The Role of Immune Cells in Post-Stroke Angiogenesis and Neuronal Remodeling: The Known and the Unknown

Impaired regulatory T cell control of astroglial overdrive and microglial pruning in schizophrenia

(2021) Fabiana Corsi-Zuelli et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Neutrophil extracellular traps promote tPA-induced brain hemorrhage via cGAS in mice with stroke

(2021) Ranran Wang et al.   BLOOD

Treg cell-derived osteopontin promotes microglia-mediated white matter repair after ischemic stroke

(2021) Ligen Shi et al.   IMMUNITY

Biomarkers of Angiogenesis and Neuroplasticity as Promising Clinical Tools for Stroke Recovery Evaluation

(2021) Lidia Wlodarczyk et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Inflammation-Mediated Angiogenesis in Ischemic Stroke

(2021) Hua Zhu et al.   Frontiers in Cellular Neuroscience

Capillary-associated microglia regulate vascular structure and function through PANX1-P2RY12 coupling in mice

(2021) Kanchan Bisht et al.   Nature Communications

New Insight Into Neutrophils: A Potential Therapeutic Target for Cerebral Ischemia

(2021) Ran Chen et al.   Frontiers in Immunology

Immune Cells in the BBB Disruption After Acute Ischemic Stroke: Targets for Immune Therapy?

(2021) Yan-mei Qiu et al.   Frontiers in Immunology

Management of acute ischemic stroke

(2020) Michael S Phipps et al.   BMJ-British Medical Journal

Progress in Research on the Role of FGF in the Formation and Treatment of Corneal Neovascularization

(2020) Mengji Chen et al.   Frontiers in Pharmacology

Meningeal Immunity and Its Function in Maintenance of the Central Nervous System in Health and Disease

(2020) Kalil Alves de Lima et al.   Annual Review of Immunology

A novel hydrogel-based treatment for complete transection spinal cord injury repair is driven by microglia/macrophages repopulation

(2020) Dezun Ma et al.   BIOMATERIALS

Repopulating Microglia Promote Brain Repair in an IL-6-Dependent Manner

(2020) Emily F. Willis et al.   CELL

CCR2 deficiency in monocytes impairs angiogenesis and functional recovery after ischemic stroke in mice

(2020) Jordi Pedragosa et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Neutrophil extracellular traps released by neutrophils impair revascularization and vascular remodeling after stroke

(2020) Lijing Kang et al.   Nature Communications

Antigen-Dependent T Cell Response to Neural Peptides After Human Ischemic Stroke

(2020) Francesc Miró-Mur et al.   Frontiers in Cellular Neuroscience

A new neutrophil subset promotes CNS neuron survival and axon regeneration

(2020) Andrew R. Sas et al.   NATURE IMMUNOLOGY

Stem Cell Repair of the Microvascular Damage in Stroke

(2020) Madeline Saft et al.   Cells

Functional Dynamics of Neutrophils After Ischemic Stroke

(2019) Wei Cai et al.   Translational Stroke Research

Global, regional, and national burden of stroke, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016

(2019) Catherine Owens Johnson et al.   LANCET NEUROLOGY

Nuclear positioning facilitates amoeboid migration along the path of least resistance

(2019) Jörg Renkawitz et al.   NATURE

Thrombo-inflammation in acute ischaemic stroke — implications for treatment

(2019) Guido Stoll et al.   Nature Reviews Neurology

Blood vessels as a scaffold for neuronal migration

(2019) Teppei Fujioka et al.   NEUROCHEMISTRY INTERNATIONAL

Next-generation regulatory T cell therapy

(2019) Leonardo M. R. Ferreira et al.   NATURE REVIEWS DRUG DISCOVERY

The Involvement and Therapy Target of Immune Cells After Ischemic Stroke

(2019) Zhihong Jian et al.   Frontiers in Immunology

Macrophages reprogram after ischemic stroke and promote efferocytosis and inflammation resolution in the mouse brain

(2019) Wenting Zhang et al.   CNS Neuroscience & Therapeutics

RNA sequencing reveals novel macrophage transcriptome favoring neurovascular plasticity after ischemic stroke

(2019) Rongrong Wang et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Correction to: Depletion of regulatory T cells increases T cell brain infiltration, reactive astrogliosis, and interferon-γ gene expression in acute experimental traumatic brain injury

(2019) Tobias J. Krämer et al.   Journal of Neuroinflammation

Neutrophil Extracellular Traps Induce Endothelial Cell Activation and Tissue Factor Production Through Interleukin-1α and Cathepsin G

(2018) Eduardo J. Folco et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Regulatory T cells increase after treatment with poly (ADP-ribose) polymerase-1 inhibitor in ischemic stroke patients

(2018) Min-Young Noh et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

The Janus Face of VEGF in Stroke

(2018) Samuel Geiseler et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Temporal Trends in the Levels of Peripherally Circulating Leukocyte Subtypes in the Hours after Ischemic Stroke

(2018) Dipender Gill et al.   Journal of Stroke & Cerebrovascular Diseases

Peripheral Th17/Treg imbalance in elderly patients with ischemic stroke

(2018) Sanam Dolati et al.   NEUROLOGICAL SCIENCES

Temporal Trends in the Levels of Peripherally Circulating Leukocyte Subtypes in the Hours after Ischemic Stroke

(2018) Dipender Gill et al.   Journal of Stroke & Cerebrovascular Diseases

Interleukin 8 (CXCL8)-CXC chemokine receptor 2 (CXCR2) axis contributes to MiR-4437-associated recruitment of granulocytes and natural killer cells in ischemic stroke

(2018) Qianyi He et al.   MOLECULAR IMMUNOLOGY

Brain regulatory T cells suppress astrogliosis and potentiate neurological recovery

(2018) Minako Ito et al.   NATURE

Molecular, cellular and functional events in axonal sprouting after stroke

(2017) S. Thomas Carmichael et al.   EXPERIMENTAL NEUROLOGY

Interleukin 17A Promotes Lymphocytes Adhesion and Induces CCL2 and CXCL1 Release from Brain Endothelial Cells

(2017) Dagmara Wojkowska et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Depletion of microglia exacerbates postischemic inflammation and brain injury

(2017) Wei-Na Jin et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

How and why do T cells and their derived cytokines affect the injured and healthy brain?

(2017) Anthony J. Filiano et al.   NATURE REVIEWS NEUROSCIENCE

The biphasic function of microglia in ischemic stroke

(2017) Yuanyuan Ma et al.   PROGRESS IN NEUROBIOLOGY

Treatment and Outcome of Hemorrhagic Transformation After Intravenous Alteplase in Acute Ischemic Stroke: A Scientific Statement for Healthcare Professionals From the American Heart Association/American Stroke Association

(2017) Shadi Yaghi et al.   STROKE

β1 integrin signaling promotes neuronal migration along vascular scaffolds in the post-stroke brain

(2017) Teppei Fujioka et al.   EBioMedicine

Microglia preconditioned by oxygen-glucose deprivation promote functional recovery in ischemic rats

(2017) Masato Kanazawa et al.   Scientific Reports

Relief of hypoxia by angiogenesis promotes neural stem cell differentiation by targeting glycolysis

(2016) Christian Lange et al.   EMBO JOURNAL

Macrophages Mediate the Repair of Brain Vascular Rupture through Direct Physical Adhesion and Mechanical Traction

(2016) Chi Liu et al.   IMMUNITY

The effect of phosphatidylinositol-3 kinase inhibition on matrix metalloproteinase-9 and reactive oxygen species release from chronic obstructive pulmonary disease neutrophils

(2016) V. Gupta et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

MerTK Is a Functional Regulator of Myelin Phagocytosis by Human Myeloid Cells

(2016) Luke M. Healy et al.   JOURNAL OF IMMUNOLOGY

Spatio-temporal profile, phenotypic diversity, and fate of recruited monocytes into the post-ischemic brain

(2016) Lidia Garcia-Bonilla et al.   Journal of Neuroinflammation

Monocyte-Derived Macrophages Contribute to Spontaneous Long-Term Functional Recovery after Stroke in Mice

(2016) S. Wattananit et al.   JOURNAL OF NEUROSCIENCE

Antigen Presentation After Stroke

(2016) Francesc Miró-Mur et al.   Neurotherapeutics

Heterogeneity of B Cell Functions in Stroke-Related Risk, Prevention, Injury, and Repair

(2016) Uma Maheswari Selvaraj et al.   Neurotherapeutics

Critical role of astrocytic interleukin-17 A in post-stroke survival and neuronal differentiation of neural precursor cells in adult mice

(2016) Y Lin et al.   Cell Death & Disease

Inflammation after Ischemic Stroke: The Role of Leukocytes and Glial Cells

(2016) Jong Youl Kim et al.   Experimental Neurobiology

Microglia–blood vessel interactions: a double-edged sword in brain pathologies

(2015) Nevenka Dudvarski Stankovic et al.   ACTA NEUROPATHOLOGICA

Heart Disease and Stroke Statistics—2016 Update

(2015) Dariush Mozaffarian et al.   CIRCULATION

IL-1alpha induces angiogenesis in brain endothelial cellsin vitro: implications for brain angiogenesis after acute injury

(2015) Kathleen Salmeron et al.   JOURNAL OF NEUROCHEMISTRY

B-Lymphocyte-Mediated Delayed Cognitive Impairment following Stroke

(2015) K. P. Doyle et al.   JOURNAL OF NEUROSCIENCE

Understanding the Mysterious M2 Macrophage through Activation Markers and Effector Mechanisms

(2015) Tamás Rőszer   MEDIATORS OF INFLAMMATION

Evidence That Ly6ChiMonocytes Are Protective in Acute Ischemic Stroke by Promoting M2 Macrophage Polarization

(2015) Hannah X. Chu et al.   STROKE

Activated regulatory T cell regulates neural stem cell proliferation in the subventricular zone of normal and ischemic mouse brain through interleukin 10

(2015) Jixian Wang et al.   Frontiers in Cellular Neuroscience

Brain pericytes acquire a microglial phenotype after stroke

(2014) Ilknur Özen et al.   ACTA NEUROPATHOLOGICA

Very-late-antigen-4 (VLA-4)-mediated brain invasion by neutrophils leads to interactions with microglia, increased ischemic injury and impaired behavior in experimental stroke

(2014) Jens Neumann et al.   ACTA NEUROPATHOLOGICA

Neutrophil recruitment to the brain in mouse and human ischemic stroke

(2014) Isabel Perez-de-Puig et al.   ACTA NEUROPATHOLOGICA

Perivascular microglia promote blood vessel disintegration in the ischemic penumbra

(2014) Valérie Jolivel et al.   ACTA NEUROPATHOLOGICA

Evidence that Meningeal Mast Cells Can Worsen Stroke Pathology in Mice

(2014) Ahmet Arac et al.   AMERICAN JOURNAL OF PATHOLOGY

Toll-like receptor 4 modulates cell migration and cortical neurogenesis after focal cerebral ischemia

(2014) Ana Moraga et al.   FASEB JOURNAL

Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines

(2014) Peter J. Murray et al.   IMMUNITY

Role of Spleen-Derived Monocytes/Macrophages in Acute Ischemic Brain Injury

(2014) Eunhee Kim et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Antigen Dependently Activated Cluster of Differentiation 8-Positive T Cells Cause Perforin-Mediated Neurotoxicity in Experimental Stroke

(2014) E. Mracsko et al.   JOURNAL OF NEUROSCIENCE

Imbalance between IL-17A-Producing Cells and Regulatory T Cells during Ischemic Stroke

(2014) Yuehua Hu et al.   MEDIATORS OF INFLAMMATION

Stepwise Recruitment of Transcellular and Paracellular Pathways Underlies Blood-Brain Barrier Breakdown in Stroke

(2014) Daniel Knowland et al.   NEURON

Ischemic neurons recruit natural killer cells that accelerate brain infarction

(2014) Y. Gan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Vascular and Neurogenic Rejuvenation of the Aging Mouse Brain by Young Systemic Factors

(2014) L. Katsimpardi et al.   SCIENCE

Clinical significance of plasma VEGF value in ischemic stroke - research for biomarkers in ischemic stroke (REBIOS) study

(2013) Ryu Matsuo et al.   BMC Neurology

Negative regulation of TLX by IL-1β correlates with an inhibition of adult hippocampal neural precursor cell proliferation

(2013) Sinead M. Ryan et al.   BRAIN BEHAVIOR AND IMMUNITY

A Novel Role of the STAT3 Pathway in Brain Inflammation-induced Human Neural Progenitor Cell Differentiation

(2013) E. Chen et al.   CURRENT MOLECULAR MEDICINE

p21Ciprestrains hippocampal neurogenesis and protects neuronal progenitors from apoptosis during acute systemic inflammation

(2013) Svetlana Zonis et al.   HIPPOCAMPUS

Lipopolysaccharide Activates Toll-like Receptor 4 (TLR4)-mediated NF-κB Signaling Pathway and Proinflammatory Response in Human Pericytes

(2013) Irene Guijarro-Muñoz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interleukin-10 regulates progenitor differentiation and modulates neurogenesis in adult brain

(2013) F. J. Perez-Asensio et al.   JOURNAL OF CELL SCIENCE

Immune Cell Infiltration in Malignant Middle Cerebral Artery Infarction: Comparison with Transient Cerebral Ischemia

(2013) Hannah X Chu et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Leukocyte infiltration in experimental stroke

(2013) Nina Vindegaard Grønberg et al.   Journal of Neuroinflammation

Immune cell subtyping in the cerebrospinal fluid of patients with neurological diseases

(2013) M. C. Kowarik et al.   JOURNAL OF NEUROLOGY

Astrocytic therapies for neuronal repair in stroke

(2013) Amy J. Gleichman et al.   NEUROSCIENCE LETTERS

Brain-Derived Neurotrophic Factor Promotes Vasculature-Associated Migration of Neuronal Precursors toward the Ischemic Striatum

(2013) Sofia Grade et al.   PLoS One

Neutrophil histone modification by peptidylarginine deiminase 4 is critical for deep vein thrombosis in mice

(2013) K. Martinod et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

WKYMVm-Induced Activation of Formyl Peptide Receptor 2 Stimulates Ischemic Neovasculogenesis by Promoting Homing of Endothelial Colony-Forming Cells

(2013) Soon Chul Heo et al.   STEM CELLS

Evidence of Intrathecal Immunoglobulin Synthesis in Stroke

(2012) Harald Prüss et al.   ARCHIVES OF NEUROLOGY

Neutralization of the IL-17 axis diminishes neutrophil invasion and protects from ischemic stroke

(2012) M. Gelderblom et al.   BLOOD

Essential role of interleukin-6 in post-stroke angiogenesis

(2012) Karen Gertz et al.   BRAIN

VCAM1 Is Essential to Maintain the Structure of the SVZ Niche and Acts as an Environmental Sensor to Regulate SVZ Lineage Progression

(2012) Erzsebet Kokovay et al.   Cell Stem Cell

IL-4 and IL-13 employ discrete signaling pathways for target gene expression in alternatively activated monocytes/macrophages

(2012) Ashish Bhattacharjee et al.   FREE RADICAL BIOLOGY AND MEDICINE

PAMPs and DAMPs: signal 0s that spur autophagy and immunity

(2012) Daolin Tang et al.   IMMUNOLOGICAL REVIEWS

A Transient Decrease in Spleen Size Following Stroke Corresponds to Splenocyte Release into Systemic Circulation

(2012) Hilary A. Seifert et al.   Journal of Neuroimmune Pharmacology

Glucocorticoid-induced TNF receptor-triggered T cells are key modulators for survival/death of neural stem/progenitor cells induced by ischemic stroke

(2011) M Takata et al.   CELL DEATH AND DIFFERENTIATION

Hypoxia in the regulation of neural stem cells

(2011) Lidia De Filippis et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Exposure of foetal neural progenitor cells to IL-1β impairs their proliferation and alters their differentiation - a role for maternal inflammation?

(2011) Sean J. Crampton et al.   JOURNAL OF NEUROCHEMISTRY

Regulatory B Cells Limit CNS Inflammation and Neurologic Deficits in Murine Experimental Stroke

(2011) X. Ren et al.   JOURNAL OF NEUROSCIENCE

A new role for interferon gamma in neural stem/precursor cell dysregulation

(2011) Janine Walter et al.   Molecular Neurodegeneration

The immunology of stroke: from mechanisms to translation

(2011) Costantino Iadecola et al.   NATURE MEDICINE

Interleukin-1β: A New Regulator of the Kynurenine Pathway Affecting Human Hippocampal Neurogenesis

(2011) Patricia A Zunszain et al.   NEUROPSYCHOPHARMACOLOGY

Early detrimental T-cell effects in experimental cerebral ischemia are neither related to adaptive immunity nor thrombus formation

(2010) C. Kleinschnitz et al.   BLOOD

Hypoxic tissues are associated with microvessel density following brain ischemia–reperfusion

(2010) Jin-rui Pan et al.   NEUROLOGICAL SCIENCES

Cellular mechanisms of IL-17-induced blood-brain barrier disruption

(2009) Jula Huppert et al.   FASEB JOURNAL

Histone hypercitrullination mediates chromatin decondensation and neutrophil extracellular trap formation

(2009) Yanming Wang et al.   JOURNAL OF CELL BIOLOGY

Regulatory T cells are key cerebroprotective immunomodulators in acute experimental stroke

(2009) Arthur Liesz et al.   NATURE MEDICINE

Endothelial Cells Support Survival, Proliferation, and Neuronal Differentiation of Transplanted Adult Ischemia-Induced Neural Stem/Progenitor Cells After Cerebral Infarction

(2009) Nami Nakagomi et al.   STEM CELLS

Temporal and Spatial Dynamics of Cerebral Immune Cell Accumulation in Stroke

(2009) Mathias Gelderblom et al.   STROKE

In vitro neuronal and glial differentiation from embryonic or adult neural precursor cells are differently affected by chronic or acute activation of microglia

(2008) Emanuele Cacci et al.   GLIA

HIV-1-infected and/or immune-activated macrophage-secreted TNF-α affects human fetal cortical neural progenitor cell proliferation and differentiation

(2008) Hui Peng et al.   GLIA

Microglia Cells Protect Neurons by Direct Engulfment of Invading Neutrophil Granulocytes: A New Mechanism of CNS Immune Privilege

(2008) J. Neumann et al.   JOURNAL OF NEUROSCIENCE

Effect of Inflammatory Cytokines on Major Histocompatibility Complex Expression and Differentiation of Human Neural Stem/Progenitor Cells

(2008) Saga Johansson et al.   STEM CELLS

Small heat shock proteins associated with cerebral amyloid angiopathy of hereditary cerebral hemorrhage with amyloidosis (Dutch type) induce interleukin-6 secretion

(2007) Micha M.M. Wilhelmus et al.   NEUROBIOLOGY OF AGING