Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 134, Issue 16, Pages 6960-6963Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ja301868p
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Funding
- Natural Sciences and Engineering Research Council of Canada
- Spanish MICINN [CTQ2011-24800]
- Spanish MEC
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Reversible photocontrol of biomolecules requires chromophores that can efficiently undergo large conformational changes upon exposure to wavelengths of light that are compatible with living systems. We designed a benzylidene-pyrroline chromophore that mimics the Schiff base of rhodopsin and can be used to introduce light-switchable intramolecular cross-links in peptides and proteins. This new class of photoswitch undergoes an similar to 10 angstrom change in end-to-end distance upon isomerization and can be used to control the conformation of a target peptide efficiently and reversibly using, alternately, violet (400 nm) and blue (446 nm) light.
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