Role of the Wnt-Frizzled system in cardiac pathophysiology: a rapidly developing, poorly understood area with enormous potential

Contribution of Global Rare Copy-Number Variants to the Risk of Sporadic Congenital Heart Disease

(2012) Rachel Soemedi et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Premature myocardial infarction is associated with low serum levels of Wnt-1

(2012) Georg Goliasch et al.   ATHEROSCLEROSIS

MiR-499 induces cardiac differentiation of rat mesenchymal stem cells through wnt/β-catenin signaling pathway

(2012) Lu-lu Zhang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Canonical Wnt/β-catenin signaling in epicardial fibrosis of failed pediatric heart allografts with diastolic dysfunction

(2012) Bo Ye et al.   CARDIOVASCULAR PATHOLOGY

Arrhythmogenic Implications of Fibroblast-Myocyte Interactions

(2012) Stephan Rohr   Circulation-Arrhythmia and Electrophysiology

Reduced Cx43 Expression Triggers Increased Fibrosis Due to Enhanced Fibroblast Activity

(2012) John A. Jansen et al.   Circulation-Arrhythmia and Electrophysiology

Adult mammalian stem cells: the role of Wnt, Lgr5 and R-spondins

(2012) Jurian Schuijers et al.   EMBO JOURNAL

Defining the cellular repertoire of GPCRs identifies a profibrotic role for the most highly expressed receptor, protease-activated receptor 1, in cardiac fibroblasts

(2012) Aaron N. Snead et al.   FASEB JOURNAL

Myofibroblasts in the Infarct Area: Concepts and Challenges

(2012) Evangelos P. Daskalopoulos et al.   MICROSCOPY AND MICROANALYSIS

Meta-analysis identifies six new susceptibility loci for atrial fibrillation

(2012) Patrick T Ellinor et al.   NATURE GENETICS

Cozzarelli Prize Winner: Robust cardiomyocyte differentiation from human pluripotent stem cells via temporal modulation of canonical Wnt signaling

(2012) X. Lian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of canonical Wnt signalling is required for TGF-β-mediated fibrosis

(2012) Alfiya Akhmetshina et al.   Nature Communications

Pathophysiology of myocardial reperfusion injury: preconditioning, postconditioning, and translational aspects of protective measures

(2011) Shoji Sanada et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Secreted Frizzled-Related Protein-1 Improves Postinfarction Scar Formation Through a Modulation of Inflammatory Response

(2011) Laurent Barandon et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Canonical Wnt signaling induces skin fibrosis and subcutaneous lipoatrophy: A novel mouse model for scleroderma?

(2011) Jun Wei et al.   ARTHRITIS AND RHEUMATISM

Yellow submarine of the Wnt/Frizzled signaling: Submerging from the G protein harbor to the targets

(2011) Alexey Koval et al.   BIOCHEMICAL PHARMACOLOGY

The Other Side of Arrhythmogenic Right Ventricular Cardiomyopathy

(2011) Marc W. Deyell et al.   CANADIAN JOURNAL OF CARDIOLOGY

New and Emerging Drugs and Device Therapies for Chronic Heart Failure in Patients With Systolic Ventricular Dysfunction

(2011) Jean L. Rouleau   CANADIAN JOURNAL OF CARDIOLOGY

Recommendations for the Use of Genetic Testing in the Clinical Evaluation of Inherited Cardiac Arrhythmias Associated with Sudden Cardiac Death: Canadian Cardiovascular Society/Canadian Heart Rhythm Society Joint Position Paper

(2011) Michael H. Gollob et al.   CANADIAN JOURNAL OF CARDIOLOGY

GSK-3β at the crossroads in the signalling of heart preconditioning: implication of mTOR and Wnt pathways

(2011) François Vigneron et al.   CARDIOVASCULAR RESEARCH

Blocking of Frizzled Signaling With a Homologous Peptide Fragment of Wnt3a/Wnt5a Reduces Infarct Expansion and Prevents the Development of Heart Failure After Myocardial Infarction

(2011) Hilde Laeremans et al.   CIRCULATION

Wnt Signaling Exerts an Antiproliferative Effect on Adult Cardiac Progenitor Cells Through IGFBP3

(2011) Angelos Oikonomopoulos et al.   CIRCULATION RESEARCH

β-catenin signaling

(2011) Anna P. Lam et al.   CURRENT OPINION IN RHEUMATOLOGY

Experimental myocardial infarction triggers canonical Wnt signaling and endothelial-to-mesenchymal transition

(2011) O. Aisagbonhi et al.   Disease Models & Mechanisms

Wnt1/βcatenin injury response activates the epicardium and cardiac fibroblasts to promote cardiac repair

(2011) Jinzhu Duan et al.   EMBO JOURNAL

miR-145 is differentially regulated by TGF-β1 and ischaemia and targets Disabled-2 expression and wnt/β-catenin activity

(2011) Maritza E. Mayorga et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The Wnt antagonist Wif-1 interacts with CTGF and inhibits CTGF activity

(2011) Cordula Surmann-Schmitt et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Wnt2 accelerates cardiac myocyte differentiation from ES-cell derived mesodermal cells via non-canonical pathway

(2011) Takeshi Onizuka et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Metabolic characterization of volume overload heart failure due to aorto-caval fistula in rats

(2011) Vojtech Melenovsky et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Lentivirus-mediated Wnt11 Gene Transfer Enhances Cardiomyogenic Differentiation of Skeletal Muscle-derived Stem Cells

(2011) Guosheng Xiang et al.   MOLECULAR THERAPY

Modular mechanism of Wnt signaling inhibition by Wnt inhibitory factor 1

(2011) Tomas Malinauskas et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Molecular Genetics and Pathogenesis of Arrhythmogenic Right Ventricular Cardiomyopathy: A Disease of Cardiac Stem Cells

(2011) Raffaella Lombardi et al.   PEDIATRIC CARDIOLOGY

Wnt3a Induces Myofibroblast Differentiation by Upregulating TGF-β Signaling Through SMAD2 in a β-Catenin-Dependent Manner

(2011) Jon M. Carthy et al.   PLoS One

Paracrine Effect of Wnt11-Overexpressing Mesenchymal Stem Cells on Ischemic Injury

(2011) Shi Zuo et al.   STEM CELLS AND DEVELOPMENT

Active Wnt signaling in response to cardiac injury

(2010) Martinus I. F. J. Oerlemans et al.   BASIC RESEARCH IN CARDIOLOGY

Wnt signal transduction pathway and apoptosis: a review

(2010) Nives Pećina-Šlaus   Cancer Cell International

Wnt/frizzled signalling modulates the migration and differentiation of immortalized cardiac fibroblasts

(2010) Hilde Laeremans et al.   CARDIOVASCULAR RESEARCH

Constitutive glycogen synthase kinase-3α/β activity protects against chronic β-adrenergic remodelling of the heart

(2010) Ian G. Webb et al.   CARDIOVASCULAR RESEARCH

Cardiac Arrhythmogenic Remodeling in a Rat Model of Long-Term Intensive Exercise Training

(2010) Begoña Benito et al.   CIRCULATION

Potential Therapeutic Targets for Cardiac Fibrosis

(2010) Andrew Leask   CIRCULATION RESEARCH

The Multiple Phases and Faces of Wnt Signaling During Cardiac Differentiation and Development

(2010) Susanne Gessert et al.   CIRCULATION RESEARCH

An Updated Overview on Wnt Signaling Pathways

(2010) Tata Purushothama Rao et al.   CIRCULATION RESEARCH

WNT Signaling in Adult Cardiac Hypertrophy and Remodeling

(2010) Martin W. Bergmann   CIRCULATION RESEARCH

Non-conventional Frizzled ligands and Wnt receptors

(2010) Marijke Hendrickx et al.   DEVELOPMENT GROWTH & DIFFERENTIATION

Wnt Signaling Is Critical for Maladaptive Cardiac Hypertrophy and Accelerates Myocardial Remodeling

(2010) Pratima Malekar et al.   HYPERTENSION

Effects of Regulator of G Protein Signaling 19 (RGS19) on Heart Development and Function

(2010) Young Rae Ji et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The opposing effects of CCN2 and CCN5 on the development of cardiac hypertrophy and fibrosis

(2010) Pyoung Oh Yoon et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Involvement of GSK-3β in attenuation of the cardioprotective effect of ischemic preconditioning in diabetic rat heart

(2010) Harlokesh Narayan Yadav et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Wnt11 patterns a myocardial electrical gradient through regulation of the L-type Ca2+ channel

(2010) Daniela Panáková et al.   NATURE

Pyrvinium, a Potent Small Molecule Wnt Inhibitor, Promotes Wound Repair and Post-MI Cardiac Remodeling

(2010) Sarika Saraswati et al.   PLoS One

Exogenously administered secreted frizzled related protein 2 (Sfrp2) reduces fibrosis and improves cardiac function in a rat model of myocardial infarction

(2010) W. He et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of Wnt/ -catenin/CREB binding protein (CBP) signaling reverses pulmonary fibrosis

(2010) W. R. Henderson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Secreted Frizzled Related Protein 4 Reduces Fibrosis Scar Size and Ameliorates Cardiac Function After Ischemic Injury

(2010) Kentaro Matsushima et al.   TISSUE ENGINEERING PART A

The Advantages and Disadvantages of Sfrp1 and Sfrp2 Expression in Pathological Events

(2010) Pilar Esteve et al.   TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE

β-Catenin/TCF/LEF1 can directly regulate phenylephrine-induced cell hypertrophy and Anf transcription in cardiomyocytes

(2009) Chen-Guang Zhang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Wnt-11 signalling controls ventricular myocardium development by patterning N-cadherin and β-catenin expression

(2009) Irina I. Nagy et al.   CARDIOVASCULAR RESEARCH

Dishevelled: The hub of Wnt signaling

(2009) Chan Gao et al.   CELLULAR SIGNALLING

Changes in Connexin Expression and the Atrial Fibrillation Substrate in Congestive Heart Failure

(2009) Brett Burstein et al.   CIRCULATION RESEARCH

Genetic Fate Mapping Identifies Second Heart Field Progenitor Cells As a Source of Adipocytes in Arrhythmogenic Right Ventricular Cardiomyopathy

(2009) Raffaella Lombardi et al.   CIRCULATION RESEARCH

Wnt/ -Catenin Signaling Promotes Renal Interstitial Fibrosis

(2009) W. He et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Molecular targets and regulators of cardiac hypertrophy

(2009) Agrawal Rohini et al.   PHARMACOLOGICAL RESEARCH

Proteomic-Based Detection of a Protein Cluster Dysregulated during Cardiovascular Development Identifies Biomarkers of Congenital Heart Defects

(2009) Anjali K. Nath et al.   PLoS One

Wnt1 Overexpression Leads to Enforced Cardiomyogenesis and Inhibition of Hematopoiesis in Murine Embryonic Stem Cells

(2009) Katja C. Weisel et al.   STEM CELLS AND DEVELOPMENT

Mammalian Wnt3a is Released on Lipoprotein Particles

(2009) Sylvia Neumann et al.   TRAFFIC

Glycogen Synthase Kinase-3 Inactivation Is Not Required for Ischemic Preconditioning or Postconditioning in the Mouse

(2008) Yasuhiro Nishino et al.   CIRCULATION RESEARCH

Deciphering the function of canonical Wnt signals in development and disease: conditional loss- and gain-of-function mutations of  -catenin in mice

(2008) T. Grigoryan et al.   GENES & DEVELOPMENT

Ryk cooperates with Frizzled 7 to promote Wnt11-mediated endocytosis and is essential forXenopus laevisconvergent extension movements

(2008) Gun-Hwa Kim et al.   JOURNAL OF CELL BIOLOGY

Secreted Frizzled-related protein 2 is a procollagen C proteinase enhancer with a role in fibrosis associated with myocardial infarction

(2008) Koichi Kobayashi et al.   NATURE CELL BIOLOGY

The Netrin-related domain of Sfrp1 interacts with Wnt ligands and antagonizes their activity in the anterior neural plate

(2008) Javier Lopez-Rios et al.   Neural Development

Mechanisms Underlying Acute Protection From Cardiac Ischemia-Reperfusion Injury

(2008) Elizabeth Murphy et al.   PHYSIOLOGICAL REVIEWS

Distinct roles of GSK-3  and GSK-3  phosphorylation in the heart under pressure overload

(2008) T. Matsuda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Wnt/frizzled/GSK-3β pathway: a novel therapeutic target for cardiac hypertrophy

(2008) W BLANKESTEIJN et al.   TRENDS IN PHARMACOLOGICAL SCIENCES