Elevated Wnt2 and Wnt4 activate NF-κB signaling to promote cardiac fibrosis by cooperation of Fzd4/2 and LRP6 following myocardial infarction

WNT2b activates epithelial-mesenchymal transition through FZD4: relevance in penetrating Crohn´s disease

(2019) Dolores Ortiz-Masià et al.   Journal of Crohns & Colitis

Cancer‐associated fibroblasts secrete Wnt2 to promote cancer progression in colorectal cancer

(2019) Takashi Aizawa et al.   Cancer Medicine

Wnt4 negatively regulates the TGF-β1-induced human dermal fibroblast-to-myofibroblast transition via targeting Smad3 and ERK

(2019) Jiaqi Liu et al.   CELL AND TISSUE RESEARCH

Knockdown of LRP6 activates Drp1 to inhibit survival of cardiomyocytes during glucose deprivation

(2018) Zhidan Chen et al.   BIOMEDICINE & PHARMACOTHERAPY

Fourth Universal Definition of Myocardial Infarction (2018)

(2018) Kristian Thygesen et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Wnt4 is significantly upregulated during the early phases of cisplatin-induced acute kidney injury

(2018) Yi-Xin He et al.   Scientific Reports

Wnt5a is elevated in heart failure and affects cardiac fibroblast function

(2017) Aurelija Abraityte et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Blockade to pathological remodeling of infarcted heart tissue using a porcupine antagonist

(2017) Jesung Moon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Downregulation of β-catenin blocks fibrosis via Wnt2 signaling in human keloid fibroblasts

(2017) Yumei Cai et al.   TUMOR BIOLOGY

Wnt2 and WISP-1/CCN4 Induce Intimal Thickening via Promotion of Smooth Muscle Cell MigrationHighlights

(2016) Helen Williams et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Cardiac fibrosis in myocardial infarction—from repair and remodeling to regeneration

(2016) Virpi Talman et al.   CELL AND TISSUE RESEARCH

A Simplified, Langendorff-Free Method for Concomitant Isolation of Viable Cardiac Myocytes and Nonmyocytes From the Adult Mouse HeartNovelty and Significance

(2016) Matthew Ackers-Johnson et al.   CIRCULATION RESEARCH

Cardiovascular disease in Europe: epidemiological update 2016

(2016) Nick Townsend et al.   EUROPEAN HEART JOURNAL

The role of cardiac fibroblasts in post-myocardial heart tissue repair

(2016) Dimitry A. Chistiakov et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

TGF-β-induced profibrotic signaling is regulated in part by the WNT receptor Frizzled-8

(2016) Anita I. R. Spanjer et al.   FASEB JOURNAL

FGF23 promotes myocardial fibrosis in mice through activation of β-catenin

(2016) Huixin Hao et al.   Oncotarget

Wnt10b Gain-of-Function Improves Cardiac Repair by Arteriole Formation and Attenuation of FibrosisNovelty and Significance

(2015) David T. Paik et al.   CIRCULATION RESEARCH

The WNT system: background and its role in bone

(2015) U. H. Lerner et al.   JOURNAL OF INTERNAL MEDICINE

Anti-Inflammatory Strategies for Ventricular Remodeling Following ST-Segment Elevation Acute Myocardial Infarction

(2014) Ignacio M. Seropian et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Regulation of Wnt4 in chronic obstructive pulmonary disease

(2013) Andrew L. Durham et al.   FASEB JOURNAL

Wnt4/ -Catenin Signaling in Medullary Kidney Myofibroblasts

(2013) D. P. DiRocco et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Wnt/β-Catenin Signaling and Disease

(2012) Hans Clevers et al.   CELL

Defining the cellular repertoire of GPCRs identifies a profibrotic role for the most highly expressed receptor, protease-activated receptor 1, in cardiac fibroblasts

(2012) Aaron N. Snead et al.   FASEB JOURNAL

Deficiency ofCapn4Gene Inhibits Nuclear Factor-κB (NF-κB) Protein Signaling/Inflammation and Reduces Remodeling after Myocardial Infarction

(2012) Jian Ma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NF-κB mediated miR-26a regulation in cardiac fibrosis

(2012) Chuanyu Wei et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Role of the Wnt-Frizzled system in cardiac pathophysiology: a rapidly developing, poorly understood area with enormous potential

(2012) Kristin Dawson et al.   JOURNAL OF PHYSIOLOGY-LONDON

Experimental myocardial infarction triggers canonical Wnt signaling and endothelial-to-mesenchymal transition

(2011) O. Aisagbonhi et al.   Disease Models & Mechanisms

Wnt2 accelerates cardiac myocyte differentiation from ES-cell derived mesodermal cells via non-canonical pathway

(2011) Takeshi Onizuka et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Differential Palmit(e)oylation of Wnt1 on C93 and S224 Residues Has Overlapping and Distinct Consequences

(2011) Lisa M. Galli et al.   PLoS One

Wnt/frizzled signalling modulates the migration and differentiation of immortalized cardiac fibroblasts

(2010) Hilde Laeremans et al.   CARDIOVASCULAR RESEARCH

A Novel and Efficient Model of Coronary Artery Ligation and Myocardial Infarction in the Mouse

(2010) Erhe Gao et al.   CIRCULATION RESEARCH

Wnt4/β-Catenin Signaling Induces VSMC Proliferation and Is Associated With Intimal Thickening

(2010) Aikaterini Tsaousi et al.   CIRCULATION RESEARCH

Expression profiling of Wnt family of genes in normal and inflammatory bowel disease primary human intestinal myofibroblasts and normal human colonic crypt epithelial cells

(2010) K. R. Hughes et al.   INFLAMMATORY BOWEL DISEASES

Myocardial remodeling after infarction: the role of myofibroblasts

(2009) Susanne W. M. van den Borne et al.   Nature Reviews Cardiology

Increased Expression of Wnt2 and SFRP4 in Tsk Mouse Skin: Role of Wnt Signaling in Altered Dermal Fibrillin Deposition and Systemic Sclerosis

(2007) Julie Bayle et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY