Metabolomics in epidemiology: from metabolite concentrations to integrative reaction networks

The Infant Nasopharyngeal Microbiome Impacts Severity of Lower Respiratory Infection and Risk of Asthma Development

(2015) Shu Mei Teo et al.   Cell Host & Microbe

The Dynamics of the Human Infant Gut Microbiome in Development and in Progression toward Type 1 Diabetes

(2015) Aleksandar D. Kostic et al.   Cell Host & Microbe

Quantitative Serum Nuclear Magnetic Resonance Metabolomics in Cardiovascular Epidemiology and Genetics

(2015) Pasi Soininen et al.   Circulation-Cardiovascular Genetics

High-throughput discovery metabolomics

(2015) Tobias Fuhrer et al.   CURRENT OPINION IN BIOTECHNOLOGY

The Human Blood Metabolome-Transcriptome Interface

(2015) Jörg Bartel et al.   PLoS Genetics

Quantitative Serum Nuclear Magnetic Resonance Metabolomics in Cardiovascular Epidemiology and Genetics

(2015) Pasi Soininen et al.   Circulation-Cardiovascular Genetics

A model integration approach linking signalling and gene-regulatory logic with kinetic metabolic models

(2014) A. Ryll et al.   BIOSYSTEMS

Metabolic Flux as a Predictor of Heart Failure Prognosis

(2014) Craig A. Lygate et al.   CIRCULATION RESEARCH

Mendelian randomization: genetic anchors for causal inference in epidemiological studies

(2014) G. Davey Smith et al.   HUMAN MOLECULAR GENETICS

Network Mendelian randomization: using genetic variants as instrumental variables to investigate mediation in causal pathways

(2014) S. Burgess et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Mass-spectrometry-based draft of the human proteome

(2014) Mathias Wilhelm et al.   NATURE

Ubiquinone accumulation improves osmotic-stress tolerance in Escherichia coli

(2014) Daniel C Sévin et al.   Nature Chemical Biology

An atlas of genetic influences on human blood metabolites

(2014) So-Youn Shin et al.   NATURE GENETICS

Metabolic Signatures of Adiposity in Young Adults: Mendelian Randomization Analysis and Effects of Weight Change

(2014) Peter Würtz et al.   PLOS MEDICINE

Biomarker Profiling by Nuclear Magnetic Resonance Spectroscopy for the Prediction of All-Cause Mortality: An Observational Study of 17,345 Persons

(2014) Krista Fischer et al.   PLOS MEDICINE

Metabolomics in Epidemiology: Sources of Variability in Metabolite Measurements and Implications

(2013) J. N. Sampson et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Influence of Metabolism on Epigenetics and Disease

(2013) William G. Kaelin et al.   CELL

Glycomics meets genomics, epigenomics and other high throughput omics for system biology studies

(2013) Vlatka Zoldoš et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

High resolution mass spectrometry based techniques at the crossroads of metabolic pathways

(2013) Christophe Junot et al.   MASS SPECTROMETRY REVIEWS

The big challenges of big data

(2013) Vivien Marx   NATURE

A community-driven global reconstruction of human metabolism

(2013) Ines Thiele et al.   NATURE BIOTECHNOLOGY

The Reactome pathway knowledgebase

(2013) David Croft et al.   NUCLEIC ACIDS RESEARCH

The NHGRI GWAS Catalog, a curated resource of SNP-trait associations

(2013) Danielle Welter et al.   NUCLEIC ACIDS RESEARCH

Data, information, knowledge and principle: back to metabolism in KEGG

(2013) Minoru Kanehisa et al.   NUCLEIC ACIDS RESEARCH

Metabolic Rates of ATP Transfer Through Creatine Kinase (CK Flux) Predict Clinical Heart Failure Events and Death

(2013) P. A. Bottomley et al.   Science Translational Medicine

Metabolic Imaging of Patients with Prostate Cancer Using Hyperpolarized [1-13C]Pyruvate

(2013) S. J. Nelson et al.   Science Translational Medicine

Five Years of GWAS Discovery

(2012) Peter M. Visscher et al.   AMERICAN JOURNAL OF HUMAN GENETICS

On the hypothesis-free testing of metabolite ratios in genome-wide and metabolome-wide association studies

(2012) Ann-Kristin Petersen et al.   BMC BIOINFORMATICS

Network methods for describing sample relationships in genomic datasets: application to Huntington’s disease

(2012) Michael C Oldham et al.   BMC Systems Biology

Metabolomics platforms for genome wide association studies—linking the genome to the metabolome

(2012) Jerzy Adamski et al.   CURRENT OPINION IN BIOTECHNOLOGY

Two-step epigenetic Mendelian randomization: a strategy for establishing the causal role of epigenetic processes in pathways to disease

(2012) Caroline L Relton et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Make way for the ‘next generation’: application and prospects for genome-wide, epigenome-specific technologies in endocrine research

(2012) Richard D Emes et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Effect of Long-Term Exposure to Lower Low-Density Lipoprotein Cholesterol Beginning Early in Life on the Risk of Coronary Heart Disease

(2012) Brian A. Ference et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study

(2012) Benjamin F Voight et al.   LANCET

Comprehensive molecular portraits of human breast tumours

(2012) Daniel C. Koboldt et al.   NATURE

Functional interactions between the gut microbiota and host metabolism

(2012) Valentina Tremaroli et al.   NATURE

Genome-wide association study identifies multiple loci influencing human serum metabolite levels

(2012) Johannes Kettunen et al.   NATURE GENETICS

Genetic variation in metabolic phenotypes: study designs and applications

(2012) Karsten Suhre et al.   NATURE REVIEWS GENETICS

Body Fat Free Mass Is Associated with the Serum Metabolite Profile in a Population-Based Study

(2012) Carolin Jourdan et al.   PLoS One

A Systematic Survey of Loss-of-Function Variants in Human Protein-Coding Genes

(2012) D. G. MacArthur et al.   SCIENCE

Host-Gut Microbiota Metabolic Interactions

(2012) J. K. Nicholson et al.   SCIENCE

NEW: Network-Enabled Wisdom in Biology, Medicine, and Health Care

(2012) E. E. Schadt et al.   Science Translational Medicine

Genome-wide association studies with metabolomics

(2012) Jerzy Adamski   Genome Medicine

Metabolomics: the final frontier?

(2012) Timothy D Veenstra   Genome Medicine

Ten Years of Pathway Analysis: Current Approaches and Outstanding Challenges

(2012) Purvesh Khatri et al.   PLoS Computational Biology

Novel Loci for Metabolic Networks and Multi-Tissue Expression Studies Reveal Genes for Atherosclerosis

(2012) Michael Inouye et al.   PLoS Genetics

Genome-Wide Association Study Identifies Novel Loci Associated with Circulating Phospho- and Sphingolipid Concentrations

(2012) Ayşe Demirkan et al.   PLoS Genetics

Gaussian graphical modeling reconstructs pathway reactions from high-throughput metabolomics data

(2011) Jan Krumsiek et al.   BMC Systems Biology

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Detailed metabolic and genetic characterization reveals new associations for 30 known lipid loci

(2011) T. Tukiainen et al.   HUMAN MOLECULAR GENETICS

LCAT, HDL Cholesterol and Ischemic Cardiovascular Disease: A Mendelian Randomization Study of HDL Cholesterol in 54,500 Individuals

(2011) Christiane L. Haase et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Multi-dimensional mass spectrometry-based shotgun lipidomics and novel strategies for lipidomic analyses

(2011) Xianlin Han et al.   MASS SPECTROMETRY REVIEWS

Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease

(2011) Zeneng Wang et al.   NATURE

Human metabolic individuality in biomedical and pharmaceutical research

(2011) Karsten Suhre et al.   NATURE

Metabolite profiles and the risk of developing diabetes

(2011) Thomas J Wang et al.   NATURE MEDICINE

Metagenomic systems biology of the human gut microbiome reveals topological shifts associated with obesity and inflammatory bowel disease

(2011) S. Greenblum et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genome-wide association studies and systems biology: together at last

(2011) Mika Ala-Korpela et al.   TRENDS IN GENETICS

Competition of pyruvate with physiological substrates for oxidation by the heart: implications for studies with hyperpolarized [1-13C]pyruvate

(2010) Karlos X. Moreno et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Gene Coexpression Network Topology of Cardiac Development, Hypertrophy, and Failure

(2010) Frederick E. Dewey et al.   Circulation-Cardiovascular Genetics

Metabolic Profiling and the Metabolome-Wide Association Study: Significance Level For Biomarker Identification

(2010) Marc Chadeau-Hyam et al.   JOURNAL OF PROTEOME RESEARCH

Metabonomic, transcriptomic, and genomic variation of a population cohort

(2010) Michael Inouye et al.   Molecular Systems Biology

Mass spectrometry in high-throughput proteomics: ready for the big time

(2010) Tommy Nilsson et al.   NATURE METHODS

MSEA: a web-based tool to identify biologically meaningful patterns in quantitative metabolomic data

(2010) J. Xia et al.   NUCLEIC ACIDS RESEARCH

An Immune Response Network Associated with Blood Lipid Levels

(2010) Michael Inouye et al.   PLoS Genetics

Mechanisms of liver disease: cross-talk between the NF-κB and JNK pathways

(2009) Salvatore Papa et al.   BIOLOGICAL CHEMISTRY

A comprehensive definition for metabolic syndrome

(2009) P. L. Huang   Disease Models & Mechanisms

Metabolic systems biology

(2009) Bernhard Palsson   FEBS LETTERS

A genome-wide perspective of genetic variation in human metabolism

(2009) Thomas Illig et al.   NATURE GENETICS

mRNA-Seq whole-transcriptome analysis of a single cell

(2009) Fuchou Tang et al.   NATURE METHODS

Multi-tissue coexpression networks reveal unexpected subnetworks associated with disease

(2009) Radu Dobrin et al.   GENOME BIOLOGY

WGCNA: an R package for weighted correlation network analysis

(2008) Peter Langfelder et al.   BMC BIOINFORMATICS

A Metabolic Throttle Regulates the Epigenetic State of rDNA

(2008) Ingrid Grummt et al.   CELL

High-throughput 1H NMR-based metabolic analysis of human serum and urine for large-scale epidemiological studies: validation study

(2008) R. H Barton et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

The Metabolome-Wide Association Study: A New Look at Human Disease Risk Factors

(2008) Jeremy K. Nicholson et al.   JOURNAL OF PROTEOME RESEARCH

Variations in DNA elucidate molecular networks that cause disease

(2008) Yanqing Chen et al.   NATURE

In vivo assessment of pyruvate dehydrogenase flux in the heart using hyperpolarized carbon-13 magnetic resonance

(2008) M. A. Schroeder et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetics Meets Metabolomics: A Genome-Wide Association Study of Metabolite Profiles in Human Serum

(2008) Christian Gieger et al.   PLoS Genetics