A novel small molecule inhibitor of MDM2-p53 (APG-115) enhances radiosensitivity of gastric adenocarcinoma

Phosphorylation of the Mdm2 oncoprotein by the c-Abl tyrosine kinase regulates p53 tumor suppression and the radiosensitivity of mice

(2016) Michael I. Carr et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mdm2 Phosphorylation Regulates Its Stability and Has Contrasting Effects on Oncogene and Radiation-Induced Tumorigenesis

(2016) Michael I. Carr et al.   Cell Reports

MDM2 Inhibition Sensitizes Prostate Cancer Cells to Androgen Ablation and Radiotherapy in a p53-Dependent Manner

(2016) Felix Y. Feng et al.   NEOPLASIA

Small Molecule Inhibition of MDM2-p53 Interaction Augments Radiation Response in Human Tumors

(2015) L. R. Werner et al.   MOLECULAR CANCER THERAPEUTICS

Wild type p53 reactivation: From lab bench to clinic

(2014) Galina Selivanova   FEBS LETTERS

Activation of p53 with Nutlin-3a radiosensitizes lung cancer cells via enhancing radiation-induced premature senescence

(2013) Hongmei Luo et al.   LUNG CANCER

ATM Phosphorylation of Mdm2 Ser394 Regulates the Amplitude and Duration of the DNA Damage Response in Mice

(2012) Hugh S. Gannon et al.   CANCER CELL

Updated Analysis of SWOG-Directed Intergroup Study 0116: A Phase III Trial of Adjuvant Radiochemotherapy Versus Observation After Curative Gastric Cancer Resection

(2012) Stephen R. Smalley et al.   JOURNAL OF CLINICAL ONCOLOGY

Effect of MDM2 and vascular endothelial growth factor inhibition on tumor angiogenesis and metastasis in neuroblastoma

(2011) Danielle M. Patterson et al.   ANGIOGENESIS

A p53-independent role for the MDM2 antagonist Nutlin-3 in DNA damage response initiation

(2011) Jane M Valentine et al.   BMC CANCER

Blinded by the Light: The Growing Complexity of p53

(2009) Karen H. Vousden et al.   CELL

Temporal activation of p53 by a specific MDM2 inhibitor is selectively toxic to tumors and leads to complete tumor growth inhibition

(2008) S. Shangary et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA