kakkalide in Rats

(2009) X. Bai et al.   DRUG METABOLISM AND DISPOSITION

Glucuronide Production by Whole-Cell Biotransformation Using Genetically Engineered Fission Yeast Schizosaccharomyces pombe

(2009) C.-A. Dragan et al.   DRUG METABOLISM AND DISPOSITION

The Role of Human UDP-Glucuronyltransferases on the Formation of the Methylenedioxymethamphetamine (Ecstasy) Phase II Metabolites R- and S-3-Methoxymethamphetamine 4-O-Glucuronides

(2009) A. E. Schwaninger et al.   DRUG METABOLISM AND DISPOSITION

Synthesis, structure characterization, and enzyme screening of clenbuterol glucuronides

(2009) Anna Alonen et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Use of fission yeast heterologously expressing human cytochrome P450 2B6 in biotechnological synthesis of the designer drug metabolite N-(1-phenylcyclohexyl)-2-hydroxyethanamine

(2009) Frank T. Peters et al.   FORENSIC SCIENCE INTERNATIONAL

Application of a Fed-Batch Bioprocess for the Heterologous Production of hSCOMT in Escherichia coli

(2009) L. A. Passarinha   JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY

Engineering the Pichia pastoris methanol oxidation pathway for improved NADH regeneration during whole-cell biotransformation

(2009) Kirsten Schroer et al.   METABOLIC ENGINEERING

Genome sequence of the recombinant protein production host Pichia pastoris

(2009) Kristof De Schutter et al.   NATURE BIOTECHNOLOGY

Biotechnological synthesis of drug metabolites using human cytochrome P450 isozymes heterologously expressed in fission yeast

(2009) Frank T Peters et al.   Bioanalysis

Topological aspects of oligomeric UDP-glucuronosyltransferases in endoplasmic reticulum membranes: Advances and open questions

(2008) Karl Walter Bock et al.   BIOCHEMICAL PHARMACOLOGY

Human CYP4Z1 catalyzes the in-chain hydroxylation of lauric acid and myristic acid

(2008) Andy Zöllner et al.   BIOLOGICAL CHEMISTRY

Heme-iron oxygenases: powerful industrial biocatalysts?

(2008) Mattijs K Julsing et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Role of active metabolites in the use of opioids

(2008) Janet K. Coller et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Purification and functional characterization of human 11β hydroxylase expressed in Escherichia coli

(2008) Andy Zöllner et al.   FEBS Journal

Screening Enantioselective Epoxide Hydrolase Activities from Marine Microorganisms: Detection of Activities in Erythrobacter spp.

(2008) Young-Ok Hwang et al.   MARINE BIOTECHNOLOGY

Biocatalytical production of (5S)-hydroxy-2-hexanone

(2008) Michael Katzberg et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Flavin-containing monooxygenases: mutations, disease and drug response

(2008) I PHILLIPS et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

A new approach on the purification of recombinant human soluble catechol-O-methyltransferase from an Escherichia coli extract using hydrophobic interaction chromatography

(2007) L.A. Passarinha et al.   JOURNAL OF CHROMATOGRAPHY A

Heterologous expression and characterization of wild-type human cytochrome P450 1A2 without conventional N-terminal modification in Escherichia coli

(2007) Dong-Hyun Kim et al.   PROTEIN EXPRESSION AND PURIFICATION