Tumor Cell Infiltration into the Brain in Glioblastoma: From Mechanisms to Clinical Perspectives

Fibrinogen in the glioblastoma microenvironment contributes to the invasiveness of brain tumor‐initiating cells

(2021) Lauren Dzikowski et al.   BRAIN PATHOLOGY

Decoding Cancer Biology One Cell at a Time

(2021) L. Nicolas Gonzalez Castro et al.   Cancer Discovery

TRIM28 Selective Nanobody Reduces Glioblastoma Stem Cell Invasion

(2021) Andrej Porčnik et al.   MOLECULES

TGF- promotes microtube formation in glioblastoma through Thrombospondin 1

(2021) Justin V Joseph et al.   NEURO-ONCOLOGY

P4HA2 promotes cell proliferation and migration in glioblastoma

(2021) Yuying Wu et al.   Oncology Letters

lnc‑NLC1‑C inhibits migration, invasion and autophagy of glioma cells by targeting miR‑383 and regulating PRDX‑3 expression

(2021) Zhou Xu et al.   Oncology Letters

Detection of glioma infiltration at the tumor margin using quantitative stimulated Raman scattering histology

(2021) Melike Pekmezci et al.   Scientific Reports

Acid-Sensing Ion Channel 1 Contributes to Weak Acid-Induced Migration of Human Malignant Glioma Cells

(2021) Sareena Shah et al.   Frontiers in Physiology

P4HA2 Promotes Epithelial-to-Mesenchymal Transition and Glioma Malignancy through the Collagen-Dependent PI3K/AKT Pathway

(2021) Jing Lin et al.   Journal of Oncology

Decorin Suppresses Invasion and EMT Phenotype of Glioma by Inducing Autophagy via c-Met/Akt/mTOR Axis

(2021) Yanfei Jia et al.   Frontiers in Oncology

Knockdown of long non-coding RNA SLC8A1-AS1 attenuates cell invasion and migration in glioma via suppression of Wnt/β-catenin signaling pathways

(2021) Ling He et al.   BRAIN RESEARCH BULLETIN

Glioma invasion along white matter tracts: A dilemma for neurosurgeons

(2021) Jun Wang et al.   CANCER LETTERS

Microglial-stimulation of glioma invasion involves the EGFR ligand amphiregulin

(2021) Salvatore J. Coniglio et al.   PLoS One

Efficacy and safety of bevacizumab in the treatment of adult gliomas: a systematic review and meta-analysis

(2021) Huan Wang et al.   BMJ Open

RBM8A Promotes Glioblastoma Growth and Invasion Through the Notch/STAT3 Pathway

(2021) Yan Lin et al.   Frontiers in Oncology

Arg kinase mediates CXCL12/CXCR4-induced invadopodia formation and invasion of glioma cells

(2020) Lei Chen et al.   EXPERIMENTAL CELL RESEARCH

Integrin Signaling in Glioma Pathogenesis: From Biology to Therapy

(2020) Aleksandra Ellert-Miklaszewska et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Phase 1b/2a study of galunisertib, a small molecule inhibitor of transforming growth factor-beta receptor I, in combination with standard temozolomide-based radiochemotherapy in patients with newly diagnosed malignant glioma

(2020) Antje Wick et al.   INVESTIGATIONAL NEW DRUGS

Modeling glioblastoma invasion using human brain organoids and single-cell transcriptomics

(2020) Teresa G Krieger et al.   NEURO-ONCOLOGY

PHIP drives glioblastoma motility and invasion by regulating the focal adhesion complex

(2020) David de Semir et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NKCC1 involvement in the epithelial-to-mesenchymal transition is a prognostic biomarker in gliomas

(2020) Huaiyu Sun et al.   PeerJ

EMT, MET, Plasticity, and Tumor Metastasis

(2020) Basil Bakir et al.   TRENDS IN CELL BIOLOGY

Glioma-initiating cells at tumor edge gain signals from tumor core cells to promote their malignancy

(2020) Soniya Bastola et al.   Nature Communications

Inhibition of TRPM7 with waixenicin A reduces glioblastoma cellular functions

(2020) Raymond Wong et al.   CELL CALCIUM

Deeper and Deeper on the Role of BK and Kir4.1 Channels in Glioblastoma Invasiveness: A Novel Summative Mechanism?

