The Functional and Mechanistic Roles of Immunoproteasome Subunits in Cancer

Pro- and anti-tumorigenic capacity of immunoproteasomes in shaping the tumor microenvironment

(2021) Hanna Leister et al.   Cancer Immunology Research

Are there indeed spliced peptides in the immunopeptidome?

(2021) Arie Admon   MOLECULAR & CELLULAR PROTEOMICS

Structure-Based Optimization and Discovery of M3258, a Specific Inhibitor of the Immunoproteasome Subunit LMP7 (β5i)

(2021) Markus Klein et al.   JOURNAL OF MEDICINAL CHEMISTRY

M3258 Is a Selective Inhibitor of the Immunoproteasome Subunit LMP7 (β5i) Delivering Efficacy in Multiple Myeloma Models

(2021) Michael P. Sanderson et al.   MOLECULAR CANCER THERAPEUTICS

miR‐451a is downregulated and targets PSMB8 in prostate cancer

(2020) Yun Liu et al.   KAOHSIUNG JOURNAL OF MEDICAL SCIENCES

Proteasome Inhibitors: Harnessing Proteostasis to Combat Disease

(2020) David J. Sherman et al.   MOLECULES

Immunoproteasome expression is associated with better prognosis and response to checkpoint therapies in melanoma

(2020) Shelly Kalaora et al.   Nature Communications

Evaluating the immunoproteasome as a potential therapeutic target in cisplatin-resistant small cell and non-small cell lung cancer

(2020) Tetsuaki Shoji et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Induction and Regulation of the Immunoproteasome Subunit β5i (PSMB8) in Laryngeal and Hypopharyngeal Carcinoma Cells

(2020) Nan-Xiang Chen et al.   MEDICAL SCIENCE MONITOR

Genetic polymorphisms of proteasome subunit genes of the MHC-I antigen-presenting system are associated with cervical cancer in a Chinese Han population

(2020) Chuanyin Li et al.   HUMAN IMMUNOLOGY

Tradeoff between metabolic i-proteasome addiction and immune evasion in triple-negative breast cancer

(2020) Alaknanda Adwal et al.   Life Science Alliance

PSMB8 inhibition decreases tumor angiogenesis in glioblastoma through vascular endothelial growth factor A reduction

(2020) Hsin‐Han Chang et al.   CANCER SCIENCE

Expression of the immunoproteasome subunit β5i in non-small cell lung carcinomas

(2020) Takayuki Kiuchi et al.   JOURNAL OF CLINICAL PATHOLOGY

Gene signature of antigen processing and presentation machinery predicts response to checkpoint blockade in non-small cell lung cancer (NSCLC) and melanoma

(2020) Jeffrey C Thompson et al.   Journal for ImmunoTherapy of Cancer

Comparative Assessment of the WNT/β-Catenin Pathway, CacyBP/SIP, and the Immunoproteasome Subunit LMP7 in Various Histological Types of Renal Cell Carcinoma

(2020) Żaneta Piotrowska et al.   Frontiers in Oncology

Novel Proteasome Assembly Chaperone mutations in PSMG2/PAC2, cause the autoinflammatory interferonopathy, CANDLE/PRAAS4

(2019) Adriana A. de Jesus et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

miR‐451a inhibits cancer growth, epithelial‐mesenchymal transition and induces apoptosis in papillary thyroid cancer by targeting PSMB8

(2019) Xinlong Fan et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

PSMB10, the last immunoproteasome gene missing for PRAAS

(2019) Guillaume Sarrabay et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

PA28α/β Promote Breast Cancer Cell Invasion and Metastasis via Down-Regulation of CDK15

(2019) Shengnan Li et al.   Frontiers in Oncology

Heterozygous Truncating Variants in POMP Escape Nonsense-Mediated Decay and Cause a Unique Immune Dysregulatory Syndrome

(2018) M. Cecilia Poli et al.   AMERICAN JOURNAL OF HUMAN GENETICS

PSMB8 regulates glioma cell migration, proliferation, and apoptosis through modulating ERK1/2 and PI3K/AKT signaling pathways

(2018) Bing-ya Yang et al.   BIOMEDICINE & PHARMACOTHERAPY

Distinct methylation profile of mucinous ovarian carcinoma reveals susceptibility to proteasome inhibitors

(2018) Phui-Ly Liew et al.   INTERNATIONAL JOURNAL OF CANCER

Production of spliced peptides by the proteasome

(2018) Nathalie Vigneron et al.   MOLECULAR IMMUNOLOGY

Immunoproteasome-selective and non-selective inhibitors: A promising approach for the treatment of multiple myeloma

(2018) Roberta Ettari et al.   PHARMACOLOGY & THERAPEUTICS

Expression of Immunoproteasome Subunit LMP7 in Breast Cancer and Its Association with Immune-Related Markers

(2018) Miseon Lee et al.   Cancer Research and Treatment

The immunoproteasome and thymoproteasome: functions, evolution and human disease

(2018) Shigeo Murata et al.   NATURE IMMUNOLOGY

Identification of PA28β as a potential novel biomarker in human esophageal squamous cell carcinoma

(2017) Jin-Yan Chen et al.   TUMOR BIOLOGY

Inhibition and deficiency of the immunoproteasome subunit LMP7 suppress the development and progression of colorectal carcinoma in mice

(2017) Julia Koerner et al.   Oncotarget

Prevention of colitis-associated cancer by selective targeting of immunoproteasome subunit LMP7

(2017) Niyati Vachharajani et al.   Oncotarget

Enhanced Degradation of Misfolded Proteins Promotes Tumorigenesis

(2017) Liang Chen et al.   Cell Reports

Immunoproteasome functions explained by divergence in cleavage specificity and regulation

(2017) Michael B Winter et al.   eLife

PA28 modulates antigen processing and viral replication during coxsackievirus B3 infection

(2017) Dorota Respondek et al.   PLoS One

A practical review on carfilzomib in multiple myeloma

(2016) Eli Muchtar et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

Additive loss-of-function proteasome subunit mutations in CANDLE/PRAAS patients promote type I IFN production

(2016) Anja Brehm et al.   JOURNAL OF CLINICAL INVESTIGATION

Overexpression of proteasomal activator PA28α serves as a prognostic factor in oral squamous cell carcinoma

(2016) Xiaodong Feng et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Immunoproteasome deficiency is a feature of non-small cell lung cancer with a mesenchymal phenotype and is associated with a poor outcome

(2016) Satyendra C. Tripathi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A large fraction of HLA class I ligands are proteasome-generated spliced peptides

(2016) Juliane Liepe et al.   SCIENCE

Comparative proteomic profiling of refractory/relapsed multiple myeloma reveals biomarkers involved in resistance to bortezomib-based therapy

(2016) Dominik Dytfeld et al.   Oncotarget

PSMB8 and PBK as potential gastric cancer subtype-specific biomarkers associated with prognosis

(2016) Chae Hwa Kwon et al.   Oncotarget

Proteasomes generate spliced epitopes by two different mechanisms and as efficiently as non-spliced epitopes

(2016) F. Ebstein et al.   Scientific Reports

Expression of immunoproteasome genes is regulated by cell-intrinsic and –extrinsic factors in human cancers

(2016) Alexandre Rouette et al.   Scientific Reports

The transporter associated with antigen processing: a key player in adaptive immunity

(2015) Sabine Eggensperger et al.   BIOLOGICAL CHEMISTRY

The proteasome immunosubunits, PA28 and ER-aminopeptidase 1 protect melanoma cells from efficient MART-126-35-specific T-cell recognition

(2015) Martin Keller et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The novel  2-selective proteasome inhibitor LU-102 synergizes with bortezomib and carfilzomib to overcome proteasome inhibitor resistance of myeloma cells

(2015) M. Kraus et al.   HAEMATOLOGICA

Peptide Splicing in the Proteasome Creates a Novel Type of Antigen with an Isopeptide Linkage

(2015) Celia R. Berkers et al.   JOURNAL OF IMMUNOLOGY

Genetic polymorphisms associated with increased risk of developing chronic myelogenous leukemia

(2015) Heriberto Bruzzoni-Giovanelli et al.   Oncotarget

Regulation of Immunoproteasome Function in the Lung

(2015) Ilona E. Keller et al.   Scientific Reports

The novel  2-selective proteasome inhibitor LU-102 synergizes with bortezomib and carfilzomib to overcome proteasome inhibitor resistance of myeloma cells

(2015) M. Kraus et al.   HAEMATOLOGICA

Anti-leukemic activity and mechanisms underlying resistance to the novel immunoproteasome inhibitor PR-924

(2014) Denise Niewerth et al.   BIOCHEMICAL PHARMACOLOGY

Proteotoxic crisis, the ubiquitin-proteasome system, and cancer therapy

(2014) Raymond J Deshaies   BMC BIOLOGY

Tumor Hypomethylation at 6p21.3 Associates with Longer Time to Recurrence of High-Grade Serous Epithelial Ovarian Cancer

(2014) C. Wang et al.   CANCER RESEARCH

PA28αβ Reduces Size and Increases Hydrophilicity of 20S Immunoproteasome Peptide Products

(2014) Mary Raule et al.   CHEMISTRY & BIOLOGY

Subunit specific inhibitors of proteasomes and their potential for immunomodulation

(2014) Alexei F Kisselev et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Proteasome isoforms exhibit only quantitative differences in cleavage and epitope generation

(2014) Michele Mishto et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Efficacy of therapy with bortezomib in solid tumors: a review based on 32 clinical trials

(2014) Zebo Huang et al.   Future Oncology

Carfilzomib demonstrates broad anti-tumor activity in pre-clinical non-small cell and small cell lung cancer models

(2014) Amanda F Baker et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Interferon-γ-induced upregulation of immunoproteasome subunit assembly overcomes bortezomib resistance in human hematological cell lines

(2014) Denise Niewerth et al.   Journal of Hematology & Oncology

A Spliced Antigenic Peptide Comprising a Single Spliced Amino Acid Is Produced in the Proteasome by Reverse Splicing of a Longer Peptide Fragment followed by Trimming

(2014) A. Michaux et al.   JOURNAL OF IMMUNOLOGY

Pathways of Antigen Processing

(2013) Janice S. Blum et al.   Annual Review of Immunology

A Genome-wide siRNA Screen Identifies Proteasome Addiction as a Vulnerability of Basal-like Triple-Negative Breast Cancer Cells

(2013) Fabio Petrocca et al.   CANCER CELL

Identification of the Immunoproteasome as a Novel Regulator of Skeletal Muscle Differentiation

(2013) Z. Cui et al.   MOLECULAR AND CELLULAR BIOLOGY

Coordinated regulation of the immunoproteasome subunits by PML/RARα and PU.1 in acute promyelocytic leukemia

(2013) X-W Yang et al.   ONCOGENE

β5i Subunit Deficiency of the Immunoproteasome Leads to Reduced Th2 Response in OVA Induced Acute Asthma

(2013) Anton Volkov et al.   PLoS One

Proteasome activator complex PA28 identified as an accessible target in prostate cancer by in vivo selection of human antibodies

(2013) David Sánchez-Martín et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A selective inhibitor of the immunoproteasome subunit LMP2 induces apoptosis in PC-3 cells and suppresses tumour growth in nude mice

(2012) M Wehenkel et al.   BRITISH JOURNAL OF CANCER

Immuno- and Constitutive Proteasome Crystal Structures Reveal Differences in Substrate and Inhibitor Specificity

(2012) Eva M. Huber et al.   CELL

Proteasome Inhibitors: An Expanding Army Attacking a Unique Target

(2012) Alexei F. Kisselev et al.   CHEMISTRY & BIOLOGY

Prophylactic and therapeutic efficacies of a selective inhibitor of the immunoproteasome for Hashimoto's thyroiditis, but not for Graves' hyperthyroidism, in mice

(2012) Y. Nagayama et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

The immunoproteasome in antigen processing and other immunological functions

(2012) Michael Basler et al.   CURRENT OPINION IN IMMUNOLOGY

The C-terminal fragment of the immunoproteasome PA28S (Reg alpha) as an early diagnosis and tumor-relapse biomarker: evidence from mass spectrometry profiling

(2012) Rémi Longuespée et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Why the Structure but Not the Activity of the Immunoproteasome Subunit Low Molecular Mass Polypeptide 2 Rescues Antigen Presentation

(2012) M. Basler et al.   JOURNAL OF IMMUNOLOGY

Analysis of the Processing of Seven Human Tumor Antigens by Intermediate Proteasomes

(2012) B. Guillaume et al.   JOURNAL OF IMMUNOLOGY

Immunoproteasome Subunit LMP7 Deficiency and Inhibition Suppresses Th1 and Th17 but Enhances Regulatory T Cell Differentiation

(2012) K. W. Kalim et al.   JOURNAL OF IMMUNOLOGY

Revisiting the role of the immunoproteasome in the activation of the canonical NF-κB pathway

(2012) Eun Ryoung Jang et al.   Molecular BioSystems

A Critical Role for the Inducible Proteasomal Subunits LMP7 and MECL1 in Cytokine Production by Activated Murine Splenocytes

(2012) Cheryl E. Rockwell et al.   PHARMACOLOGY

Targeting monocytes/macrophages in the treatment of rheumatoid arthritis

(2012) J.-L. Davignon et al.   RHEUMATOLOGY

The LMP7-K Allele of the Immunoproteasome Exhibits Reduced Transcript Stability and Predicts High Risk of Colon Cancer

(2011) B. Fellerhoff et al.   CANCER RESEARCH

The role of the proteasome in the generation of MHC class I ligands and immune responses

(2011) E. J. A. M. Sijts et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

In Vitro and In Vivo Selective Antitumor Activity of a Novel Orally Bioavailable Proteasome Inhibitor MLN9708 against Multiple Myeloma Cells

(2011) Dharminder Chauhan et al.   CLINICAL CANCER RESEARCH

Chemotherapy-induced peripheral neurotoxicity (CIPN): An update

(2011) Andreas A. Argyriou et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Bortezomib as the First Proteasome Inhibitor Anticancer Drug: Current Status and Future Perspectives

(2011) D. Chen et al.   CURRENT CANCER DRUG TARGETS

PA28 and the proteasome immunosubunits play a central and independent role in the production of MHC class I-binding peptides in vivo

(2011) Natascha de Graaf et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

A mutation in the immunoproteasome subunit PSMB8 causes autoinflammation and lipodystrophy in humans

(2011) Akiko Kitamura et al.   JOURNAL OF CLINICAL INVESTIGATION

Novel Proteasome Inhibitors to Overcome Bortezomib Resistance

(2011) Amy M. Ruschak et al.   JNCI-Journal of the National Cancer Institute

Mice completely lacking immunoproteasomes show major changes in antigen presentation

(2011) Eleanor Z Kincaid et al.   NATURE IMMUNOLOGY

A phase II study of the combination of endocrine treatment and bortezomib in patients with endocrine-resistant metastatic breast cancerA phase II study of the combination of endocrine treatment and bortezomib in patients with endocrine-resistant metastatic breast cancer

(2011) L. Dirix   ONCOLOGY REPORTS

An antigenic peptide produced by reverse splicing and double asparagine deamidation

(2011) A. Dalet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proteasome assembly defect due to a proteasome subunit beta type 8 (PSMB8) mutation causes the autoinflammatory disorder, Nakajo-Nishimura syndrome

(2011) K. Arima et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PSMB8 Encoding the β5i Proteasome Subunit Is Mutated in Joint Contractures, Muscle Atrophy, Microcytic Anemia, and Panniculitis-Induced Lipodystrophy Syndrome

(2010) Anil K. Agarwal et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Studies on immunoproteasome in human liver. Part I: Absence in fetuses, presence in normal subjects, and increased levels in chronic active hepatitis and cirrhosis

(2010) Francesco Vasuri et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The immunoproteasome, the 20S proteasome and the PA28αβ proteasome regulator are oxidative-stress-adaptive proteolytic complexes

(2010) Andrew M. Pickering et al.   BIOCHEMICAL JOURNAL

A novel orally active proteasome inhibitor ONX 0912 triggers in vitro and in vivo cytotoxicity in multiple myeloma

(2010) D. Chauhan et al.   BLOOD

PR-924, a selective inhibitor of the immunoproteasome subunit LMP-7, blocks multiple myeloma cell growth both in vitro and in vivo

(2010) Ajita V. Singh et al.   BRITISH JOURNAL OF HAEMATOLOGY

The Immunoproteasome Cleans up after Inflammation

(2010) Sjoerd van Deventer et al.   CELL

Immunoproteasomes Preserve Protein Homeostasis upon Interferon-Induced Oxidative Stress

(2010) Ulrike Seifert et al.   CELL

PTEN Inhibition Improves Muscle Regeneration in Mice Fed a High-Fat Diet

(2010) Z. Hu et al.   DIABETES

Immunoproteasomes are essential for survival and expansion of T cells in virus-infected mice

(2010) Jacqueline Moebius et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Targeting the proteasome: partial inhibition of the proteasome by bortezomib or deletion of the immunosubunit LMP7 attenuates experimental colitis

(2010) N. Schmidt et al.   GUT

Unexpected Role for the Immunoproteasome Subunit LMP2 in Antiviral Humoral and Innate Immune Responses

(2010) S. E. Hensley et al.   JOURNAL OF IMMUNOLOGY

Prevention of Experimental Colitis by a Selective Inhibitor of the Immunoproteasome

(2010) M. Basler et al.   JOURNAL OF IMMUNOLOGY

Evidence for a role of immunoproteasomes in regulating cardiac muscle mass in diabetic mice

(2010) Lingyun Zu et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Deletion of Immunoproteasome Subunits Imprints on the Transcriptome and Has a Broad Impact on Peptides Presented by Major Histocompatibility Complex I molecules

(2010) Danielle de Verteuil et al.   MOLECULAR & CELLULAR PROTEOMICS

Two abundant proteasome subtypes that uniquely process some antigens presented by HLA class I molecules

(2010) B. Guillaume et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differential Interferon Responses Enhance Viral Epitope Generation by Myocardial Immunoproteasomes in Murine Enterovirus Myocarditis

(2009) Sandra Jäkel et al.   AMERICAN JOURNAL OF PATHOLOGY

Carfilzomib can induce tumor cell death through selective inhibition of the chymotrypsin-like activity of the proteasome

(2009) F. Parlati et al.   BLOOD

Catalytic Mechanism and Assembly of the Proteasome

(2009) António J. Marques et al.   CHEMICAL REVIEWS

Expression of catalytic proteasome subunits in the gut of patients with Crohn’s disease

(2009) Alexander Visekruna et al.   INTERNATIONAL JOURNAL OF COLORECTAL DISEASE

Molecular Mechanisms of IFN-γ to Up-Regulate MHC Class I Antigen Processing and Presentation

(2009) Fang Zhou   INTERNATIONAL REVIEWS OF IMMUNOLOGY

A selective inhibitor of the immunoproteasome subunit LMP7 blocks cytokine production and attenuates progression of experimental arthritis

(2009) Tony Muchamuel et al.   NATURE MEDICINE

The proteasome: Overview of structure and functions

(2009) Keiji TANAKA   PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES

Targeted inhibition of the immunoproteasome is a potent strategy against models of multiple myeloma that overcomes resistance to conventional drugs and nonspecific proteasome inhibitors

(2008) Deborah J. Kuhn et al.   BLOOD

Sensitivity of tumor cells to proteasome inhibitors is associated with expression levels and composition of proteasome subunits

(2008) Antonia Busse et al.   CANCER

Age-related increase in the immunoproteasome content in rat hippocampus: molecular and functional aspects

(2008) M. Paz Gavilán et al.   JOURNAL OF NEUROCHEMISTRY

Crystal structure of a chaperone complex that contributes to the assembly of yeast 20S proteasomes

(2008) Hideki Yashiroda et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY