Genetic variation in metabolic phenotypes: study designs and applications

On the hypothesis-free testing of metabolite ratios in genome-wide and metabolome-wide association studies

(2012) Ann-Kristin Petersen et al.   BMC BIOINFORMATICS

The dynamic range of the human metabolome revealed by challenges

(2012) Susanne Krug et al.   FASEB JOURNAL

PSEA: Phenotype Set Enrichment Analysis-A New Method for Analysis of Multiple Phenotypes

(2012) Janina S. Ried et al.   GENETIC EPIDEMIOLOGY

Genome-wide association study identifies multiple loci influencing human serum metabolite levels

(2012) Johannes Kettunen et al.   NATURE GENETICS

Genome-Wide Association Study Identifies Novel Loci Associated with Circulating Phospho- and Sphingolipid Concentrations

(2012) Ayşe Demirkan et al.   PLoS Genetics

Gaussian graphical modeling reconstructs pathway reactions from high-throughput metabolomics data

(2011) Jan Krumsiek et al.   BMC Systems Biology

Detailed metabolic and genetic characterization reveals new associations for 30 known lipid loci

(2011) T. Tukiainen et al.   HUMAN MOLECULAR GENETICS

FADS1 Genetic Variability Interacts with Dietary α-Linolenic Acid Intake to Affect Serum Non-HDL–Cholesterol Concentrations in European Adolescents

(2011) Julie Dumont et al.   JOURNAL OF NUTRITION

Recent and potential developments of biofluid analyses in metabolomics

(2011) Aihua Zhang et al.   Journal of Proteomics

Human metabolic profiles are stably controlled by genetic and environmental variation

(2011) G. Nicholson et al.   Molecular Systems Biology

Human metabolic individuality in biomedical and pharmaceutical research

(2011) Karsten Suhre et al.   NATURE

Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians

(2011) Norihiro Kato et al.   NATURE GENETICS

A genome-wide association study of metabolic traits in human urine

(2011) Karsten Suhre et al.   NATURE GENETICS

KEGG for integration and interpretation of large-scale molecular data sets

(2011) M. Kanehisa et al.   NUCLEIC ACIDS RESEARCH

The Human Serum Metabolome

(2011) Nikolaos Psychogios et al.   PLoS One

Differences between Human Plasma and Serum Metabolite Profiles

(2011) Zhonghao Yu et al.   PLoS One

Discovery of Sexual Dimorphisms in Metabolic and Genetic Biomarkers

(2011) Kirstin Mittelstrass et al.   PLoS Genetics

Genome-Wide Meta-Analysis Identifies Regions on 7p21 (AHR) and 15q24 (CYP1A2) As Determinants of Habitual Caffeine Consumption

(2011) Marilyn C. Cornelis et al.   PLoS Genetics

Eight Common Genetic Variants Associated with Serum DHEAS Levels Suggest a Key Role in Ageing Mechanisms

(2011) Guangju Zhai et al.   PLoS Genetics

A Genome-Wide Metabolic QTL Analysis in Europeans Implicates Two Loci Shaped by Recent Positive Selection

(2011) George Nicholson et al.   PLoS Genetics

Dietary n−3 and n−6 polyunsaturated fatty acid intake interacts with FADS1 genetic variation to affect total and HDL-cholesterol concentrations in the Doetinchem Cohort Study

(2010) Yingchang Lu et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

metaP-Server: A Web-Based Metabolomics Data Analysis Tool

(2010) Gabi Kastenmüller et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Metabonomic, transcriptomic, and genomic variation of a population cohort

(2010) Michael Inouye et al.   Molecular Systems Biology

Biological, clinical and population relevance of 95 loci for blood lipids

(2010) Tanya M. Teslovich et al.   NATURE

Inborn variation in metabolism

(2010) Vamsi K Mootha et al.   NATURE GENETICS

A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci

(2010) Nathaniel Rothman et al.   NATURE GENETICS

New loci associated with kidney function and chronic kidney disease

(2010) Anna Köttgen et al.   NATURE GENETICS

Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci

(2010) Andre Franke et al.   NATURE GENETICS

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

(2010) Josée Dupuis et al.   NATURE GENETICS

Genetic loci influencing kidney function and chronic kidney disease

(2010) John C Chambers et al.   NATURE GENETICS

Genotype imputation for genome-wide association studies

(2010) Jonathan Marchini et al.   NATURE REVIEWS GENETICS

Metabolic Footprint of Diabetes: A Multiplatform Metabolomics Study in an Epidemiological Setting

(2010) Karsten Suhre et al.   PLoS One

Genome-wide association meta-analysis for total serum bilirubin levels

(2009) A. D. Johnson et al.   HUMAN MOLECULAR GENETICS

Common variants in the SLCO1B3 locus are associated with bilirubin levels and unconjugated hyperbilirubinemia

(2009) Serena Sanna et al.   HUMAN MOLECULAR GENETICS

A genome-wide perspective of genetic variation in human metabolism

(2009) Thomas Illig et al.   NATURE GENETICS

Genetic Determinants of Circulating Sphingolipid Concentrations in European Populations

(2009) Andrew A. Hicks et al.   PLoS Genetics

Genome-Wide Association Study of Plasma Polyunsaturated Fatty Acids in the InCHIANTI Study

(2009) Toshiko Tanaka et al.   PLoS Genetics

Meta-Analysis of 28,141 Individuals Identifies Common Variants within Five New Loci That Influence Uric Acid Concentrations

(2009) Melanie Kolz et al.   PLoS Genetics

Identifying Relationships among Genomic Disease Regions: Predicting Genes at Pathogenic SNP Associations and Rare Deletions

(2009) Soumya Raychaudhuri et al.   PLoS Genetics

Genome-wide Association Study Identifies Genes for Biomarkers of Cardiovascular Disease: Serum Urate and Dyslipidemia

(2008) Chris Wallace et al.   AMERICAN JOURNAL OF HUMAN GENETICS

A multivariate test of association

(2008) Manuel A. R. Ferreira et al.   BIOINFORMATICS

Bioinformatics Analysis of Targeted Metabolomics—Uncovering Old and New Tales of Diabetic Mice under Medication

(2008) Elisabeth Altmaier et al.   ENDOCRINOLOGY

Common variants at 30 loci contribute to polygenic dyslipidemia

(2008) Sekar Kathiresan et al.   NATURE GENETICS

SLC2A9 influences uric acid concentrations with pronounced sex-specific effects

(2008) Angela Döring et al.   NATURE GENETICS

Newly identified loci that influence lipid concentrations and risk of coronary artery disease

(2008) Cristen J Willer et al.   NATURE GENETICS

Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans

(2008) Sekar Kathiresan et al.   NATURE GENETICS

SLCO1B1Variants and Statin-Induced Myopathy — A Genomewide Study

(2008)   NEW ENGLAND JOURNAL OF MEDICINE

HMDB: a knowledgebase for the human metabolome

(2008) D. S. Wishart et al.   NUCLEIC ACIDS RESEARCH

Genetics Meets Metabolomics: A Genome-Wide Association Study of Metabolite Profiles in Human Serum

(2008) Christian Gieger et al.   PLoS Genetics