Excitotoxicity, calcium and mitochondria: a triad in synaptic neurodegeneration

α-Synuclein Oligomers Induce Glutamate Release from Astrocytes and Excessive Extrasynaptic NMDAR Activity in Neurons, Thus Contributing to Synapse Loss

(2021) Dorit Trudler et al.   JOURNAL OF NEUROSCIENCE

Defective Mitochondrial Pyruvate Flux Affects Cell Bioenergetics in Alzheimer’s Disease-Related Models

(2020) Alice Rossi et al.   Cell Reports

Chronic treatment with the complex I inhibitor MPP+ depletes endogenous PTEN-induced kinase 1(PINK1) via upregulation of BCL-2-associated athanogene 6

(2020) Manish Verma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Calpain-Inhibitors Protect Frataxin-Deficient Dorsal Root Ganglia Neurons from Loss of Mitochondrial Na+/Ca2+ Exchanger, NCLX, and Apoptosis

(2020) Elena Britti et al.   NEUROCHEMICAL RESEARCH

Increased mitochondrial calcium levels associated with neuronal death in a mouse model of Alzheimer’s disease

(2020) Maria Calvo-Rodriguez et al.   Nature Communications

The Emerging Functions of LRRK2 and Rab GTPases in the Endolysosomal System

(2020) Tomoki Kuwahara et al.   Frontiers in Neuroscience

Chemical inhibition of FBXO7 reduces inflammation and confers neuroprotection by stabilizing the mitochondrial kinase PINK1

(2020) Yuan Liu et al.   JCI Insight

PINK1 alleviates thermal hypersensitivity in a paclitaxel-induced Drosophila model of peripheral neuropathy

(2020) Young Yeon Kim et al.   PLoS One

Excitotoxicity: Still Hammering the Ischemic Brain in 2020

(2020) Dennis W. Choi   Frontiers in Neuroscience

Presenilin-2 and Calcium Handling: Molecules, Organelles, Cells and Brain Networks

(2020) Paola Pizzo et al.   Cells

Increased glutamate transmission onto dorsal striatum spiny projection neurons in Pink1 knockout rats

(2020) Rose B. Creed et al.   NEUROBIOLOGY OF DISEASE

LRRK2 deficiency induced mitochondrial Ca2+ efflux inhibition can be rescued by Na+/Ca2+/Li+ exchanger upregulation

(2019) Marthe H. R. Ludtmann et al.   Cell Death & Disease

PINK1 Silencing Modifies Dendritic Spine Dynamics of Mouse Hippocampal Neurons

(2019) C. J. Hernández et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Axonal transport defects and neurodegeneration: Molecular mechanisms and therapeutic implications

(2019) Wenting Guo et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Restriction of mitochondrial calcium overload by mcu inactivation renders neuroprotective effect in Zebrafish models of Parkinson's disease

(2019) Smijin K. Soman et al.   Biology Open

Impaired cellular bioenergetics caused by GBA1 depletion sensitizes neurons to calcium overload

(2019) Nicoletta Plotegher et al.   CELL DEATH AND DIFFERENTIATION

Profiles of brain oxidative damage, ventricular alterations, and neurochemical metabolites in the striatum of PINK1 knockout rats as functions of age and gender: Relevance to Parkinson disease

(2019) Xiaojia Ren et al.   FREE RADICAL BIOLOGY AND MEDICINE

The Interplay between Ca2+ Signaling Pathways and Neurodegeneration

(2019) Ureshino et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Overexpression of Mitochondrial Calcium Uniporter Causes Neuronal Death

(2019) Veronica Granatiero et al.   Oxidative Medicine and Cellular Longevity

Impaired mitochondrial calcium efflux contributes to disease progression in models of Alzheimer’s disease

(2019) Pooja Jadiya et al.   Nature Communications

Calcium Dyshomeostasis and Lysosomal Ca2+ Dysfunction in Amyotrophic Lateral Sclerosis

(2019) Tedeschi et al.   Cells

Tau inhibits mitochondrial calcium efflux and makes neurons vulnerable to calcium-induced cell death

(2019) Elena Britti et al.   CELL CALCIUM

Molecular Tuning of the Axonal Mitochondrial Ca2+ Uniporter Ensures Metabolic Flexibility of Neurotransmission

(2019) Ghazaleh Ashrafi et al.   NEURON

Basal Mitophagy Occurs Independently of PINK1 in Mouse Tissues of High Metabolic Demand

(2018) Thomas G. McWilliams et al.   Cell Metabolism

Basal mitophagy is widespread inDrosophilabut minimally affected by loss of Pink1 or parkin

(2018) Juliette J. Lee et al.   JOURNAL OF CELL BIOLOGY

Mechanisms of selective autophagy and mitophagy: Implications for neurodegenerative diseases

(2018) Charleen T. Chu   NEUROBIOLOGY OF DISEASE

Tamoxifen-induced knockdown of the mitochondrial calcium uniporter in Thy1-expressing neurons protects mice from hypoxic/ischemic brain injury

(2018) Matthew Nichols et al.   Cell Death & Disease

Pharmacological Inhibition of Necroptosis Protects from Dopaminergic Neuronal Cell Death in Parkinson’s Disease Models

(2018) Angelo Iannielli et al.   Cell Reports

NMDA antagonists for treating the non-motor symptoms in Parkinson’s disease

(2018) Brigitte Vanle et al.   Translational Psychiatry

Deletion of mitochondrial calcium uniporter incompletely inhibits calcium uptake and induction of the permeability transition pore in brain mitochondria

(2018) James Hamilton et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Enhanced autophagy contributes to excitotoxic lesions in a rat model of preterm brain injury

(2018) Céline Descloux et al.   Cell Death & Disease

Spatial Separation of Mitochondrial Calcium Uptake and Extrusion for Energy-Efficient Mitochondrial Calcium Signaling in the Heart

(2018) Sergio De La Fuente et al.   Cell Reports

Neurite Collapse and Altered ER Ca2+ Control in Human Parkinson Disease Patient iPSC-Derived Neurons with LRRK2 G2019S Mutation

(2018) Joanna A. Korecka et al.   Stem Cell Reports

Investigation of mitochondrial calcium uniporter role in embryonic and adult motor neurons from G93AhSOD1 mice

(2018) Vedrana Tadić et al.   NEUROBIOLOGY OF AGING

Mitochondrial Calcium Dysregulation Contributes to Dendrite Degeneration Mediated by PD/LBD-Associated LRRK2 Mutants

(2017) Manish Verma et al.   JOURNAL OF NEUROSCIENCE

Parkinson's Disease-Associated LRRK2 Hyperactive Kinase Mutant Disrupts Synaptic Vesicle Trafficking in Ventral Midbrain Neurons

(2017) Ping-Yue Pan et al.   JOURNAL OF NEUROSCIENCE

Soluble oligomeric amyloid-β induces calcium dyshomeostasis that precedes synapse loss in the living mouse brain

(2017) Michal Arbel-Ornath et al.   Molecular Neurodegeneration

The role of mitochondria in amyotrophic lateral sclerosis

(2017) Emma F. Smith et al.   NEUROSCIENCE LETTERS

PINK1-mediated phosphorylation of LETM1 regulates mitochondrial calcium transport and protects neurons against mitochondrial stress

(2017) En Huang et al.   Nature Communications

Protein Quality Control by Molecular Chaperones in Neurodegeneration

(2017) Aaron Ciechanover et al.   Frontiers in Neuroscience

Mitochondrial DNA Depletion in Respiratory Chain-Deficient Parkinson Disease Neurons

(2016) Anne Grünewald et al.   ANNALS OF NEUROLOGY

Miro1‐dependent mitochondrial positioning drives the rescaling of presynaptic Ca 2+ signals during homeostatic plasticity

(2016) Victoria Vaccaro et al.   EMBO REPORTS

Inhibition of the mitochondrial calcium uniporter rescues dopaminergic neurons inpink1−/−zebrafish

(2016) Smijin Soman et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Global ablation of the mitochondrial calcium uniporter increases glycolysis in cortical neurons subjected to energetic stressors

(2016) Matthew Nichols et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Parkin Deficiency Reduces Hippocampal Glutamatergic Neurotransmission by Impairing AMPA Receptor Endocytosis

(2016) G. P. Cortese et al.   JOURNAL OF NEUROSCIENCE

Inhibition of mitochondrial calcium uniporter protects neurocytes from ischemia/reperfusion injury via the inhibition of excessive mitophagy

(2016) Shoushui Yu et al.   NEUROSCIENCE LETTERS

Subtle alterations of excitatory transmission are linked to presynaptic changes in the hippocampus of PINK1-deficient mice

(2016) Marco Feligioni et al.   SYNAPSE

Calcium at the Center of Cell Signaling: Interplay between Endoplasmic Reticulum, Mitochondria, and Lysosomes

(2016) Anna Raffaello et al.   TRENDS IN BIOCHEMICAL SCIENCES

LKB1 Regulates Mitochondria-Dependent Presynaptic Calcium Clearance and Neurotransmitter Release Properties at Excitatory Synapses along Cortical Axons

(2016) Seok-Kyu Kwon et al.   PLOS BIOLOGY

LRRK2 Regulates Voltage-Gated Calcium Channel Function

(2016) Cade Bedford et al.   Frontiers in Molecular Neuroscience

Cortical synaptic and dendritic spine abnormalities in a presymptomatic TDP-43 model of amyotrophic lateral sclerosis

(2016) Matthew J. Fogarty et al.   Scientific Reports

Glutamate and GABA Imbalance Following Traumatic Brain Injury

(2015) Réjean M. Guerriero et al.   Current Neurology and Neuroscience Reports

An early endosome regulator, Rab5b, is an LRRK2 kinase substrate

(2015) Hye Jin Yun et al.   JOURNAL OF BIOCHEMISTRY

Mitochondrial Calcium Uptake Modulates Synaptic Vesicle Endocytosis in Central Nerve Terminals

(2015) Jamie Roslin Keynes Marland et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Role of Mitochondrially Derived ATP in Synaptic Vesicle Recycling

(2015) Divya Pathak et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Parkinson's Disease-Associated Mutation LRRK2-G2019S Impairs Synaptic Plasticity in Mouse Hippocampus

(2015) E. S. Sweet et al.   JOURNAL OF NEUROSCIENCE

Glutamate excitotoxicity in neurons triggers mitochondrial and endoplasmic reticulum accumulation of Parkin, and, in the presence of N-acetyl cysteine, mitophagy

(2015) Victor S. Van Laar et al.   NEUROBIOLOGY OF DISEASE

PKA Phosphorylation of NCLX Reverses Mitochondrial Calcium Overload and Depolarization, Promoting Survival of PINK1-Deficient Dopaminergic Neurons

(2015) Marko Kostic et al.   Cell Reports

Mutant LRRK2 enhances glutamatergic synapse activity and evokes excitotoxic dendrite degeneration

(2014) Edward D. Plowey et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Activity-Driven Local ATP Synthesis Is Required for Synaptic Function

(2014) Vidhya Rangaraju et al.   CELL

AMBRA1 is able to induce mitophagy via LC3 binding, regardless of PARKIN and p62/SQSTM1

(2014) F Strappazzon et al.   CELL DEATH AND DIFFERENTIATION

LETM1-dependent mitochondrial Ca2+ flux modulates cellular bioenergetics and proliferation

(2014) Patrick J. Doonan et al.   FASEB JOURNAL

NCLX Protein, but Not LETM1, Mediates Mitochondrial Ca2+Extrusion, Thereby Limiting Ca2+-induced NAD(P)H Production and Modulating Matrix Redox State

(2014) Umberto De Marchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ERK-mediated phosphorylation of TFAM downregulates mitochondrial transcription: Implications for Parkinson's disease

(2014) Kent Z.Q. Wang et al.   MITOCHONDRION

Leucine-Rich Repeat Kinase 2 Binds to Neuronal Vesicles through Protein Interactions Mediated by Its C-Terminal WD40 Domain

(2014) G. Piccoli et al.   MOLECULAR AND CELLULAR BIOLOGY

The Complex I Subunit NDUFA10 Selectively Rescues Drosophila pink1 Mutants through a Mechanism Independent of Mitophagy

(2014) Joe H. Pogson et al.   PLoS Genetics

Enhanced parkin levels favor ER-mitochondria crosstalk and guarantee Ca2+ transfer to sustain cell bioenergetics

(2013) Tito Calì et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

ERKed by LRRK2: A cell biological perspective on hereditary and sporadic Parkinson's disease

(2013) Manish Verma et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Calcium channel blockers and dementia

(2013) V Nimmrich et al.   BRITISH JOURNAL OF PHARMACOLOGY

Terminal Axon Branching Is Regulated by the LKB1-NUAK1 Kinase Pathway via Presynaptic Mitochondrial Capture

(2013) Julien Courchet et al.   CELL

A Neo-Substrate that Amplifies Catalytic Activity of Parkinson’s-Disease-Related Kinase PINK1

(2013) Nicholas T. Hertz et al.   CELL

Genetic Correction of a LRRK2 Mutation in Human iPSCs Links Parkinsonian Neurodegeneration to ERK-Dependent Changes in Gene Expression

(2013) Peter Reinhardt et al.   Cell Stem Cell

Amyloid β, Glutamate, Excitotoxicity in Alzheimer's Disease: Are We on the Right Track?

(2013) Zaira Esposito et al.   CNS Neuroscience & Therapeutics

The mitochondrial calcium uniporter is a multimer that can include a dominant-negative pore-forming subunit

(2013) Anna Raffaello et al.   EMBO JOURNAL

Loss of iron triggers PINK1/Parkin-independent mitophagy

(2013) George F G Allen et al.   EMBO REPORTS

Inhibition of excessive mitochondrial fission reduced aberrant autophagy and neuronal damage caused by LRRK2 G2019S mutation

(2013) Yu-Chin Su et al.   HUMAN MOLECULAR GENETICS

Beyond the mitochondrion: cytosolic PINK1 remodels dendrites through Protein Kinase A

(2013) Ruben K. Dagda et al.   JOURNAL OF NEUROCHEMISTRY

Cardiolipin externalization to the outer mitochondrial membrane acts as an elimination signal for mitophagy in neuronal cells

(2013) Charleen T. Chu et al.   NATURE CELL BIOLOGY

The CAMKK2-AMPK Kinase Pathway Mediates the Synaptotoxic Effects of Aβ Oligomers through Tau Phosphorylation

(2013) Georges Mairet-Coello et al.   NEURON

MICU2, a Paralog of MICU1, Resides within the Mitochondrial Uniporter Complex to Regulate Calcium Handling

(2013) Molly Plovanich et al.   PLoS One

EMRE Is an Essential Component of the Mitochondrial Calcium Uniporter Complex

(2013) Y. Sancak et al.   SCIENCE

Mitochondrial calcium uniporter Mcu controls excitotoxicity and is transcriptionally repressed by neuroprotective nuclear calcium signals

(2013) Jing Qiu et al.   Nature Communications

nNOS(+) striatal neurons, a subpopulation spared in Huntington's Disease, possess functional NMDA receptors but fail to generate mitochondrial ROS in response to an excitotoxic challenge

(2013) Lorella M. T. Canzoniero et al.   Frontiers in Physiology

Mutant LRRK2 Elicits Calcium Imbalance and Depletion of Dendritic Mitochondria in Neurons

(2012) Salvatore J. Cherra et al.   AMERICAN JOURNAL OF PATHOLOGY

MCUR1 is an essential component of mitochondrial Ca2+ uptake that regulates cellular metabolism

(2012) Karthik Mallilankaraman et al.   NATURE CELL BIOLOGY

The Subtype of GluN2 C-terminal Domain Determines the Response to Excitotoxic Insults

(2012) Marc-André Martel et al.   NEURON

Critical role of soluble amyloid-  for early hippocampal hyperactivity in a mouse model of Alzheimer's disease

(2012) M. A. Busche et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Calcium Signaling in Dendritic Spines

(2012) M. J. Higley et al.   Cold Spring Harbor Perspectives in Biology

Impaired mitochondrial biogenesis contributes to depletion of functional mitochondria in chronic MPP+ toxicity: dual roles for ERK1/2

(2012) J H Zhu et al.   Cell Death & Disease

Depletion of PINK1 affects mitochondrial metabolism, calcium homeostasis and energy maintenance

(2011) B. Heeman et al.   JOURNAL OF CELL SCIENCE

Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter

(2011) Joshua M. Baughman et al.   NATURE

A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter

(2011) Diego De Stefani et al.   NATURE

The L-type channel antagonist isradipine is neuroprotective in a mouse model of Parkinson's disease

(2011) E. Ilijic et al.   NEUROBIOLOGY OF DISEASE

Regulation of axonal mitochondrial transport and its impact on synaptic transmission

(2011) Qian Cai et al.   NEUROSCIENCE RESEARCH

Dopaminergic Neuronal Loss, Reduced Neurite Complexity and Autophagic Abnormalities in Transgenic Mice Expressing G2019S Mutant LRRK2

(2011) David Ramonet et al.   PLoS One

DAPK1 Interaction with NMDA Receptor NR2B Subunits Mediates Brain Damage in Stroke

(2010) Weihong Tu et al.   CELL

A pivotal role for PINK1 and autophagy in mitochondrial quality control: implications for Parkinson disease

(2010) C. T. Chu   HUMAN MOLECULAR GENETICS

Regulation of the autophagy protein LC3 by phosphorylation

(2010) Salvatore J. Cherra et al.   JOURNAL OF CELL BIOLOGY

Expression of  -Amyloid Induced Age-Dependent Presynaptic and Axonal Changes in Drosophila

(2010) X.-L. Zhao et al.   JOURNAL OF NEUROSCIENCE

Amyloid   Induces the Morphological Neurodegenerative Triad of Spine Loss, Dendritic Simplification, and Neuritic Dystrophies through Calcineurin Activation

(2010) H.-Y. Wu et al.   JOURNAL OF NEUROSCIENCE

A  Oligomers Cause Localized Ca2+ Elevation, Missorting of Endogenous Tau into Dendrites, Tau Phosphorylation, and Destruction of Microtubules and Spines

(2010) H. Zempel et al.   JOURNAL OF NEUROSCIENCE

MICU1 encodes a mitochondrial EF hand protein required for Ca2+ uptake

(2010) Fabiana Perocchi et al.   NATURE

Adult neurogenesis and neurite outgrowth are impaired in LRRK2 G2019S mice

(2010) B. Winner et al.   NEUROBIOLOGY OF DISEASE

Imaging extrasynaptic glutamate dynamics in the brain

(2010) Y. Okubo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Early deficits in synaptic mitochondria in an Alzheimer's disease mouse model

(2010) H. Du et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondria, calcium and cell death: A deadly triad in neurodegeneration

(2009) Fulvio Celsi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Glutamate, excitotoxicity, and programmed cell death in parkinson disease

(2009) W. Michael Caudle et al.   EXPERIMENTAL NEUROLOGY

Role of cyclophilin D-dependent mitochondrial permeability transition in glutamate-induced calcium deregulation and excitotoxic neuronal death

(2009) Viacheslav Li et al.   EXPERIMENTAL NEUROLOGY

Loss of PINK1 Function Promotes Mitophagy through Effects on Oxidative Stress and Mitochondrial Fission

(2009) Ruben K. Dagda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mutant Pink1 induces mitochondrial dysfunction in a neuronal cell model of Parkinson’s disease by disturbing calcium flux

(2009) Roberta Marongiu et al.   JOURNAL OF NEUROCHEMISTRY

PINK1-Associated Parkinson's Disease Is Caused by Neuronal Vulnerability to Calcium-Induced Cell Death

(2009) Sonia Gandhi et al.   MOLECULAR CELL

NADPH oxidase is the primary source of superoxide induced by NMDA receptor activation

(2009) Angela M Brennan et al.   NATURE NEUROSCIENCE

Cyclophilin D deficiency improves mitochondrial function and learning/memory in aging Alzheimer disease mouse model

(2009) Heng Du et al.   NEUROBIOLOGY OF AGING

Miro1 Is a Calcium Sensor for Glutamate Receptor-Dependent Localization of Mitochondria at Synapses

(2009) Andrew F. MacAskill et al.   NEURON

Coupling diverse routes of calcium entry to mitochondrial dysfunction and glutamate excitotoxicity

(2009) R. I. Stanika et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NCLX is an essential component of mitochondrial Na+/Ca2+ exchange

(2009) R. Palty et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanisms underlying the loss of mitochondrial membrane potential in glutamate excitotoxicity

(2008) Andrey Y. Abramov et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Docking of Axonal Mitochondria by Syntaphilin Controls Their Mobility and Affects Short-Term Facilitation

(2008) Jian-Sheng Kang et al.   CELL

LRRK2 regulates synaptic vesicle endocytosis

(2008) Narae Shin et al.   EXPERIMENTAL CELL RESEARCH

Impaired Regulation of Brain Mitochondria by Extramitochondrial Ca2+in Transgenic Huntington Disease Rats

(2008) Frank N. Gellerich et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Increased intraneuronal resting [Ca2+] in adult Alzheimer’s disease mice

(2008) José R. Lopez et al.   JOURNAL OF NEUROCHEMISTRY

Mitochondrial Ca2+ Overload Underlies Aβ Oligomers Neurotoxicity Providing an Unexpected Mechanism of Neuroprotection by NSAIDs

(2008) Sara Sanz-Blasco et al.   PLoS One

Pruning and loss of excitatory synapses by the parkin ubiquitin ligase

(2008) T. D. Helton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA