The Emerging Role of Bile Acids in the Pathogenesis of Inflammatory Bowel Disease

Microbial and metabolic features associated with outcome of infliximab therapy in pediatric Crohn’s disease

(2021) Yizhong Wang et al.   Gut Microbes

TGR5 Regulates Macrophage Inflammation in Nonalcoholic Steatohepatitis by Modulating NLRP3 Inflammasome Activation

(2021) Yong Shi et al.   Frontiers in Immunology

Metabolic modelling reveals broad changes in gut microbial metabolism in inflammatory bowel disease patients with dysbiosis

(2021) Almut Heinken et al.   npj Systems Biology and Applications

A bacterial bile acid metabolite modulates Treg activity through the nuclear hormone receptor NR4A1

(2021) Wei Li et al.   Cell Host & Microbe

Multi-omics reveal microbial determinants impacting responses to biologic therapies in inflammatory bowel disease

(2021) Jonathan Wei Jie Lee et al.   Cell Host & Microbe

Fecal microbiota transplantation therapy in Crohn's disease: Systematic review

(2021) Sasha R Fehily et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

A metabolomics pipeline for the mechanistic interrogation of the gut microbiome

(2021) Shuo Han et al.   NATURE

Bile Acids, Their Receptors, and the Gut Microbiota

(2021) James C. Poland et al.   PHYSIOLOGY

Bile Acid–Gut Microbiota Axis in Inflammatory Bowel Disease: From Bench to Bedside

(2021) Min Yang et al.   Nutrients

Review: microbial transformations of human bile acids

(2021) Douglas V. Guzior et al.   Microbiome

Bile Acids Activated Receptors in Inflammatory Bowel Disease

(2021) Michele Biagioli et al.   Cells

Dysbiosis-Induced Secondary Bile Acid Deficiency Promotes Intestinal Inflammation

(2020) Sidhartha R. Sinha et al.   Cell Host & Microbe

Metabonomics and the gut microbiome associated with primary response to anti-TNF therapy in Crohn’s disease

(2020) N S Ding et al.   Journal of Crohns & Colitis

Is CYP2C70 the key to new mouse models to understand bile acids in humans?

(2020) Grace L. Guo et al.   JOURNAL OF LIPID RESEARCH

Global chemical effects of the microbiome include new bile-acid conjugations

(2020) Robert A. Quinn et al.   NATURE

Gut microbiota-derived metabolites as key actors in inflammatory bowel disease

(2020) Aonghus Lavelle et al.   Nature Reviews Gastroenterology & Hepatology

Ex vivo mimicking of inflammation in organoids derived from patients with ulcerative colitis

(2020) Arnauts Kaline et al.   GASTROENTEROLOGY

Bile Acids Signal via TGR5 to Activate Intestinal Stem Cells and Epithelial Regeneration

(2020) Giovanni Sorrentino et al.   GASTROENTEROLOGY

Bacterial metabolism of bile acids promotes generation of peripheral regulatory T cells

(2020) Clarissa Campbell et al.   NATURE

Clinical Predictors of response to Faecal Microbiota Transplantation in patients with active ulcerative colitis

(2020) Ajit Sood et al.   Journal of Crohns & Colitis

A metabolic pathway for bile acid dehydroxylation by the gut microbiome

(2020) Masanori Funabashi et al.   NATURE

Characterization of Human Colon Organoids From Inflammatory Bowel Disease Patients

(2020) Emilie d’Aldebert et al.   Frontiers in Cell and Developmental Biology

The Gut Microbiota at the Service of Immunometabolism

(2020) Chloé Michaudel et al.   Cell Metabolism

Dietary fat, bile acid metabolism and colorectal cancer

(2020) Soeren Ocvirk et al.   SEMINARS IN CANCER BIOLOGY

Hepatic autophagy deficiency remodels gut microbiota for an adaptive protection via FGF15-FGFR4 signaling

(2020) Shengmin Yan et al.   Cellular and Molecular Gastroenterology and Hepatology

Bile Acid Signaling in Inflammatory Bowel Diseases

(2020) Stefano Fiorucci et al.   DIGESTIVE DISEASES AND SCIENCES

Organoid-based models to study the role of host-microbiota interactions in IBD

(2020) Martina Poletti et al.   Journal of Crohns & Colitis

Effect of Fecal Microbiota Transplantation on 8-Week Remission in Patients With Ulcerative Colitis

(2019) Samuel P. Costello et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Effects of ursodeoxycholic acid on the gut microbiome and colorectal adenoma development

(2019) Talima Pearson et al.   Cancer Medicine

Controlling Epithelial Polarity: A Human Enteroid Model for Host-Pathogen Interactions

(2019) Julia Y. Co et al.   Cell Reports

Microbial bile salt hydrolases mediate the efficacy of faecal microbiota transplant in the treatment of recurrent Clostridioides difficile infection

(2019) Benjamin H Mullish et al.   GUT

Polymorphisms in the NFkB, TNF-alpha, IL-1beta, and IL-18 pathways are associated with response to anti-TNF therapy in Danish patients with inflammatory bowel disease

(2019) Steffen Bank et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Multi-omics of the gut microbial ecosystem in inflammatory bowel diseases

(2019) Jason Lloyd-Price et al.   NATURE

Systematic assessment of secondary bile acid metabolism in gut microbes reveals distinct metabolic capabilities in inflammatory bowel disease

(2019) Almut Heinken et al.   Microbiome

Role of Bile Acids in Dysbiosis and Treatment of Nonalcoholic Fatty Liver Disease

(2019) Caihua Wang et al.   MEDIATORS OF INFLAMMATION

MRGPRX4 is a bile acid receptor for human cholestatic itch

(2019) Huasheng Yu et al.   eLife

Bile acid metabolites control TH17 and Treg cell differentiation

(2019) Saiyu Hang et al.   NATURE

The relationship between fecal bile acids and microbiome community structure in pediatric Crohn’s disease

(2019) Jessica Connors et al.   ISME Journal

Microbial bile acid metabolites modulate gut RORγ+ regulatory T cell homeostasis

(2019) Xinyang Song et al.   NATURE

The global, regional, and national burden of inflammatory bowel disease in 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017

(2019) Sudabeh Alatab et al.   Lancet Gastroenterology & Hepatology

Exclusive enteral nutrition in pediatric inflammatory bowel disease

(2018) Talya Miller et al.   CURRENT OPINION IN PEDIATRICS

25 - Microbiome and Metabolic Markers of Clostridium Difficile Recurrance

(2018) Jessica R. Allegretti et al.   GASTROENTEROLOGY

The role of diet in the aetiopathogenesis of inflammatory bowel disease

(2018) Hamed Khalili et al.   Nature Reviews Gastroenterology & Hepatology

Reprogramming of pro-inflammatory human macrophages to an anti-inflammatory phenotype by bile acids

(2018) Marianne Wammers et al.   Scientific Reports

Deoxycholic Acid-Mediated Sphingosine-1-Phosphate Receptor 2 Signaling Exacerbates DSS-Induced Colitis through Promoting Cathepsin B Release

(2018) Shengnan Zhao et al.   Journal of Immunology Research

Precision editing of the gut microbiota ameliorates colitis

(2018) Wenhan Zhu et al.   NATURE

Specific Bacteria and Metabolites Associated with Response to Fecal Microbiota Transplantation in Patients with Ulcerative Colitis

(2018) Sudarshan Paramsothy et al.   GASTROENTEROLOGY

NLRP3-Dependent and -Independent Processing of Interleukin (IL)-1β in Active Ulcerative Colitis

(2018) Nicole Ranson et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Gut microbiome structure and metabolic activity in inflammatory bowel disease

(2018) Eric A. Franzosa et al.   Nature Microbiology

The Bile Acid Receptor GPBAR1 Regulates the M1/M2 Phenotype of Intestinal Macrophages and Activation of GPBAR1 Rescues Mice from Murine Colitis

(2017) Michele Biagioli et al.   JOURNAL OF IMMUNOLOGY

Multidonor intensive faecal microbiota transplantation for active ulcerative colitis: a randomised placebo-controlled trial

(2017) Sudarshan Paramsothy et al.   LANCET

Inflammasomes and intestinal inflammation

(2017) N Zmora et al.   Mucosal Immunology

Lithocholic acid controls adaptive immune responses by inhibition of Th1 activation through the Vitamin D receptor

(2017) Thijs W. H. Pols et al.   PLoS One

Remodelling of the gut microbiota by hyperactive NLRP3 induces regulatory T cells to maintain homeostasis

(2017) Xiaomin Yao et al.   Nature Communications

Epithelial Cell Inflammasomes in Intestinal Immunity and Inflammation

(2017) Andrea C. Lei-Leston et al.   Frontiers in Immunology

RecurrentClostridium difficileinfection associates with distinct bile acid and microbiome profiles

(2016) J. R. Allegretti et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Modeling Development and Disease with Organoids

(2016) Hans Clevers   CELL

Alterations in the epithelial stem cell compartment could contribute to permanent changes in the mucosa of patients with ulcerative colitis

(2016) Isabella Dotti et al.   GUT

Bile Acids Control Inflammation and Metabolic Disorder through Inhibition of NLRP3 Inflammasome

(2016) Chuansheng Guo et al.   IMMUNITY

Systematic review: bile acids and intestinal inflammation-luminal aggressors or regulators of mucosal defence?

(2015) P. Pavlidis et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Interactions between Diet, Bile Acid Metabolism, Gut Microbiota, and Inflammatory Bowel Diseases

(2015) Suzanne Devkota et al.   DIGESTIVE DISEASES

Fecal Microbiota Transplantation Induces Remission in Patients With Active Ulcerative Colitis in a Randomized Controlled Trial

(2015) Paul Moayyedi et al.   GASTROENTEROLOGY

Fat, fibre and cancer risk in African Americans and rural Africans

(2015) Stephen J. D. O’Keefe et al.   Nature Communications

Bile acids and the gut microbiome

(2014) Jason M. Ridlon et al.   CURRENT OPINION IN GASTROENTEROLOGY

Precision microbiome reconstitution restores bile acid mediated resistance to Clostridium difficile

(2014) Charlie G. Buffie et al.   NATURE

Atg16L1 T300A variant decreases selective autophagy resulting in altered cytokine signaling and decreased antibacterial defense

(2014) K. G. Lassen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Diet, microbiota, and microbial metabolites in colon cancer risk in rural Africans and African Americans

(2013) Junhai Ou et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Risk of Surgery for Inflammatory Bowel Diseases Has Decreased Over Time: A Systematic Review and Meta-analysis of Population-Based Studies

(2013) Alexandra D. Frolkis et al.   GASTROENTEROLOGY

Genomic ATG16L1 risk allele-restricted Paneth cell ER stress in quiescent Crohn's disease

(2013) J Jasper Deuring et al.   GUT

Recent advances in inflammatory bowel disease: mucosal immune cells in intestinal inflammation

(2013) M Zaeem Cader et al.   GUT

TGR5 signalling inhibits the production of pro-inflammatory cytokines byin vitrodifferentiated inflammatory and intestinal macrophages in Crohn's disease

(2013) Kazuaki Yoneno et al.   IMMUNOLOGY

Farnesoid X Receptor Expression Is Decreased in Colonic Mucosa of Patients with Primary Sclerosing Cholangitis and Colitis-associated Neoplasia

(2013) Joana Torres et al.   INFLAMMATORY BOWEL DISEASES

Paneth cells as a site of origin for intestinal inflammation

(2013) Timon E. Adolph et al.   NATURE

Bile acid receptors as targets for drug development

(2013) Frank G. Schaap et al.   Nature Reviews Gastroenterology & Hepatology

A novel mechanism for gut barrier dysfunction by dietary fat: epithelial disruption by hydrophobic bile acids

(2012) Lotta K. Stenman et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Connecting dysbiosis, bile-acid dysmetabolism and gut inflammation in inflammatory bowel diseases

(2012) Henri Duboc et al.   GUT

Dose-dependent antiinflammatory effect of ursodeoxycholic acid in experimental colitis

(2012) Patricia Martínez-Moya et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

The influence of infliximab and adalimumab on the expression of apoptosis-related proteins in lamina propria mononuclear cells and enterocytes in Crohn's disease — An immunohistochemical study

(2012) Piotr Eder et al.   Journal of Crohns & Colitis

High-fat-induced intestinal permeability dysfunction associated with altered fecal bile acids

(2012) Lotta K Stenman   WORLD JOURNAL OF GASTROENTEROLOGY

The Inflammasomes

(2010) Kate Schroder et al.   CELL

Colitis induced in mice with dextran sulfate sodium (DSS) is mediated by the NLRP3 inflammasome

(2010) C. Bauer et al.   GUT

The NLRP3 Inflammasome Protects against Loss of Epithelial Integrity and Mortality during Experimental Colitis

(2010) Md. Hasan Zaki et al.   IMMUNITY

Autophagy: cellular and molecular mechanisms

(2010) Danielle Glick et al.   JOURNAL OF PATHOLOGY

STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing

(2009) Geethanjali Pickert et al.   JOURNAL OF EXPERIMENTAL MEDICINE