Review
Biotechnology & Applied Microbiology
Yongfa Wang, Hao Pan, Fuhao Wang, Chen Shen
Summary: This review focuses on the P450 groups in microorganisms, including their distribution and application. Microbial P450 enzymes have great potential for applications, but the functions of most of them have not been studied. Therefore, selecting suitable P450 enzymes from a large P450 library, combined with engineering and immobilization technologies, can promote the large-scale application of microbial P450 enzymes.
BIOTECHNOLOGY AND BIOENGINEERING
(2023)
Review
Chemistry, Physical
Donya Valikhani, Juan M. Bolivar, Joelle N. Pelletier
Summary: Cytochrome P450s are a large superfamily of heme proteins with important applications in drug metabolism studies and biocatalytic transformations. Immobilization of P450 enzymes on biosensing platforms and in biocatalytic reactions plays a key role in improving operational stability. Various methods and materials have been developed to address the challenges associated with the unique characteristics of P450s in different applications.
Review
Biochemistry & Molecular Biology
Aminah Alchakee, Munazza Ahmed, Leen Eldohaji, Hamid Alhaj, Maha Saber-Ayad
Summary: The review focuses on cytochrome P450 enzymes and their association with the metabolism of psychotropic medications, variations among different populations, impact on neurotransmitters, and the influence of non-genetic factors. It also discusses the association between adverse effects of psychiatric medications and human leukocytic antigen genotypes. The importance of pharmacogenetics implementation in psychiatry clinics is emphasized.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Engineering, Chemical
Mehakpreet Singh, Saeed Shirazian, Vivek Ranade, Gavin M. Walker, Ashish Kumar
Summary: Wet granulation is a crucial step in the manufacturing of solid-dosage forms in the pharmaceutical industry. Modelling wet granulation plays a vital role in shifting from batch mode to continuous production and implementing the Quality-by-Design approach. Three major models, including population balance model, discrete element method, and data-driven models, are evaluated in this review. Each approach has its advantages and can provide insights into different aspects of wet granulation. However, further research is needed to improve the accuracy and applicability of these models.
Review
Biotechnology & Applied Microbiology
Robert Haas, Pablo I. Nikel
Summary: The limited range of chemical elements in the microbial 'biochemical palate' hinders the application of biotechnology, as some valuable compounds can only be produced through traditional organic chemistry. Synthetic biology provides tools to overcome this constraint by facilitating the incorporation of non-canonical chemical atoms into engineered microbes. This review explores natural assimilation routes for elements beyond the essential biology atoms and proposes a computational framework to identify elements amenable to biologization, offering sustainable alternatives for chemical production when combined with robust microbial hosts.
TRENDS IN BIOTECHNOLOGY
(2023)
Review
Computer Science, Information Systems
Urvish Thakker, Ruhi Patel, Sudeep Tanwar, Neeraj Kumar, Houbing Song
Summary: The integration of blockchain technology in the diamond industry provides new possibilities for addressing issues in the industry, while also bringing convenience and confidence to investors and consumers. By integrating blockchain technology, the diamond industry can improve security, transparency, and traceability.
IEEE INTERNET OF THINGS JOURNAL
(2021)
Article
Engineering, Environmental
Hyung-Sool Lee, Baoqiang Liao
Summary: Anaerobic membrane bioreactors (AnMBRs) are widely used in wastewater treatment, but challenges such as nitrogen and dissolved methane control, membrane fouling, and high costs need to be addressed to facilitate their application. Efforts to decrease capital and O & M costs associated with dissolved methane nitrogen control and membrane fouling are necessary to improve the wide application of AnMBRs.
WATER ENVIRONMENT RESEARCH
(2021)
Article
Green & Sustainable Science & Technology
Neil E. Coughlan, Eamonn Walsh, Paul Bolger, Gavin Burnell, Niall O'Leary, Maria O'Mahoney, Simona Paolacci, David Wall, Marcel A. K. Jansen
Summary: Duckweeds, a type of Lemnaceae, have gained attention as a sustainable source of nutrition, biofuel, and pharmaceuticals, as well as for their ability to remediate wastewaters. Indoor cultivation of duckweed can maximize yields, provide pest-free and sterile conditions, and enable crop manipulation. Technological advances in urban and vertical farming can be utilized to design and operate novel duckweed cultivation systems, including recirculating flow-through technology and sensor support systems with artificial intelligence. Despite challenges and knowledge gaps, there are realistic opportunities to develop and operate high-capacity, autonomous, controlled cultivation of duckweed under indoor conditions for various purposes.
JOURNAL OF CLEANER PRODUCTION
(2022)
Article
Engineering, Chemical
Miriam Sarkis, Andrea Bernardi, Nilay Shah, Maria M. Papathanasiou
Summary: The rise of personalised and complex drug products requires significant advancements in pharmaceutical manufacturing and distribution. This paper discusses the challenges and opportunities in this area, emphasizing the application of digital tools and process systems engineering in pharmaceutical operations.
Article
Green & Sustainable Science & Technology
Mari Lie Larsen, Kendra Dupuy
Summary: The article examines the impact of the electricity allocation process on the establishment, growth, and geographical location of new green industry firms. Through a study in Norway, it is found that the management of the electrical grid hinders green industry firms in accessing power, due to regional variation in electricity availability, unclear rules and queue systems for accessing the grid, and a lengthy and potentially costly process for gaining access. These findings highlight the importance of formal and informal rules in determining the establishment of green industry firms and may impede progress on climate goals.
JOURNAL OF CLEANER PRODUCTION
(2023)
Article
Automation & Control Systems
Christopher J. Turner, Ohn Oyekan, Lampros Stergioulas, David Griffin
Summary: In recent years, there has been a significant increase in the adoption of Industry 4.0 technologies by manufacturers and industrial organizations, including within the construction industry. The use of these technologies is driven by the increasing complexity of onsite construction projects and the need for higher productivity. Industrial connectivity is crucial for ensuring the full benefits of Industry 4.0 technologies are realized.
IEEE TRANSACTIONS ON INDUSTRIAL INFORMATICS
(2021)
Review
Pharmacology & Pharmacy
Deniz Ceylan Tuncaboylu, Christian Wischke
Summary: Switchable polymeric materials are a major focus for parenteral controlled delivery systems, allowing for externally induced drug release adaptive to in vivo stimuli. While offering new functionalities, challenges may arise in their clinical use.
Review
Chemistry, Medicinal
Ziru Dai, Yue Wu, Yuan Xiong, Jingjing Wu, Min Wang, Xiao Sun, Xinxin Ding, Ling Yang, Xiaobo Sun, Guangbo Ge
Summary: Mammalian cytochrome P450 1A (CYP1A) is an essential enzyme involved in the metabolism of xenobiotics. Inhibiting CYP1A activity has shown potential for cancer chemoprevention and overcoming drug resistance. This review summarizes recent advances in the discovery and characterization of CYP1A inhibitors and provides comprehensive information on their inhibitory properties. The structural features and structure-activity relationships of different classes of inhibitors are also analyzed.
MEDICINAL RESEARCH REVIEWS
(2023)
Review
Pharmacology & Pharmacy
Mengsuo Cui, Hao Pan, Yupei Su, Dongyang Fang, Sen Qiao, Pingtian Ding, Weisan Pan
Summary: Three-dimensional printing technology prints products layer by layer, offering competitive advantages in product design complexity, personalization, and on-demand manufacturing. This technology shows innovative potential in drug delivery systems, while also facing limitations and challenges in pharmaceutical formulation development.
ACTA PHARMACEUTICA SINICA B
(2021)
Article
Business
Pei-Hsuan Tsai, Chih-Jou Chen
Summary: This study investigates key development evaluation indicators in the TV game console industry using a hybrid multiple attribute decision making model. The results indicate that the improvement priorities for the model's dimensions are benefits, opportunity, costs, and risks, in that order. Several implications for industry management are also discussed.
JOURNAL OF RETAILING AND CONSUMER SERVICES
(2021)
