Intrinsic Interferon Signaling Regulates the Cell Death and Mesenchymal Phenotype of Glioblastoma Stem Cells

Glioblastomas acquire myeloid-affiliated transcriptional programs via epigenetic immunoediting to elicit immune evasion

(2021) Ester Gangoso et al.   CELL

Surveying brain tumor heterogeneity by single-cell RNA sequencing of multi-sector biopsies

(2020) Kai Yu et al.   National Science Review

A map of tumor–host interactions in glioma at single-cell resolution

(2020) Francesca Pia Caruso et al.   GigaScience

JAK/STAT inhibition with ruxolitinib enhances oncolytic virotherapy in non-small cell lung cancer models

(2019) Manish R. Patel et al.   CANCER GENE THERAPY

Neoadjuvant anti-PD-1 immunotherapy promotes a survival benefit with intratumoral and systemic immune responses in recurrent glioblastoma

(2019) Timothy F. Cloughesy et al.   NATURE MEDICINE

Current State of Immunotherapy for Treatment of Glioblastoma

(2019) Tresa McGranahan et al.   CURRENT TREATMENT OPTIONS IN ONCOLOGY

Stem cell-associated heterogeneity in Glioblastoma results from intrinsic tumor plasticity shaped by the microenvironment

(2019) Anne Dirkse et al.   Nature Communications

Comprehensive Integration of Single-Cell Data

(2019) Tim Stuart et al.   CELL

An Integrative Model of Cellular States, Plasticity, and Genetics for Glioblastoma

(2019) Cyril Neftel et al.   CELL

Mechanisms of immunotherapy resistance: lessons from glioblastoma

(2019) Christopher M. Jackson et al.   NATURE IMMUNOLOGY

Development and validation of an interferon signature predicting prognosis and treatment response for glioblastoma

(2019) Chen Zhu et al.   OncoImmunology

Intrinsic Immunity Shapes Viral Resistance of Stem Cells

(2018) Xianfang Wu et al.   CELL

Constitutive Interferon Pathway Activation in Tumors as an Efficacy Determinant Following Oncolytic Virotherapy

(2018) Cheyne Kurokawa et al.   JNCI-Journal of the National Cancer Institute

Constitutive Interferon Pathway Activation in Tumors as an Efficacy Determinant Following Oncolytic Virotherapy

(2018) Cheyne Kurokawa et al.   JNCI-Journal of the National Cancer Institute

An Update on Immunotherapy for Solid Tumors: A Review

(2018) Toan Pham et al.   ANNALS OF SURGICAL ONCOLOGY

Plasticity of Type I Interferon-Mediated Responses in Cancer Therapy: From Anti-tumor Immunity to Resistance

(2018) Megha Budhwani et al.   Frontiers in Oncology

Interferon-β signal may up-regulate PD-L1 expression through IRF9-dependent and independent pathways in lung cancer cells

(2018) Yoshie Morimoto et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The IFN-γ/PD-L1 axis between T cells and tumor microenvironment: hints for glioma anti-PD-1/PD-L1 therapy

(2018) Jiawen Qian et al.   Journal of Neuroinflammation

Type I interferon pathway in CNS homeostasis and neurological disorders

(2017) Thomas Blank et al.   GLIA

Intracranial AAV-IFN-β gene therapy eliminates invasive xenograft glioblastoma and improves survival in orthotopic syngeneic murine model

(2017) Dwijit GuhaSarkar et al.   Molecular Oncology

Autocrine activation of the IFN signaling pathway may promote immune escape in glioblastoma

(2017) Manuela Silginer et al.   NEURO-ONCOLOGY

Interferon-beta represses cancer stem cell properties in triple-negative breast cancer

(2017) Mary R. Doherty et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CD95/Fas Increases Stemness in Cancer Cells by Inducing a STAT1-Dependent Type I Interferon Response

