A brain proteomic signature of incipient Alzheimer’s disease in young APOE ε4 carriers identifies novel drug targets

APOE immunotherapy reduces cerebral amyloid angiopathy and amyloid plaques while improving cerebrovascular function

(2021) Monica Xiong et al.   Science Translational Medicine

Dasatinib dose optimisation based on therapeutic drug monitoring reduces pleural effusion rates in chronic myeloid leukaemia patients

(2021) Philippe Rousselot et al.   BRITISH JOURNAL OF HAEMATOLOGY

Blood Metabolite Signature of Metabolic Syndrome Implicates Alterations in Amino Acid Metabolism: Findings from the Baltimore Longitudinal Study of Aging (BLSA) and the Tsuruoka Metabolomics Cohort Study (TMCS)

(2020) Jackson A. Roberts et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Large-scale proteomic analysis of Alzheimer’s disease brain and cerebrospinal fluid reveals early changes in energy metabolism associated with microglia and astrocyte activation

(2020) Erik C. B. Johnson et al.   NATURE MEDICINE

Deep Multilayer Brain Proteomics Identifies Molecular Networks in Alzheimer’s Disease Progression

(2020) Bing Bai et al.   NEURON

Rational Design and Synthesis of Methyl-β-d-galactomalonyl Phenyl Esters as Potent Galectin-8N Antagonists

(2020) Brijesh Patel et al.   JOURNAL OF MEDICINAL CHEMISTRY

Fyn Kinase Controls Tau Aggregation In Vivo

(2020) Adam Briner et al.   Cell Reports

Degradation and Transmission of Tau by Autophagic-Endolysosomal Networks and Potential Therapeutic Targets for Tauopathy

(2020) Shanya Jiang et al.   Frontiers in Molecular Neuroscience

Inhibition of Stat3‐mediated astrogliosis ameliorates pathology in an Alzheimer's disease model

(2019) Nicole Reichenbach et al.   EMBO Molecular Medicine

Galectin-3, a novel endogenous TREM2 ligand, detrimentally regulates inflammatory response in Alzheimer’s disease

(2019) Antonio Boza-Serrano et al.   ACTA NEUROPATHOLOGICA

Single-cell transcriptomic analysis of Alzheimer’s disease

(2019) Hansruedi Mathys et al.   NATURE

LC8/DYNLL1 is a 53BP1 effector and regulates checkpoint activation

(2019) Kirk L West et al.   NUCLEIC ACIDS RESEARCH

Ultrafast optical clearing method for three-dimensional imaging with cellular resolution

(2019) Xinpei Zhu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Death-Associated Protein Kinase 1 Phosphorylation in Neuronal Cell Death and Neurodegenerative Disease

(2019) Nami Kim et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Altered Insulin Signaling in Alzheimer’s Disease Brain – Special Emphasis on PI3K-Akt Pathway

(2019) Sami Gabbouj et al.   Frontiers in Neuroscience

CCL19 and CCR7 Expression, Signaling Pathways, and Adjuvant Functions in Viral Infection and Prevention

(2019) Yan Yan et al.   Frontiers in Cell and Developmental Biology

Increased ileal bile acid binding protein and galectin-9 are associated with mild cognitive impairment and Alzheimer's disease

(2019) Xin Wang et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Evidence for brain glucose dysregulation in Alzheimer's disease

(2018) Yang An et al.   Alzheimers & Dementia

Targeting Fyn Kinase in Alzheimer’s Disease

(2018) Haakon B. Nygaard   BIOLOGICAL PSYCHIATRY

Ablation of the mammalian lectin galectin-8 induces bone defects in mice

(2018) Yaron Vinik et al.   FASEB JOURNAL

Religious Orders Study and Rush Memory and Aging Project

(2018) David A. Bennett et al.   JOURNAL OF ALZHEIMERS DISEASE

Free Heme and Amyloid-β: A Fatal Liaison in Alzheimer’s Disease

(2018) Elisabeth Chiziane et al.   JOURNAL OF ALZHEIMERS DISEASE

GGA1 regulates signal-dependent sorting of BACE1 to recycling endosomes, which moderates Aβ production

(2018) Wei Hong Toh et al.   MOLECULAR BIOLOGY OF THE CELL

Galectins Control mTOR in Response to Endomembrane Damage

(2018) Jingyue Jia et al.   MOLECULAR CELL

Macrophage-Associated PGK1 Phosphorylation Promotes Aerobic Glycolysis and Tumorigenesis

(2018) Yajuan Zhang et al.   MOLECULAR CELL

The transition to modernity and chronic disease: mismatch and natural selection

(2018) Stephen Corbett et al.   NATURE REVIEWS GENETICS

Atypical PKC, PKCλ/ι, activates β-secretase and increases Aβ 1–40/42 and phospho-tau in mouse brain and isolated neuronal cells, and may link hyperinsulinemia and other aPKC activators to development of pathological and memory abnormalities in Alzheimer's disease

(2018) Mini P. Sajan et al.   NEUROBIOLOGY OF AGING

The spectrum of preclinical Alzheimer’s pathology and its modulation by ApoE genotype

(2018) Olga Pletnikova et al.   NEUROBIOLOGY OF AGING

Stability and reproducibility of proteomic profiles measured with an aptamer-based platform

(2018) Claire H. Kim et al.   Scientific Reports

Brain and blood metabolite signatures of pathology and progression in Alzheimer disease: A targeted metabolomics study

(2018) Vijay R. Varma et al.   PLOS MEDICINE

De novo variants in CAMK2A and CAMK2B cause neurodevelopmental disorders

(2018) Tenpei Akita et al.   Annals of Clinical and Translational Neurology

Neuron-Specific Alterations in Signal Transduction Pathways associated with Alzheimer's Disease

(2018) Anne Gerschütz et al.   JOURNAL OF ALZHEIMERS DISEASE

DAPK1: a Novel Pathology and Treatment Target for Alzheimer’s Disease

(2018) Ling-zhi Xu et al.   MOLECULAR NEUROBIOLOGY

The Mount Sinai cohort of large-scale genomic, transcriptomic and proteomic data in Alzheimer's disease

(2018) Minghui Wang et al.   Scientific Data

Sex differences in Alzheimer’s disease and common neuropathologies of aging

(2018) Shahram Oveisgharan et al.   ACTA NEUROPATHOLOGICA

Re-exploring the core genes and modules in the human frontal cortex during chronological aging: insights from network-based analysis of transcriptomic studies

(2018) Mulin Xu et al.   Aging-US

STRING v11: protein–protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets

(2018) Damian Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

Amyloid β toxic conformer has dynamic localization in the human inferior parietal cortex in absence of amyloid plaques

(2018) Yusuke Kageyama et al.   Scientific Reports

CaMKII Isoforms in Learning and Memory: Localization and Function

(2018) Gisela Zalcman et al.   Frontiers in Molecular Neuroscience

Modulation of astrocyte reactivity improves functional deficits in mouse models of Alzheimer’s disease

(2018) Kelly Ceyzériat et al.   Acta Neuropathologica Communications

Intranasal insulin activates Akt2 signaling pathway in the hippocampus of wild-type but not in APP/PS1 Alzheimer model mice

(2018) Sami Gabbouj et al.   NEUROBIOLOGY OF AGING

Apolipoprotein E4 is associated with improved cognitive function in Amazonian forager-horticulturalists with a high parasite burden

(2017) Benjamin C. Trumble et al.   FASEB JOURNAL

Adverse Effects of the Apolipoprotein E ε4 Allele on Episodic Memory, Task Switching and Gray Matter Volume in Healthy Young Adults

(2017) Jianfei Nao et al.   Frontiers in Human Neuroscience

Galectin-8–mediated selective autophagy protects against seeded tau aggregation

(2017) Benjamin Falcon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Complementarity of SOMAscan to LC-MS/MS and RNA-seq for quantitative profiling of human embryonic and mesenchymal stem cells

(2017) Anja M. Billing et al.   Journal of Proteomics

Selective deletion of apolipoprotein E in astrocytes ameliorates the spatial learning and memory deficits in Alzheimer's disease (APP/PS1) mice by inhibiting TGF-β/Smad2/STAT3 signaling

(2017) Jin-yu Zheng et al.   NEUROBIOLOGY OF AGING

Lyn and Fyn function as molecular switches that control immunoreceptors to direct homeostasis or inflammation

(2017) Sanae Ben Mkaddem et al.   Nature Communications

Sorting nexin-4 regulates β-amyloid production by modulating β-site-activating cleavage enzyme-1

(2017) Na-Young Kim et al.   Alzheimers Research & Therapy

Apolipoprotein E Genotype and Sex Risk Factors for Alzheimer Disease

(2017) Scott C. Neu et al.   JAMA Neurology

Brain insulin resistance deteriorates cognition by altering the topological features of brain networks

(2017) Fan Su et al.   NeuroImage-Clinical

Neuropathologic Studies of the Baltimore Longitudinal Study of Aging (BLSA)

(2017) Richard J. O'Brien et al.   JOURNAL OF ALZHEIMERS DISEASE

Assessment of Variability in the SOMAscan Assay

(2017) Julián Candia et al.   Scientific Reports

PRKCI negatively regulates autophagy via PIK3CA/AKT–MTOR signaling

(2016) Liujing Qu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Nitric Oxide Homeostasis in Neurodegenerative Diseases

(2016) Luciana Hannibal   Current Alzheimer Research

Gastrin-releasing peptide receptor mediates the excitation of preoptic GABAergic neurons by bombesin

(2016) Karine Blais et al.   NEUROSCIENCE LETTERS

Heme Oxygenases in Cardiovascular Health and Disease

(2016) Anita Ayer et al.   PHYSIOLOGICAL REVIEWS

Increased global transcription activity as a mechanism of replication stress in cancer

(2016) Panagiotis Kotsantis et al.   Nature Communications

MetAP1 and MetAP2 drive cell selectivity for a potent anti-cancer agent in synergy, by controlling glutathione redox state

(2016) Frédéric Frottin et al.   Oncotarget

LRRTM3 Regulates Excitatory Synapse Development through Alternative Splicing and Neurexin Binding

(2016) Ji Won Um et al.   Cell Reports

VRK3-mediated nuclear localization of HSP70 prevents glutamate excitotoxicity-induced apoptosis and Aβ accumulation via enhancement of ERK phosphatase VHR activity

(2016) Haengjin Song et al.   Scientific Reports

Fyn inhibition rescues established memory and synapse loss in Alzheimer mice

(2015) Adam C. Kaufman et al.   ANNALS OF NEUROLOGY

Prevalence of Cerebral Amyloid Pathology in Persons Without Dementia

(2015) Willemijn J. Jansen et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Deficiency of Neuronal p38α MAPK Attenuates Amyloid Pathology in Alzheimer Disease Mouse and Cell Models through Facilitating Lysosomal Degradation of BACE1

(2015) Laura Schnöder et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Altered Blood Gene Expression of Tumor-Related Genes (PRKCB, BECN1, and CDKN2A) in Alzheimer’s Disease

(2015) Anna Antonell et al.   MOLECULAR NEUROBIOLOGY

limma powers differential expression analyses for RNA-sequencing and microarray studies

(2015) Matthew E. Ritchie et al.   NUCLEIC ACIDS RESEARCH

Differential ligand-signaling network of CCL19/CCL21-CCR7 system

(2015) Rajesh Raju et al.   Database-The Journal of Biological Databases and Curation

Crizotinib induces autophagy through inhibition of the STAT3 pathway in multiple lung cancer cell lines

(2015) Liangkun You et al.   Oncotarget

Efficient Test and Visualization of Multi-Set Intersections

(2015) Minghui Wang et al.   Scientific Reports

Calcium/calmodulin-dependent kinase II and Alzheimer’s disease

(2015) Anshua Ghosh et al.   Molecular Brain

Improvement of Spatial Memory Disorder and Hippocampal Damage by Exposure to Electromagnetic Fields in an Alzheimer’s Disease Rat Model

(2015) Xiao Liu et al.   PLoS One

DAPK2 is a novel regulator of mTORC1 activity and autophagy

(2014) Y Ber et al.   CELL DEATH AND DIFFERENTIATION

Glycans and galectins in prostate cancer biology, angiogenesis and metastasis

(2014) D. Compagno et al.   GLYCOBIOLOGY

The chemotaxis of M1 and M2 macrophages is regulated by different chemokines

(2014) Wenjuan Xuan et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Control of histone H3 phosphorylation by CaMKIIδ in response to haemodynamic cardiac stress

(2014) Salma Awad et al.   JOURNAL OF PATHOLOGY

DUSP3/VHR is a pro-angiogenic atypical dual-specificity phosphatase

(2014) Mathieu Amand et al.   Molecular Cancer

Early induction of oxidative stress in a mouse model of Alzheimer’s disease with heme oxygenase activity

(2014) SANLI XING et al.   Molecular Medicine Reports

Tau promotes neurodegeneration through global chromatin relaxation

(2014) Bess Frost et al.   NATURE NEUROSCIENCE

The impact of the interferon-lambda family on the innate and adaptive immune response to viral infections

(2014) Adrian Egli et al.   Emerging Microbes & Infections

DAPK2 positively regulates motility of neutrophils and eosinophils in response to intermediary chemoattractants

(2013) Barbara Geering et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Nuclear Factor  B-Dependent Histone Acetylation is Specifically Involved in Persistent Forms of Memory

(2013) N. Federman et al.   JOURNAL OF NEUROSCIENCE

PDK1 decreases TACE-mediated α-secretase activity and promotes disease progression in prion and Alzheimer's diseases

(2013) Mathéa Pietri et al.   NATURE MEDICINE

LRRTM3 Interacts with APP and BACE1 and Has Variants Associating with Late-Onset Alzheimer’s Disease (LOAD)

(2013) Sarah Lincoln et al.   PLoS One

1–42 β-Amyloid peptide requires PDK1/nPKC/Rac 1 pathway to induce neuronal death

(2013) L Manterola et al.   Translational Psychiatry

Drugging Topoisomerases: Lessons and Challenges

(2012) Yves Pommier   ACS Chemical Biology

Effect of Genetic Variation in LRRTM3 on Risk of Alzheimer Disease

(2012) Christiane Reitz et al.   ARCHIVES OF NEUROLOGY

HDAC4 Governs a Transcriptional Program Essential for Synaptic Plasticity and Memory

(2012) Richard Sando et al.   CELL

Conservation between the RNA Polymerase I, II, and III Transcription Initiation Machineries

(2012) Alessandro Vannini et al.   MOLECULAR CELL

Galectin 8 targets damaged vesicles for autophagy to defend cells against bacterial invasion

(2012) Teresa L. M. Thurston et al.   NATURE

The DNA Replication Stress Hypothesis of Alzheimer’s Disease

(2012) Yuri B. Yurov et al.   TheScientificWorldJOURNAL

Inhibition of Src Family Kinases and Receptor Tyrosine Kinases by Dasatinib: Possible Combinations in Solid Tumors

(2011) J. C. Montero et al.   CLINICAL CANCER RESEARCH

p38MAPK is a novel DNA damage response-independent regulator of the senescence-associated secretory phenotype

(2011) Adam Freund et al.   EMBO JOURNAL

Effect of topoisomerase inhibitors and DNA-binding drugs on the cell proliferation and ultrastructure of Trypanosoma cruzi

(2011) Aline Araujo Zuma et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Normalization of gene expression using SYBR green qPCR: A case for paraoxonase 1 and 2 in Alzheimer's disease brains

(2011) Valérie Leduc et al.   JOURNAL OF NEUROSCIENCE METHODS

The Baltimore Longitudinal Study of Aging (BLSA): A 50-Year-Long Journey and Plans for the Future

(2011) L. Ferrucci   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

APOE and Alzheimer disease: a major gene with semi-dominant inheritance

(2011) E Genin et al.   MOLECULAR PSYCHIATRY

Aptamer-Based Multiplexed Proteomic Technology for Biomarker Discovery

(2011) Larry Gold et al.   PLoS One

Topoisomerase II binds nucleosome-free DNA and acts redundantly with topoisomerase I to enhance recruitment of RNA Pol II in budding yeast

(2011) A. S. Sperling et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nuclear import impairment causes cytoplasmic trans-activation response DNA-binding protein accumulation and is associated with frontotemporal lobar degeneration

(2010) Agnes L. Nishimura et al.   BRAIN

Novel insights into CaMKII function and regulation during memory formation

(2010) Walter Lucchesi et al.   BRAIN RESEARCH BULLETIN

Topoisomerase I regulates open chromatin and controls gene expression in vivo

(2010) Mickaël Durand-Dubief et al.   EMBO JOURNAL

Interferon lambda inhibits herpes simplex virus type I infection of human astrocytes and neurons

(2010) Jieliang Li et al.   GLIA

A scaling normalization method for differential expression analysis of RNA-seq data

(2010) Mark D Robinson et al.   GENOME BIOLOGY

Targeting the JAK2/STAT3 axis in Alzheimer's disease

(2009) Tomohiro Chiba et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

SNX4 in Complex with Clathrin and Dynein: Implications for Endosome Movement

(2009) Sigrid S. Skånland et al.   PLoS One

Estimating Precision Using Duplicate Measurements

(2009) Nicole Pauly Hyslop et al.   JOURNAL OF THE AIR & WASTE MANAGEMENT ASSOCIATION

Effect of infarcts on dementia in the Baltimore longitudinal study of aging

(2008) Juan C. Troncoso et al.   ANNALS OF NEUROLOGY

APOE ε4 lowers age at onset and is a high risk factor for Alzheimer's disease; A case control study from central Norway

(2008) Sigrid B Sando et al.   BMC Neurology

LRP-associated protein gene (LRPAP1) and susceptibility to degenerative dementia

(2008) P. Pandey et al.   GENES BRAIN AND BEHAVIOR

Distinct motifs in the chemokine receptor CCR7 regulate signal transduction, receptor trafficking and chemotaxis

(2008) C. Otero et al.   JOURNAL OF CELL SCIENCE

Aberrant early-phase ERK inactivation impedes neuronal function in fragile X syndrome

(2008) S. H. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

APOE genotype-specific differences in the innate immune response

(2007) Michael P. Vitek et al.   NEUROBIOLOGY OF AGING