Active Site Crowding of Cytochrome P450 3A4 as a Strategy To Alter Its Selectivity
Published 2016 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Active Site Crowding of Cytochrome P450 3A4 as a Strategy To Alter Its Selectivity
Authors
Keywords
-
Journal
CHEMBIOCHEM
Volume 18, Issue 3, Pages 248-252
Publisher
Wiley
Online
2016-11-29
DOI
10.1002/cbic.201600546
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Structural basis of steroid binding and oxidation by the cytochrome P450 CYP109E1 fromBacillus megaterium
- (2016) Ilona K. Jóźwik et al. FEBS Journal
- Recent Advances in C–H Functionalization
- (2016) Huw M. L. Davies et al. JOURNAL OF ORGANIC CHEMISTRY
- Minimalist Protein Engineering of an Aldolase Provokes Unprecedented Substrate Promiscuity
- (2016) Deniz Güclü et al. ACS Catalysis
- Expanding the toolbox of organic chemists: directed evolution of P450 monooxygenases as catalysts in regio- and stereoselective oxidative hydroxylation
- (2015) Gheorghe-Doru Roiban et al. CHEMICAL COMMUNICATIONS
- Single-Point Mutation with a Rotamer Library Toolkit: Toward Protein Engineering
- (2015) Joshua Pottel et al. Journal of Chemical Information and Modeling
- Methods for the directed evolution of proteins
- (2015) Michael S. Packer et al. NATURE REVIEWS GENETICS
- Extending the biocatalytic scope of regiocomplementary flavin-dependent halogenase enzymes
- (2015) Sarah A. Shepherd et al. Chemical Science
- Selective allylic hydroxylation of acyclic terpenoids by CYP154E1 fromThermobifida fuscaYX
- (2014) Anna M Bogazkaya et al. Beilstein Journal of Organic Chemistry
- Synthesis of Transition-Metal Steroid Derivatives
- (2013) Franck Le Bideau et al. CHEMICAL REVIEWS
- NDM-1, the ultimate promiscuous enzyme: substrate recognition and catalytic mechanism
- (2013) Youngchang Kim et al. FASEB JOURNAL
- Biocatalysis in Organic Chemistry and Biotechnology: Past, Present, and Future
- (2013) Manfred T. Reetz JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Engineering an Enantioselective Amine Oxidase for the Synthesis of Pharmaceutical Building Blocks and Alkaloid Natural Products
- (2013) Diego Ghislieri et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Cytochrome P450 enzymes in drug metabolism: Regulation of gene expression, enzyme activities, and impact of genetic variation
- (2013) Ulrich M. Zanger et al. PHARMACOLOGY & THERAPEUTICS
- Dual use of a chemical auxiliary: molecularly imprinted polymers for the selective recovery of products from biocatalytic reaction mixtures
- (2012) Aaron T. Larsen et al. GREEN CHEMISTRY
- Development of a Computational Tool to Rival Experts in the Prediction of Sites of Metabolism of Xenobiotics by P450s
- (2012) Valérie Campagna-Slater et al. Journal of Chemical Information and Modeling
- Controlled Oxidation of Remote sp3 C–H Bonds in Artemisinin via P450 Catalysts with Fine-Tuned Regio- and Stereoselectivity
- (2012) Kaidong Zhang et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Tuning P450 Enzymes as Oxidation Catalysts
- (2012) Rudi Fasan ACS Catalysis
- C–H functionalization logic in total synthesis
- (2011) Will R. Gutekunst et al. CHEMICAL SOCIETY REVIEWS
- P450BM3(CYP102A1): connecting the dots
- (2011) Christopher J. C. Whitehouse et al. CHEMICAL SOCIETY REVIEWS
- Integrating Medicinal Chemistry, Organic/Combinatorial Chemistry, and Computational Chemistry for the Discovery of Selective Estrogen Receptor Modulators with Forecaster, a Novel Platform for Drug Discovery
- (2011) Eric Therrien et al. Journal of Chemical Information and Modeling
- P450 Fingerprinting Method for Rapid Discovery of Terpene Hydroxylating P450 Catalysts with Diversified Regioselectivity
- (2011) Kaidong Zhang et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Predictable Stereoselective and Chemoselective Hydroxylations and Epoxidations with P450 3A4
- (2011) Aaron T. Larsen et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Regio- and stereoselectivity of P450-catalysed hydroxylation of steroids controlled by laboratory evolution
- (2011) Sabrina Kille et al. Nature Chemistry
- Cytochrome P450 monooxygenases: an update on perspectives for synthetic application
- (2011) Vlada B. Urlacher et al. TRENDS IN BIOTECHNOLOGY
- Regioselective hydroxylation of norisoprenoids by CYP109D1 from Sorangium cellulosum So ce56
- (2010) Yogan Khatri et al. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
- Screening of a minimal enriched P450 BM3 mutant library for hydroxylation of cyclic and acyclic alkanes
- (2010) Evelyne Weber et al. CHEMICAL COMMUNICATIONS
- Enzymatic functionalization of carbon–hydrogen bonds
- (2010) Jared C. Lewis et al. CHEMICAL SOCIETY REVIEWS
- Inclusion of Dispersion Effects Significantly Improves Accuracy of Calculated Reaction Barriers for Cytochrome P450 Catalyzed Reactions
- (2010) Richard Lonsdale et al. Journal of Physical Chemistry Letters
- Directed evolution drives the next generation of biocatalysts
- (2009) Nicholas J Turner Nature Chemical Biology
- Flexibility of Human Cytochromes P450: Molecular Dynamics Reveals Differences between CYPs 3A4, 2C9, and 2A6, which Correlate with Their Substrate Preferences
- (2008) Josef Skopalík et al. JOURNAL OF PHYSICAL CHEMISTRY B
- A Quantitative Index of Substrate Promiscuity†
- (2007) Abhinav Nath et al. BIOCHEMISTRY
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationAdd your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload Now