(2017) Abdul S. Qadir et al.   Cell Reports

Single-Cell RNA-Seq Analysis of Infiltrating Neoplastic Cells at the Migrating Front of Human Glioblastoma

(2017) Spyros Darmanis et al.   Cell Reports

Tumor Interferon Signaling Regulates a Multigenic Resistance Program to Immune Checkpoint Blockade

(2016) Joseph L. Benci et al.   CELL

GlioVis data portal for visualization and analysis of brain tumor expression datasets

(2016) Robert L. Bowman et al.   NEURO-ONCOLOGY

Interferon alpha-inducible protein 27 promotes epithelial–mesenchymal transition and induces ovarian tumorigenicity and stemness

(2015) Shuqin Li et al.   JOURNAL OF SURGICAL RESEARCH

Interferon-regulatory factor-1 (IRF1) regulates bevacizumab induced autophagy

(2015) Ji Liang et al.   Oncotarget

The Molecular Signatures Database Hallmark Gene Set Collection

(2015) Arthur Liberzon et al.   Cell Systems

Interferons, Signal Transduction Pathways, and the Central Nervous System

(2014) Shreeram C. Nallar et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

STAT-1 expression is regulated by IGFBP-3 in malignant glioma cells and is a strong predictor of poor survival in patients with glioblastoma

(2014) Balaram Thota et al.   JOURNAL OF NEUROSURGERY

Interferon-  Induces Loss of Spherogenicity and Overcomes Therapy Resistance of Glioblastoma Stem Cells

(2014) C. Happold et al.   MOLECULAR CANCER THERAPEUTICS

Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma

(2014) A. P. Patel et al.   SCIENCE

The Somatic Genomic Landscape of Glioblastoma

(2013) Cameron W. Brennan et al.   CELL

Neutrophils Promote the Malignant Glioma Phenotype through S100A4

(2013) J. Liang et al.   CLINICAL CANCER RESEARCH

Interferon regulatory factor 3 alters glioma inflammatory and invasive properties

(2013) Leonid Tarassishin et al.   JOURNAL OF NEURO-ONCOLOGY

The Cancer Genome Atlas Pan-Cancer analysis project

(2013) John N Weinstein et al.   NATURE GENETICS

Immune Heterogeneity of Glioblastoma Subtypes: Extrapolation from the Cancer Genome Atlas

(2013) T. Doucette et al.   Cancer Immunology Research

Interferon regulatory factor 7 regulates glioma stem cells via interleukin-6 and Notch signalling

(2012) X. Jin et al.   BRAIN

Expression Signature of IFN/STAT1 Signaling Genes Predicts Poor Survival Outcome in Glioblastoma Multiforme in a Subtype-Specific Manner

(2012) Christine W. Duarte et al.   PLoS One

Current concepts and management of glioblastoma

(2011) Matthias Preusser et al.   ANNALS OF NEUROLOGY

Type I IFNs signaling and apoptosis resistance in glioblastoma cells

(2011) Andrea Sgorbissa et al.   APOPTOSIS

Review of the clinical evidence for interferon β 1a (Rebif®) in the treatment of multiple sclerosis

(2011) F Monzani   Neuropsychiatric Disease and Treatment

Benefits of interferon-β and temozolomide combination therapy for newly diagnosed primary glioblastoma with the unmethylated MGMT promoter

(2010) Kazuya Motomura et al.   CANCER

Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA, IDH1, EGFR, and NF1

(2010) Roel G.W. Verhaak et al.   CANCER CELL

Interferon-gamma in Brain Tumor Immunotherapy

(2009) Ari Kane et al.   NEUROSURGERY CLINICS OF NORTH AMERICA

Targeting Interleukin 6 Signaling Suppresses Glioma Stem Cell Survival and Tumor Growth

(2009) Hui Wang et al.   STEM CELLS

STAT3 Is Required for Proliferation and Maintenance of Multipotency in Glioblastoma Stem Cells

(2009) Maureen M. Sherry et al.   STEM CELLS