Intracranial AAV-IFN-β gene therapy eliminates invasive xenograft glioblastoma and improves survival in orthotopic syngeneic murine model

The role of microglia and macrophages in glioma maintenance and progression

(2016) Dolores Hambardzumyan et al.   NATURE NEUROSCIENCE

AAV9-mediated central nervous system–targeted gene delivery via cisterna magna route in mice

(2016) Vera Lukashchuk et al.   Molecular Therapy-Methods & Clinical Development

Does Early Postsurgical Temozolomide Plus Concomitant Radiochemotherapy Regimen Have Any Benefit in Newly-diagnosed Glioblastoma Patients? A Multi-center, Randomized, Parallel, Open-label, Phase II Clinical Trial

(2015) Liang-Fu Zhou et al.   CHINESE MEDICAL JOURNAL

The role of regulatory T cells and microglia in glioblastoma-associated immunosuppression

(2015) Alfred P. See et al.   JOURNAL OF NEURO-ONCOLOGY

Prospects of immune checkpoint modulators in the treatment of glioblastoma

(2015) Matthias Preusser et al.   Nature Reviews Neurology

Interferon-β Modulates the Innate Immune Response against Glioblastoma Initiating Cells

(2015) Fabian Wolpert et al.   PLoS One

Interferon-Stimulated Genes: A Complex Web of Host Defenses

(2014) William M. Schneider et al.   Annual Review of Immunology

Targeting the Tumor Microenvironment with Interferon-β Bridges Innate and Adaptive Immune Responses

(2014) Xuanming Yang et al.   CANCER CELL

Interferon-  Induces Loss of Spherogenicity and Overcomes Therapy Resistance of Glioblastoma Stem Cells

(2014) C. Happold et al.   MOLECULAR CANCER THERAPEUTICS

Bridging the Species Divide: Transgenic Mice Humanized for Type-I Interferon Response

(2014) Daniel Harari et al.   PLoS One

Standards of care and novel approaches in the management of glioblastoma multiforme

(2014) Andreas F. Hottinger et al.   Chinese Journal of Cancer

Elevated CD3+ and CD8+ tumor-infiltrating immune cells correlate with prolonged survival in glioblastoma patients despite integrated immunosuppressive mechanisms in the tumor microenvironment and at the systemic level

(2013) Justyna Kmiecik et al.   JOURNAL OF NEUROIMMUNOLOGY

The molecular profile of microglia under the influence of glioma

(2012) W. Li et al.   NEURO-ONCOLOGY

Current concepts and management of glioblastoma

(2011) Matthias Preusser et al.   ANNALS OF NEUROLOGY

Interferon-β efficiently inhibited endothelial progenitor cell-induced tumor angiogenesis

(2011) H-B Xiao et al.   GENE THERAPY

Identification and functional characterization of glioma-specific promoters and their application in suicide gene therapy

(2011) Toshio Yawata et al.   JOURNAL OF NEURO-ONCOLOGY

Continuous local delivery of interferon-β stabilizes tumor vasculature in an orthotopic glioblastoma xenograft resection model

(2011) Jason W. Denbo et al.   SURGERY

Benefits of interferon-β and temozolomide combination therapy for newly diagnosed primary glioblastoma with the unmethylated MGMT promoter

(2010) Kazuya Motomura et al.   CANCER

Controlling brain tumor growth by intraventricular administration of an AAV vector encoding IFN-β

(2009) D H Meijer et al.   CANCER GENE THERAPY

Human Glioblastoma-Derived Cancer Stem Cells: Establishment of Invasive Glioma Models and Treatment with Oncolytic Herpes Simplex Virus Vectors

(2009) H. Wakimoto et al.   CANCER RESEARCH

Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial

(2009) Roger Stupp et al.   LANCET ONCOLOGY

Combinatorial Control of Suicide Gene Expression by Tissue-specific Promoter and microRNA Regulation for Cancer Therapy

(2009) Chunxiao Wu et al.   MOLECULAR THERAPY

Preventing Growth of Brain Tumors by Creating a Zone of Resistance

(2008) Casey A Maguire et al.   MOLECULAR THERAPY

Self-complementary AAV Vectors; Advances and Applications

(2008) Douglas M McCarty   MOLECULAR THERAPY