Article
Neurosciences
Andrej Roczkowsky, Matthew A. L. Doan, Brittyne A. Hlavay, Manmeet K. Mamik, William G. Branton, Brienne A. McKenzie, Leina B. Saito, Laura Schmitt, Gary Eitzen, Francesca Di Cara, Melinda Wuest, Frank Wuest, Richard Rachubinski, Christopher Power
Summary: This study investigates the peroxisomal injury and the effects of peroxisome-restorative therapy on inflammatory demyelination in multiple sclerosis (MS) models. It reveals that peroxisomes play critical roles in CNS homeostasis and their dysfunction is associated with neuroinflammation and demyelination in MS. The therapeutic peroxisome proliferator, 4-phenylbutyrate (4-PBA), shows potential in mitigating neuroinflammation and promoting myelin repair in MS.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Immunology
Kazue Hisaoka-Nakashima, Kodai Moriwaki, Natsuki Yoshimoto, Toshiki Yoshii, Yoki Nakamura, Yukio Ago, Norimitsu Morioka
Summary: Neuropathic pain causes severe pain and comorbidities such as cognitive impairment, which are not effectively treated with current analgesics. This study demonstrates the role of interleukin-6 (IL-6) in neuropathic pain and cognitive impairment. Blocking the IL-6 receptor improves cognitive impairment, while inhibiting IL-6 activity reduces allodynia.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Clinical Neurology
Domenico Plantone, Catello Vollono, Matteo Pardini, Guido Primiano, Virxhina Myftari, Francesca Vitetta, Patrizia Sola, Massimiliano Mirabella, Diana Ferraro
Summary: The study found an association between lesion localization and persistent pain in multiple sclerosis patients, with lesions of the right dorsolateral prefrontal area being significantly more prevalent in patients without pain, while periventricular posterior lesions were significantly more prevalent in patients with persistent pain.
NEUROLOGICAL SCIENCES
(2021)
Article
Anesthesiology
Anna L. Kratz, Daniel Whibley, Kevin N. Alschuler, Dawn M. Ehde, David A. Williams, Daniel J. Clauw, Tiffany J. Braley
Summary: Research on chronic pain in individuals with multiple sclerosis revealed four main pain phenotypes, with nociplastic pain associated with higher frequency of chronic overlapping pain conditions. High frequency of pain medication use was reported across all pain types, with generally poor-moderate pain relief outcomes.
Review
Immunology
George Sideris-Lampretsas, Marzia Malcangio
Summary: This review summarizes the existing preclinical evidence on how the CNS compartment and sex impact microglia functions in health, emphasizing recent advances in transcriptomics analyses for characterizing disease-associated microglial states. The specific scenario of peripheral nerve or tissue injury inducing expression of a specific subset of genes in microglia in the dorsal horn of the spinal cord is discussed, along with the possibility of a unique microglia transcriptional profile associated with chronic pain conditions. The evidence also suggests microglial activation in pain-related areas of the brain can be observed in models of neuropathic pain, highlighting the potential for future studies to further explore neuroimmune interactions in chronic pain using novel approaches like scRNA-seq and CYTOF.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Review
Oncology
Takahiro Masuda, Lukas Amann, Marco Prinz
Summary: This mini-review provides an overview of the current knowledge on the ontogenetic relationship and underlying mechanism for the establishment of CNS macrophages, highlighting their comparison with microglia.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Neurosciences
Wenyao Wu, Xianwei Zhang, Shuo Wang, Tian Li, Quanshui Hao, Shiyong Li, Wenlong Yao, Rao Sun
Summary: The cGAS-STING pathway may be a potential therapeutic target for treating neuropathic pain by suppressing microglial M1 polarization. Activation of the cGAS-STING pathway occurs mainly in neurons and microglia, and inhibition of the pathway can suppress microglial M1 polarization and improve mechanical allodynia.
Review
Biochemistry & Molecular Biology
Aijun Ji, Jinbin Xu
Summary: NP is a common accompanying symptom of many diseases, seriously affecting the quality of life of patients. Neuron-microglia interaction has been found by experts to play a vital role in the occurrence and development of NP. Advanced studies and interventions using pharmaceuticals and traditional herbal medicines extracts have been attempted to address NP due to its unsatisfactory clinical treatments.
Article
Pharmacology & Pharmacy
Qianqian Liu, Rui Li, Wei Yang, Ranji Cui, Bingjin Li
Summary: This study summarized the role of neuroglia in neuropathic pain and depression, revealing a bridging role of neuroglia in both conditions.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Chih-Cheng Wu, Cheng-Yi Chang, Chung-Yuh Tzeng, Jen-Hsuan Huang, Chih-Jen Hung, Wen-Ying Chen, Su-Lan Liao, Yu-Hsiang Kuan, Chun-Jung Chen
Summary: In this study, the preventive effects of intrathecal bupivacaine administration against neuropathic pain were investigated. Bupivacaine attenuated pain behaviors and inflammatory alternations by suppressing microglia M1 polarization and pro-inflammatory cytokine expression. The Interferon Regulatory Factor 5 (IRF5)/P2X Purinoceptor 4 (P2X4R) and High Mobility Group Box 1 (HMGB1)/Toll-Like Receptor 4 (TLR4)/NF-kappa B inflammatory axes were identified as key players in microglia polarization and cytokine expression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Fabiolla Rocha Santos Passos, Erik W. M. Pereira, Luana Heimfarth, Brenda S. Monteiro, Yasmim Maria Barbosa Gomes de Carvalho, Pollyana S. Siqueira-Lima, Henrique Douglas Melo Coutinho, Adriano Antunes de Souza Araujo, Jackson Roberto Guedes da Silva Almeida, Rosana S. S. Barreto, Laurent Picot, Lucindo J. Quintans-Junior, Jullyana S. S. Quintans
Summary: Neuropathic pain arises from damage to the somatosensory system, impacting quality of life. Hecogenin acetate (HA), a steroidal sapogenin with anti-inflammatory and antinociceptive properties, has low water solubility affecting bioavailability. Both pure and complexed HA/I3CD demonstrated anti-hyperalgesic activity in animal models.
Article
Biotechnology & Applied Microbiology
Yuanxing Cai, Jing Xu, Qinghao Cheng
Summary: Chronic neuroinflammation contributes to neuropathic pain development, and inhibiting Src can protect against neuroinflammation induced by microglia, reducing mechanical allodynia in mouse models of neuropathic pain.
Article
Oncology
Yuyin Zheng, Chengqian Jia, Xia Jiang, Jie Chen, Xiao-Long Chen, Xinwang Ying, Jiayu Wu, Mingchen Jiang, Guanhu Yang, Wenzhan Tu, Kecheng Zhou, Songhe Jiang
Summary: The study found that electroacupuncture could alleviate neuropathic pain in rats with spinal nerve ligation, possibly by regulating P2X4R in the spinal cord to achieve pain relief.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Neurosciences
Siyuan Wang, Chao Jiang, Kelei Cao, Run Li, Zhihua Gao, Yue Wang
Summary: Neuropathic pain is a complex pain condition accompanied by neuroinflammation, and HK2 plays an important role in regulating immune cell responses in neuropathic pain.
Article
Biochemistry & Molecular Biology
Nobuhiko Nakajima, Yuichiro Ohnishi, Masamichi Yamamoto, Daiki Setoyama, Hirohiko Imai, Tomofumi Takenaka, Mari Matsumoto, Koichi Hosomi, Yoichi Saitoh, Hidemasa Furue, Haruhiko Kishima
Summary: Intractable neuropathic pain following spinal cord injury (NP-SCI) reduces a patient's quality of life. Excessive buildup of intracellular ATP at the lesion site leads to the release of ATP with mechanical stimulation, causing NP-SCI. Neuroinflammation plays an important role in this process.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Immunology
Julia Kolter, Reinhild Feuerstein, Patrice Zeis, Nora Hagemeyer, Neil Paterson, Paolo d'Errico, Sebastian Baasch, Lukas Amann, Takahiro Masuda, Anne Loesslein, Kourosh Gharun, Melanie Meyer-Luehmann, Claudia Waskow, Claus-Werner Franzke, Dominic Gruen, Tim Lammermann, Marco Prinz, Philipp Henneke
Article
Immunology
Louise Chappell-Maor, Masha Kolesnikov, Jung-Seok Kim, Anat Shemer, Zhana Haimon, Jonathan Grozovski, Sigalit Boura-Halfon, Takahiro Masuda, Marco Prinz, Steffen Jung
EUROPEAN JOURNAL OF IMMUNOLOGY
(2020)
Review
Cell Biology
Takahiro Masuda, Roman Sankowski, Ori Staszewski, Marco Prinz
Article
Neurosciences
Elke Ydens, Lukas Amann, Bob Asselbergh, Charlotte L. Scott, Liesbet Martens, Dorine Sichien, Omar Mossad, Thomas Blank, Sofie De Prijck, Donovan Low, Takahiro Masuda, Yvan Saeys, Vincent Timmerman, Ralf Stumm, Florent Ginhoux, Marco Prinz, Sophie Janssens, Martin Guilliams
NATURE NEUROSCIENCE
(2020)
Article
Immunology
Takahiro Masuda, Lukas Amann, Roman Sankowski, Ori Staszewski, Maximilian Lenz, Paolo d'Errico, Nicolas Snaidero, Marta Joana Costa Jordao, Chotima Boettcher, Katrin Kierdorf, Steffen Jung, Josef Priller, Thomas Misgeld, Andreas Vlachos, Melanie Meyer Luehmann, Klaus-Peter Knobeloch, Marco Prinz
Correction
Immunology
Takahiro Masuda, Lukas Amann, Roman Sankowski, Ori Staszewski, Maximilian Lenz, Paolo d'Errico, Nicolas Snaidero, Marta Joana Costa Jordao, Chotima Boettcher, Katrin Kierdorf, Steffen Jung, Josef Priller, Thomas Misgeld, Andreas Vlachos, Melanie Meyer-Luehmann, Klaus-Peter Knobeloch, Marco Prinz
Article
Multidisciplinary Sciences
Takahiro Masuda, Lukas Amann, Gianni Monaco, Roman Sankowski, Ori Staszewski, Martin Krueger, Francesca Del Gaudio, Liqun He, Neil Paterson, Elisa Nent, Francisco Fernandez-Klett, Ayato Yamasaki, Maximilian Frosch, Maximilian Fliegauf, Lance Fredrick Pahutan Bosch, Hatice Ulupinar, Nora Hagemeyer, Dietmar Schreiner, Cayce Dorrier, Makoto Tsuda, Claudia Grothe, Anne Joutel, Richard Daneman, Christer Betsholtz, Urban Lendahl, Klaus-Peter Knobeloch, Tim Laemmermann, Josef Priller, Katrin Kierdorf, Marco Prinz
Summary: This study reveals the ontogenetic relationships and development of different subsets of macrophages in the central nervous system (CNS). Microglia and meningeal macrophages share a common prenatal progenitor, while perivascular macrophages originate from the perinatal meningeal macrophages after birth in an integrin-dependent manner. The presence of arterial vascular smooth muscle cells is crucial for the establishment of perivascular macrophages.
Correction
Neurosciences
Roman Sankowski, Chotima Bottcher, Takahiro Masuda, Laufey Geirsdottir, Sagar, Elena Sindram, Tamara Seredenina, Andreas Muhs, Christian Scheiwe, Mukesch Johannes Shah, Dieter Henrik Heiland, Oliver Schnell, Dominic Grun, Josef Priller, Marco Prinz
NATURE NEUROSCIENCE
(2022)
Article
Multidisciplinary Sciences
Keita Kohno, Ryoji Shirasaka, Kohei Yoshihara, Satsuki Mikuriya, Kaori Tanaka, Keiko Takanami, Kazuhide Inoue, Hirotaka Sakamoto, Yasuyuki Ohkawa, Takahiro Masuda, Makoto Tsuda
Summary: This study reveals the role of CD11c-expressing spinal microglia in the remission and recurrence of neuropathic pain. These microglia express IGF1, and interference with IGF1 signaling impairs pain recovery. Depletion of CD11c(+) microglia or interruption of IGF1 signaling leads to relapse in pain hypersensitivity.
Correction
Multidisciplinary Sciences
Takahiro Masuda, Lukas Amann, Gianni Monaco, Roman Sankowski, Ori Staszewski, Martin Krueger, Francesca Del Gaudio, Liqun He, Neil Paterson, Elisa Nent, Francisco Fernandez-Klett, Ayato Yamasaki, Maximilian Frosch, Maximilian Fliegauf, Lance Fredrick Pahutan Bosch, Hatice Ulupinar, Nora Hagemeyer, Dietmar Schreiner, Cayce Dorrier, Makoto Tsuda, Claudia Grothe, Anne Joutel, Richard Daneman, Christer Betsholtz, Urban Lendahl, Klaus-Peter Knobeloch, Tim Lammermann, Josef Priller, Katrin Kierdorf, Marco Prinz
Review
Biochemistry & Molecular Biology
Takahiro Masuda
Summary: The central nervous system (CNS) consists of neurons and various stromal cells, with microglia being a type of glial cells that play an important role in maintaining tissue homeostasis. They respond early to CNS abnormalities and can impact neuronal functions through their plasticity. There are also distinct macrophage populations at the border of the CNS, such as meninges and choroid plexus, which have different morphology and gene expression profiles compared to microglia. This review summarizes recent advances in understanding the heterogeneity, plasticity, and ontogenetic relationship of these CNS-resident macrophage populations.
JOURNAL OF BIOCHEMISTRY
(2023)
Review
Oncology
Takahiro Masuda, Lukas Amann, Marco Prinz
Summary: This mini-review provides an overview of the current knowledge on the ontogenetic relationship and underlying mechanism for the establishment of CNS macrophages, highlighting their comparison with microglia.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Correction
Endocrinology & Metabolism
Mar Bosch-Queralt, Ludovico Cantuti-Castelvetri, Alkmini Damkou, Martina Schifferer, Kai Schlepckow, Ioannis Alexopoulos, Dieter Lutjohann, Christian Klose, Lenka Vaculciakova, Takahiro Masuda, Marco Prinz, Kathryn M. Monroe, Gilbert Di Paolo, Joseph W. Lewcock, Christian Haass, Mikael Simons
Review
Immunology
Shota Yamamoto, Takahiro Masuda
Summary: Microglia, resident macrophages in the CNS, play various roles in brain development and CNS diseases. Reprogramming of microglial cellular energetic metabolism has been identified as a crucial mechanism for their functionality diversification. Lipids, essential components of cell membranes, are tightly involved in microglial biology. This review provides a summary of current knowledge on microglial lipid metabolism in health and disease.
INFLAMMATION AND REGENERATION
(2023)
Article
Endocrinology & Metabolism
Mar Bosch-Queralt, Ludovico Cantuti-Castelvetri, Alkmini Damkou, Martina Schifferer, Kai Schlepckow, Ioannis Alexopoulos, Dieter Luetjohann, Christian Klose, Lenka Vaculciakova, Takahiro Masuda, Marco Prinz, Kathryn M. Monroe, Gilbert Di Paolo, Joseph W. Lewcock, Christian Haass, Mikael Simons
Summary: The study reveals that diet-induced obesity impairs restoration of CNS demyelination by suppressing cholesterol efflux through TGF beta signaling, hindering microglial myelin-debris clearance and lesion recovery. Targeting TGF beta or promoting TREM2 activity could restore microglia responsiveness and improve myelin-debris clearance after demyelination.
