Metabolic reprogramming during hyperammonemia targets mitochondrial function and postmitotic senescence

Compound Sarcopenia in Hospitalized Patients with Cirrhosis Worsens Outcomes with Increasing Age

(2021) Nicole Welch et al.   Nutrients

Integrated multiomics analysis identifies molecular landscape perturbations during hyperammonemia in skeletal muscle and myotubes

(2021) Nicole Welch et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Senescence in Post-Mitotic Cells: A Driver of Aging?

(2020) Thomas von Zglinicki et al.   ANTIOXIDANTS & REDOX SIGNALING

Role of Cyclin-Dependent Kinase 1 in Translational Regulation in the M-Phase

(2020) Jaroslav Kalous et al.   Cells

Alpha-Ketoglutarate, an Endogenous Metabolite, Extends Lifespan and Compresses Morbidity in Aging Mice

(2020) Azar Asadi Shahmirzadi et al.   Cell Metabolism

Activated protein phosphatase 2A disrupts nutrient sensing balance between mTORC1 and AMPK causing sarcopenia in alcoholic liver disease

(2020) Gangarao Davuluri et al.   HEPATOLOGY

Ethanol sensitizes skeletal muscle to ammonia-induced molecular perturbations

(2019) Sashi Kant et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Impaired Ribosomal Biogenesis by Non-Canonical Degradation of β-catenin during Hyperammonemia

(2019) Gangarao Davuluri et al.   MOLECULAR AND CELLULAR BIOLOGY

Mitochondrial Homeostasis and Cellular Senescence

(2019) Panagiotis V.S. Vasileiou et al.   Cells

Oxidative stress mediates ethanol-induced skeletal muscle mitochondrial dysfunction and dysregulated protein synthesis and autophagy

(2019) Avinash Kumar et al.   FREE RADICAL BIOLOGY AND MEDICINE

Hyperammonemia and proteostasis in cirrhosis

(2018) Srinivasan Dasarathy et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Mechanisms and functions of cellular senescence

(2018) Nicolás Herranz et al.   JOURNAL OF CLINICAL INVESTIGATION

The PRIDE database and related tools and resources in 2019: improving support for quantification data

(2018) Yasset Perez-Riverol et al.   NUCLEIC ACIDS RESEARCH

CDK Phosphorylation of Translation Initiation Factors Couples Protein Translation with Cell-Cycle Transition

(2018) Tai An et al.   Cell Reports

Ammonia lowering reverses sarcopenia of cirrhosis by restoring skeletal muscle proteostasis

(2017) Avinash Kumar et al.   HEPATOLOGY

Human Ageing Genomic Resources: new and updated databases

(2017) Robi Tacutu et al.   NUCLEIC ACIDS RESEARCH

Hyperammonemia results in reduced muscle function independent of muscle mass

(2016) John McDaniel et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Mitochondrial Dysfunction Induces Senescence with a Distinct Secretory Phenotype

(2016) Christopher D. Wiley et al.   Cell Metabolism

Metabolic adaptation of skeletal muscle to hyperammonemia drives the beneficial effects of l-leucine in cirrhosis

(2016) Gangarao Davuluri et al.   JOURNAL OF HEPATOLOGY

Senescence in chronic liver disease: Is the future in aging?

(2016) Aloysious D. Aravinthan et al.   JOURNAL OF HEPATOLOGY

Hyperammonaemia-induced skeletal muscle mitochondrial dysfunction results in cataplerosis and oxidative stress

(2016) Gangarao Davuluri et al.   JOURNAL OF PHYSIOLOGY-LONDON

Ammonia toxicity: from head to toe?

(2016) Srinivasan Dasarathy et al.   METABOLIC BRAIN DISEASE

CSGene: a literature-based database for cell senescence genes and its application to identify critical cell aging pathways and associated diseases

(2016) M Zhao et al.   Cell Death & Disease

The Cost of Protein Production

(2016) Moshe Kafri et al.   Cell Reports

Ammonia as a Potential Neurotoxic Factor in Alzheimer's Disease

(2016) Aida Adlimoghaddam et al.   Frontiers in Molecular Neuroscience

dendextend: an R package for visualizing, adjusting and comparing trees of hierarchical clustering

(2015) Tal Galili   BIOINFORMATICS

Ammonia-induced senescence in cultured rat astrocytes and in human cerebral cortex in hepatic encephalopathy

(2014) Boris Görg et al.   GLIA

Mitochondrial Respiratory Supercomplex Association Limits Production of Reactive Oxygen Species from Complex I

(2013) Evelina Maranzana et al.   ANTIOXIDANTS & REDOX SIGNALING

Hyperammonemia in cirrhosis induces transcriptional regulation of myostatin by an NF- B-mediated mechanism

(2013) J. Qiu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hyperammonemia-mediated autophagy in skeletal muscle contributes to sarcopenia of cirrhosis

(2012) Jia Qiu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Ammonium metabolism in humans

(2012) Maria M. Adeva et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Sealing the Mitochondrial Respirasome

(2012) D. R. Winge   MOLECULAR AND CELLULAR BIOLOGY

Assessing mitochondrial dysfunction in cells

(2011) Martin D. Brand et al.   BIOCHEMICAL JOURNAL

Autophagy and Metabolism

(2010) J. D. Rabinowitz et al.   SCIENCE

A comparative analysis of the cell biology of senescence and aging

(2009) Eun Seong Hwang et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Interaction of oxidative stress, astrocyte swelling and cerebral ammonia toxicity

(2009) Dieter Häussinger et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE