Using azobenzene photocontrol to set proteins in motion

Intrinsic Dynamics of Protein–Peptide Unbinding

(2021) Brankica Jankovic et al.   BIOCHEMISTRY

The Speed of Allosteric Signaling Within a Single-Domain Protein

(2021) Olga Bozovic et al.   Journal of Physical Chemistry Letters

Sequence of Events during Peptide Unbinding from RNase S: A Complete Experimental Description

(2021) Brankica Jankovic et al.   Journal of Physical Chemistry Letters

Photocontrolled Reversible Binding between the Protein A-Derived Z Domain and Immunoglobulin G

(2020) Anders Myrhammar et al.   BIOCONJUGATE CHEMISTRY

Femtosecond-to-millisecond structural changes in a light-driven sodium pump

(2020) Petr Skopintsev et al.   NATURE

Real-time observation of ligand-induced allosteric transitions in a PDZ domain

(2020) Olga Bozovic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nanosecond protein dynamics in a red/green cyanobacteriochrome revealed by transient IR spectroscopy

(2020) David Buhrke et al.   JOURNAL OF CHEMICAL PHYSICS

Sensing the allosteric force

(2020) Olga Bozovic et al.   Nature Communications

Modulating Protein-Protein Interactions with Visible-Light Responsive Peptide Backbone Photoswitches

(2019) Lea Albert et al.   CHEMBIOCHEM

Heteroaryl azo dyes as molecular photoswitches

(2019) Stefano Crespi et al.   Nature Reviews Chemistry

Photocontrolling Protein–Peptide Interactions: From Minimal Perturbation to Complete Unbinding

(2019) Brankica Jankovic et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Optical control of neuronal ion channels and receptors

(2019) Pierre Paoletti et al.   NATURE REVIEWS NEUROSCIENCE

Membrane protein dynamics studied by X-ray lasers – or why only time will tell

(2019) Jörg Standfuss   CURRENT OPINION IN STRUCTURAL BIOLOGY

Photocontrol of peptide secondary structure through non-azobenzene photoswitches

(2019) Victoria Peddie et al.   JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY C-PHOTOCHEMISTRY REVIEWS

Optochemical Control of Biological Processes in Cells and Animals

(2018) Nicholas Ankenbruck et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Modular design of optically controlled protein affinity reagents

(2018) A. Babalhavaeji et al.   CHEMICAL COMMUNICATIONS

Time-resolved infrared studies of the unfolding of a light triggered β-hairpin peptide

(2018) Michael S. Rampp et al.   CHEMICAL PHYSICS

In Vivo Photopharmacology

(2018) Katharina Hüll et al.   CHEMICAL REVIEWS

A non-equilibrium approach to allosteric communication

(2018) Gerhard Stock et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Markov models for the elucidation of allosteric regulation

(2018) Ushnish Sengupta et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Retinal isomerization in bacteriorhodopsin captured by a femtosecond x-ray laser

(2018) Przemyslaw Nogly et al.   SCIENCE

Protein dynamics observed by tunable mid-IR quantum cascade lasers across the time range from 10 ns to 1 s

(2018) Bernd-Joachim Schultz et al.   SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY

Single-Shot Sub-microsecond Mid-infrared Spectroscopy on Protein Reactions with Quantum Cascade Laser Frequency Combs

(2018) Jessica L. Klocke et al.   ANALYTICAL CHEMISTRY

Observation of Site-Resolved Vibrational Energy Transfer Using a Genetically Encoded Ultrafast Heater

(2018) Tobias Baumann et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Near-Infrared Photoswitching of Azobenzenes under Physiological Conditions

(2017) Mingxin Dong et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Computational Design of a Photocontrolled Cytosine Deaminase

(2017) Kristin M. Blacklock et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Time-resolved observation of protein allosteric communication

(2017) Sebastian Buchenberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A 100 kHz Time-Resolved Multiple-Probe Femtosecond to Second Infrared Absorption Spectrometer

(2016) Gregory M. Greetham et al.   APPLIED SPECTROSCOPY

Light Absorption and Energy Transfer in the Antenna Complexes of Photosynthetic Organisms

(2016) Tihana Mirkovic et al.   CHEMICAL REVIEWS

Conformational Selection and Induced Fit Mechanisms in the Binding of an Anticancer Drug to the c-Src Kinase

(2016) Maria Agnese Morando et al.   Scientific Reports

Engineering a light-controlled F1ATPase using structure-based protein design

(2016) Daniel Hoersch   PeerJ

Red-Shifting Azobenzene Photoswitches for in Vivo Use

(2015) Mingxin Dong et al.   ACCOUNTS OF CHEMICAL RESEARCH

A Roadmap to Success in Photopharmacology

(2015) Johannes Broichhagen et al.   ACCOUNTS OF CHEMICAL RESEARCH

Photoswitchable Inhibitors of Microtubule Dynamics Optically Control Mitosis and Cell Death

(2015) Malgorzata Borowiak et al.   CELL

Absence of a Stable Secondary Structure Is Not a Limitation for Photoswitchable Inhibitors of β-Arrestin/β-Adaptin 2 Protein-Protein Interaction

(2015) Andrés Martín-Quirós et al.   CHEMISTRY & BIOLOGY

Fast infrared spectroscopy of protein dynamics: advancing sensitivity and selectivity

(2015) Klemens L Koziol et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

pH-Jump Induced Leucine Zipper Folding beyond the Diffusion Limit

(2015) Mateusz L. Donten et al.   JOURNAL OF PHYSICAL CHEMISTRY B

In Situ Formation of an Azo Bridge on Proteins Controllable by Visible Light

(2015) Christian Hoppmann et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Genetically Encoding Photoswitchable Click Amino Acids inEscherichia coliand Mammalian Cells

(2014) Christian Hoppmann et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Applications of Absorption Spectroscopy Using Quantum Cascade Lasers

(2014) Lizhu Zhang et al.   APPLIED SPECTROSCOPY

Distinguishing induced fit from conformational selection

(2014) Stefano Gianni et al.   BIOPHYSICAL CHEMISTRY

Effect of viscogens on the kinetic response of a photoperturbed allosteric protein

(2014) Steven A. Waldauer et al.   JOURNAL OF CHEMICAL PHYSICS

Optogenetics: the age of light

(2014) Michael Häusser   NATURE METHODS

Light-Regulated Stapled Peptides to Inhibit Protein-Protein Interactions Involved in Clathrin-Mediated Endocytosis

(2013) Laura Nevola et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Reversible Photocontrol of Biological Systems by the Incorporation of Molecular Photoswitches

(2013) Wiktor Szymański et al.   CHEMICAL REVIEWS

Design of a Photoswitchable Cadherin

(2013) Ryan S. Ritterson et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Kinetic response of a photoperturbed allosteric protein

(2013) B. Buchli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Simultaneous Femtosecond X-ray Spectroscopy and Diffraction of Photosystem II at Room Temperature

(2013) J. Kern et al.   SCIENCE

Structural and Energetic Basis of Allostery

(2012) Vincent J. Hilser et al.   Annual Review of Biophysics

Conformational Selection or Induced Fit? A Critical Appraisal of the Kinetic Mechanism

(2012) Austin D. Vogt et al.   BIOCHEMISTRY

Plasticity of PDZ domains in ligand recognition and signaling

(2012) Ylva Ivarsson   FEBS LETTERS

Reversible Photocontrol of Peptide Conformation with a Rhodopsin-like Photoswitch

(2012) Marina Blanco-Lomas et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The Role of Flexibility and Conformational Selection in the Binding Promiscuity of PDZ Domains

(2012) Márton Münz et al.   PLoS Computational Biology

Fluorescence Imaging of Azobenzene Photoswitching In Vivo

(2011) Andrew A. Beharry et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Azobenzene photoswitches for biomolecules

(2011) Andrew A. Beharry et al.   CHEMICAL SOCIETY REVIEWS

Phosphorylation of a PDZ Domain Extension Modulates Binding Affinity and Interdomain Interactions in Postsynaptic Density-95 (PSD-95) Protein, a Membrane-associated Guanylate Kinase (MAGUK)

(2011) Jun Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Markov models of molecular kinetics: Generation and validation

(2011) Jan-Hendrik Prinz et al.   JOURNAL OF CHEMICAL PHYSICS

Femtosecond X-ray protein nanocrystallography

(2011) Henry N. Chapman et al.   NATURE

Genome-Wide Analysis of PDZ Domain Binding Reveals Inherent Functional Overlap within the PDZ Interaction Network

(2011) Aartjan J. W. te Velthuis et al.   PLoS One

Mapping backbone and side-chain interactions in the transition state of a coupled protein folding and binding reaction

(2011) A. Bachmann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Photocontrol of Coiled-Coil Proteins in Living Cells

(2010) Fuzhong Zhang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Unveiling the Timescale of the R–T Transition in Human Hemoglobin

(2010) M. Cammarata et al.   JOURNAL OF MOLECULAR BIOLOGY

Everything you wanted to know about Markov State Models but were afraid to ask

(2010) Vijay S. Pande et al.   METHODS

Proteins in dynamic equilibrium

(2010) Pau Bernadó et al.   NATURE

Optogenetics

(2010) Karl Deisseroth   NATURE METHODS

Atomic-Level Characterization of the Structural Dynamics of Proteins

(2010) D. E. Shaw et al.   SCIENCE

Induced fit, conformational selection and independent dynamic segments: an extended view of binding events

(2010) Peter Csermely et al.   TRENDS IN BIOCHEMICAL SCIENCES

Spectral Tuning of Azobenzene Photoswitches for Biological Applications

(2009) Oleg Sadovski et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Ezrin Induces Long-Range Interdomain Allostery in the Scaffolding Protein NHERF1

(2009) Jianquan Li et al.   JOURNAL OF MOLECULAR BIOLOGY

Structure-Based Approach to the Photocontrol of Protein Folding

(2009) Fuzhong Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The role of dynamic conformational ensembles in biomolecular recognition

(2009) David D Boehr et al.   Nature Chemical Biology

Time-resolved methods in biophysics. 10. Time-resolved FT-IR difference spectroscopy and the application to membrane proteins

(2009) Ionela Radu et al.   PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES

Conformational selection or induced fit: A flux description of reaction mechanism

(2009) G. G. Hammes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hidden dynamic allostery in a PDZ domain

(2009) C. M. Petit et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Controlling the enzymatic activity of a restriction enzyme by light

(2009) B. Schierling et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of specificity and promiscuity of PDZ domain interactions through their dynamic behavior

(2009) Z. Nevin Gerek et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Sending Signals Dynamically

(2009) R. G. Smock et al.   SCIENCE

Algal Sensory Photoreceptors

(2008) Peter Hegemann   Annual Review of Plant Biology

Photocontrollable Peptide-Based Switches Target the Anti-Apoptotic Protein Bcl-xL

(2008) Sabine Kneissl et al.   CHEMBIOCHEM

Allostery: Absence of a Change in Shape Does Not Imply that Allostery Is Not at Play

(2008) Chung-Jung Tsai et al.   JOURNAL OF MOLECULAR BIOLOGY

Site-Specific Relaxation Kinetics of a Tryptophan Zipper Hairpin Peptide Using Temperature-Jump IR Spectroscopy and Isotopic Labeling

(2008) Karin Hauser et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

 -Helix folding in the presence of structural constraints

(2008) J. A. Ihalainen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Specificity Map for the PDZ Domain Family

(2008) Raffi Tonikian et al.   PLOS BIOLOGY

Large-Scale Identification and Evolution Indexing of Tyrosine Phosphorylation Sites from Murine Brain

(2007) Bryan A. Ballif et al.   JOURNAL OF PROTEOME RESEARCH