(2020) Federico Brandalise et al.   Frontiers in Neuroscience

Behaviors of Glioblastoma Cells in in Vitro Microenvironments

(2019) Wenwen Diao et al.   Scientific Reports

The Volume-Regulated Anion Channel in Glioblastoma

(2019) Martino Caramia et al.   Cancers

Virus-Based Immunotherapy of Glioblastoma

(2019) Miika Martikainen et al.   Cancers

Intravital imaging of glioma border morphology reveals distinctive cellular dynamics and contribution to tumor cell invasion

(2019) Maria Alieva et al.   Scientific Reports

What is the Role of Tumor-treating Fields in Newly Diagnosed Glioblastoma?

(2019) Abbie S. Ornelas et al.   NEUROLOGIST

Glioblastoma vs temozolomide: can the red queen race be won?

(2019) Anjali Arora et al.   CANCER BIOLOGY & THERAPY

Current approaches and challenges in the molecular therapeutic targeting of glioblastoma

(2019) James Mooney et al.   World Neurosurgery

Notch1 signaling pathway promotes invasion, self-renewal and growth of glioma initiating cells via modulating chemokine system CXCL12/CXCR4

(2019) Li Yi et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Glioblastoma Multiforme: An Overview of Emerging Therapeutic Targets

(2019) Olivia G. Taylor et al.   Frontiers in Oncology

TRPM2‐AS inhibits the growth, migration, and invasion of gliomas through JNK, c‐Jun, and RGS4

(2019) Mei‐Hua Bao et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Identification of SERPINE1 as a Regulator of Glioblastoma Cell Dispersal with Transcriptome Profiling

(2019) Fidan Seker et al.   Cancers

Glioblastoma quo vadis : Will migration and invasiveness reemerge as therapeutic targets?

(2018) Florence Lefranc et al.   CANCER TREATMENT REVIEWS

MiR-129-5p inhibits glioma cell progression in vitro and in vivo by targeting TGIF2

(2018) Yuling Diao et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Drug delivery challenges and future of chemotherapeutic nanomedicine for glioblastoma treatment

(2018) Lakshmi Pallavi Ganipineni et al.   JOURNAL OF CONTROLLED RELEASE

Alternating electric tumor treating fields for treatment of glioblastoma: rationale, preclinical, and clinical studies

(2018) Sandeep Mittal et al.   JOURNAL OF NEUROSURGERY

Inhibition of GPR158 by microRNA-449a suppresses neural lineage of glioma stem/progenitor cells and correlates with higher glioma grades

(2018) Ningning Li et al.   ONCOGENE

Patterns of Invasive Growth in Malignant Gliomas—The Hippocampus Emerges as an Invasion-Spared Brain Region

(2018) Awais A. Mughal et al.   NEOPLASIA

Cell Adhesion and Matrix Stiffness: Coordinating Cancer Cell Invasion and Metastasis

(2018) Vasiliki Gkretsi et al.   Frontiers in Oncology

Knockdown of long non-coding RNA NEAT1 inhibits glioma cell migration and invasion via modulation of SOX2 targeted by miR-132

(2018) Ke Zhou et al.   Molecular Cancer

An Experimenter’s Guide to Glioblastoma Invasion Pathways

(2018) Mark C. de Gooijer et al.   TRENDS IN MOLECULAR MEDICINE

Extracellular matrix differences in glioblastoma patients with different prognoses

(2018) J�zsef Virga et al.   Oncology Letters

Recapitulating in vivo-like plasticity of glioma cell invasion along blood vessels and in astrocyte-rich stroma

(2017) Pavlo Gritsenko et al.   HISTOCHEMISTRY AND CELL BIOLOGY

The Molecular and Phenotypic Basis of the Glioma Invasive Perivascular Niche

(2017) et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Effect of Tumor-Treating Fields Plus Maintenance Temozolomide vs Maintenance Temozolomide Alone on Survival in Patients With Glioblastoma

(2017) Roger Stupp et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Rindopepimut with temozolomide for patients with newly diagnosed, EGFRvIII-expressing glioblastoma (ACT IV): a randomised, double-blind, international phase 3 trial

(2017) Michael Weller et al.   LANCET ONCOLOGY

EMT- and MET-related processes in nonepithelial tumors: importance for disease progression, prognosis, and therapeutic opportunities

(2017) Ulf D. Kahlert et al.   Molecular Oncology

Modulation of the inwardly rectifying potassium channel Kir4.1 by the pro-invasive miR-5096 in glioblastoma cells

(2017) Dominique Thuringer et al.   Oncotarget

Development of an integrated Monte Carlo model for glioblastoma multiforme treated with boron neutron capture therapy

(2017) Leyla Moghaddasi et al.   Scientific Reports

The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary

(2016) David N. Louis et al.   ACTA NEUROPATHOLOGICA

The Epithelial-to-Mesenchymal Transition-Like Process in Glioblastoma: An Updated Systematic Review and In Silico Investigation

(2016) Isabele C. Iser et al.   MEDICINAL RESEARCH REVIEWS

Epithelial-mesenchymal transition in glioblastoma progression

(2016) YASUO IWADATE   Oncology Letters

EGF induces epithelial-mesenchymal transition through phospho-Smad2/3-Snail signaling pathway in breast cancer cells

(2016) Jinkyoung Kim et al.   Oncotarget

Bistability in the Rac1, PAK, and RhoA Signaling Network Drives Actin Cytoskeleton Dynamics and Cell Motility Switches

(2016) Kate M. Byrne et al.   Cell Systems

Strategies of Mesenchymal Invasion of Patient-derived Brain Tumors: Microenvironmental Adaptation

(2016) Junghwa Cha et al.   Scientific Reports

Confinement and Low Adhesion Induce Fast Amoeboid Migration of Slow Mesenchymal Cells

(2015) Yan-Jun Liu et al.   CELL

Toward an effective strategy in glioblastoma treatment. Part I: resistance mechanisms and strategies to overcome resistance of glioblastoma to temozolomide

(2015) Khaled Messaoudi et al.   DRUG DISCOVERY TODAY

Overcoming the blood–brain tumor barrier for effective glioblastoma treatment

(2015) O. van Tellingen et al.   DRUG RESISTANCE UPDATES

HIF-2alpha-dependent PAI-1 induction contributes to angiogenesis in hepatocellular carcinoma

(2015) Theresa Geis et al.   EXPERIMENTAL CELL RESEARCH

Membrane Proteome Analysis of Glioblastoma Cell Invasion

(2015) Duthika M. Mallawaaratchy et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Brain tumour cells interconnect to a functional and resistant network

(2015) Matthias Osswald et al.   NATURE

First clinical results of a personalized immunotherapeutic vaccine against recurrent, incompletely resected, treatment-resistant glioblastoma multiforme (GBM) tumors, based on combined allo- and auto-immune tumor reactivity

(2015) Virgil E.J.C. Schijns et al.   VACCINE

Cancer as a channelopathy: ion channels and pumps in tumor development and progression

(2015) Alisa Litan et al.   Frontiers in Cellular Neuroscience

Mitotic Spindle Disruption by Alternating Electric Fields Leads to Improper Chromosome Segregation and Mitotic Catastrophe in Cancer Cells

(2015) Moshe Giladi et al.   Scientific Reports

Membrane lipids in invadopodia and podosomes: Key structures for cancer invasion and metastasis

(2015)   Oncotarget

Transforming Growth Factor-  as a Therapeutic Target in Hepatocellular Carcinoma

(2014) G. Giannelli et al.   CANCER RESEARCH

TRPM7 channels regulate glioma stem cell through STAT3 and Notch signaling pathways

(2014) Mingli Liu et al.   CELLULAR SIGNALLING

The Role of Snail in EMT and Tumorigenesis

(2014) Yifan Wang et al.   CURRENT CANCER DRUG TARGETS

A neurocentric perspective on glioma invasion

(2014) Vishnu Anand Cuddapah et al.   NATURE REVIEWS NEUROSCIENCE

The epidemiology of glioma in adults: a "state of the science" review

(2014) Q. T. Ostrom et al.   NEURO-ONCOLOGY

Targeting adaptive glioblastoma: an overview of proliferation and invasion

(2014) Q. Xie et al.   NEURO-ONCOLOGY

Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma

(2014) A. P. Patel et al.   SCIENCE

Post Hoc Analyses of Intention-to-Treat Population in Phase III Comparison of NovoTTF-100A™ System Versus Best Physician’s Choice Chemotherapy

(2014) Andrew A. Kanner et al.   SEMINARS IN ONCOLOGY

Disruption of astrocyte–vascular coupling and the blood–brain barrier by invading glioma cells

(2014) Stacey Watkins et al.   Nature Communications

Radiotherapy of high-grade gliomas: current standards and new concepts, innovations in imaging and radiotherapy, and new therapeutic approaches

(2014) Frederic Dhermain   Chinese Journal of Cancer

Identifying new small molecule anti-invasive compounds for glioma treatment

(2013) Jennifer Munson et al.   CELL CYCLE

The ZEB1 pathway links glioblastoma initiation, invasion and chemoresistance

(2013) Florian A. Siebzehnrubl et al.   EMBO Molecular Medicine

Mechanism of temozolomide-induced antitumour effects on glioma cells

(2013) Wei Shen et al.   JOURNAL OF INTERNATIONAL MEDICAL RESEARCH

Tax-interacting protein 1 coordinates the spatiotemporal activation of Rho GTPases and regulates the infiltrative growth of human glioblastoma

(2013) H Wang et al.   ONCOGENE

NovoTTF-100A versus physician’s choice chemotherapy in recurrent glioblastoma: A randomised phase III trial of a novel treatment modality

(2012) Roger Stupp et al.   EUROPEAN JOURNAL OF CANCER

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(2012) Salvatore Coniglio et al.   MOLECULAR MEDICINE

Glioblastoma resistance to anti-VEGF therapy is associated with myeloid cell infiltration, stem cell accumulation, and a mesenchymal phenotype

(2012) Y. Piao et al.   NEURO-ONCOLOGY

Role of MMP-2 in the regulation of IL-6/Stat3 survival signaling via interaction with α5β1 integrin in glioma

(2012) D Kesanakurti et al.   ONCOGENE

Cancer Invasion and the Microenvironment: Plasticity and Reciprocity

(2011) Peter Friedl et al.   CELL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Bradykinin Promotes the Chemotactic Invasion of Primary Brain Tumors

(2011) V. Montana et al.   JOURNAL OF NEUROSCIENCE

Secretome Signature of Invasive Glioblastoma Multiforme

(2011) Catherine A. Formolo et al.   JOURNAL OF PROTEOME RESEARCH

Temozolomide: Mechanisms of Action, Repair and Resistance

(2011) Jihong Zhang et al.   Current Molecular Pharmacology

SNAI2/Slug promotes growth and invasion in human gliomas

(2010) Hong Wei Yang et al.   BMC CANCER

Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA, IDH1, EGFR, and NF1

(2010) Roel G.W. Verhaak et al.   CANCER CELL

A Dual PI3K/mTOR Inhibitor, PI-103, Cooperates with Stem Cell-Delivered TRAIL in Experimental Glioma Models

(2010) T. Bagci-Onder et al.   CANCER RESEARCH

Signalling to cancer cell invasion through PAK family kinases

(2010) Andrew Whale   Frontiers in Bioscience-Landmark

TNFalpha up-regulates SLUG via the NF-kappaB/HIF1alpha axis, which imparts breast cancer cells with a stem cell-like phenotype

(2010) Gianluca Storci et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Phase I/IIa Study of Cilengitide and Temozolomide With Concomitant Radiotherapy Followed by Cilengitide and Temozolomide Maintenance Therapy in Patients With Newly Diagnosed Glioblastoma

(2010) Roger Stupp et al.   JOURNAL OF CLINICAL ONCOLOGY

High expression of cathepsin B and plasminogen activator inhibitor type-1 are strong predictors of survival in glioblastomas

(2009) Carole Colin et al.   ACTA NEUROPATHOLOGICA

The Mechanical Rigidity of the Extracellular Matrix Regulates the Structure, Motility, and Proliferation of Glioma Cells

(2009) T. A. Ulrich et al.   CANCER RESEARCH

Epithelial-Mesenchymal Transitions in Development and Disease

(2009) Jean Paul Thiery et al.   CELL

The molecular mechanisms of transition between mesenchymal and amoeboid invasiveness in tumor cells

(2009) K. Paňková et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The basics of epithelial-mesenchymal transition

(2009) Raghu Kalluri et al.   JOURNAL OF CLINICAL INVESTIGATION

Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial

(2009) Roger Stupp et al.   LANCET ONCOLOGY

Autocrine semaphorin 3A signaling promotes glioblastoma dispersal

(2009) T Bagci et al.   ONCOGENE

Glioma cells on the run – the migratory transcriptome of 10 human glioma cell lines

(2008) Tim Demuth et al.   BMC GENOMICS

A highly invasive human glioblastoma pre-clinical model for testing therapeutics

(2008) Qian Xie et al.   Journal of Translational Medicine

Chemoresistance in gliomas

(2008) Chen Lu et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY