SIRT1: A Potential Therapeutic Target in Autoimmune Diseases

Sirtuin 1, Visfatin and IL-27 Serum Levels of Type 1 Diabetic Females in Relation to Cardiovascular Parameters and Autoimmune Thyroid Disease

(2021) Magdalena Łukawska-Tatarczuk et al.   Biomolecules

Implication of the deacetylase sirtuin-1 on synovial angiogenesis and persistence of experimental arthritis

(2020) Agathe Leblond et al.   ANNALS OF THE RHEUMATIC DISEASES

Research progress on sirtuins family members and cell senescence

(2020) Ting Wang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Role of Silent Information Regulator 1 (SIRT1) in Regulating Oxidative Stress and Inflammation

(2020) Vivek Singh et al.   INFLAMMATION

B cell Sirt1 deacetylates histone and non-histone proteins for epigenetic modulation of AID expression and the antibody response

(2020) Huoqun Gan et al.   Science Advances

Dual role of sirtuin 1 in inflammatory bowel disease

(2020) Karam Devi et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

The immunology of rheumatoid arthritis

(2020) Cornelia M. Weyand et al.   NATURE IMMUNOLOGY

The Versatility of Sirtuin-1 in Endocrinology and Immunology

(2020) Fahmida Rasha et al.   Frontiers in Cell and Developmental Biology

The Intestine Harbors Functionally Distinct Homeostatic Tissue-Resident and Inflammatory Th17 Cells

(2019) Sara Omenetti et al.   IMMUNITY

Regulation of sirtuin expression in autoimmune neuroinflammation: Induction of SIRT1 in oligodendrocyte progenitor cells

(2019) Tim Prozorovski et al.   NEUROSCIENCE LETTERS

The Beneficial Roles of SIRT1 in Drug-Induced Liver Injury

(2019) Tingdong Yan et al.   Oxidative Medicine and Cellular Longevity

Update on Autoimmune Diseases Pathogenesis

(2019) M. Kechida   CURRENT PHARMACEUTICAL DESIGN

SIRT6, a Mammalian deacylase with multitasking abilities

(2019) Andrew R Chang et al.   PHYSIOLOGICAL REVIEWS

Sirtuin 1 alleviates endoplasmic reticulum stress-mediated apoptosis of intestinal epithelial cells in ulcerative colitis

(2019) Meng-Ting Ren et al.   WORLD JOURNAL OF GASTROENTEROLOGY

NLRP3: A promising therapeutic target for autoimmune diseases

(2018) Hui-Hui Shen et al.   AUTOIMMUNITY REVIEWS

SIRT1 inhibits rheumatoid arthritis fibroblast-like synoviocyte aggressiveness and inflammatory response via suppressing NF-κB pathway

(2018) Guoqing Li et al.   BIOSCIENCE REPORTS

Urinary levels of sirtuin-1 associated with disease activity in lupus nephritis

(2018) Dolores Olivares et al.   CLINICAL SCIENCE

Phosphorylated SIRT1 as a biomarker of relapse and response to treatment with glatiramer acetate in multiple sclerosis

(2018) Jonathan Ciriello et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

SIRT1 and microRNAs: The role in breast, lung and prostate cancers

(2018) Hedyieh Karbasforooshan et al.   EXPERIMENTAL CELL RESEARCH

Sirtuins in Renal Health and Disease

(2018) Marina Morigi et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Histone Deacetylase Inhibitors and Diabetic Kidney Disease

(2018) Mitchell Hadden et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Resveratrol Alleviates Rheumatoid Arthritis via Reducing ROS and Inflammation, Inhibiting MAPK Signaling Pathways, and Suppressing Angiogenesis

(2018) Guliang Yang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

SIRT1 as a potential biomarker of response to treatment with glatiramer acetate in multiple sclerosis

(2017) Daniel Hewes et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Ultraviolet B inhibition of DNMT1 activity via AhR activation dependent SIRT1 suppression in CD4+ T cells from systemic lupus erythematosus patients

(2017) Zhouwei Wu et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Serum CCL20 and its association with SIRT1 activity in multiple sclerosis patients

(2017) Rui Li et al.   JOURNAL OF NEUROIMMUNOLOGY

Role of NAD+ and mitochondrial sirtuins in cardiac and renal diseases

(2017) Kathleen A. Hershberger et al.   Nature Reviews Nephrology

SIRT3 and mitochondrial metabolism in neurodegenerative diseases

(2017) Illari Salvatori et al.   NEUROCHEMISTRY INTERNATIONAL

The lysine deacetylase Sirtuin 1 modulates the localization and function of the Notch1 receptor in regulatory T cells

(2017) Nimi Marcel et al.   Science Signaling

Sirtinol regulates the balance of Th17/Treg to prevent allograft rejection

(2017) Qing Ye et al.   Cell and Bioscience

Sirtuin-1 Activation Controls Tumor Growth by Impeding Th17 Differentiation via STAT3 Deacetylation

(2017) Emeric Limagne et al.   Cell Reports

Sirtuin 1 (Sirt1) Overexpression in BaF3 Cells Contributes to Cell Proliferation Promotion, Apoptosis Resistance and Pro-Inflammatory Cytokine Production

(2017) Qian Wang et al.   MEDICAL SCIENCE MONITOR

The lysine deacetylase Sirtuin 1 modulates the localization and function of the Notch1 receptor in regulatory T cells

(2017) Nimi Marcel et al.   Science Signaling

Macromolecular crowding effect is critical for maintaining SIRT1's nuclear localization in cancer cells

(2016) Lidong Sun et al.   CELL CYCLE

AIRE-mutations and autoimmune disease

(2016) Øyvind Bruserud et al.   CURRENT OPINION IN IMMUNOLOGY

Histone Deacetylase SIRT1 Negatively Regulates the Differentiation of Interleukin-9-Producing CD4 + T Cells

(2016) Yu Wang et al.   IMMUNITY

Expression patterns of sirtuin 1-AMPK-autophagy pathway in chronic colitis and inflammation-associated colon neoplasia in IL-10-deficient mice

(2016) Elena Talero et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Treatment with NAD + inhibited experimental autoimmune encephalomyelitis by activating AMPK/SIRT1 signaling pathway and modulating Th1/Th17 immune responses in mice

(2016) Jueqiong Wang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Methylene blue alleviates experimental autoimmune encephalomyelitis by modulating AMPK/SIRT1 signaling pathway and Th17/Treg immune response

(2016) Jueqiong Wang et al.   JOURNAL OF NEUROIMMUNOLOGY

Human sirtuins: Structures and flexibility

(2016) Lionel Sacconnay et al.   JOURNAL OF STRUCTURAL BIOLOGY

Targeting Sirtuin-1 prolongs murine renal allograft survival and function

(2016) Matthew H. Levine et al.   KIDNEY INTERNATIONAL

Adiponectin Suppresses T Helper 17 Cell Differentiation and Limits Autoimmune CNS Inflammation via the SIRT1/PPARγ/RORγt Pathway

(2016) Kai Zhang et al.   MOLECULAR NEUROBIOLOGY

TNFα Regulates SIRT1 Cleavage during Ocular Autoimmune Disease

(2015) Peter J. Gardner et al.   AMERICAN JOURNAL OF PATHOLOGY

Maintaining Ancient Organelles: Mitochondrial Biogenesis and Maturation

(2015) R. B. Vega et al.   CIRCULATION RESEARCH

Intercellular interplay between Sirt1 signalling and cell metabolism in immune cell biology

(2015) Xi Chen et al.   IMMUNOLOGY

SIRT1 deacetylates RORγt and enhances Th17 cell generation

(2015) Hyung W. Lim et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Sirtuin 1 Regulates Dendritic Cell Activation and Autophagy during Respiratory Syncytial Virus–Induced Immune Responses

(2015) Anna B. Owczarczyk et al.   JOURNAL OF IMMUNOLOGY

Regulation and function of SIRT1 in rheumatoid arthritis synovial fibroblasts

(2015) Anna Engler et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

The deacetylase Sirt1 is an essential regulator of Aire-mediated induction of central immunological tolerance

(2015) Anna Chuprin et al.   NATURE IMMUNOLOGY

Dendritic cell SIRT1–HIF1α axis programs the differentiation of CD4+T cells through IL-12 and TGF-β1

(2015) Guangwei Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Involvement of TACE in colon inflammation: A novel mechanism of regulation via SIRT-1 activation

(2014) Manoranjan Sharma et al.   CYTOKINE

SIRT1 is decreased during relapses in patients with multiple sclerosis

(2014) Cosmin A. Tegla et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Role of SIRT1 in autoimmune demyelination and neurodegeneration

(2014) Alvaro Martin et al.   IMMUNOLOGIC RESEARCH

The sirtuin class of histone deacetylases: Regulation and roles in lipid metabolism

(2014) Erika Fiorino et al.   IUBMB LIFE

Sirtuin-1 (SIRT1) Is Required for Promoting Chondrogenic Differentiation of Mesenchymal Stem Cells

(2014) Constanze Buhrmann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SIRT1 promoter polymorphisms as clinical modifiers on systemic lupus erythematosus

(2014) Camila Rosat Consiglio et al.   MOLECULAR BIOLOGY REPORTS

Defective expression of SIRT1 contributes to sustain inflammatory pathways in the gut

(2014) R Caruso et al.   Mucosal Immunology

Targeting sirtuin-1 alleviates experimental autoimmune colitis by induction of Foxp3+ T-regulatory cells

(2014) T Akimova et al.   Mucosal Immunology

Myeloid Deletion of SIRT1 Aggravates Serum Transfer Arthritis in Mice via Nuclear Factor-κB Activation

(2014) Young-Sool Hah et al.   PLoS One

Loss of Sirt1 Function Improves Intestinal Anti-Bacterial Defense and Protects from Colitis-Induced Colorectal Cancer

(2014) Giuseppe Lo Sasso et al.   PLoS One

Resveratrol Possesses Protective Effects in a Pristane-Induced Lupus Mouse Model

(2014) Zhuo-Long Wang et al.   PLoS One

SIRT1 Activating compounds reduce oxidative stress mediated neuronal loss in viral induced CNS demyelinating disease

(2014) Reas S Khan et al.   Acta Neuropathologica Communications

Sirtuins as Possible Drug Targets in Type 2 Diabetes

(2013) Munehiro Kitada et al.   CURRENT DRUG TARGETS

SIRT1 activation protects against autoimmune T cell-driven retinal disease in mice via inhibition of IL-2/Stat5 signaling

(2013) Peter J. Gardner et al.   JOURNAL OF AUTOIMMUNITY

Histone Deacetylase Sirtuin 1 Deacetylates IRF1 Protein and Programs Dendritic Cells to Control Th17 Protein Differentiation during Autoimmune Inflammation

(2013) Heeyoung Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Overexpression of SIRT1 Protein in Neurons Protects against Experimental Autoimmune Encephalomyelitis through Activation of Multiple SIRT1 Targets

(2013) V. K. Nimmagadda et al.   JOURNAL OF IMMUNOLOGY

Structural and Functional Analysis of Human SIRT1

(2013) Andrew M. Davenport et al.   JOURNAL OF MOLECULAR BIOLOGY

Metabolism of inflammation limited by AMPK and pseudo-starvation

(2013) Luke A. J. O'Neill et al.   NATURE

Resveratrol Inhibits CD4+ T Cell Activation by Enhancing the Expression and Activity of Sirt1

(2013) Ting Zou et al.   PLoS One

Silent information regulator (Sir)T1 inhibits NF-κB signaling to maintain normal skeletal remodeling

(2012) James R Edwards et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Three Novel Acetylation Sites in the Foxp3 Transcription Factor Regulate the Suppressive Activity of Regulatory T Cells

(2012) H.-S. Kwon et al.   JOURNAL OF IMMUNOLOGY

Negative regulation of inflammation by SIRT1

(2012) Jun Xie et al.   PHARMACOLOGICAL RESEARCH

Regulation of Sirtuin Function by Posttranslational Modifications

(2012) Franziska Flick et al.   Frontiers in Pharmacology

Resveratrol Neuroprotection in a Chronic Mouse Model of Multiple Sclerosis

(2012) Zoe Fonseca-Kelly et al.   Frontiers in Neurology

SIRT1 overexpression in the rheumatoid arthritis synovium contributes to proinflammatory cytokine production and apoptosis resistance

(2011) F. Niederer et al.   ANNALS OF THE RHEUMATIC DISEASES

Sirtuin 1 in malignant transformation: Friend or foe?

(2011) Yujiang Fang et al.   CANCER LETTERS

Sirt1 Is a Regulator of Bone Mass and a Repressor ofSostEncoding for Sclerostin, a Bone Formation Inhibitor

(2011) Einav Cohen-Kfir et al.   ENDOCRINOLOGY

Resveratrol inhibits interleukin 1β-mediated inducible nitric oxide synthase expression in articular chondrocytes by activating SIRT1 and thereby suppressing nuclear factor-κB activity

(2011) Ming Lei et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The Type III Histone Deacetylase Sirt1 Protein Suppresses p300-mediated Histone H3 Lysine 56 Acetylation at Bclaf1 Promoter to Inhibit T Cell Activation

(2011) Sinyi Kong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sirtuin 1 Promotes Th2 Responses and Airway Allergy by Repressing Peroxisome Proliferator-Activated Receptor-  Activity in Dendritic Cells

(2011) A. Legutko et al.   JOURNAL OF IMMUNOLOGY

Sirtuin-1 Targeting Promotes Foxp3+ T-Regulatory Cell Function and Prolongs Allograft Survival

(2011) U. H. Beier et al.   MOLECULAR AND CELLULAR BIOLOGY

Peptide Switch Is Essential for Sirt1 Deacetylase Activity

(2011) Hyeog Kang et al.   MOLECULAR CELL

Rapid Temporal Control of Foxp3 Protein Degradation by Sirtuin-1

(2011) Jorg van Loosdregt et al.   PLoS One

Oral Resveratrol Reduces Neuronal Damage in a Model of Multiple Sclerosis

(2010) Kenneth S Shindler et al.   JOURNAL OF NEURO-OPHTHALMOLOGY

Myeloid Deletion of SIRT1 Induces Inflammatory Signaling in Response to Environmental Stress

(2010) T. T. Schug et al.   MOLECULAR AND CELLULAR BIOLOGY

SIRT1 inhibits inflammatory pathways in macrophages and modulates insulin sensitivity

(2009) Takeshi Yoshizaki et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Regulation of Treg functionality by acetylation-mediated Foxp3 protein stabilization

(2009) J. van Loosdregt et al.   BLOOD

SIRT1: Regulation of longevity via autophagy

(2009) Antero Salminen et al.   CELLULAR SIGNALLING

SIRT1 Suppresses Activator Protein-1 Transcriptional Activity and Cyclooxygenase-2 Expression in Macrophages

(2009) Ran Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The type III histone deacetylase Sirt1 is essential for maintenance of T cell tolerance in mice

(2009) Jinping Zhang et al.   JOURNAL OF CLINICAL INVESTIGATION

Recent progress in the biology and physiology of sirtuins

(2009) Toren Finkel et al.   NATURE

Aberrant expression pattern of histone acetylation modifiers and mitigation of lupus by SIRT1-siRNA in MRL/lprmice

(2009) N Hu et al.   SCANDINAVIAN JOURNAL OF RHEUMATOLOGY

Essential role for Bclaf1 in lung development and immune system function

(2008) J Peter McPherson et al.   CELL DEATH AND DIFFERENTIATION

sirt1-null mice develop an autoimmune-like condition

(2008) Jedon Sequeira et al.   EXPERIMENTAL CELL RESEARCH

Decreased severity of experimental autoimmune encephalomyelitis during resveratrol administration is associated with increased IL-17+IL-10+ T cells, CD4− IFN-γ+ cells, and decreased macrophage IL-6 expression

(2008) Toby J. Imler et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Early suppression of familial Mediterranean fever attacks by single medium dose methyl-prednisolone infusion

(2008) Eren Erken et al.   JOINT BONE SPINE

The Rpd3/Hda1 family of lysine deacetylases: from bacteria and yeast to mice and men

(2008) Xiang-Jiao Yang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY