Parkin Mutation Affects Clock Gene-Dependent Energy Metabolism

Crosstalk between metabolism and circadian clocks

(2019) Hans Reinke et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Increased Levels of cAMP by the Calcium-Dependent Activation of Soluble Adenylyl Cyclase in Parkin-Mutant Fibroblasts

(2019) Paola Tanzarella et al.   Cells

Circadian clock protein Rev-erbα regulates neuroinflammation

(2019) Percy Griffin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Circadian Control of DRP1 Activity Regulates Mitochondrial Dynamics and Bioenergetics

(2018) Karen Schmitt et al.   Cell Metabolism

Mitochondria and the dynamic control of stem cell homeostasis

(2018) Pawel Lisowski et al.   EMBO REPORTS

Comparative analysis of Parkinson's disease–associated genes in mice reveals altered survival and bioenergetics of Parkin-deficient dopamine neurons

(2018) Nicolas Giguère et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Circadian rhythms in mitochondrial respiration

(2018) Paul de Goede et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Mitochondria/metabolic reprogramming in the formation of neurons from peripheral cells: Cause or consequence and the implications to their utility

(2018) Gary E. Gibson et al.   NEUROCHEMISTRY INTERNATIONAL

Pyrosequencing analysis of methylation levels of clock genes in leukocytes from Parkinson’s disease patients

(2018) Wei Mao et al.   NEUROSCIENCE LETTERS

Disruption of the Circadian Clock Alters Antioxidative Defense via the SIRT1-BMAL1 Pathway in 6-OHDA-Induced Models of Parkinson’s Disease

(2018) Yali Wang et al.   Oxidative Medicine and Cellular Longevity

The Circadian Clock Regulates Metabolic Phenotype Rewiring Via HKDC1 and Modulates Tumor Progression and Drug Response in Colorectal Cancer

(2018) Luise Fuhr et al.   EBioMedicine

Establishment of stable iPS-derived human neural stem cell lines suitable for cell therapies

(2018) Jessica Rosati et al.   Cell Death & Disease

Using Patient-Derived Induced Pluripotent Stem Cells to Identify Parkinson’s Disease-Relevant Phenotypes

(2018) S. L. Sison et al.   Current Neurology and Neuroscience Reports

Circadian Rhythms and Mitochondria: Connecting the Dots

(2018) Laura Sardon Puig et al.   Frontiers in Genetics

Involvement of posttranscriptional regulation ofClockin the emergence of circadian clock oscillation during mouse development

(2017) Yasuhiro Umemura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PINK1, Parkin, and Mitochondrial Quality Control: What can we Learn about Parkinson’s Disease Pathobiology?

(2017) Dominika Truban et al.   Journal of Parkinsons Disease

Clock-genes and mitochondrial respiratory activity: Evidence of a reciprocal interplay

(2016) Rosella Scrima et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Clock genes-dependent acetylation of complex I sets rhythmic activity of mitochondrial OxPhos

(2016) Olga Cela et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Circadian control of oscillations in mitochondrial rate-limiting enzymes and nutrient utilization by PERIOD proteins

(2016) Adi Neufeld-Cohen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A New Perspective for Parkinson’s Disease: Circadian Rhythm

(2016) Siyue Li et al.   Neuroscience Bulletin

The Circadian Nature of Mitochondrial Biology

(2016) Gal Manella et al.   Frontiers in Endocrinology

Negative reciprocal regulation between Sirt1 and Per2 modulates the circadian clock and aging

(2016) Rui-Hong Wang et al.   Scientific Reports

Hepatic Bmal1 Regulates Rhythmic Mitochondrial Dynamics and Promotes Metabolic Fitness

(2015) David Jacobi et al.   Cell Metabolism

Neuroinflammation in Parkinson’s disease and its potential as therapeutic target

(2015) Qinqin Wang et al.   Translational Neurodegeneration

Development of Circadian Oscillators in Neurosphere Cultures during Adult Neurogenesis

(2015) Astha Malik et al.   PLoS One

Effect of resveratrol on mitochondrial function: Implications in parkin-associated familiar Parkinson's disease

(2014) Anna Ferretta et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Daily rhythms of serotonin metabolism and the expression of clock genes in suprachiasmatic nucleus of rotenone-induced Parkinson’s disease male Wistar rat model and effect of melatonin administration

(2014) Ushodaya Mattam et al.   BIOGERONTOLOGY

Cosinor-based rhythmometry

(2014) Germaine Cornelissen   Theoretical Biology and Medical Modelling

Sleep and Circadian Rhythm Regulation in Early Parkinson Disease

(2014) David P. Breen et al.   JAMA Neurology

Enhanced parkin levels favor ER-mitochondria crosstalk and guarantee Ca2+ transfer to sustain cell bioenergetics

(2013) Tito Calì et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Mitochondrial Regulation in Pluripotent Stem Cells

(2013) Xiuling Xu et al.   Cell Metabolism

Interference with the mitochondrial bioenergetics fuels reprogramming to pluripotency via facilitation of the glycolytic transition

(2013) Myung Jin Son et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Rev-erb-α modulates skeletal muscle oxidative capacity by regulating mitochondrial biogenesis and autophagy

(2013) Estelle Woldt et al.   NATURE MEDICINE

Circadian Clock NAD+ Cycle Drives Mitochondrial Oxidative Metabolism in Mice

(2013) C. B. Peek et al.   SCIENCE

Molecular architecture of the mammalian circadian clock

(2013) Carrie L. Partch et al.   TRENDS IN CELL BIOLOGY

Guidelines for the use and interpretation of assays for monitoring autophagy

(2012) Daniel J. Klionsky et al.   Autophagy

Circadian Dysfunction in a Rotenone-Induced Parkinsonian Rodent Model

(2012) Pedro Lax et al.   CHRONOBIOLOGY INTERNATIONAL

Toward the Beginning of Time: Circadian Rhythms in Metabolism Precede Rhythms in Clock Gene Expression in Mouse Embryonic Stem Cells

(2012) Jiffin K. Paulose et al.   PLoS One

Mitochondrial defect and PGC-1α dysfunction in parkin-associated familial Parkinson's disease

(2011) Consiglia Pacelli et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

PARIS (ZNF746) Repression of PGC-1α Contributes to Neurodegeneration in Parkinson's Disease

(2011) Joo-Ho Shin et al.   CELL

Circadian dysfunction in a mouse model of Parkinson's disease

(2011) Takashi Kudo et al.   EXPERIMENTAL NEUROLOGY

Mechanisms of mitophagy

(2010) Richard J. Youle et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Development of the circadian oscillator during differentiation of mouse embryonic stem cells in vitro

(2010) Kazuhiro Yagita et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Expression of clock genesPer1andBmal1in total leukocytes in health and Parkinson’s disease

(2009) Y. Cai et al.   EUROPEAN JOURNAL OF NEUROLOGY

Parkin deficiency disrupts calcium homeostasis by modulating phospholipase C signalling

(2009) Anna Sandebring et al.   FEBS Journal

The PINK1/Parkin pathway: a mitochondrial quality control system?

(2009) Alexander J. Whitworth et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Metabolism control by the circadian clock and vice versa

(2009) Kristin Eckel-Mahan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Modelling Parkinson’s Disease in Drosophila

(2009) José A. Botella et al.   NEUROMOLECULAR MEDICINE

Circadian Control of the NAD+ Salvage Pathway by CLOCK-SIRT1

(2009) Y. Nakahata et al.   SCIENCE

Mitochondrial function and morphology are impaired inparkin-mutant fibroblasts

(2008) Heather Mortiboys et al.   ANNALS OF NEUROLOGY

SIRT1 Is a Circadian Deacetylase for Core Clock Components

(2008) William J. Belden et al.   CELL

SIRT1 Regulates Circadian Clock Gene Expression through PER2 Deacetylation

(2008) Gad Asher et al.   CELL

Mitochondrial biogenesis and turnover

(2008) F DIAZ et al.   CELL CALCIUM

The PINK1/Parkin pathway regulates mitochondrial morphology

(2008) A. C. Poole et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Parkinson's disease genes pink1 and parkin promote mitochondrial fission and/or inhibit fusion in Drosophila

(2008) H. Deng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA