Changes in the tumor microenvironment and outcome for TME-targeting therapy in glioblastoma: A pilot study

The CXCR2/CXCL2 signalling pathway – An alternative therapeutic approach in high-grade glioma

(2020) Güliz Acker et al.   EUROPEAN JOURNAL OF CANCER

Alterations of the tumor microenvironment in glioblastoma following radiation and temozolomide with or without bevacizumab

(2020) Ryota Tamura et al.   Annals of Translational Medicine

Glioblastoma Treatment with Temozolomide and Bevacizumab and Overall Survival in a Rural Tertiary Healthcare Practice

(2019) Tonia C. Carter et al.   Biomed Research International

The Role of Platelets in the Tumor-Microenvironment and the Drug Resistance of Cancer Cells

(2019) Phung Huong et al.   Cancers

Primary tumor-induced immunity eradicates disseminated tumor cells in syngeneic mouse model

(2019) Raziye Piranlioglu et al.   Nature Communications

Phase I/IIa study of concomitant radiotherapy with olaparib and temozolomide in unresectable or partially resectable glioblastoma: OLA-TMZ-RTE-01 trial protocol

(2019) Paul Lesueur et al.   BMC CANCER

Potential roles and targeted therapy of the CXCLs/CXCR2 axis in cancer and inflammatory diseases

(2019) Yuan Cheng et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

CYP4A/20-HETE regulates ischemia-induced neovascularization via its actions on endothelial progenitor and preexisting endothelial cells

(2019) Li Chen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Re-education of Tumor-Associated Macrophages by CXCR2 Blockade Drives Senescence and Tumor Inhibition in Advanced Prostate Cancer

(2019) Diletta Di Mitri et al.   Cell Reports

Single-agent Bevacizumab in Recurrent Glioblastoma After Second-line Chemotherapy With Fotemustine

(2018) Francesco Pasqualetti et al.   AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS

Myeloid-derived suppressor cells (MDSC): an important partner in cellular/tissue senescence

(2018) Antero Salminen et al.   BIOGERONTOLOGY

Current state of immunotherapy for glioblastoma

(2018) Michael Lim et al.   Nature Reviews Clinical Oncology

Drug Repositioning in Glioblastoma: A Pathway Perspective

(2018) Sze Kiat Tan et al.   Frontiers in Pharmacology

Advances in Radiotherapy for Glioblastoma

(2018) Justin Mann et al.   Frontiers in Neurology

The role of myeloid-derived suppressor cells (MDSC) in the inflammaging process

(2018) Antero Salminen et al.   AGEING RESEARCH REVIEWS

Bevacizumab and Glioblastoma

(2018) Michelle M. Kim et al.   CANCER JOURNAL

Tumor-associated macrophages in breast cancer: Innocent bystander or important player?

(2018) Si-Qi Qiu et al.   CANCER TREATMENT REVIEWS

Delineating Pro-Angiogenic Myeloid Cells in Cancer Therapy

(2018) Benjamin Johnson et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Challenges in the Treatment of Glioblastoma: Multisystem Mechanisms of Therapeutic Resistance

(2018) Evan K. Noch et al.   World Neurosurgery

CXCR2-Expressing Tumor Cells Drive Vascular Mimicry in Antiangiogenic Therapy–Resistant Glioblastoma

(2018) Kartik Angara et al.   NEOPLASIA

Role of platelets and platelet receptors in cancer metastasis

(2018) Martin Schlesinger   Journal of Hematology & Oncology

MDSC; the Most Important Cell You Have Never Heard Of

(2018) R.J. Tesi   TRENDS IN PHARMACOLOGICAL SCIENCES

Radiation-Induced Alterations in the Recurrent Glioblastoma Microenvironment: Therapeutic Implications

(2018) Kshama Gupta et al.   Frontiers in Oncology

Clinical outcomes in recurrent glioblastoma with bevacizumab therapy: An analysis of the literature

(2017) Matthew Tipping et al.   JOURNAL OF CLINICAL NEUROSCIENCE

Treatment outcome of patients with recurrent glioblastoma multiforme: a retrospective multicenter analysis

(2017) Myra E. van Linde et al.   JOURNAL OF NEURO-ONCOLOGY

The role of bevacizumab in the treatment of glioblastoma

(2017) Roberto Jose Diaz et al.   JOURNAL OF NEURO-ONCOLOGY

HET0016 decreases lung metastasis from breast cancer in immune-competent mouse model

(2017) Thaiz F. Borin et al.   PLoS One

Monocytic and granulocytic myeloid derived suppressor cells differentially regulate spatiotemporal tumour plasticity during metastatic cascade

(2017) Maria Ouzounova et al.   Nature Communications

Survival benefit of glioblastoma patients after FDA approval of temozolomide concomitant with radiation and bevacizumab: A population-based study

(2017) Ping Zhu et al.   Oncotarget

Colony-stimulating factor 1 receptor (CSF1R) inhibitors in cancer therapy

(2017) Michael A. Cannarile et al.   Journal for ImmunoTherapy of Cancer

Intravenous Formulation of HET0016 Decreased Human Glioblastoma Growth and Implicated Survival Benefit in Rat Xenograft Models

(2017) Meenu Jain et al.   Scientific Reports

Canonical NFκB signaling in myeloid cells is required for the glioblastoma growth

(2017) B. R. Achyut et al.   Scientific Reports

The role of platelets in the tumor microenvironment: From solid tumors to leukemia

(2016) MengJie Yan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Chimeric Mouse model to track the migration of bone marrow derived cells in glioblastoma following anti-angiogenic treatments

(2016) B. R. Achyut et al.   CANCER BIOLOGY & THERAPY

CXCR2 Inhibition Profoundly Suppresses Metastases and Augments Immunotherapy in Pancreatic Ductal Adenocarcinoma

(2016) Colin W. Steele et al.   CANCER CELL

The tumor microenvironment underlies acquired resistance to CSF-1R inhibition in gliomas

(2016) D. F. Quail et al.   SCIENCE

Fluvoxamine, an anti-depressant, inhibits human glioblastoma invasion by disrupting actin polymerization

(2016) Keiichiro Hayashi et al.   Scientific Reports

Bone marrow derived myeloid cells orchestrate antiangiogenic resistance in glioblastoma through coordinated molecular networks

(2015) B.R. Achyut et al.   CANCER LETTERS

Orally administered colony stimulating factor 1 receptor inhibitor PLX3397 in recurrent glioblastoma: an Ivy Foundation Early Phase Clinical Trials Consortium phase II study

(2015) Nicholas Butowski et al.   NEURO-ONCOLOGY

Colony stimulating factor 1 receptor inhibition delays recurrence of glioblastoma after radiation by altering myeloid cell recruitment and polarization

(2015) Jason H. Stafford et al.   NEURO-ONCOLOGY

Targeting YAP-Dependent MDSC Infiltration Impairs Tumor Progression

(2015) G. Wang et al.   Cancer Discovery

Fluoxetine, an antidepressant, suppresses glioblastoma by evoking AMPAR-mediated calcium-dependent apoptosis

(2015) Kao-Hui Liu et al.   Oncotarget

Intratumoral Myeloid Cells Regulate Responsiveness and Resistance to Antiangiogenic Therapy

(2015) Lee B. Rivera et al.   Cell Reports

Macrophages are recruited to hypoxic tumor areas and acquire a Pro-Angiogenic M2-Polarized phenotype via hypoxic cancer cell derived cytokines Oncostatin M and Eotaxin

(2015) Chakrapani Tripathi et al.   Oncotarget

Immunosuppressive Myeloid Cells Induced by Chemotherapy Attenuate Antitumor CD4+ T-Cell Responses through the PD-1-PD-L1 Axis

(2014) Z.-C. Ding et al.   CANCER RESEARCH

CSF1/CSF1R Blockade Reprograms Tumor-Infiltrating Macrophages and Improves Response to T-cell Checkpoint Immunotherapy in Pancreatic Cancer Models

(2014) Y. Zhu et al.   CANCER RESEARCH

Discordant In Vitro and In Vivo Chemopotentiating Effects of the PARP Inhibitor Veliparib in Temozolomide-Sensitive versus -Resistant Glioblastoma Multiforme Xenografts

(2014) S. K. Gupta et al.   CLINICAL CANCER RESEARCH

Key determinants of short-term and long-term glioblastoma survival: A 14-year retrospective study of patients from the Hermelin Brain Tumor Center at Henry Ford Hospital

(2014) Paul Mazaris et al.   CLINICAL NEUROLOGY AND NEUROSURGERY

HET0016, a Selective Inhibitor of 20-HETE Synthesis, Decreases Pro-Angiogenic Factors and Inhibits Growth of Triple Negative Breast Cancer in Mice

(2014) Thaiz Ferraz Borin et al.   PLoS One

Platelets guide the formation of early metastatic niches

(2014) M. Labelle et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Disruption of CXCR2-Mediated MDSC Tumor Trafficking Enhances Anti-PD1 Efficacy

(2014) S. L. Highfill et al.   Science Translational Medicine

Recent Updates in the Treatment of Glioblastoma: Introduction

(2014) Minesh Mehta et al.   SEMINARS IN ONCOLOGY

Effects of Tyrosine Kinase Inhibitors and CXCR4 Antagonist on Tumor Growth and Angiogenesis in Rat Glioma Model: MRI and Protein Analysis Study

(2014) Meser M. Ali et al.   Translational Oncology

CSF-1 Receptor Signaling in Myeloid Cells

(2014) E. R. Stanley et al.   Cold Spring Harbor Perspectives in Biology

Chemotherapy Alters Monocyte Differentiation to Favor Generation of Cancer-Supporting M2 Macrophages in the Tumor Microenvironment

(2013) E. M. Dijkgraaf et al.   CANCER RESEARCH

CSF1R Signaling Blockade Stanches Tumor-Infiltrating Myeloid Cells and Improves the Efficacy of Radiotherapy in Prostate Cancer

(2013) J. Xu et al.   CANCER RESEARCH

Mechanisms of neovascularization and resistance to anti-angiogenic therapies in glioblastoma multiforme

(2013) Yasushi Soda et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Treatment outcomes in glioblastoma patients aged 76 years or older: a multicenter retrospective cohort study

(2013) Takeo Uzuka et al.   JOURNAL OF NEURO-ONCOLOGY

Anti-CD47 antibody-mediated phagocytosis of cancer by macrophages primes an effective antitumor T-cell response

(2013) D. Tseng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Subcurative radiation significantly increases cell proliferation, invasion, and migration of primary glioblastoma multiforme in vivo

(2013) Adarsh Shankar et al.   Chinese Journal of Cancer

Tumor angiogenesis and anti-angiogenic therapy in malignant gliomas revisited

(2012) Karl H. Plate et al.   ACTA NEUROPATHOLOGICA

Interleukin-8 and its receptor CXCR2 in the tumour microenvironment promote colon cancer growth, progression and metastasis

(2012) Y S Lee et al.   BRITISH JOURNAL OF CANCER

Macrophage plasticity and polarization: in vivo veritas

(2012) Antonio Sica et al.   JOURNAL OF CLINICAL INVESTIGATION

Development of a novel animal model to differentiate radiation necrosis from tumor recurrence

(2012) Sanath Kumar et al.   JOURNAL OF NEURO-ONCOLOGY

Chemotherapy-triggered cathepsin B release in myeloid-derived suppressor cells activates the Nlrp3 inflammasome and promotes tumor growth

(2012) Mélanie Bruchard et al.   NATURE MEDICINE

MRI Tracking of FePro Labeled Fresh and Cryopreserved Long Term In Vitro Expanded Human Cord Blood AC133+ Endothelial Progenitor Cells in Rat Glioma

(2012) Branislava Janic et al.   PLoS One

Prognostic Significance of Tumor-Associated Macrophages in Solid Tumor: A Meta-Analysis of the Literature

(2012) Qiong-wen Zhang et al.   PLoS One

Therapeutic applications of macrophage colony-stimulating factor-1 (CSF-1) and antagonists of CSF-1 receptor (CSF-1R) signaling

(2011) D. A. Hume et al.   BLOOD

Treatment for glioblastoma multiforme: current guidelines and Canadian practice

(2011) A. Ghose et al.   Current Oncology

Macrophages and cathepsin proteases blunt chemotherapeutic response in breast cancer

(2011) T. Shree et al.   GENES & DEVELOPMENT

MDSC as a mechanism of tumor escape from sunitinib mediated anti-angiogenic therapy

(2011) James Finke et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Selective Serotonin Reuptake Inhibitors, Glioblastoma Multiforme, and Impact on Toxicities and Overall Survival

(2010) Jonathan S. Caudill et al.   AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS

Tumors as Organs: Complex Tissues that Interface with the Entire Organism

(2010) Mikala Egeblad et al.   DEVELOPMENTAL CELL

Phase I trial with biomarker studies of vatalanib (PTK787) in patients with newly diagnosed glioblastoma treated with enzyme inducing anti-epileptic drugs and standard radiation and temozolomide

(2010) Elizabeth R. Gerstner et al.   JOURNAL OF NEURO-ONCOLOGY

Changes in Vascular Permeability and Expression of Different Angiogenic Factors Following Anti-Angiogenic Treatment in Rat Glioma

(2010) Meser M. Ali et al.   PLoS One

Targeting distinct tumor-infiltrating myeloid cells by inhibiting CSF-1 receptor: combating tumor evasion of antiangiogenic therapy

(2009) S. J. Priceman et al.   BLOOD

IL-33 Amplifies the Polarization of Alternatively Activated Macrophages That Contribute to Airway Inflammation

(2009) M. Kurowska-Stolarska et al.   JOURNAL OF IMMUNOLOGY

Identification of discrete tumor-induced myeloid-derived suppressor cell subpopulations with distinct T cell-suppressive activity

(2008) K. Movahedi et al.   BLOOD

Chemokine-mediated rapid turnover of myeloid-derived suppressor cells in tumor-bearing mice

(2008) Y. Sawanobori et al.   BLOOD

HIF1α Induces the Recruitment of Bone Marrow-Derived Vascular Modulatory Cells to Regulate Tumor Angiogenesis and Invasion

(2008) Rose Du et al.   CANCER CELL

Cytokines as a key component of cancer-related inflammation

(2008) Giovanni Germano et al.   CYTOKINE

Cancer cell fusion with migratory bone marrow-derived cells as an explanation for metastasis: new therapeutic paradigms

(2008) John M Pawelek   Future Oncology

Cancer-related inflammation

(2008) Alberto Mantovani et al.   NATURE