A new FGF1 variant protects against adriamycin-induced cardiotoxicity via modulating p53 activity

Molecular mechanisms of doxorubicin-induced cardiotoxicity: novel roles of sirtuin 1-mediated signaling pathways

(2021) Jie Wang(a) et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The SGLT-2 inhibitor empagliflozin improves myocardial strain, reduces cardiac fibrosis and pro-inflammatory cytokines in non-diabetic mice treated with doxorubicin

(2021) Vincenzo Quagliariello et al.   Cardiovascular Diabetology

Regulatory role of endogenous and exogenous fibroblast growth factor 1 in the cardiovascular system and related diseases

(2021) Mengjie Xiao et al.   PHARMACOLOGICAL RESEARCH

Assessment of the Preventive Effect Against Diabetic Cardiomyopathy of FGF1-Loaded Nanoliposomes Combined With Microbubble Cavitation by Ultrasound

(2020) Lei Zheng et al.   Frontiers in Pharmacology

Dihydromyricetin alleviates doxorubicin-induced cardiotoxicity by inhibiting NLRP3 inflammasome through activation of SIRT1

(2020) Zhenzhu Sun et al.   BIOCHEMICAL PHARMACOLOGY

The Tumor-Suppressive Human Circular RNA CircITCH Sponges miR-330-5p to Ameliorate Doxorubicin-Induced Cardiotoxicity Through Upregulating SIRT6, Survivin, and SERCA2a

(2020) Dong Han et al.   CIRCULATION RESEARCH

Osteocrin attenuates inflammation, oxidative stress, apoptosis, and cardiac dysfunction in doxorubicin‐induced cardiotoxicity

(2020) Can Hu et al.   Clinical and Translational Medicine

Activating AMP‐activated Protein Kinase Mediates Fibroblast Growth Factor 1 Protection from Nonalcoholic Fatty Liver Disease in Mice

(2020) Qian Lin et al.   HEPATOLOGY

UFMylation maintains tumour suppressor p53 stability by antagonizing its ubiquitination

(2020) Jiang Liu et al.   NATURE CELL BIOLOGY

FGF1 protects against APAP-induced hepatotoxicity via suppression of oxidative and endoplasmic reticulum stress

(2019) Xiaofang Wang et al.   Clinics and Research in Hepatology and Gastroenterology

FNDC5 alleviates oxidative stress and cardiomyocyte apoptosis in doxorubicin-induced cardiotoxicity via activating AKT

(2019) Xin Zhang et al.   CELL DEATH AND DIFFERENTIATION

FGF1ΔHBS ameliorates chronic kidney disease via PI3K/AKT mediated suppression of oxidative stress and inflammation

(2019) Dezhong Wang et al.   Cell Death & Disease

PGC1α activation by pterostilbene ameliorates acute doxorubicin cardiotoxicity by reducing oxidative stress via enhancing AMPK and SIRT1 cascades

(2019) Dong Liu et al.   Aging-US

Inhibition of mTOR Signaling Enhances Maturation of Cardiomyocytes Derived from Human Induced Pluripotent Stem Cells via p53-Induced Quiescence

(2019) Jessica C. Garbern et al.   CIRCULATION

miR-200a Attenuated Doxorubicin-Induced Cardiotoxicity through Upregulation of Nrf2 in Mice

(2019) Xiaoping Hu et al.   Oxidative Medicine and Cellular Longevity

Berberine Ameliorates Doxorubicin-Induced Cardiotoxicity via a SIRT1/p66Shc-Mediated Pathway

(2019) Yan-Zhao Wu et al.   Oxidative Medicine and Cellular Longevity

Calycosin ameliorates doxorubicin‐induced cardiotoxicity by suppressing oxidative stress and inflammation via the sirtuin 1–NOD‐like receptor protein 3 pathway

(2019) Jinghui Zhai et al.   PHYTOTHERAPY RESEARCH

Trichostatin A inhibits deacetylation of histone H3 and p53 by SIRT6

(2018) Marci Wood et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

A novel small molecule inhibitor of MDM2-p53 (APG-115) enhances radiosensitivity of gastric adenocarcinoma

(2018) Hanjie Yi et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Inhibition of p53 prevents diabetic cardiomyopathy by preventing early-stage apoptosis and cell senescence, reduced glycolysis, and impaired angiogenesis

(2018) Junlian Gu et al.   Cell Death & Disease

MicroRNA-140-5p aggravates doxorubicin-induced cardiotoxicity by promoting myocardial oxidative stress via targeting Nrf2 and Sirt2

(2018) Lisha Zhao et al.   Redox Biology

Prevention of doxorubicin-induced cardiomyopathy using targeted MaFGF mediated by nanoparticles combined with ultrasound-targeted MB destruction

(2017) Xin-Qiao Tian et al.   International Journal of Nanomedicine

Sirt6 deficiency exacerbates podocyte injury and proteinuria through targeting Notch signaling

(2017) Min Liu et al.   Nature Communications

Uncoupling the Mitogenic and Metabolic Functions of FGF1 by Tuning FGF1-FGF Receptor Dimer Stability

(2017) Zhifeng Huang et al.   Cell Reports

Transcriptional Regulation by Nrf2

(2017) Claudia Tonelli et al.   ANTIOXIDANTS & REDOX SIGNALING

Pathways of cardiac toxicity: comparison between chemotherapeutic drugs doxorubicin and mitoxantrone

(2016) Roberto Marques Damiani et al.   ARCHIVES OF TOXICOLOGY

Metallothionein Is Downstream of Nrf2 and Partially Mediates Sulforaphane Prevention of Diabetic Cardiomyopathy

(2016) Junlian Gu et al.   DIABETES

Prevent diabetic cardiomyopathy in diabetic rats by combined therapy of aFGF-loaded nanoparticles and ultrasound-targeted microbubble destruction technique

(2016) Ying-Zheng Zhao et al.   JOURNAL OF CONTROLLED RELEASE

The role of sirtuins in cardiac disease

(2015) Shouji Matsushima et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Sulforaphane protects the heart from doxorubicin-induced toxicity

(2015) Preeti Singh et al.   FREE RADICAL BIOLOGY AND MEDICINE

Resveratrol protects cardiomyocytes from doxorubicin-induced apoptosis through the AMPK/P53 pathway

(2015) MI-HUA LIU et al.   Molecular Medicine Reports

Endocrinization of FGF1 produces a neomorphic and potent insulin sensitizer

(2014) Jae Myoung Suh et al.   NATURE

Controlled delivery of fibroblast growth factor-1 and neuregulin-1 from biodegradable microparticles promotes cardiac repair in a rat myocardial infarction model through activation of endogenous regeneration

(2013) Fabio R. Formiga et al.   JOURNAL OF CONTROLLED RELEASE

Molecular Mechanisms of Fibroblast Growth Factor Signaling in Physiology and Pathology

(2013) A. A. Belov et al.   Cold Spring Harbor Perspectives in Biology

AMPK Promotes p53 Acetylation via Phosphorylation and Inactivation of SIRT1 in Liver Cancer Cells

(2012) C.-W. Lee et al.   CANCER RESEARCH

A small molecule Inauhzin inhibits SIRT1 activity and suppresses tumour growth through activation of p53

(2012) Qi Zhang et al.   EMBO Molecular Medicine

Inhibition of AMP-activated Protein Kinase α (AMPKα) by Doxorubicin Accentuates Genotoxic Stress and Cell Death in Mouse Embryonic Fibroblasts and Cardiomyocytes

(2012) Shaobin Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Improving the cardio protective effect of aFGF in ischemic myocardium with ultrasound-mediated cavitation of heparin modified microbubbles: preliminary experiment

(2012) Ying-Zheng Zhao et al.   JOURNAL OF DRUG TARGETING

Doxorubicin-induced cardiomyopathy: From molecular mechanisms to therapeutic strategies

(2012) Yanti Octavia et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

A PPARγ–FGF1 axis is required for adaptive adipose remodelling and metabolic homeostasis

(2012) Johan W. Jonker et al.   NATURE

Resveratrol attenuates doxorubicin-induced cardiomyocyte apoptosis in mice through SIRT1-mediated deacetylation of p53

(2011) C. Zhang et al.   CARDIOVASCULAR RESEARCH

Inactivation of GSK-3  by Metallothionein Prevents Diabetes-Related Changes in Cardiac Energy Metabolism, Inflammation, Nitrosative Damage, and Remodeling

(2009) Y. Wang et al.   DIABETES

Sirt7 Increases Stress Resistance of Cardiomyocytes and Prevents Apoptosis and Inflammatory Cardiomyopathy in Mice

(2008) Olesya Vakhrusheva et al.   CIRCULATION RESEARCH