Article
Biochemistry & Molecular Biology
Alexandra-Gela Lazar, Mihaela-Loredana Vlad, Adrian Manea, Maya Simionescu, Simona-Adriana Manea
Summary: Accumulating evidence supports the involvement of histone acetylation-based epigenetic mechanisms in the pathoetiology of diabetes-associated micro-/macrovascular complications, with a focus on diabetic kidney disease. Pharmacological inhibition of p300/CBP shows promise in down-regulating the expression of Nox subtypes, inflammation, and fibrosis in the diabetic kidney, potentially reducing the burden of DKD.
Review
Endocrinology & Metabolism
Heng-Cheng Lu, Wen-Ni Dai, Li-Yu He
Summary: Diabetic kidney disease (DKD) is a major complication of diabetes mellitus, affecting a significant percentage of patients with type 1 and type 2 diabetes. Current treatments can alleviate but not prevent the progression of DKD into end-stage renal disease (ESRD). The disease is influenced by both genetic and environmental factors, with emerging research suggesting a role for epigenetic mechanisms such as histone post-translational modifications.
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2021)
Review
Biochemistry & Molecular Biology
Rossella Indellicato, Marco Trinchera
Summary: Studying the epigenetic regulation of glycosylation is crucial for gaining insights into the glycan field, especially in relation to cancer and other diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Aniko Farago, Nora Zsindely, Anita Farkas, Alexandra Neller, Fruzsina Siagi, Marton Richard Szabo, Tamas Csont, Laszlo Bodai
Summary: Huntington's Disease is a fatal neurodegenerative disorder caused by the expansion of a polyglutamine-coding CAG repeat in the Huntingtin gene. One of the main causes of neurodegeneration in HD is transcriptional dysregulation, which is partly caused by the inhibition of histone acetyltransferase enzymes. Increasing the activity of specific HATs or inhibiting histone deacetylase enzymes can alleviate HD pathology. This study suggests that Gcn5-dependent acetylation of H3.3K14 may be an important epigenetic contributor to HD pathology.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Aanchal Aggarwal, Binduma Yadav, Nishtha Sharma, Raminder Kaur, Vikas Rishi
Summary: Epigenetic mechanisms related to diabetes-afflicted CNS complications are largely unknown. This study investigated the role of histone acetylation mechanisms in triggering cognitive dysfunction in Type 1 and 2 diabetic mice. The results showed that cognitive performance was significantly diminished in diabetic mice, correlated with reduced histone acetylation and transcriptional repression of memory-related genes. Pharmacological inhibition of histone deacetylase activity improved cognitive changes in diabetic mice.
NEUROCHEMISTRY INTERNATIONAL
(2023)
Review
Genetics & Heredity
Jinkun Xia, Wangsen Cao
Summary: Studies show that epigenetic modifications affect the Klotho gene in renal diseases, impacting disease progression. Lowered Klotho levels worsen the condition, but beneficial changes can be made through epigenetic interventions.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2021)
Article
Biotechnology & Applied Microbiology
Nando D. Das, Jen-Chien Chang, Chung-Chau Hon, S. Thomas Kelly, Shinsuke Ito, Marina Lizio, Bogumil Kaczkowski, Hisami Watanabe, Keisuke Katsushima, Atsushi Natsume, Haruhiko Koseki, Yutaka Kondo, Aki Minoda, Takashi Umehara
Summary: This study found that H4K5acK8ac and H3K27ac signals have some overlap in binding to the super-enhancer transcription factor BRD4 at higher levels, but they also have distinct specificities, especially in glioblastoma stem-like cell lines. Deletion of H4K5acK8ac-preferred super-enhancers associated with MYCN and NFIC resulted in a reduction in stem-like properties.
Review
Biochemistry & Molecular Biology
Disha Agarwal, Ruchika Kumari, Ashal Ilyas, Shweta Tyagi, Rajnish Kumar, Nitesh Kumar Poddar
Summary: Epigenetics has opened a new dimension in exploring unanswered questions in genetics, particularly in neurodegenerative diseases like Alzheimer's and cancers. The alterations in DNA methylation levels, histone acetylation, and methylation play a significant role in conditions such as Alzheimer's disease. Studying the interplay between the mTOR regulatory pathway and epigenetic machinery may lead to early diagnosis and novel therapeutic strategies for Alzheimer's disease.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Review
Genetics & Heredity
Merrick S. Fallah, Dora Szarics, Clara M. Robson, James H. Eubanks
Summary: Epigenetic processes play a critical role in regulating gene expression patterns in neurodevelopment, including the dynamic network of post-translational histone modifications. Mutations in histone-modifying enzymes can disrupt this system and lead to developmental consequences. This review examines neurodevelopmental conditions associated with histone methylation and acetylation, discussing clinical phenotypes, genetic bases, and model systems for studying pathological mechanisms.
FRONTIERS IN GENETICS
(2021)
Article
Neurosciences
Bryan McClarty, Guadalupe Rodriguez, Hongxin Dong
Summary: The study showed that the HDAC inhibitor CI-994 at different doses could reduce motor and memory side effects induced by haloperidol in aged mice. A dose of 20 mg/kg was effective in improving motor coordination and mitigating memory impairment in aged mice. Biochemical analyses indicated an increase in histone acetylation and expression of the dopamine 2 receptor gene in aged mice after administration of CI-994 at 20 mg/kg.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Giordano Proietti, Yali Wang, Chiara Punzo, Jasmin Mecinovic
Summary: KAT8 is capable of acetylating selective lysine analogues with subtle changes in side chains and main chains, in addition to natural lysine. This study contributes to the design of new chemical probes targeting KAT8 and other members of the histone lysine acetyltransferase family.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Chemistry, Medicinal
Mauricio T. Tavares, Alan P. Kozikowski, Sida Shen
Summary: Histone deacetylase 6 (HDAC6) is a zinc-dependent enzyme that regulates the acetylation of non-histone substrates, impacting various cellular processes. The discovery of mercaptoacetamide (MCA)-based HDAC6 inhibitors has shown promising potential due to their selectivity and lack of mutagenicity. Further research on the structure-activity relationships, selectivity, and pharmacological properties of MCA-based HDAC6 inhibitors could lead to improved drug-like properties.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Psychiatry
Anil Srivastava, Oluwagbenga Dada, Jessica Qian, Nzaar Al-Chalabi, Ali Bani Fatemi, Philip Gerretsen, Ariel Graff, Vincenzo De Luca
Summary: Schizophrenia is a chronic psychotic disorder that significantly impacts behavior, thought, and cognition, with possible contributions from both genetic and epigenetic factors. Current research focuses on DNA methylation, histone modification, and non-coding RNA, offering potential new avenues for diagnosis and treatment of schizophrenia. Limitations in current knowledge and potential future research directions are also discussed.
PSYCHIATRY RESEARCH
(2021)
Review
Genetics & Heredity
Simeng Wang, Xinyu Zhang, Qinglian Wang, Rong Wang
Summary: This review summarizes the pathogenesis of podocyte injury in diabetic nephropathy (DN), focusing on the role of histone modification. It provides new insights for further molecular research, diagnosis, and treatment.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2022)
Review
Plant Sciences
Rocio Nunez-Vazquez, Benedicte Desvoyes, Crisanto Gutierrez
Summary: Plants have developed various mechanisms to adapt to abiotic stresses, which involve transcriptional regulation and chromatin modifications. Understanding and manipulating these regulatory networks are crucial for enhancing crop resilience and performance against stress.
FRONTIERS IN PLANT SCIENCE
(2022)