Dysfunction of RNA/RNA-Binding Proteins in ALS Astrocytes and Microglia
Published 2021 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Dysfunction of RNA/RNA-Binding Proteins in ALS Astrocytes and Microglia
Authors
Keywords
-
Journal
Cells
Volume 10, Issue 11, Pages 3005
Publisher
MDPI AG
Online
2021-11-04
DOI
10.3390/cells10113005
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Aberrant cytoplasmic intron retention is a blueprint for RNA binding protein mislocalization in amyotrophic lateral sclerosis
- (2021) Giulia E Tyzack et al. BRAIN
- Reactive astrocytes in ALS display diminished intron retention
- (2021) Oliver J Ziff et al. NUCLEIC ACIDS RESEARCH
- Emerging Perspectives on Dipeptide Repeat Proteins in C9ORF72 ALS/FTD
- (2021) Alexander Schmitz et al. Frontiers in Cellular Neuroscience
- C9ORF72: What It Is, What It Does, and Why It Matters
- (2021) Julie Smeyers et al. Frontiers in Cellular Neuroscience
- Lysosome dysfunction as a cause of neurodegenerative diseases: Lessons from frontotemporal dementia and amyotrophic lateral sclerosis
- (2021) Jessica Root et al. NEUROBIOLOGY OF DISEASE
- RNA Is a Double-Edged Sword in ALS Pathogenesis
- (2021) Benjamin L. Zaepfel et al. Frontiers in Cellular Neuroscience
- Multiple pathways of toxicity induced by C9orf72 dipeptide repeat aggregates and G4C2 RNA in a cellular model
- (2021) Frédéric Frottin et al. eLife
- FUS-ALS mutants alter FMRP phase separation equilibrium and impair protein translation
- (2021) Nicol Birsa et al. Science Advances
- Microglial transcriptome analysis in the rNLS8 mouse model of TDP-43 proteinopathy reveals discrete expression profiles associated with neurodegenerative progression and recovery
- (2021) Mandana Hunter et al. Acta Neuropathologica Communications
- ALS-related FUS mutations alter axon growth in motoneurons and affect HuD/ELAVL4 and FMRP activity
- (2021) Maria Giovanna Garone et al. Communications Biology
- Mutant TDP-43 Expression Triggers TDP-43 Pathology and Cell Autonomous Effects on Primary Astrocytes: Implications for Non-cell Autonomous Pathology in ALS
- (2020) Samantha K. Barton et al. NEUROCHEMICAL RESEARCH
- ALS/FTD-Linked Mutation in FUS Suppresses Intra-axonal Protein Synthesis and Drives Disease Without Nuclear Loss-of-Function of FUS
- (2020) Jone López-Erauskin et al. NEURON
- FUS ALS-causative mutations impair FUS autoregulation and splicing factor networks through intron retention
- (2020) Jack Humphrey et al. NUCLEIC ACIDS RESEARCH
- Regulation of RNA granules by FMRP and implications for neurological diseases
- (2020) Austin Lai et al. TRAFFIC
- Natural killer cells modulate motor neuron-immune cell cross talk in models of Amyotrophic Lateral Sclerosis
- (2020) Stefano Garofalo et al. Nature Communications
- Astrocytes with TDP-43 inclusions exhibit reduced noradrenergic cAMP and Ca2+ signaling and dysregulated cell metabolism
- (2020) Jelena Velebit et al. Scientific Reports
- Congenic expression of poly-GA but not poly-PR in mice triggers selective neuron loss and interferon responses found in C9orf72 ALS
- (2020) Katherine D. LaClair et al. ACTA NEUROPATHOLOGICA
- Amyotrophic lateral sclerosis: a clinical review
- (2020) P. Masrori et al. EUROPEAN JOURNAL OF NEUROLOGY
- C9orf72 arginine-rich dipeptide repeats inhibit UPF1-mediated RNA decay via translational repression
- (2020) Yu Sun et al. Nature Communications
- Quantitative patterns of motor cortex proteinopathy across ALS genotypes
- (2020) Matthew Nolan et al. Acta Neuropathologica Communications
- C9orf72 loss-of-function: a trivial, stand-alone or additive mechanism in C9 ALS/FTD?
- (2020) Elke Braems et al. ACTA NEUROPATHOLOGICA
- Widespread intron retention impairs protein homeostasis in C9orf72 ALS brains
- (2020) Qingqing Wang et al. GENOME RESEARCH
- The overexpression of TDP-43 in astrocytes causes neurodegeneration via a PTP1B-mediated inflammatory response
- (2020) Shinrye Lee et al. Journal of Neuroinflammation
- ALS Genetics: Gains, Losses, and Implications for Future Therapies
- (2020) Garam Kim et al. NEURON
- The microglial component of amyotrophic lateral sclerosis
- (2020) Benjamin E Clarke et al. BRAIN
- Aberrant interaction of FUS with the U1 snRNA provides a molecular mechanism of FUS induced amyotrophic lateral sclerosis
- (2020) Daniel Jutzi et al. Nature Communications
- QUAKING Regulates Microexon Alternative Splicing of the Rho GTPase Pathway and Controls Microglia Homeostasis
- (2020) Jeesan Lee et al. Cell Reports
- C9orf72 arginine-rich dipeptide proteins interact with ribosomal proteins in vivo to induce a toxic translational arrest that is rescued by eIF1A
- (2019) Thomas G. Moens et al. ACTA NEUROPATHOLOGICA
- RNA Dysregulation in Amyotrophic Lateral Sclerosis
- (2019) Zoe Butti et al. Frontiers in Genetics
- Cytotoxic CD8+T lymphocytes expressing ALS-causing SOD1 mutant selectively trigger death of spinal motoneurons
- (2019) Emmanuelle Coque et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Astrocyte adenosine deaminase loss increases motor neuron toxicity in amyotrophic lateral sclerosis
- (2019) Scott P Allen et al. BRAIN
- Disruption of RNA Metabolism in Neurological Diseases and Emerging Therapeutic Interventions
- (2019) Julia K. Nussbacher et al. NEURON
- Astrocytes: Emerging Therapeutic Targets in Neurological Disorders
- (2019) Chiara F. Valori et al. TRENDS IN MOLECULAR MEDICINE
- Astrocytes and Microglia as Potential Contributors to the Pathogenesis of C9orf72 Repeat Expansion-Associated FTLD and ALS
- (2019) Hannah Rostalski et al. Frontiers in Neuroscience
- Splicing repression is a major function of TDP-43 in motor neurons
- (2019) Aneesh Donde et al. ACTA NEUROPATHOLOGICA
- Cytoplasmic functions of TDP-43 and FUS and their role in ALS
- (2019) Nicol Birsa et al. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
- Repeat-associated non-AUG (RAN) translation mechanisms are running into focus for GGGGCC-repeat associated ALS/FTD
- (2019) Lindsey D. Goodman et al. PROGRESS IN NEUROBIOLOGY
- C9orf72 expansion within astrocytes reduces metabolic flexibility in amyotrophic lateral sclerosis
- (2019) Scott P Allen et al. BRAIN
- MCP1-CCR2 and neuroinflammation in the ALS motor cortex with TDP-43 pathology
- (2019) Javier H. Jara et al. Journal of Neuroinflammation
- Mutant C9orf72 human iPSC‐derived astrocytes cause non‐cell autonomous motor neuron pathophysiology
- (2019) Chen Zhao et al. GLIA
- TDP-43 knockdown causes innate immune activation via protein kinase R in astrocytes
- (2019) Thomas J. LaRocca et al. NEUROBIOLOGY OF DISEASE
- ALS Genetics, Mechanisms, and Therapeutics: Where Are We Now?
- (2019) Rita Mejzini et al. Frontiers in Neuroscience
- Human iPSC-derived astrocytes from ALS patients with mutated C9ORF72 show increased oxidative stress and neurotoxicity
- (2019) Anastasya Birger et al. EBioMedicine
- The snowball effect of RNA binding protein dysfunction in amyotrophic lateral sclerosis
- (2018) Pietro Fratta et al. BRAIN
- Exploring the genetics and non-cell autonomous mechanisms underlying ALS/FTLD
- (2018) Hongbo Chen et al. CELL DEATH AND DIFFERENTIATION
- Mice with endogenous TDP‐43 mutations exhibit gain of splicing function and characteristics of amyotrophic lateral sclerosis
- (2018) Pietro Fratta et al. EMBO JOURNAL
- Astrocytes expressing ALS-linked mutant FUS induce motor neuron death through release of tumor necrosis factor-alpha
- (2018) Azadeh Kia et al. GLIA
- Poly(GR) impairs protein translation and stress granule dynamics in C9orf72-associated frontotemporal dementia and amyotrophic lateral sclerosis
- (2018) Yong-Jie Zhang et al. NATURE MEDICINE
- Haploinsufficiency leads to neurodegeneration in C9ORF72 ALS/FTD human induced motor neurons
- (2018) Yingxiao Shi et al. NATURE MEDICINE
- TDP-43 gains function due to perturbed autoregulation in a Tardbp knock-in mouse model of ALS-FTD
- (2018) Matthew A. White et al. NATURE NEUROSCIENCE
- Intron retention and nuclear loss of SFPQ are molecular hallmarks of ALS
- (2018) Raphaelle Luisier et al. Nature Communications
- TDP-43 regulation of stress granule dynamics in neurodegenerative disease-relevant cell types
- (2018) Yousra Khalfallah et al. Scientific Reports
- Unexpected similarities between C9ORF72 and sporadic forms of ALS/FTD suggest a common disease mechanism
- (2018) Erin G Conlon et al. eLife
- The C9ORF72 gene, implicated in ALS/FTD, encodes a protein that functions in control of endothelin and glutamate signaling
- (2018) Vitalay Fomin et al. MOLECULAR AND CELLULAR BIOLOGY
- C9orf72-mediated ALS and FTD: multiple pathways to disease
- (2018) Rubika Balendra et al. Nature Reviews Neurology
- Inflammation in ALS/FTD pathogenesis
- (2018) Madelyn E. McCauley et al. ACTA NEUROPATHOLOGICA
- Extracellular TDP-43 aggregates target MAPK/MAK/MRK overlapping kinase (MOK) and trigger caspase-3/IL-18 signaling in microglia
- (2017) María M. Leal-Lasarte et al. FASEB JOURNAL
- TDP-43 and FUS en route from the nucleus to the cytoplasm
- (2017) Helena Ederle et al. FEBS LETTERS
- TDP-43 mutations causing amyotrophic lateral sclerosis are associated with altered expression of RNA-binding protein hnRNP K and affect the Nrf2 antioxidant pathway
- (2017) Diane Moujalled et al. HUMAN MOLECULAR GENETICS
- Reactive Astrocytes: Production, Function, and Therapeutic Potential
- (2017) Shane A. Liddelow et al. IMMUNITY
- Amyotrophic lateral sclerosis
- (2017) Michael A van Es et al. LANCET
- Neurotoxic reactive astrocytes are induced by activated microglia
- (2017) Shane A. Liddelow et al. NATURE
- Microglia emerge as central players in brain disease
- (2017) Michael W Salter et al. NATURE MEDICINE
- Amyotrophic Lateral Sclerosis
- (2017) Robert H. Brown et al. NEW ENGLAND JOURNAL OF MEDICINE
- Astrocytes locally translate transcripts in their peripheral processes
- (2017) Kristina Sakers et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- SRSF1-dependent nuclear export inhibition of C9ORF72 repeat transcripts prevents neurodegeneration and associated motor deficits
- (2017) Guillaume M. Hautbergue et al. Nature Communications
- Cell-type specific differences in promoter activity of the ALS-linked C9orf72 mouse ortholog
- (2017) Abraham J. Langseth et al. Scientific Reports
- Functional interaction between FUS and SMN underlies SMA-like splicing changes in wild-type hFUS mice
- (2017) Alessia Mirra et al. Scientific Reports
- Evidence that C9ORF72 Dipeptide Repeat Proteins Associate with U2 snRNP to Cause Mis-splicing in ALS/FTD Patients
- (2017) Shanye Yin et al. Cell Reports
- Amyotrophic lateral sclerosis patient iPSC-derived astrocytes impair autophagy via non-cell autonomous mechanisms
- (2017) Martin Madill et al. Molecular Brain
- Control of mRNA Translation in ALS Proteinopathy
- (2017) Gianluca Cestra et al. Frontiers in Molecular Neuroscience
- Sporadic ALS Astrocytes Induce Neuronal Degeneration In Vivo
- (2017) Kun Qian et al. Stem Cell Reports
- Minor intron splicing is regulated by FUS and affected by ALS‐associated FUS mutants
- (2016) Stefan Reber et al. EMBO JOURNAL
- Loss of C9ORF72 impairs autophagy and synergizes with polyQ Ataxin‐2 to induce motor neuron dysfunction and cell death
- (2016) Chantal Sellier et al. EMBO JOURNAL
- The C9orf72 protein interacts with Rab1a and the ULK1 complex to regulate initiation of autophagy
- (2016) Christopher P Webster et al. EMBO JOURNAL
- Poly-dipeptides encoded by the C9ORF72 repeats block global protein translation
- (2016) Kohsuke Kanekura et al. HUMAN MOLECULAR GENETICS
- A polarizing question: do M1 and M2 microglia exist?
- (2016) Richard M Ransohoff NATURE NEUROSCIENCE
- C9orf72 BAC Mouse Model with Motor Deficits and Neurodegenerative Features of ALS/FTD
- (2016) Yuanjing Liu et al. NEURON
- Prevalence of brain and spinal cord inclusions, including dipeptide repeat proteins, in patients with the C9ORF72 hexanucleotide repeat expansion: a systematic neuropathological review
- (2016) L. J. Schipper et al. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
- C9orf72 is required for proper macrophage and microglial function in mice
- (2016) J. G. ORourke et al. SCIENCE
- Loss-of-function mutations in the C9ORF72 mouse ortholog cause fatal autoimmune disease
- (2016) Aaron Burberry et al. Science Translational Medicine
- ALS-associated mutant FUS induces selective motor neuron degeneration through toxic gain of function
- (2016) Aarti Sharma et al. Nature Communications
- The C9ORF72 GGGGCC expansion forms RNA G-quadruplex inclusions and sequesters hnRNP H to disrupt splicing in ALS brains
- (2016) Erin G Conlon et al. eLife
- A C9ORF72/SMCR8-containing complex regulates ULK1 and plays a dual role in autophagy
- (2016) M. Yang et al. Science Advances
- The ALS/FTLD associated protein C9orf72 associates with SMCR8 and WDR41 to regulate the autophagy-lysosome pathway
- (2016) Peter M. Sullivan et al. Acta Neuropathologica Communications
- Astrocytes and Microglia as Non-cell Autonomous Players in the Pathogenesis of ALS
- (2016) Junghee Lee et al. Experimental Neurobiology
- C9orf72 ablation causes immune dysregulation characterized by leukocyte expansion, autoantibody production and glomerulonephropathy in mice
- (2016) Amanda Atanasio et al. Scientific Reports
- TDP-43 activates microglia through NF-κB and NLRP3 inflammasome
- (2015) Weihua Zhao et al. EXPERIMENTAL NEUROLOGY
- Glial TDP-43 regulates axon wrapping, GluRIIA clustering and fly motility by autonomous and non-autonomous mechanisms
- (2015) Giulia Romano et al. HUMAN MOLECULAR GENETICS
- Nuclear accumulation of mRNAs underlies G4C2-repeat-induced translational repression in a cellular model of C9orf72 ALS
- (2015) S. Rossi et al. JOURNAL OF CELL SCIENCE
- Distinct brain transcriptome profiles in C9orf72-associated and sporadic ALS
- (2015) Mercedes Prudencio et al. NATURE NEUROSCIENCE
- Human C9ORF72 Hexanucleotide Expansion Reproduces RNA Foci and Dipeptide Repeat Proteins but Not Neurodegeneration in BAC Transgenic Mice
- (2015) Owen M. Peters et al. NEURON
- C9orf72 BAC Transgenic Mice Display Typical Pathologic Features of ALS/FTD
- (2015) Jacqueline G. O’Rourke et al. NEURON
- Review: Prion-like mechanisms of transactive response DNA binding protein of 43 kDa (TDP-43) in amyotrophic lateral sclerosis (ALS)
- (2015) Phillip Smethurst et al. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
- An age-related reduction of brain TBPH/TDP-43 levels precedes the onset of locomotion defects in a Drosophila ALS model
- (2015) L. Cragnaz et al. NEUROSCIENCE
- C9ORF72 repeat expansions in mice cause TDP-43 pathology, neuronal loss, and behavioral deficits
- (2015) J. Chew et al. SCIENCE
- TDP-43 repression of nonconserved cryptic exons is compromised in ALS-FTD
- (2015) J. P. Ling et al. SCIENCE
- Induction of COX-2-PGE2 synthesis by activation of the MAPK/ERK pathway contributes to neuronal death triggered by TDP-43-depleted microglia
- (2015) Q Xia et al. Cell Death & Disease
- ALS-causative mutations in FUS/TLS confer gain and loss of function by altered association with SMN and U1-snRNP
- (2015) Shuying Sun et al. Nature Communications
- Inflammation Induces TDP-43 Mislocalization and Aggregation
- (2015) Ana Sofia Correia et al. PLoS One
- Sequestration of multiple RNA recognition motif-containing proteins by C9orf72 repeat expansions
- (2014) Johnathan Cooper-Knock et al. BRAIN
- Glial cells in amyotrophic lateral sclerosis
- (2014) T. Philips et al. EXPERIMENTAL NEUROLOGY
- C9ORF72, implicated in amytrophic lateral sclerosis and frontotemporal dementia, regulates endosomal trafficking
- (2014) Manal A. Farg et al. HUMAN MOLECULAR GENETICS
- Hu Antigen R (HuR) Is a Positive Regulator of the RNA-binding Proteins TDP-43 and FUS/TLS
- (2014) Liang Lu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Poly-dipeptides encoded by the C9orf72 repeats bind nucleoli, impede RNA biogenesis, and kill cells
- (2014) I. Kwon et al. SCIENCE
- Astrocytes expressing mutant SOD1 and TDP43 trigger motoneuron death that is mediated via sodium channels and nitroxidative stress
- (2014) Fabiola Rojas et al. Frontiers in Cellular Neuroscience
- An ALS-associated mutation in the FUS 3′-UTR disrupts a microRNA–FUS regulatory circuitry
- (2014) Stefano Dini Modigliani et al. Nature Communications
- hnRNP A3 binds to GGGGCC repeats and is a constituent of p62-positive/TDP43-negative inclusions in the hippocampus of patients with C9orf72 mutations
- (2013) Kohji Mori et al. ACTA NEUROPATHOLOGICA
- The product of C9orf72, a gene strongly implicated in neurodegeneration, is structurally related to DENN Rab-GEFs
- (2013) Timothy P. Levine et al. BIOINFORMATICS
- Motor neurons and glia exhibit specific individualized responses to TDP-43 expression in a Drosophila model of amyotrophic lateral sclerosis
- (2013) P. S. Estes et al. Disease Models & Mechanisms
- Expression of ALS-linked TDP-43 mutant in astrocytes causes non-cell-autonomous motor neuron death in rats
- (2013) Jianbin Tong et al. EMBO JOURNAL
- Altered astrocytic expression of TDP-43 does not influence motor neuron survival
- (2013) Amanda M. Haidet-Phillips et al. EXPERIMENTAL NEUROLOGY
- Astroglial FMRP-dependent translational down-regulation of mGluR5 underlies glutamate transporter GLT1 dysregulation in the fragile X mouse
- (2013) Haruki Higashimori et al. HUMAN MOLECULAR GENETICS
- Drosophila TDP-43 dysfunction in glia and muscle cells cause cytological and behavioural phenotypes that characterize ALS and FTLD
- (2013) Danielle C. Diaper et al. HUMAN MOLECULAR GENETICS
- Mutations in the 3′ untranslated region of FUS causing FUS overexpression are associated with amyotrophic lateral sclerosis
- (2013) Mario Sabatelli et al. HUMAN MOLECULAR GENETICS
- RNA Toxicity from the ALS/FTD C9ORF72 Expansion Is Mitigated by Antisense Intervention
- (2013) Christopher J. Donnelly et al. NEURON
- Molecular Imaging of Microglial Activation in Amyotrophic Lateral Sclerosis
- (2013) Philippe Corcia et al. PLoS One
- Direct conversion of patient fibroblasts demonstrates non-cell autonomous toxicity of astrocytes to motor neurons in familial and sporadic ALS
- (2013) K. Meyer et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Astrocyte pathology and the absence of non-cell autonomy in an induced pluripotent stem cell model of TDP-43 proteinopathy
- (2013) A. Serio et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- ALS-linked TDP-43 mutations produce aberrant RNA splicing and adult-onset motor neuron disease without aggregation or loss of nuclear TDP-43
- (2013) E. S. Arnold et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Targeting RNA Foci in iPSC-Derived Motor Neurons from ALS Patients with a C9ORF72 Repeat Expansion
- (2013) D. Sareen et al. Science Translational Medicine
- Hexanucleotide Repeats in ALS/FTD Form Length-Dependent RNA Foci, Sequester RNA Binding Proteins, and Are Neurotoxic
- (2013) Youn-Bok Lee et al. Cell Reports
- Pattern of ubiquilin pathology in ALS and FTLD indicates presence of C9ORF72 hexanucleotide expansion
- (2012) Johannes Brettschneider et al. ACTA NEUROPATHOLOGICA
- Overexpression of human wild-type FUS causes progressive motor neuron degeneration in an age- and dose-dependent fashion
- (2012) Jacqueline C. Mitchell et al. ACTA NEUROPATHOLOGICA
- Clinico-pathological features in amyotrophic lateral sclerosis with expansions in C9ORF72
- (2012) Johnathan Cooper-Knock et al. BRAIN
- Wild type TDP-43 induces neuro-inflammation and alters APP metabolism in lentiviral gene transfer models
- (2012) Alexander M. Herman et al. EXPERIMENTAL NEUROLOGY
- Entorhinal cortical neurons are the primary targets of FUS mislocalization and ubiquitin aggregation in FUS transgenic rats
- (2012) Cao Huang et al. HUMAN MOLECULAR GENETICS
- Discovery of Novel DENN Proteins: Implications for the Evolution of Eukaryotic Intracellular Membrane Structures and Human Disease
- (2012) Dapeng Zhang et al. Frontiers in Genetics
- p62 positive, TDP-43 negative, neuronal cytoplasmic and intranuclear inclusions in the cerebellum and hippocampus define the pathology of C9orf72-linked FTLD and MND/ALS
- (2011) Safa Al-Sarraj et al. ACTA NEUROPATHOLOGICA
- Pathological hallmarks of amyotrophic lateral sclerosis/frontotemporal lobar degeneration in transgenic mice produced with TDP-43 genomic fragments
- (2011) Vivek Swarup et al. BRAIN
- Deregulation of TDP-43 in amyotrophic lateral sclerosis triggers nuclear factor κB–mediated pathogenic pathways
- (2011) Vivek Swarup et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Expression of mutant TDP-43 induces neuronal dysfunction in transgenic mice
- (2011) Ya-Fei Xu et al. Molecular Neurodegeneration
- Astrocytes from familial and sporadic ALS patients are toxic to motor neurons
- (2011) Amanda M Haidet-Phillips et al. NATURE BIOTECHNOLOGY
- FUS Transgenic Rats Develop the Phenotypes of Amyotrophic Lateral Sclerosis and Frontotemporal Lobar Degeneration
- (2011) Cao Huang et al. PLoS Genetics
- Elevated CSF TDP-43 levels in amyotrophic lateral sclerosis: Specificity, sensitivity, and a possible prognostic value
- (2010) Yu-Ichi Noto et al. Amyotrophic Lateral Sclerosis
- Exome Sequencing Reveals VCP Mutations as a Cause of Familial ALS
- (2010) Janel O. Johnson et al. NEURON
- Non–cell autonomous toxicity in neurodegenerative disorders: ALS and beyond
- (2009) Hristelina Ilieva et al. JOURNAL OF CELL BIOLOGY
- TDP-43 mutant transgenic mice develop features of ALS and frontotemporal lobar degeneration
- (2009) I. Wegorzewska et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Mutations in FUS, an RNA Processing Protein, Cause Familial Amyotrophic Lateral Sclerosis Type 6
- (2009) C. Vance et al. SCIENCE
- Mutations in the FUS/TLS Gene on Chromosome 16 Cause Familial Amyotrophic Lateral Sclerosis
- (2009) T. J. Kwiatkowski et al. SCIENCE
- Increased TDP-43 protein in cerebrospinal fluid of patients with amyotrophic lateral sclerosis
- (2008) Takashi Kasai et al. ACTA NEUROPATHOLOGICA
- Sporadic amyotrophic lateral sclerosis: two pathological patterns shown by analysis of distribution of TDP-43-immunoreactive neuronal and glial cytoplasmic inclusions
- (2008) Yasushi Nishihira et al. ACTA NEUROPATHOLOGICA
- TDP-43 in Cerebrospinal Fluid of Patients With Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis
- (2008) Petra Steinacker et al. ARCHIVES OF NEUROLOGY
- TDP-43 Mutations in Familial and Sporadic Amyotrophic Lateral Sclerosis
- (2008) J. Sreedharan et al. SCIENCE
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started