The Colony Stimulating Factor-1 Receptor (CSF-1R)-Mediated Regulation of Microglia/Macrophages as a Target for Neurological Disorders (Glioma, Stroke)

In Vitro Evaluation of [3H]CPPC as a Tool Radioligand for CSF-1R

(2021) Ashley C. Knight et al.   ACS Chemical Neuroscience

Changes in the tumor microenvironment and outcome for TME-targeting therapy in glioblastoma: A pilot study

(2021) Sehar Ali et al.   PLoS One

PET imaging of colony-stimulating factor 1 receptor: A head-to-head comparison of a novel radioligand, 11C-GW2580, and 11C-CPPC, in mouse models of acute and chronic neuroinflammation and a rhesus monkey

(2021) Xiaoyun Zhou et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Single-cell profiling of myeloid cells in glioblastoma across species and disease stage reveals macrophage competition and specialization

(2021) Ana Rita Pombo Antunes et al.   NATURE NEUROSCIENCE

Targeting CSF1R Alone or in Combination with PD1 in Experimental Glioma

(2021) Justyna M. Przystal et al.   Cancers

A longitudinal PET/MR imaging study of colony stimulating factor-1 receptor-mediated microglia depletion in experimental stroke

(2021) Cristina Barca et al.   JOURNAL OF NUCLEAR MEDICINE

Prognostic Gene Expression Signature in Patients With Distinct Glioma Grades

(2021) Saadia Ait Ssi et al.   Frontiers in Immunology

Patterns of Expression of Purinergic Receptor P2RY12, a Putative Marker for Non-Activated Microglia, in Aged and Alzheimer’s Disease Brains

(2020) Douglas G. Walker et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Microglial depletion and repopulation in brain slice culture normalizes sensitized proinflammatory signaling

(2020) Leon G. Coleman et al.   Journal of Neuroinflammation

Microglial depletion with CSF1R inhibitor during chronic phase of experimental traumatic brain injury reduces neurodegeneration and neurological deficits

(2020) Rebecca J. Henry et al.   JOURNAL OF NEUROSCIENCE

Modulators of microglia activation and polarization in ischemic stroke (Review)

(2020) Cheng‑Ting Jiang et al.   Molecular Medicine Reports

Immunotherapeutic approaches for small-cell lung cancer

(2020) Wade T. Iams et al.   Nature Reviews Clinical Oncology

Cerebrospinal fluid penetration of the colony-stimulating factor-1 receptor (CSF-1R) inhibitor, pexidartinib

(2020) Priya S. Shankarappa et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Establishment and Maintenance of the Macrophage Niche

(2020) Martin Guilliams et al.   IMMUNITY

Pexidartinib, a Novel Small Molecule CSF-1R Inhibitor in Use for Tenosynovial Giant Cell Tumor: A Systematic Review of Pre-Clinical and Clinical Development

(2020) Brooke Benner et al.   Drug Design Development and Therapy

To Kill a Microglia: A Case for CSF1R Inhibitors

(2020) Kim N. Green et al.   TRENDS IN IMMUNOLOGY

Immunotherapy in the Treatment of Metastatic Melanoma: Current Knowledge and Future Directions

(2020) Massimo Ralli et al.   Journal of Immunology Research

CSF1R inhibition by a small-molecule inhibitor is not microglia specific; affecting hematopoiesis and the function of macrophages

(2020) Fengyang Lei et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Single cell RNA sequencing of human microglia uncovers a subset associated with Alzheimer’s disease

(2020) Marta Olah et al.   Nature Communications

Myeloid Cells in Glioblastoma Microenvironment

(2020) Alessandra De Leo et al.   Cells

PET imaging of microglia by targeting macrophage colony-stimulating factor 1 receptor (CSF1R)

(2019) Andrew G. Horti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proximal recolonization by self-renewing microglia re-establishes microglial homeostasis in the adult mouse brain

(2019) Lihong Zhan et al.   PLOS BIOLOGY

Therapeutic targeting of macrophages enhances chemotherapy efficacy by unleashing type I interferon response

(2019) Camilla Salvagno et al.   NATURE CELL BIOLOGY

Spatial and temporal heterogeneity of mouse and human microglia at single-cell resolution

(2019) Takahiro Masuda et al.   NATURE

Single-cell transcriptomic analysis of Alzheimer’s disease

(2019) Hansruedi Mathys et al.   NATURE

Dual Functions of Microglia in Ischemic Stroke

(2019) Chuan Qin et al.   Neuroscience Bulletin

Targeting Myeloid Cells in Combination Treatments for Glioma and Other Tumors

(2019) Andy S. Ding et al.   Frontiers in Immunology

A 89Zr-HDL PET tracer monitors response to a CSF1R inhibitor

(2019) Christian Mason et al.   JOURNAL OF NUCLEAR MEDICINE

CSF1R Ligands IL-34 and CSF1 Are Differentially Required for Microglia Development and Maintenance in White and Gray Matter Brain Regions

(2019) Courtney Easley-Neal et al.   Frontiers in Immunology

Pexidartinib: First Approval

(2019) Yvette N. Lamb   DRUGS

Microglia/Brain Macrophages as Central Drivers of Brain Tumor Pathobiology

(2019) David H. Gutmann et al.   NEURON

Resolution of neuroinflammation: mechanisms and potential therapeutic option

(2019) Nikolaos Dokalis et al.   Seminars in Immunopathology

Sustained microglial depletion with CSF1R inhibitor impairs parenchymal plaque development in an Alzheimer’s disease model

(2019) Elizabeth Spangenberg et al.   Nature Communications

Csf1R inhibition attenuates experimental autoimmune encephalomyelitis and promotes recovery

(2018) Jillian C. Nissen et al.   EXPERIMENTAL NEUROLOGY

When Immune Cells Turn Bad—Tumor-Associated Microglia/Macrophages in Glioma

(2018) Saskia Roesch et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Repopulated microglia are solely derived from the proliferation of residual microglia after acute depletion

(2018) Yubin Huang et al.   NATURE NEUROSCIENCE

Pembrolizumab plus Chemotherapy in Metastatic Non–Small-Cell Lung Cancer

(2018) Leena Gandhi et al.   NEW ENGLAND JOURNAL OF MEDICINE

IL-34 and CSF-1 display an equivalent macrophage differentiation ability but a different polarization potential

(2018) Sonia Boulakirba et al.   Scientific Reports

18F-JNJ-64413739, a novel PET ligand for the P2X7 ion channel: radiation dosimetry, kinetic modeling, test-retest variability and occupancy of the P2X7 antagonist JNJ-54175446

(2018) Michel Koole et al.   JOURNAL OF NUCLEAR MEDICINE

Microglial signatures and their role in health and disease

(2018) Oleg Butovsky et al.   NATURE REVIEWS NEUROSCIENCE

Microglial cell loss after ischemic stroke favors brain neutrophil accumulation

(2018) Amaia Otxoa-de-Amezaga et al.   ACTA NEUROPATHOLOGICA

Replacement of microglia in the aged brain reverses cognitive, synaptic, and neuronal deficits in mice

(2018) Monica R. P. Elmore et al.   AGING CELL

A limited capacity for microglial repopulation in the adult brain

(2018) Allison R. Najafi et al.   GLIA

Single-Cell RNA Sequencing of Microglia throughout the Mouse Lifespan and in the Injured Brain Reveals Complex Cell-State Changes

(2018) Timothy R. Hammond et al.   IMMUNITY

Targeting macrophages: therapeutic approaches in cancer

(2018) Luca Cassetta et al.   NATURE REVIEWS DRUG DISCOVERY

Atezolizumab and Nab-Paclitaxel in Advanced Triple-Negative Breast Cancer

(2018) Peter Schmid et al.   NEW ENGLAND JOURNAL OF MEDICINE

Beyond the M-CSF receptor - novel therapeutic targets in tumor-associated macrophages

(2017) Stefano Bonelli et al.   FEBS Journal

Microglial repopulation resolves inflammation and promotes brain recovery after injury

(2017) Rachel A. Rice et al.   GLIA

The P2X7 Receptor in Infection and Inflammation

(2017) Francesco Di Virgilio et al.   IMMUNITY

Microglia and Monocytes/Macrophages Polarization Reveal Novel Therapeutic Mechanism against Stroke

(2017) Masato Kanazawa et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Depletion of microglia exacerbates postischemic inflammation and brain injury

(2017) Wei-Na Jin et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Immunosuppressive tumor-infiltrating myeloid cells mediate adaptive immune resistance via a PD-1/PD-L1 mechanism in glioblastoma

(2017) Joseph P. Antonios et al.   NEURO-ONCOLOGY

Transformation of Astrocytes to a Neuroprotective Phenotype by Microglia via P2Y 1 Receptor Downregulation

(2017) Youichi Shinozaki et al.   Cell Reports

The Lifespan and Turnover of Microglia in the Human Brain

(2017) Pedro Réu et al.   Cell Reports

An updated assessment of microglia depletion: current concepts and future directions

(2017) Jinming Han et al.   Molecular Brain

Microglial depletion and activation: A [11C]PBR28 PET study in nonhuman primates

(2017) Ansel T. Hillmer et al.   EJNMMI Research

Microglia: A Unique Versatile Cell in the Central Nervous System

(2016) Takahiro Masuda et al.   ACS Chemical Neuroscience

Eliminating microglia in Alzheimer’s mice prevents neuronal loss without modulating amyloid-β pathology

(2016) Elizabeth E. Spangenberg et al.   BRAIN

Dynamic microglial modulation of spatial learning and social behavior

(2016) Luisa Torres et al.   BRAIN BEHAVIOR AND IMMUNITY

CSF1 Overexpression Promotes High-Grade Glioma Formation without Impacting the Polarization Status of Glioma-Associated Microglia and Macrophages

(2016) I. De et al.   CANCER RESEARCH

Molecular Pathways: Deciphering Mechanisms of Resistance to Macrophage-Targeted Therapies

(2016) Daniela F. Quail et al.   CLINICAL CANCER RESEARCH

The tumor microenvironment underlies acquired resistance to CSF-1R inhibition in gliomas

(2016) D. F. Quail et al.   SCIENCE

Emerging Roles for CSF-1 Receptor and its Ligands in the Nervous System

(2016) Violeta Chitu et al.   TRENDS IN NEUROSCIENCES

Microglia protect against brain injury and their selective elimination dysregulates neuronal network activity after stroke

(2016) Gergely Szalay et al.   Nature Communications

M-CSF and GM-CSF Receptor Signaling Differentially Regulate Monocyte Maturation and Macrophage Polarization in the Tumor Microenvironment

(2015) E. Van Overmeire et al.   CANCER RESEARCH

CSF-1/CSF-1R targeting agents in clinical development for cancer therapy

(2015) Carola H Ries et al.   CURRENT OPINION IN PHARMACOLOGY

Genetic Cell Ablation Reveals Clusters of Local Self-Renewing Microglia in the Mammalian Central Nervous System

(2015) Julia Bruttger et al.   IMMUNITY

Tumor-induced myeloid deviation: when myeloid-derived suppressor cells meet tumor-associated macrophages

(2015) Stefano Ugel et al.   JOURNAL OF CLINICAL INVESTIGATION

Colony-stimulating factor 1 receptor inhibition prevents microglial plaque association and improves cognition in 3xTg-AD mice

(2015) Nabil N. Dagher et al.   Journal of Neuroinflammation

Orally administered colony stimulating factor 1 receptor inhibitor PLX3397 in recurrent glioblastoma: an Ivy Foundation Early Phase Clinical Trials Consortium phase II study

(2015) Nicholas Butowski et al.   NEURO-ONCOLOGY

CD4+T effector memory cell dysfunction is associated with the accumulation of granulocytic myeloid-derived suppressor cells in glioblastoma patients

(2015) Daniel Dubinski et al.   NEURO-ONCOLOGY

Colony stimulating factor 1 receptor inhibition delays recurrence of glioblastoma after radiation by altering myeloid cell recruitment and polarization

(2015) Jason H. Stafford et al.   NEURO-ONCOLOGY

Homeostasis of Microglia in the Adult Brain: Review of Novel Microglia Depletion Systems

(2015) Ari Waisman et al.   TRENDS IN IMMUNOLOGY

The role of microglia and myeloid immune cells in acute cerebral ischemia

(2015) Corinne Benakis et al.   Frontiers in Cellular Neuroscience

Macrophage depletion reduces postsurgical tumor recurrence and metastatic growth in a spontaneous murine model of melanoma

(2015) Muly Tham et al.   Oncotarget

Characterizing Newly Repopulated Microglia in the Adult Mouse: Impacts on Animal Behavior, Cell Morphology, and Neuroinflammation

(2015) Monica R. P. Elmore et al.   PLoS One

Targeting Tumor-Associated Macrophages with Anti-CSF-1R Antibody Reveals a Strategy for Cancer Therapy

(2014) Carola H. Ries et al.   CANCER CELL

CSF1/CSF1R Blockade Reprograms Tumor-Infiltrating Macrophages and Improves Response to T-cell Checkpoint Immunotherapy in Pancreatic Cancer Models

(2014) Y. Zhu et al.   CANCER RESEARCH

Neuroinflammation and M2 microglia: the good, the bad, and the inflamed

(2014) Jonathan D Cherry et al.   Journal of Neuroinflammation

Microglia and brain macrophages in the molecular age: from origin to neuropsychiatric disease

(2014) Marco Prinz et al.   NATURE REVIEWS NEUROSCIENCE

Colony-Stimulating Factor 1 Receptor Signaling Is Necessary for Microglia Viability, Unmasking a Microglia Progenitor Cell in the Adult Brain

(2014) Monica R.P. Elmore et al.   NEURON

CSF-1 Receptor Signaling in Myeloid Cells

(2014) E. R. Stanley et al.   Cold Spring Harbor Perspectives in Biology

Functional Relationship between Tumor-Associated Macrophages and Macrophage Colony-Stimulating Factor as Contributors to Cancer Progression

(2014) Damya Laoui et al.   Frontiers in Immunology

CSF1R inhibition delays cervical and mammary tumor growth in murine models by attenuating the turnover of tumor-associated macrophages and enhancing infiltration by CD8+T cells

(2014) Debbie C Strachan et al.   OncoImmunology

Inhibition of CSF-1 Receptor Improves the Antitumor Efficacy of Adoptive Cell Transfer Immunotherapy

(2013) S. Mok et al.   CANCER RESEARCH

Microglia Promote Learning-Dependent Synapse Formation through Brain-Derived Neurotrophic Factor

(2013) Christopher N. Parkhurst et al.   CELL

CSF-1R inhibition alters macrophage polarization and blocks glioma progression

(2013) Stephanie M Pyonteck et al.   NATURE MEDICINE

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(2012) Salvatore Coniglio et al.   MOLECULAR MEDICINE

Absence of Colony Stimulation Factor-1 Receptor Results in Loss of Microglia, Disrupted Brain Development and Olfactory Deficits

(2011) Bryna Erblich et al.   PLoS One

Possible involvement of the M2 anti-inflammatory macrophage phenotype in growth of human gliomas

(2008) Y Komohara et al.   JOURNAL OF PATHOLOGY