Brown/Beige adipose tissues and the emerging role of their secretory factors in improving metabolic health: The batokines

Inverse relationship between serum Metrnl levels and visceral fat obesity (VFO) in patients with type 2 diabetes

(2020) Yunfeng Du et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

CD137 negatively affects “browning” of white adipose tissue during cold exposure

(2020) Raj Kamal Srivastava et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endogenous FGF21-signaling controls paradoxical obesity resistance of UCP1-deficient mice

(2020) Susanne Keipert et al.   Nature Communications

EPDR1 up-regulation in human colorectal cancer is related to staging and favours cell proliferation and invasiveness

(2020) F. Gimeno-Valiente et al.   Scientific Reports

Adipose TBX1 Regulates β-Adrenergic Sensitivity in Subcutaneous Adipose Tissue and Thermogenic Capacity In Vivo

(2020) Kathleen R. Markan et al.   Molecular Metabolism

Inflammatory Signaling and Brown Fat Activity

(2020) Farah Omran et al.   Frontiers in Endocrinology

Origin and Function of Stress-Induced IL-6 in Murine Models

(2020) Hua Qing et al.   CELL

Molecular Mechanisms of Adipogenesis: The Anti-adipogenic Role of AMP-Activated Protein Kinase

(2020) Bilal Ahmad et al.   Frontiers in Molecular Biosciences

Calsyntenin 3β Is Dynamically Regulated by Temperature in Murine Brown Adipose and Marks Human Multilocular Fat

(2020) Kaja Plucińska et al.   Frontiers in Endocrinology

Adipogenesis and metabolic health

(2019) Alexandra L. Ghaben et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Neuregulin 4 Is a Novel Marker of Beige Adipocyte Precursor Cells in Human Adipose Tissue

(2019) Ferran Comas et al.   Frontiers in Physiology

Interleukin-6 released from differentiating human beige adipocytes improves browning

(2019) Endre Kristóf et al.   EXPERIMENTAL CELL RESEARCH

Innervation of thermogenic adipose tissue via a calsyntenin 3β–S100b axis

(2019) Xing Zeng et al.   NATURE

The beneficial effects of brown adipose tissue transplantation

(2019) Joseph D. White et al.   MOLECULAR ASPECTS OF MEDICINE

The endocrine function of adipose tissues in health and cardiometabolic disease

(2019) Ludger Scheja et al.   Nature Reviews Endocrinology

Adipose Tissue-Derived Signatures for Obesity and Type 2 Diabetes: Adipokines, Batokines and MicroRNAs

(2019) Min-Woo Lee et al.   Journal of Clinical Medicine

Brown Adipocytes Secrete GDF15 in Response to Thermogenic Activation

(2019) Laura Campderrós et al.   Obesity

Proteomics-Based Comparative Mapping of the Secretomes of Human Brown and White Adipocytes Reveals EPDR1 as a Novel Batokine

(2019) Atul S. Deshmukh et al.   Cell Metabolism

Brown adipose cross talk in tissue plasticity and human metabolism

(2019) Camilla Scheele et al.   ENDOCRINE REVIEWS

The Beige Adipocyte as a Therapy for Metabolic Diseases

(2019) Fernando Lizcano   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Increased Expression of Meteorin-Like Hormone in Type 2 Diabetes and Obesity and Its Association with Irisin

(2019) AlKhairi et al.   Cells

A 2A Receptor Activation Attenuates Hypertensive Cardiac Remodeling via Promoting Brown Adipose Tissue-Derived FGF21

(2018) Cheng-Chao Ruan et al.   Cell Metabolism

Distinct signalling properties of insulin receptor substrate (IRS)-1 and IRS-2 in mediating insulin/IGF-1 action

(2018) Atefeh Rabiee et al.   CELLULAR SIGNALLING

Increased plasma FGF21 level as an early biomarker for insulin resistance and metabolic disturbance in obese insulin-resistant rats

(2018) Pongpan Tanajak et al.   Diabetes & Vascular Disease Research

Inflammation of brown/beige adipose tissues in obesity and metabolic disease

(2018) F. Villarroya et al.   JOURNAL OF INTERNAL MEDICINE

The Common and Distinct Features of Brown and Beige Adipocytes

(2018) Kenji Ikeda et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Low temperature exposure induces browning of bone marrow stem cell derived adipocytes in vitro

(2018) Ksenija Velickovic et al.   Scientific Reports

Brown Adipose Tissue Controls Skeletal Muscle Function via the Secretion of Myostatin

(2018) Xingxing Kong et al.   Cell Metabolism

CXCL14, a Brown Adipokine that Mediates Brown-Fat-to-Macrophage Communication in Thermogenic Adaptation

(2018) Rubén Cereijo et al.   Cell Metabolism

Fighting obesity by targeting factors regulating beige adipocytes

(2018) Allison E. McQueen et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Small molecules for fat combustion: targeting obesity

(2018) Jingxin Liu et al.   Acta Pharmaceutica Sinica B

Transcriptional Control of Brown and Beige Fat Development and Function

(2018) Suzanne N. Shapira et al.   Obesity

Adipocyte-secreted BMP8b mediates adrenergic-induced remodeling of the neuro-vascular network in adipose tissue

(2018) Vanessa Pellegrinelli et al.   Nature Communications

UCP1-independent signaling involving SERCA2b-mediated calcium cycling regulates beige fat thermogenesis and systemic glucose homeostasis

(2017) Kenji Ikeda et al.   NATURE MEDICINE

The Lives and Times of Brown Adipokines

(2017) Francesc Villarroya et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

IL-6 Improves Energy and Glucose Homeostasis in Obesity via Enhanced Central IL-6 trans -Signaling

(2017) Katharina Timper et al.   Cell Reports

Common and distinct regulation of human and mouse brown and beige adipose tissues: a promising therapeutic target for obesity

(2017) Xuejiao Liu et al.   Protein & Cell

Nrg4 promotes fuel oxidation and a healthy adipokine profile to ameliorate diet-induced metabolic disorders

(2017) Zhimin Chen et al.   Molecular Metabolism

The significance of beige and brown fat in humans

(2017) Florian W Kiefer   Endocrine Connections

Quantification of UCP1 function in human brown adipose tissue

(2017) Craig Porter   Adipocyte

AgRP Neurons Control Systemic Insulin Sensitivity via Myostatin Expression in Brown Adipose Tissue

(2016) Sophie M. Steculorum et al.   CELL

Beige Adipocyte Maintenance Is Regulated by Autophagy-Induced Mitochondrial Clearance

(2016) Svetlana Altshuler-Keylin et al.   Cell Metabolism

A Secreted Slit2 Fragment Regulates Adipose Tissue Thermogenesis and Metabolic Function

(2016) Katrin J. Svensson et al.   Cell Metabolism

Autocrine effect of vascular endothelial growth factor-A is essential for mitochondrial function in brown adipocytes

(2016) Kiana Mahdaviani et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Brown adipose tissue as a secretory organ

(2016) Francesc Villarroya et al.   Nature Reviews Endocrinology

Control of brown and beige fat development

(2016) Wenshan Wang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Gq signalling pathway inhibits brown and beige adipose tissue

(2016) Katarina Klepac et al.   Nature Communications

The lipid sensor GPR120 promotes brown fat activation and FGF21 release from adipocytes

(2016) Tania Quesada-López et al.   Nature Communications

EBF2 promotes the recruitment of beige adipocytes in white adipose tissue

(2016) Rachel R. Stine et al.   Molecular Metabolism

A Creatine-Driven Substrate Cycle Enhances Energy Expenditure and Thermogenesis in Beige Fat

(2015) Lawrence Kazak et al.   CELL

Hepatic Acetyl CoA Links Adipose Tissue Inflammation to Hepatic Insulin Resistance and Type 2 Diabetes

(2015) Rachel J. Perry et al.   CELL

Adiponectin Enhances Cold-Induced Browning of Subcutaneous Adipose Tissue via Promoting M2 Macrophage Proliferation

(2015) Xiaoyan Hui et al.   Cell Metabolism

Brown and Beige Fat: Physiological Roles beyond Heat Generation

(2015) Shingo Kajimura et al.   Cell Metabolism

Adipocyte Metrnl Antagonizes Insulin Resistance Through PPARγ Signaling

(2015) Zhi-Yong Li et al.   DIABETES

Cold-Inducible Zfp516 Activates UCP1 Transcription to Promote Browning of White Fat and Development of Brown Fat

(2015) Jon Dempersmier et al.   MOLECULAR CELL

Could burning fat start with a brite spark? Pharmacological and nutritional ways to promote thermogenesis

(2015) Jon Merlin et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Distinct regulatory mechanisms governing embryonic versus adult adipocyte maturation

(2015) Qiong A. Wang et al.   NATURE CELL BIOLOGY

The brown fat secretome: metabolic functions beyond thermogenesis

(2015) Guo-Xiao Wang et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

The Role of Endothelin-1 and Endothelin Receptor Antagonists in Inflammatory Response and Sepsis

(2014) Agata Kowalczyk et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

Meteorin-like Is a Hormone that Regulates Immune-Adipose Interactions to Increase Beige Fat Thermogenesis

(2014) Rajesh R. Rao et al.   CELL

Prdm16 Is Required for the Maintenance of Brown Adipocyte Identity and Function in Adult Mice

(2014) Matthew J. Harms et al.   Cell Metabolism

Irisin and FGF21 Are Cold-Induced Endocrine Activators of Brown Fat Function in Humans

(2014) Paul Lee et al.   Cell Metabolism

The T-box gene family: emerging roles in development, stem cells and cancer

(2014) V. E. Papaioannou   DEVELOPMENT

From cytokine to myokine: the emerging role of interleukin-6 in metabolic regulation

(2014) Martin Pal et al.   IMMUNOLOGY AND CELL BIOLOGY

Vascular rarefaction mediates whitening of brown fat in obesity

(2014) Ippei Shimizu et al.   JOURNAL OF CLINICAL INVESTIGATION

BMP7 Drives Human Adipogenic Stem Cells into Metabolically Active Beige Adipocytes

(2014) Meshail Okla et al.   LIPIDS

The brown fat–enriched secreted factor Nrg4 preserves metabolic homeostasis through attenuation of hepatic lipogenesis

(2014) Guo-Xiao Wang et al.   NATURE MEDICINE

Ebf2 is a selective marker of brown and beige adipogenic precursor cells

(2014) Wenshan Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Brown adipose tissue derived VEGF-A modulates cold tolerance and energy expenditure

(2014) Kai Sun et al.   Molecular Metabolism

Distinction of white, beige and brown adipocytes derived from mesenchymal stem cells

(2014) Anna Park   World Journal of Stem Cells

Transcriptional fingerprinting of “browning” white fat identifies NRG4 as a novel adipokine

(2014) Mark Christian   Adipocyte

EBF2 Determines and Maintains Brown Adipocyte Identity

(2013) Sona Rajakumari et al.   Cell Metabolism

White, Brown, Beige/Brite: Different Adipose Cells for Different Functions?

(2013) Marta Giralt et al.   ENDOCRINOLOGY

Inducible Brown Adipose Tissue, or Beige Fat, Is Anabolic for the Skeleton

(2013) Sima Rahman et al.   ENDOCRINOLOGY

Adipocyte and adipogenesis

(2013) Aus Tariq Ali et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Brown and beige fat: development, function and therapeutic potential

(2013) Matthew Harms et al.   NATURE MEDICINE

Fibroblast growth factor 21 protects against cardiac hypertrophy in mice

(2013) A. Planavila et al.   Nature Communications

Cardioprotective proteins upregulated in the liver in response to experimental myocardial ischemia

(2012) Shu Q. Liu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Adipogenesis: From Stem Cell to Adipocyte

(2012) Qi Qun Tang et al.   Annual Review of Biochemistry

BMP8B Increases Brown Adipose Tissue Thermogenesis through Both Central and Peripheral Actions

(2012) Andrew J. Whittle et al.   CELL

Beige Adipocytes Are a Distinct Type of Thermogenic Fat Cell in Mouse and Human

(2012) Jun Wu et al.   CELL

PTEN Loss in the Myf5 Lineage Redistributes Body Fat and Reveals Subsets of White Adipocytes that Arise from Myf5 Precursors

(2012) Joan Sanchez-Gurmaches et al.   Cell Metabolism

Reversal of Type 1 Diabetes in Mice by Brown Adipose Tissue Transplant

(2012) S. C. Gunawardana et al.   DIABETES

Mild Cold Exposure Modulates Fibroblast Growth Factor 21 (FGF21) Diurnal Rhythm in Humans: Relationship between FGF21 Levels, Lipolysis, and Cold-Induced Thermogenesis

(2012) Paul Lee et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Blockade of the Activin Receptor IIB Activates Functional Brown Adipogenesis and Thermogenesis by Inducing Mitochondrial Oxidative Metabolism

(2012) B. Fournier et al.   MOLECULAR AND CELLULAR BIOLOGY

Cold but not sympathomimetics activates human brown adipose tissue in vivo

(2012) A. M. Cypess et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Myostatin inhibits brown adipocyte differentiation via regulation of Smad3-mediated β-catenin stabilization

(2011) Won Kon Kim et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

The Heparin-binding Domain of IGFBP-2 Has Insulin-like Growth Factor Binding-independent Biologic Activity in the Growing Skeleton

(2011) Masanobu Kawai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Thermogenic Activation Induces FGF21 Expression and Release in Brown Adipose Tissue

(2011) Elayne Hondares et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Insulin-like growth factor-binding protein-2 is required for osteoclast differentiation

(2011) Victoria E DeMambro et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Adipogenesis at a glance

(2011) C. E. Lowe et al.   JOURNAL OF CELL SCIENCE

Quantification of the effect of energy imbalance on bodyweight

(2011) Kevin D Hall et al.   LANCET

Forming functional fat: a growing understanding of adipocyte differentiation

(2011) Ana G. Cristancho et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The emergence of cold-induced brown adipocytes in mouse white fat depots is determined predominantly by white to brown adipocyte transdifferentiation

(2010) G. Barbatelli et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Human Brown Adipose Tissue

(2010) Sven Enerbäck   Cell Metabolism

Hepatic FGF21 Expression Is Induced at Birth via PPARα in Response to Milk Intake and Contributes to Thermogenic Activation of Neonatal Brown Fat

(2010) Elayne Hondares et al.   Cell Metabolism

Acute Stimulation of White Adipocyte Respiration by PKA-Induced Lipolysis

(2010) E. Yehuda-Shnaidman et al.   DIABETES

Interleukin-6-deficient mice develop hepatic inflammation and systemic insulin resistance

(2010) V. B. Matthews et al.   DIABETOLOGIA

The T3Receptor β1 Isoform Regulates UCP1 and D2 Deiodinase in Rat Brown Adipocytes

(2010) Raquel Martinez de Mena et al.   ENDOCRINOLOGY

Hypoxia-Independent Angiogenesis in Adipose Tissues during Cold Acclimation

(2009) Yuan Xue et al.   Cell Metabolism

Chronic Peroxisome Proliferator-activated Receptor γ (PPARγ) Activation of Epididymally Derived White Adipocyte Cultures Reveals a Population of Thermogenically Competent, UCP1-containing Adipocytes Molecularly Distinct from Classic Brown Adipocytes

(2009) Natasa Petrovic et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PRDM16: the interconvertible adipo-myocyte switch

(2009) Gema Frühbeck et al.   TRENDS IN CELL BIOLOGY

Serum FGF21 Levels Are Increased in Obesity and Are Independently Associated With the Metabolic Syndrome in Humans

(2008) X. Zhang et al.   DIABETES

Regulation of the brown and white fat gene programs through a PRDM16/CtBP transcriptional complex

(2008) S. Kajimura et al.   GENES & DEVELOPMENT

PRDM16 controls a brown fat/skeletal muscle switch

(2008) Patrick Seale et al.   NATURE

New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure

(2008) Yu-Hua Tseng et al.   NATURE