Senolytic agent Quercetin ameliorates intervertebral disc degeneration via the Nrf2/NF-κB axis

Mfn2 is involved in intervertebral disc degeneration through autophagy modulation

(2020) Y. Chen et al.   OSTEOARTHRITIS AND CARTILAGE

p16 deficiency attenuates intervertebral disc degeneration by adjusting oxidative stress and nucleus pulposus cell cycle

(2020) Hui Che et al.   eLife

Pharmacokinetic comparison of quercetin, isoquercitrin, and quercetin-3-O-β-D-glucuronide in rats by HPLC-MS

(2019) Hongli Yin et al.   PeerJ

Rapamycin Induced Autophagy Inhibits Inflammation-Mediated Endplate Degeneration by Enhancing Nrf2/Keap1 Signaling of Cartilage Endplate Stem Cells

(2019) Rui Zuo et al.   STEM CELLS

Systemic clearance of p16 INK4a ‐positive senescent cells mitigates age‐associated intervertebral disc degeneration

(2019) Prashanti Patil et al.   AGING CELL

Quercetin protects against cisplatin‐induced acute kidney injury by inhibiting Mincle/Syk/NF‐κB signaling maintained macrophage inflammation

(2019) Rui‐Zhi Tan et al.   PHYTOTHERAPY RESEARCH

Quercetin alleviates rat osteoarthritis by inhibiting inflammation and apoptosis of chondrocytes, modulating synovial macrophages polarization to M2 macrophages

(2019) Yue Hu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Polymeric microsphere-facilitated site-specific delivery of quercetin prevents senescence of pancreatic islets in vivo and improves transplantation outcomes in mouse model of diabetes

(2018) Shiva Pathak et al.   Acta Biomaterialia

Quercetin attenuates mitochondrial dysfunction and biogenesis via upregulated AMPK/SIRT1 signaling pathway in OA rats

(2018) Linan Qiu et al.   BIOMEDICINE & PHARMACOTHERAPY

Quercetin and chrysin inhibit nickel-induced invasion and migration by downregulation of TLR4/NF-κB signaling in A549 cells

(2018) Tzu-Chin Wu et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Analysis and Evaluation of the Inhibitory Mechanism of a Novel Angiotensin-I-Converting Enzyme Inhibitory Peptide Derived from Casein Hydrolysate

(2018) Maolin Tu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

The flavonoid quercetin inhibits titanium dioxide (TiO 2 )-induced chronic arthritis in mice

(2018) Sergio M. Borghi et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Polydatin inhibits the IL-1β-induced inflammatory response in human osteoarthritic chondrocytes by activating the Nrf2 signaling pathway and ameliorates murine osteoarthritis

(2018) Shangkun Tang et al.   Food & Function

Targeting heme oxygenase-1 by quercetin ameliorates alcohol-induced acute liver injury via inhibiting NLRP3 inflammasome activation

(2018) Shu Liu et al.   Food & Function

Cellular senescence in osteoarthritis and anti-aging strategies

(2018) Angyang Hou et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Cellular Senescence: The Sought or the Unwanted?

(2018) Yu Sun et al.   TRENDS IN MOLECULAR MEDICINE

Parkin-mediated mitophagy as a potential therapeutic target for intervertebral disc degeneration

(2018) Zengjie Zhang et al.   Cell Death & Disease

Melatonin prevents senescence of canine adipose-derived mesenchymal stem cells through activating NRF2 and inhibiting ER stress

(2018) Jia Fang et al.   Aging-US

TFEB protects nucleus pulposus cells against apoptosis and senescence via restoring autophagic flux

(2018) Gang Zheng et al.   OSTEOARTHRITIS AND CARTILAGE

Quercetin Pretreatment Attenuates Hepatic Ischemia Reperfusion-Induced Apoptosis and Autophagy by Inhibiting ERK/NF-κB Pathway

(2017) Liwei Wu et al.   Gastroenterology Research and Practice

The effect of quercetin nanoparticle on cervical cancer progression by inducing apoptosis, autophagy and anti-proliferation via JAK2 suppression

(2016) Cheng-lin Luo et al.   BIOMEDICINE & PHARMACOTHERAPY

Aging and age related stresses: a senescence mechanism of intervertebral disc degeneration

(2016) F. Wang et al.   OSTEOARTHRITIS AND CARTILAGE

Hepatoprotective Effect of Quercetin on Endoplasmic Reticulum Stress and Inflammation after Intense Exercise in Mice through Phosphoinositide 3-Kinase and Nuclear Factor-Kappa B

(2016) Yuhan Tang et al.   Oxidative Medicine and Cellular Longevity

Pharmacokinetics of single-dose cefuroxime in porcine intervertebral disc and vertebral cancellous bone determined by microdialysis

(2016) Pelle Hanberg et al.   Spine Journal

Advancing the cellular and molecular therapy for intervertebral disc disease

(2015) Daisuke Sakai et al.   ADVANCED DRUG DELIVERY REVIEWS

In vitro Penetration and in vivo Distribution of Honokiol into the Intervertebral Disc in Rat

(2015) Chia-Hsien CHEN et al.   ANALYTICAL SCIENCES

The involvement of p62–Keap1–Nrf2 antioxidative signaling pathway and JNK in the protection of natural flavonoid quercetin against hepatotoxicity

(2015) Li-Li Ji et al.   FREE RADICAL BIOLOGY AND MEDICINE

Therapeutic detoxification of quercetin against carbon tetrachloride-induced acute liver injury in mice and its mechanism

(2014) Jia-qi Zhang et al.   Journal of Zhejiang University-SCIENCE B

Quercetin protects rat dorsal root ganglion neurons against high glucose-induced injury in vitro through Nrf-2/HO-1 activation and NF-κB inhibition

(2013) Yue Shi et al.   ACTA PHARMACOLOGICA SINICA

A rat tail temporary static compression model reproduces different stages of intervertebral disc degeneration with decreased notochordal cell phenotype

(2013) Hiroaki Hirata et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

A complex secretory program orchestrated by the inflammasome controls paracrine senescence

(2013) Juan Carlos Acosta et al.   NATURE CELL BIOLOGY

Expression and Relationship of Proinflammatory Chemokine RANTES/CCL5 and Cytokine IL-1β in Painful Human Intervertebral Discs

(2013) Christopher K. Kepler et al.   SPINE

Emerging role of NF-κB signaling in the induction of senescence-associated secretory phenotype (SASP)

(2011) Antero Salminen et al.   CELLULAR SIGNALLING

Degenerative Magnetic Resonance Imaging Changes in Patients With Chronic Low Back Pain

(2011) Dean Chou et al.   SPINE

Resveratrol and quercetin cooperate to induce senescence-like growth arrest in C6 rat glioma cells

(2009) Lauren L. Zamin et al.   CANCER SCIENCE

Cell surface-bound IL-1  is an upstream regulator of the senescence-associated IL-6/IL-8 cytokine network

(2009) A. V. Orjalo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oncogene-Induced Senescence Relayed by an Interleukin-Dependent Inflammatory Network

(2008) Thomas Kuilman et al.   CELL

Expenditures and Health Status Among Adults With Back and Neck Problems

(2008) Brook I. Martin   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

A Simple Disc Degeneration Model Induced by Percutaneous Needle Puncture in the Rat Tail

(2008) Bin Han et al.   SPINE

Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor

(2008) Jean-Philippe Coppé et al.   PLOS BIOLOGY