Activation Mechanisms of the VPS34 Complexes

Unsaturation, curvature and charge: effects of membrane parameters on PIK3C3/VPS34-containing complexes

(2021) Yohei Ohashi et al.   Autophagy

Class III phosphatidylinositol 3-kinase complex I subunit NRBF2/Atg38 - from cell and structural biology to health and disease

(2021) Yohei Ohashi   Autophagy

Caveolin-1 and cavin1 act synergistically to generate a unique lipid environment in caveolae

(2021) Yong Zhou et al.   JOURNAL OF CELL BIOLOGY

Membrane bending by protein phase separation

(2021) Feng Yuan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural basis for VPS34 kinase activation by Rab1 and Rab5 on membranes

(2021) Shirley Tremel et al.   Nature Communications

Lipid metabolism in cancer: New perspectives and emerging mechanisms

(2021) Lindsay A. Broadfield et al.   DEVELOPMENTAL CELL

Metabolic View on Human Healthspan: A Lipidome-Wide Association Study

(2021) Justin Carrard et al.   Metabolites

Phosphoproteomic identification of ULK substrates reveals VPS15‐dependent ULK/VPS34 interplay in the regulation of autophagy

(2021) Thomas John Mercer et al.   EMBO JOURNAL

Revising Endosomal Trafficking under Insulin Receptor Activation

(2021) Maria J. Iraburu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

In vitro reconstitution of Sgk3 activation by phosphatidylinositol 3-phosphate

(2021) Daniel Pokorny et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PI3K inhibitors are finally coming of age

(2021) Bart Vanhaesebroeck et al.   NATURE REVIEWS DRUG DISCOVERY

Membrane perturbation by lipidated Atg8 underlies autophagosome biogenesis

(2021) Tatsuro Maruyama et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Probing the subcellular distribution of phosphatidylinositol reveals a surprising lack at the plasma membrane

(2020) James P. Zewe et al.   JOURNAL OF CELL BIOLOGY

Defining the subcellular distribution and metabolic channeling of phosphatidylinositol

(2020) Joshua G. Pemberton et al.   JOURNAL OF CELL BIOLOGY

mTOR at the nexus of nutrition, growth, ageing and disease

(2020) Grace Y. Liu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Curvature‐sensitive trans ‐assembly of human Atg8‐family proteins in autophagy‐related membrane tethering

(2020) Saki Taniguchi et al.   PROTEIN SCIENCE

PI3KC2α-dependent and VPS34-independent generation of PI3P controls primary cilium-mediated autophagy in response to shear stress

(2020) Asma Boukhalfa et al.   Nature Communications

A PI3K-WIPI2 positive feedback loop allosterically activates LC3 lipidation in autophagy

(2020) Dorotea Fracchiolla et al.   JOURNAL OF CELL BIOLOGY

Beclin 1–ATG14L Protein–Protein Interaction Inhibitor Selectively Inhibits Autophagy through Disruption of VPS34 Complex I

(2020) Ivan Pavlinov et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Multi-site-mediated entwining of the linear WIR-motif around WIPI β-propellers for autophagy

(2020) Jinqi Ren et al.   Nature Communications

Membrane Thinning Induces Sorting of Lipids and the Amphipathic Lipid Packing Sensor (ALPS) Protein Motif

(2020) Niek van Hilten et al.   Frontiers in Physiology

Emerging roles of ATG proteins and membrane lipids in autophagosome formation

(2020) Taki Nishimura et al.   Cell Discovery

ULK complex organization in autophagy by a C-shaped FIP200 N-terminal domain dimer

(2020) Xiaoshan Shi et al.   JOURNAL OF CELL BIOLOGY

Disturbed brain ether lipid metabolism and histology in Sjögren‐Larsson syndrome

(2020) Pippa Staps et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Structural basis for autophagy inhibition by the human Rubicon–Rab7 complex

(2020) Hersh K. Bhargava et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A non-linear system patterns Rab5 GTPase on the membrane

(2020) Alice Cezanne et al.   eLife

Membrane characteristics tune activities of endosomal and autophagic human VPS34 complexes

(2020) Yohei Ohashi et al.   eLife

Endocytosis: A Turnover Mechanism Controlling Ion Channel Function

(2020) Irene Estadella et al.   Cells

The RUFYs, a Family of Effector Proteins Involved in Intracellular Trafficking and Cytoskeleton Dynamics

(2020) Rémy Char et al.   Frontiers in Cell and Developmental Biology

Membrane Heterogeneity Controls Cellular Endocytic Trafficking

(2020) Gregory M. I. Redpath et al.   Frontiers in Cell and Developmental Biology

PDPK1 regulates autophagosome biogenesis by binding to PIK3C3

(2020) Boli Hu et al.   Autophagy

Protein‐carbohydrate ingestion alters Vps34 cellular localization independent of changes in kinase activity in human skeletal muscle

(2020) Nathan Hodson et al.   EXPERIMENTAL PHYSIOLOGY

Reconstitution of autophagosome nucleation defines Atg9 vesicles as seeds for membrane formation

(2020) Justyna Sawa-Makarska et al.   SCIENCE

Amphipathic Motifs Regulate N-BAR Protein Endophilin B1 Auto-inhibition and Drive Membrane Remodeling

(2020) Veer S. Bhatt et al.   STRUCTURE

Modeling Membrane Morphological Change during Autophagosome Formation

(2020) Yuji Sakai et al.   iScience

GLIPR2 is a negative regulator of autophagy and the BECN1-ATG14-containing phosphatidylinositol 3-kinase complex

(2020) Yuting Zhao et al.   Autophagy

The G-Protein Rab5A Activates VPS34 Complex II, a Class III PI3K, by a Dual Regulatory Mechanism

(2020) Thomas C. Buckles et al.   BIOPHYSICAL JOURNAL

Elevating PI3P drives select downstream membrane trafficking pathways

(2020) Noah Steinfeld et al.   MOLECULAR BIOLOGY OF THE CELL

Sorting Nexins in Protein Homeostasis

(2020) Sara E. Hanley et al.   Cells

Lipid profiles of autophagic structures isolated from wild type and Atg2 mutant Drosophila

(2020) Hajnalka Laczkó-Dobos et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Atg2 mediates direct lipid transfer between membranes for autophagosome formation

(2019) Takuo Osawa et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Cargo Receptor NDP52 Initiates Selective Autophagy by Recruiting the ULK Complex to Cytosol-Invading Bacteria

(2019) Benjamin J. Ravenhill et al.   MOLECULAR CELL

Structural Conservation of the Two Phosphoinositide-Binding Sites in WIPI Proteins

(2019) Ruobing Liang et al.   JOURNAL OF MOLECULAR BIOLOGY

ER platforms mediating autophagosome generation

(2019) Nicholas T. Ktistakis   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Members of the autophagy class III phosphatidylinositol 3-kinase complex I interact with GABARAP and GABARAPL1 via LIR motifs

(2019) Åsa Birna Birgisdottir et al.   Autophagy

GORASP2/GRASP55 collaborates with the PtdIns3K UVRAG complex to facilitate autophagosome-lysosome fusion

(2019) Xiaoyan Zhang et al.   Autophagy

ATG2 transports lipids to promote autophagosome biogenesis

(2019) Diana P. Valverde et al.   JOURNAL OF CELL BIOLOGY

PI3K isoforms in cell signalling and vesicle trafficking

(2019) Benoit Bilanges et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Towards a molecular understanding of endosomal trafficking by Retromer and Retriever

(2019) Kai‐En Chen et al.   TRAFFIC

Structure and Dynamics of the Acyl Chains in the Membrane Trafficking and Enzymatic Processing of Lipids

(2019) Stefano Vanni et al.   ACCOUNTS OF CHEMICAL RESEARCH

Phosphatidylinositol synthesis at the endoplasmic reticulum

(2019) Nicholas J. Blunsom et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Classification of the human phox homology (PX) domains based on their phosphoinositide binding specificities

(2019) Mintu Chandra et al.   Nature Communications

The autophagic membrane tether ATG2A transfers lipids between membranes

(2019) Shintaro Maeda et al.   eLife

Multilayered Control of Protein Turnover by TORC1 and Atg1

(2019) Zehan Hu et al.   Cell Reports

The Emerging Roles of mTORC1 in Macromanaging Autophagy

(2019) Akpedje S. Dossou et al.   Cancers

Distribution, dynamics and functional roles of phosphatidylserine within the cell

(2019) Jason G. Kay et al.   Cell Communication and Signaling

Structural pathway for allosteric activation of the autophagic PI 3-kinase complex I

(2019) Lindsey N. Young et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Architecture of human Rag GTPase heterodimers and their complex with mTORC1

(2019) Madhanagopal Anandapadamanaban et al.   SCIENCE

Increased fatty acyl saturation of phosphatidylinositol phosphates in prostate cancer progression

(2019) Atsushi Koizumi et al.   Scientific Reports

Auto-regulation of Rab5 GEF activity in Rabex5 by allosteric structural changes, catalytic core dynamics and ubiquitin binding

(2019) Janelle Lauer et al.   eLife

Local Fatty Acid Channeling into Phospholipid Synthesis Drives Phagophore Expansion during Autophagy

(2019) Maximilian Schütter et al.   CELL

Human ATG2B possesses a lipid transfer activity which is accelerated by negatively charged lipids and WIPI4

(2019) Takuo Osawa et al.   GENES TO CELLS

ULK1 phosphorylates Ser30 of BECN1 in association with ATG14 to stimulate autophagy induction

(2018) Ji-Man Park et al.   Autophagy

Investigation of the phosphatidylserine binding properties of the lipid biosensor, Lactadherin C2 (LactC2), in different membrane environments

(2018) Kathryn Del Vecchio et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Phospholipid subcellular localization and dynamics

(2018) Yanbo Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A molecular perspective of mammalian autophagosome biogenesis

(2018) Thomas J. Mercer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Atg9 establishes Atg2-dependent contact sites between the endoplasmic reticulum and phagophores

(2018) Rubén Gómez-Sánchez et al.   JOURNAL OF CELL BIOLOGY

Targeting the potent Beclin 1–UVRAG coiled-coil interaction with designed peptides enhances autophagy and endolysosomal trafficking

(2018) Shuai Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting autophagy by small molecule inhibitors of vacuolar protein sorting 34 (Vps34) improves the sensitivity of breast cancer cells to Sunitinib

(2018) Matheus Dyczynski et al.   CANCER LETTERS

Insights into autophagosome biogenesis from structural and biochemical analyses of the ATG2A-WIPI4 complex

(2018) Saikat Chowdhury et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Atg2-Atg18 complex tethers pre-autophagosomal membranes to the endoplasmic reticulum for autophagosome formation

(2018) Tetsuya Kotani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

VPS34 complexes from a structural perspective

(2018) Yohei Ohashi et al.   JOURNAL OF LIPID RESEARCH

Bidirectional Control of Autophagy by BECN1 BARA Domain Dynamics

(2018) Chunmei Chang et al.   MOLECULAR CELL

Phosphoinositide conversion in endocytosis and the endolysosomal system

(2017) Alexander Wallroth et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PtdIns3P controls mTORC1 signaling through lysosomal positioning

(2017) Zhi Hong et al.   JOURNAL OF CELL BIOLOGY

Sensing Membrane Curvature in Macroautophagy

(2017) Nathan Nguyen et al.   JOURNAL OF MOLECULAR BIOLOGY

Retromer-driven membrane tubulation separates endosomal recycling from Rab7/Ypt7-dependent fusion

(2017) Latha Kallur Purushothaman et al.   MOLECULAR BIOLOGY OF THE CELL

Vps34 Kinase Domain Dynamics Regulate the Autophagic PI 3-Kinase Complex

(2017) Goran Stjepanovic et al.   MOLECULAR CELL

Structure and function of yeast Atg20, a sorting nexin that facilitates autophagy induction

(2017) Hana Popelka et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

mTORC1 activity repression by late endosomal phosphatidylinositol 3,4-bisphosphate

(2017) Andrea L. Marat et al.   SCIENCE

Advances on the Transfer of Lipids by Lipid Transfer Proteins

(2017) Louise H. Wong et al.   TRENDS IN BIOCHEMICAL SCIENCES

Vps34 PI 3-kinase inactivation enhances insulin sensitivity through reprogramming of mitochondrial metabolism

(2017) Benoit Bilanges et al.   Nature Communications

Structural and functional roles of ether lipids

(2017) John M. Dean et al.   Protein & Cell

The ULK1 complex mediates MTORC1 signaling to the autophagy initiation machinery via binding and phosphorylating ATG14

(2016) Ji-Man Park et al.   Autophagy

Characterization of Atg38 and NRBF2, a fifth subunit of the autophagic Vps34/PIK3C3 complex

(2016) Yohei Ohashi et al.   Autophagy

Lipid Geometry and Bilayer Curvature Modulate LC3/GABARAP-Mediated Model Autophagosomal Elongation

(2016) Ane Landajuela et al.   BIOPHYSICAL JOURNAL

Role of the mammalian ATG8/LC3 family in autophagy: differential and compensatory roles in the spatiotemporal regulation of autophagy

(2016) You-Kyung Lee et al.   BMB Reports

The Intrinsically Disordered Protein Atg13 Mediates Supramolecular Assembly of Autophagy Initiation Complexes

(2016) Hayashi Yamamoto et al.   DEVELOPMENTAL CELL

PAQR3 controls autophagy by integrating AMPK signaling to enhance ATG14L-associated PI3K activity

(2016) D.-Q. Xu et al.   EMBO JOURNAL

Phosphatidylinositol 3‐phosphates—at the interface between cell signalling and membrane traffic

(2016) Andrea L Marat et al.   EMBO JOURNAL

The hVps34‐SGK3 pathway alleviates sustained PI3K/Akt inhibition by stimulating mTORC1 and tumour growth

(2016) Ruzica Bago et al.   EMBO JOURNAL

Nutrient-regulated Phosphorylation of ATG13 Inhibits Starvation-induced Autophagy

(2016) Cindy Puente et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PIK3C2B inhibition improves function and prolongs survival in myotubular myopathy animal models

(2016) Nesrin Sabha et al.   JOURNAL OF CLINICAL INVESTIGATION

A phosphoinositide conversion mechanism for exit from endosomes

(2016) Katharina Ketel et al.   NATURE

PtdIns(4,5)P2signaling regulates ATG14 and autophagy

(2016) Xiaojun Tan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dynamics and architecture of the NRBF2-containing phosphatidylinositol 3-kinase complex I of autophagy

(2016) Lindsey N. Young et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Atg1–kinase complex tethers Atg9-vesicles to initiate autophagy

(2016) Yijian Rao et al.   Nature Communications

Autophagy initiation by ULK complex assembly on ER tubulovesicular regions marked by ATG9 vesicles

(2016) Eleftherios Karanasios et al.   Nature Communications

Leucyl-tRNA Synthetase Activates Vps34 in Amino Acid-Sensing mTORC1 Signaling

(2016) Mee-Sup Yoon et al.   Cell Reports

Structure of the Human Autophagy Initiating Kinase ULK1 in Complex with Potent Inhibitors

(2015) Michael B. Lazarus et al.   ACS Chemical Biology

Retromer and sorting nexins in endosomal sorting

(2015) Matthew Gallon et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Atg1 family kinases in autophagy initiation

(2015) Nobuo N. Noda et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

mTOR activates the VPS34-UVRAG complex to regulate autolysosomal tubulation and cell survival

(2015) M. J. Munson et al.   EMBO JOURNAL

ER-endosome contact sites: molecular compositions and functions

(2015) C. Raiborg et al.   EMBO JOURNAL

Localization of Atg3 to autophagy-related membranes and its enhancement by the Atg8-family interacting motif to promote expansion of the membranes

(2015) Machiko Sakoh-Nakatogawa et al.   FEBS LETTERS

Membrane curvature at a glance

(2015) H. T. McMahon et al.   JOURNAL OF CELL SCIENCE

Receptor-Bound Targets of Selective Autophagy Use a Scaffold Protein to Activate the Atg1 Kinase

(2015) Roarke A. Kamber et al.   MOLECULAR CELL

mTORC1 Phosphorylates UVRAG to Negatively Regulate Autophagosome and Endosome Maturation

(2015) Young-Mi Kim et al.   MOLECULAR CELL

Small Molecule Inhibition of the Autophagy Kinase ULK1 and Identification of ULK1 Substrates

(2015) Daniel F. Egan et al.   MOLECULAR CELL

Molecular characterization of LC3-associated phagocytosis reveals distinct roles for Rubicon, NOX2 and autophagy proteins

(2015) Jennifer Martinez et al.   NATURE CELL BIOLOGY

Atg13 HORMA domain recruits Atg9 vesicles during autophagosome formation

(2015) Sho W. Suzuki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure and flexibility of the endosomal Vps34 complex reveals the basis of its function on membranes

(2015) K. Rostislavleva et al.   SCIENCE

From zero to six double bonds: phospholipid unsaturation and organelle function

(2015) Bruno Antonny et al.   TRENDS IN CELL BIOLOGY

Potent, Selective, and Orally Bioavailable Inhibitors of VPS34 Provide Chemical Tools to Modulate Autophagy in Vivo

(2015) Ayako Honda et al.   ACS Medicinal Chemistry Letters

p53 attenuates AKT signaling by modulating membrane phospholipid composition

(2015) Natalia Rueda-Rincon et al.   Oncotarget

P53 Mutations Change Phosphatidylinositol Acyl Chain Composition

(2015) Adam Naguib et al.   Cell Reports

The role of spontaneous lipid curvature in the interaction of interfacially active peptides with membranes

(2014) Daniel Koller et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Insulin activation of vacuolar protein sorting 34 mediates localized phosphatidylinositol 3-phosphate production at lamellipodia and activation of mTOR/S6K1

(2014) Dianne S. Hirsch et al.   CELLULAR SIGNALLING

A close-up view of membrane contact sites between the endoplasmic reticulum and the endolysosomal system: From yeast to man

(2014) Carina Hönscher et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

AMBRA1 Interplay with Cullin E3 Ubiquitin Ligases Regulates Autophagy Dynamics

(2014) Manuela Antonioli et al.   DEVELOPMENTAL CELL

PI3K Class II α Controls Spatially Restricted Endosomal PtdIns3P and Rab11 Activation to Promote Primary Cilium Function

(2014) Irene Franco et al.   DEVELOPMENTAL CELL

Ultrastructural analysis of autophagosome organization using mammalian autophagy-deficient cells

(2014) C. Kishi-Itakura et al.   JOURNAL OF CELL SCIENCE

Discovery of (2S)-8-[(3R)-3-Methylmorpholin-4-yl]-1-(3-methyl-2-oxobutyl)-2-(trifluoromethyl)-3,4-dihydro-2H-pyrimido[1,2-a]pyrimidin-6-one: A Novel Potent and Selective Inhibitor of Vps34 for the Treatment of Solid Tumors

(2014) Benoit Pasquier et al.   JOURNAL OF MEDICINAL CHEMISTRY

WIPI2 Links LC3 Conjugation with PI3P, Autophagosome Formation, and Pathogen Clearance by Recruiting Atg12–5-16L1

(2014) Hannah C. Dooley et al.   MOLECULAR CELL

Endophilin marks and controls a clathrin-independent endocytic pathway

(2014) Emmanuel Boucrot et al.   NATURE

Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo

(2014) William E. Dowdle et al.   NATURE CELL BIOLOGY

A highly potent and selective Vps34 inhibitor alters vesicle trafficking and autophagy

(2014) Baptiste Ronan et al.   Nature Chemical Biology

Structural basis of starvation-induced assembly of the autophagy initiation complex

(2014) Yuko Fujioka et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Phospholipid Synthesis and Transport in Mammalian Cells

(2014) Jean E. Vance   TRAFFIC

Yeast and mammalian autophagosomes exhibit distinct phosphatidylinositol 3-phosphate asymmetries

(2014) Jinglei Cheng et al.   Nature Communications

Architecture and dynamics of the autophagic phosphatidylinositol 3-kinase complex

(2014) Sulochanadevi Baskaran et al.   eLife

Regulation of PIK3C3/VPS34 complexes by MTOR in nutrient stress-induced autophagy

(2013) Hai-Xin Yuan et al.   Autophagy

Differential Regulation of Distinct Vps34 Complexes by AMPK in Nutrient Stress and Autophagy

(2013) Joungmok Kim et al.   CELL

Defects of Vps15 in skeletal muscles lead to autophagic vacuolar myopathy and lysosomal disease

(2013) Ivan Nemazanyy et al.   EMBO Molecular Medicine

Lack of myotubularin (MTM1) leads to muscle hypotrophy through unbalanced regulation of the autophagy and ubiquitin-proteasome pathways

(2013) Lama Al-Qusairi et al.   FASEB JOURNAL

Atg38 is required for autophagy-specific phosphatidylinositol 3-kinase complex integrity

(2013) Yasuhiro Araki et al.   JOURNAL OF CELL BIOLOGY

Myotubularin and PtdIns3P remodel the sarcoplasmic reticulum in muscle in vivo

(2013) L. Amoasii et al.   JOURNAL OF CELL SCIENCE

Fine mapping of autophagy-related proteins during autophagosome formation in Saccharomyces cerevisiae

(2013) K. Suzuki et al.   JOURNAL OF CELL SCIENCE

Dynamic association of the ULK1 complex with omegasomes during autophagy induction

(2013) E. Karanasios et al.   JOURNAL OF CELL SCIENCE

ER exit sites are physical and functional core autophagosome biogenesis components

(2013) Martin Graef et al.   MOLECULAR BIOLOGY OF THE CELL

Spatiotemporal control of endocytosis by phosphatidylinositol-3,4-bisphosphate

(2013) York Posor et al.   NATURE

mTOR kinase structure, mechanism and regulation

(2013) Haijuan Yang et al.   NATURE

Autophagosomes form at ER–mitochondria contact sites

(2013) Maho Hamasaki et al.   NATURE

Identification of a candidate therapeutic autophagy-inducing peptide

(2013) Sanae Shoji-Kawata et al.   NATURE

ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase

(2013) Ryan C. Russell et al.   NATURE CELL BIOLOGY

Phosphoinositides: Tiny Lipids With Giant Impact on Cell Regulation

(2013) Tamas Balla   PHYSIOLOGICAL REVIEWS

Regulation of Mammalian Autophagy by Class II and III PI 3-Kinases through PI3P Synthesis

(2013) Kelly Devereaux et al.   PLoS One

Ypt1 recruits the Atg1 kinase to the preautophagosomal structure

(2013) J. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A HORMA domain in Atg13 mediates PI 3-kinase recruitment in autophagy

(2013) C. C. Jao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

AKT-independent PI3-K signaling in cancer – emerging role for SGK3

(2013) Ross Hannan et al.   Cancer Management and Research

Allosteric Activation of the Phosphoinositide Phosphatase Sac1 by Anionic Phospholipids

(2012) Shurong Zhong et al.   BIOCHEMISTRY

Architecture of the Atg17 Complex as a Scaffold for Autophagosome Biogenesis

(2012) Michael J. Ragusa et al.   CELL

Crystal structure and biochemical analyses reveal Beclin 1 as a novel membrane binding protein

(2012) Weijiao Huang et al.   CELL RESEARCH

Phosphatidylinositol-3-Phosphate Clearance Plays a Key Role in Autophagosome Completion

(2012) Eduardo Cebollero et al.   CURRENT BIOLOGY

Curvature, Lipid Packing, and Electrostatics of Membrane Organelles: Defining Cellular Territories in Determining Specificity

(2012) Joëlle Bigay et al.   DEVELOPMENTAL CELL

Mechanism and functions of membrane binding by the Atg5-Atg12/Atg16 complex during autophagosome formation

(2012) Julia Romanov et al.   EMBO JOURNAL

Autophagic lysosome reformation

(2012) Yang Chen et al.   EXPERIMENTAL CELL RESEARCH

Autophagosome formation can be achieved in the absence of Atg18 by expressing engineered PAS-targeted Atg2

(2012) Takafumi Kobayashi et al.   FEBS LETTERS

Atg9 Vesicles Recruit Vesicle-tethering Proteins Trs85 and Ypt1 to the Autophagosome Formation Site

(2012) Soichiro Kakuta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure-based Analyses Reveal Distinct Binding Sites for Atg2 and Phosphoinositides in Atg18

(2012) Yasunori Watanabe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Atg9 vesicles are an important membrane source during early steps of autophagosome formation

(2012) Hayashi Yamamoto et al.   JOURNAL OF CELL BIOLOGY

Structures containing Atg9A and the ULK1 complex independently target depolarized mitochondria at initial stages of Parkin-mediated mitophagy

(2012) E. Itakura et al.   JOURNAL OF CELL SCIENCE

Defective Autophagy and mTORC1 Signaling in Myotubularin Null Mice

(2012) K. M. Fetalvero et al.   MOLECULAR AND CELLULAR BIOLOGY

Two-Site Recognition of Phosphatidylinositol 3-Phosphate by PROPPINs in Autophagy

(2012) Sulochanadevi Baskaran et al.   MOLECULAR CELL

Membrane Association of the PTEN Tumor Suppressor: Molecular Details of the Protein-Membrane Complex from SPR Binding Studies and Neutron Reflection

(2012) Siddharth Shenoy et al.   PLoS One

Regulation of selective autophagy onset by a Ypt/Rab GTPase module

(2012) Z. Lipatova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Myotubularin-related protein (MTMR) 9 determines the enzymatic activity, substrate specificity, and role in autophagy of MTMR8

(2012) J. Zou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Class III PI3K Vps34 plays an essential role in autophagy and in heart and liver function

(2012) N. Jaber et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rapamycin-Induced Insulin Resistance Is Mediated by mTORC2 Loss and Uncoupled from Longevity

(2012) D. W. Lamming et al.   SCIENCE

Akt-Mediated Regulation of Autophagy and Tumorigenesis Through Beclin 1 Phosphorylation

(2012) R. C. Wang et al.   SCIENCE

ULK1 inhibits the kinase activity of mTORC1 and cell proliferation

(2011) Chang Hwa Jung et al.   Autophagy

Phosphatidylserine is a critical modulator for Akt activation

(2011) Bill X. Huang et al.   JOURNAL OF CELL BIOLOGY

Class III PI-3-kinase activates phospholipase D in an amino acid–sensing mTORC1 pathway

(2011) Mee-Sup Yoon et al.   JOURNAL OF CELL BIOLOGY

High-resolution mapping reveals topologically distinct cellular pools of phosphatidylserine

(2011) Gregory D. Fairn et al.   JOURNAL OF CELL BIOLOGY

α-Synuclein and ALPS motifs are membrane curvature sensors whose contrasting chemistry mediates selective vesicle binding

(2011) Iwona M. Pranke et al.   JOURNAL OF CELL BIOLOGY

The Mammalian Class 3 PI3K (PIK3C3) Is Required for Early Embryogenesis and Cell Proliferation

(2011) Xiang Zhou et al.   PLoS One

Autophagosome targeting and membrane curvature sensing by Barkor/Atg14(L)

(2011) W. Fan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Distribution and Function of Phosphatidylserine in Cellular Membranes

(2010) Peter A. Leventis et al.   Annual Review of Biophysics

Characterization of autophagosome formation site by a hierarchical analysis of mammalian Atg proteins

(2010) Eisuke Itakura et al.   Autophagy

Lipidomics reveals membrane lipid remodelling and release of potential lipid mediators during early stress responses in a murine melanoma cell line

(2010) Gábor Balogh et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

The Structure and Function of Endophilin Proteins

(2010) Ole Kjaerulff et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

LC3 and GATE-16/GABARAP subfamilies are both essential yet act differently in autophagosome biogenesis

(2010) Hilla Weidberg et al.   EMBO JOURNAL

mTOR regulation of autophagy

(2010) Chang Hwa Jung et al.   FEBS LETTERS

Trafficking and signaling in mammalian autophagy

(2010) Sharon A. Tooze et al.   IUBMB LIFE

An Atg9-containing compartment that functions in the early steps of autophagosome biogenesis

(2010) Muriel Mari et al.   JOURNAL OF CELL BIOLOGY

Membrane Delivery to the Yeast Autophagosome from the Golgi–Endosomal System

(2010) Yohei Ohashi et al.   MOLECULAR BIOLOGY OF THE CELL

Rubicon and PLEKHM1 Negatively Regulate the Endocytic/Autophagic Pathway via a Novel Rab7-binding Domain

(2010) Keisuke Tabata et al.   MOLECULAR BIOLOGY OF THE CELL

Molecular basis for SH3 domain regulation of F-BAR-mediated membrane deformation

(2010) Y. Rao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Trs85 directs a Ypt1 GEF, TRAPPIII, to the phagophore to promote autophagy

(2010) Molly A. Lynch-Day et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rubicon controls endosome maturation as a Rab7 effector

(2010) Q. Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Shaping Development of Autophagy Inhibitors with the Structure of the Lipid Kinase Vps34

(2010) S. Miller et al.   SCIENCE

Modulation of Local PtdIns3P Levels by the PI Phosphatase MTMR3 Regulates Constitutive Autophagy

(2010) Naoko Taguchi-Atarashi et al.   TRAFFIC

Bif-1/Endophilin B1: a candidate for crescent driving force in autophagy

(2009) Y Takahashi et al.   CELL DEATH AND DIFFERENTIATION

Control of autophagy initiation by phosphoinositide 3-phosphatase jumpy

(2009) Isabelle Vergne et al.   EMBO JOURNAL

ULK1·ATG13·FIP200 Complex Mediates mTOR Signaling and Is Essential for Autophagy

(2009) Ian G. Ganley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagy pathway intersects with HIV-1 biosynthesis and regulates viral yields in macrophages

(2009) George B. Kyei et al.   JOURNAL OF CELL BIOLOGY

Nutrient-dependent mTORC1 Association with the ULK1–Atg13–FIP200 Complex Required for Autophagy

(2009) Nao Hosokawa et al.   MOLECULAR BIOLOGY OF THE CELL

ULK-Atg13-FIP200 Complexes Mediate mTOR Signaling to the Autophagy Machinery

(2009) Chang Hwa Jung et al.   MOLECULAR BIOLOGY OF THE CELL

Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin 1–phosphatidylinositol-3-kinase complex

(2009) Yun Zhong et al.   NATURE CELL BIOLOGY

Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages

(2009) Kohichi Matsunaga et al.   NATURE CELL BIOLOGY

Molecular mechanism of membrane constriction and tubulation mediated by the F-BAR protein Pacsin/Syndapin

(2009) Q. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutant p53 drives metastasis and overcomes growth arrest/senescence in pancreatic cancer

(2009) J. P. Morton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Membrane insertion of the FYVE domain is modulated by pH

(2009) Ju He et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Alternative metabolic fates of phosphatidylinositol produced by phosphatidylinositol synthase isoforms inArabidopsis thaliana

(2008) Christian Löfke et al.   BIOCHEMICAL JOURNAL

The Atg18-Atg2 Complex Is Recruited to Autophagic Membranes via Phosphatidylinositol 3-Phosphate and Exerts an Essential Function

(2008) Keisuke Obara et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum

(2008) Elizabeth L. Axe et al.   JOURNAL OF CELL BIOLOGY

FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells

(2008) Taichi Hara et al.   JOURNAL OF CELL BIOLOGY

The Atg16L Complex Specifies the Site of LC3 Lipidation for Membrane Biogenesis in Autophagy

(2008) Naonobu Fujita et al.   MOLECULAR BIOLOGY OF THE CELL

Beclin 1 Forms Two Distinct Phosphatidylinositol 3-Kinase Complexes with Mammalian Atg14 and UVRAG

(2008) Eisuke Itakura et al.   MOLECULAR BIOLOGY OF THE CELL

Beclin1-binding UVRAG targets the class C Vps complex to coordinate autophagosome maturation and endocytic trafficking

(2008) Chengyu Liang et al.   NATURE CELL BIOLOGY

Endosomal sorting and signalling: an emerging role for sorting nexins

(2008) Peter J. Cullen   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Membrane lipids: where they are and how they behave

(2008) Gerrit van Meer et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Identification of Barkor as a mammalian autophagy-specific factor for Beclin 1 and class III phosphatidylinositol 3-kinase

(2008) Q. Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Membrane Phosphatidylserine Regulates Surface Charge and Protein Localization

(2008) T. Yeung et al.   SCIENCE