Bile Acid Signaling in Inflammatory Bowel Diseases

Th17 Cells in Inflammatory Bowel Disease: An Update for the Clinician

(2020) Guoqing Hou et al.   INFLAMMATORY BOWEL DISEASES

Of mice and men: Murine bile acids explain species differences in the regulation of bile acid and cholesterol metabolism

(2020) Sara Straniero et al.   JOURNAL OF LIPID RESEARCH

Gut microbiota-derived metabolites as key actors in inflammatory bowel disease

(2020) Aonghus Lavelle et al.   Nature Reviews Gastroenterology & Hepatology

Attenuation of bile acid-mediated FXR and PXR activation in patients with Crohn’s disease

(2020) Aze Wilson et al.   Scientific Reports

The Bile Acid Receptor GPBAR1 Modulates CCL2/CCR2 Signaling at the Liver Sinusoidal/Macrophage Interface and Reverses Acetaminophen-Induced Liver Toxicity

(2020) Michele Biagioli et al.   JOURNAL OF IMMUNOLOGY

The global, regional, and national burden of psoriasis in 195 countries and territories, 1990–2017: A systematic analysis from the Global Burden of Disease Study 2017

(2020) Sino Mehrmal et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Fibroblast Growth Factor 19 modulates intestinal microbiota and inflammation in presence of Farnesoid X Receptor

(2020) Raffaella Maria Gadaleta et al.   EBioMedicine

Genetic variation in the farnesoid X-receptor predicts Crohn’s disease severity in female patients

(2020) Aze Wilson et al.   Scientific Reports

A human-origin probiotic cocktail ameliorates aging-related leaky gut and inflammation via modulating the microbiota/taurine/tight junction axis

(2020) Shokouh Ahmadi et al.   JCI Insight

Opposite effects of the FXR agonist obeticholic acid on Mafg and Nrf2 mediate the development of acute liver injury in rodent models of cholestasis

(2020) Adriana Carino et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Bile salt hydrolases: Gatekeepers of bile acid metabolism and host-microbiome crosstalk in the gastrointestinal tract

(2019) Matthew H. Foley et al.   PLoS Pathogens

1,25(OH)2D3 deficiency-induced gut microbial dysbiosis degrades the colonic mucus barrier in Cyp27b1 knockout mouse model

(2019) Wenjing Zhu et al.   Gut Pathogens

Structural weakening of the colonic mucus barrier is an early event in ulcerative colitis pathogenesis

(2019) Sjoerd van der Post et al.   GUT

Multi-omics of the gut microbial ecosystem in inflammatory bowel diseases

(2019) Jason Lloyd-Price et al.   NATURE

Nuclear Receptors Regulate Intestinal Inflammation in the Context of IBD

(2019) Victoria Klepsch et al.   Frontiers in Immunology

A Human-like Bile Acid Pool Induced by Deletion of Cyp2c70 Modulates Effects of Farnesoid X Receptor Activation in Mice

(2019) Jan Freark de Boer et al.   JOURNAL OF LIPID RESEARCH

Systematic review with meta-analysis: association of vitamin D status with clinical outcomes in adult patients with inflammatory bowel disease

(2019) John Gubatan et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Ursodeoxycholic acid is a GPBAR1 agonist and resets liver/intestinal FXR signaling in a model of diet-induced dysbiosis and NASH

(2019) Adriana Carino et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Efficacy and Safety of Etrasimod in a Phase 2 Randomized Trial of Patients with Ulcerative Colitis

(2019) William J. Sandborn et al.   GASTROENTEROLOGY

Bile acid metabolites control TH17 and Treg cell differentiation

(2019) Saiyu Hang et al.   NATURE

Microbial bile acid metabolites modulate gut RORγ+ regulatory T cell homeostasis

(2019) Xinyang Song et al.   NATURE

The Effect of Vitamin D on Intestinal Inflammation and Faecal Microbiota in Patients with Ulcerative Colitis

(2018) Mayur Garg et al.   Journal of Crohns & Colitis

Vitamin D administration leads to a shift of the intestinal bacterial composition in Crohn's disease patients, but not in healthy controls

(2018) Holger Schäffler et al.   Journal of Digestive Diseases

Effector T Helper Cell Subsets in Inflammatory Bowel Diseases

(2018) Tanbeena Imam et al.   Frontiers in Immunology

Metabolism of Oxo-Bile Acids and Characterization of Recombinant 12α-Hydroxysteroid Dehydrogenases from Bile Acid 7α-Dehydroxylating Human Gut Bacteria

(2018) Heidi Doden et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

The Sphingosine-1-Phosphate/Sphingosine-1-Phosphate Receptor 2 Axis in Intestinal Epithelial Cells Regulates Intestinal Barrier Function During Intestinal Epithelial Cells–CD4+T-Cell Interactions

(2018) Tanzhou Chen et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Bile Acids Activated Receptors Regulate Innate Immunity

(2018) Stefano Fiorucci et al.   Frontiers in Immunology

Murine Adherent and Invasive E. coli Induces Chronic Inflammation and Immune Responses in the Small and Large Intestines of Monoassociated IL-10-/- Mice Independent of Long Polar Fimbriae Adhesin A

(2018) Julia M Schmitz et al.   INFLAMMATORY BOWEL DISEASES

Gut microbiota and intestinal FXR mediate the clinical benefits of metformin

(2018) Lulu Sun et al.   NATURE MEDICINE

An RORγt Oral Inhibitor Modulates IL-17 Responses in Peripheral Blood and Intestinal Mucosa of Crohn's Disease Patients

(2018) Helena Bassolas-Molina et al.   Frontiers in Immunology

Gut microbiome structure and metabolic activity in inflammatory bowel disease

(2018) Eric A. Franzosa et al.   Nature Microbiology

Cellular pathways in the development of human and murine innate lymphoid cells

(2018) Steven D Scoville et al.   CURRENT OPINION IN IMMUNOLOGY

Pregnane X Receptor Polymorphisms and Risk of Inflammatory Bowel Disease: A Meta-Analysis

(2017) Xiaolan Guo et al.   IMMUNOLOGICAL INVESTIGATIONS

The Bile Acid Receptor GPBAR1 Regulates the M1/M2 Phenotype of Intestinal Macrophages and Activation of GPBAR1 Rescues Mice from Murine Colitis

(2017) Michele Biagioli et al.   JOURNAL OF IMMUNOLOGY

The role of vitamin D and VDR in carcinogenesis: Through epidemiology and basic sciences

(2017) Borja Bandera Merchan et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Tauroursodeoxycholic acid protects bile acid homeostasis under inflammatory conditions and dampens Crohn’s disease-like ileitis

(2017) Lien Van den Bossche et al.   LABORATORY INVESTIGATION

Multidonor intensive faecal microbiota transplantation for active ulcerative colitis: a randomised placebo-controlled trial

(2017) Sudarshan Paramsothy et al.   LANCET

Interactions between gut bacteria and bile in health and disease

(2017) Sarah L. Long et al.   MOLECULAR ASPECTS OF MEDICINE

Ectopic colonization of oral bacteria in the intestine drives TH1 cell induction and inflammation

(2017) Koji Atarashi et al.   SCIENCE

Hyodeoxycholic acid derivatives as liver X receptor α and G-protein-coupled bile acid receptor agonists

(2017) Simona De Marino et al.   Scientific Reports

Ursodeoxycholic acid inhibits TNFα-induced IL-8 release from monocytes

(2016) Aoife M. O'Dwyer et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Are We Really Vastly Outnumbered? Revisiting the Ratio of Bacterial to Host Cells in Humans

(2016) Ron Sender et al.   CELL

Tauroursodeoxycholate improves 2,4,6-trinitrobenzenesulfonic acid-induced experimental acute ulcerative colitis in mice

(2016) Yang Yang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Cyp2c70 is responsible for the species difference in bile acid metabolism between mice and humans

(2016) Shogo Takahashi et al.   JOURNAL OF LIPID RESEARCH

Transient inhibition of ROR-γt therapeutically limits intestinal inflammation by reducing TH17 cells and preserving group 3 innate lymphoid cells

(2016) David R Withers et al.   NATURE MEDICINE

Ozanimod Induction and Maintenance Treatment for Ulcerative Colitis

(2016) William J. Sandborn et al.   NEW ENGLAND JOURNAL OF MEDICINE

Bile Acid Modifications at the Microbe-Host Interface: Potential for Nutraceutical and Pharmaceutical Interventions in Host Health

(2016) Susan A. Joyce et al.   Annual Review of Food Science and Technology

Bacteriome and Mycobiome Interactions Underscore Microbial Dysbiosis in Familial Crohn’s Disease

(2016) G. Hoarau et al.   mBio

Gut Microbiota Diversity and Human Diseases: Should We Reintroduce Key Predators in Our Ecosystem?

(2016) Alexis Mosca et al.   Frontiers in Microbiology

A randomized controlled trial on the effect of vitamin D3 on inflammation and cathelicidin gene expression in ulcerative colitis patients

(2016) MohammadJavad Hosseinzadeh-Attar et al.   Saudi Journal of Gastroenterology

Bacterial bile salt hydrolase: an intestinal microbiome target for enhanced animal health

(2016) Wenjing Geng et al.   ANIMAL HEALTH RESEARCH REVIEWS

Vitamin D and the Immune System

(2016) Cynthia Aranow   JOURNAL OF INVESTIGATIVE MEDICINE

VDR/vitamin D receptor regulates autophagic activity through ATG16L1

(2015) Jun Sun   Autophagy

Disease-Specific Alterations in the Enteric Virome in Inflammatory Bowel Disease

(2015) Jason M. Norman et al.   CELL

Lack of Vitamin D Receptor Causes Dysbiosis and Changes the Functions of the Murine Intestinal Microbiome

(2015) Dapeng Jin et al.   CLINICAL THERAPEUTICS

Group 3 innate lymphoid cells (ILC3s): Origin, differentiation, and plasticity in humans and mice

(2015) Elisa Montaldo et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Fecal Microbiota Transplantation Induces Remission in Patients With Active Ulcerative Colitis in a Randomized Controlled Trial

(2015) Paul Moayyedi et al.   GASTROENTEROLOGY

Findings From a Randomized Controlled Trial of Fecal Transplantation for Patients With Ulcerative Colitis

(2015) Noortje G. Rossen et al.   GASTROENTEROLOGY

TGR5 is essential for bile acid-dependent cholangiocyte proliferation in vivo and in vitro

(2015) Maria Reich et al.   GUT

Conjugated bile acid-activated S1P receptor 2 is a key regulator of sphingosine kinase 2 and hepatic gene expression

(2015) Masayuki Nagahashi et al.   HEPATOLOGY

Critical roles of intestinal epithelial vitamin D receptor signaling in controlling gut mucosal inflammation

(2015) Yan Chun Li et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Innate lymphoid cells in the initiation, regulation and resolution of inflammation

(2015) Gregory F Sonnenberg et al.   NATURE MEDICINE

Intestine-selective farnesoid X receptor inhibition improves obesity-related metabolic dysfunction

(2015) Changtao Jiang et al.   Nature Communications

Bile acid nuclear receptor FXR and digestive system diseases

(2015) Lili Ding et al.   Acta Pharmaceutica Sinica B

The Treatment-Naive Microbiome in New-Onset Crohn’s Disease

(2014) Dirk Gevers et al.   Cell Host & Microbe

Intestinal epithelial vitamin D receptor deletion leads to defective autophagy in colitis

(2014) Shaoping Wu et al.   GUT

Elevated levels of Th17 cells and Th17-related cytokines are associated with disease activity in patients with inflammatory bowel disease

(2014) Wenyu Jiang et al.   INFLAMMATION RESEARCH

Tauroursodeoxycholic acid inhibits experimental colitis by preventing early intestinal epithelial cell death

(2014) Debby Laukens et al.   LABORATORY INVESTIGATION

Precision microbiome reconstitution restores bile acid mediated resistance to Clostridium difficile

(2014) Charlie G. Buffie et al.   NATURE

Microbiota-Dependent Crosstalk Between Macrophages and ILC3 Promotes Intestinal Homeostasis

(2014) A. Mortha et al.   SCIENCE

Farnesoid X Receptor Expression Is Decreased in Colonic Mucosa of Patients with Primary Sclerosing Cholangitis and Colitis-associated Neoplasia

(2013) Joana Torres et al.   INFLAMMATORY BOWEL DISEASES

Association of Circulating Vitamin D Concentrations with Intestinal but Not Systemic Inflammation in Inflammatory Bowel Disease

(2013) Mayur Garg et al.   INFLAMMATORY BOWEL DISEASES

Intestinal epithelial vitamin D receptor signaling inhibits experimental colitis

(2013) Weicheng Liu et al.   JOURNAL OF CLINICAL INVESTIGATION

Pretreatment 25-Hydroxyvitamin D Levels and Durability of Anti–Tumor Necrosis Factor–α Therapy in Inflammatory Bowel Diseases

(2013) Zachary A. Zator et al.   JOURNAL OF PARENTERAL AND ENTERAL NUTRITION

Duodenal Infusion of Donor Feces for Recurrent Clostridium difficile

(2013) Els van Nood et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Bile Acid Sensor FXR Is Required for Immune-Regulatory Activities of TLR-9 in Intestinal Inflammation

(2013) Barbara Renga et al.   PLoS One

Microbiome remodelling leads to inhibition of intestinal farnesoid X receptor signalling and decreased obesity

(2013) Fei Li et al.   Nature Communications

Where is the vitamin D receptor?

(2012) Yongji Wang et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Implication of intestinal VDR deficiency in inflammatory bowel disease

(2012) Jung-Hwan Kim et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

The Receptor TGR5 Mediates the Prokinetic Actions of Intestinal Bile Acids and Is Required for Normal Defecation in Mice

(2012) Farzad Alemi et al.   GASTROENTEROLOGY

Dysbiosis modulates capacity for bile acid modification in the gut microbiomes of patients with inflammatory bowel disease: a mechanism and marker of disease?: Figure 1

(2012) Lesley A Ogilvie et al.   GUT

Connecting dysbiosis, bile-acid dysmetabolism and gut inflammation in inflammatory bowel diseases

(2012) Henri Duboc et al.   GUT

Secukinumab, a human anti-IL-17A monoclonal antibody, for moderate to severe Crohn's disease: unexpected results of a randomised, double-blind placebo-controlled trial

(2012) Wolfgang Hueber et al.   GUT

Associations Between Vitamin D Receptor Polymorphisms and Susceptibility to Ulcerative Colitis and Crohnʼs Disease

(2012) Le-Ning Xue et al.   INFLAMMATORY BOWEL DISEASES

Dose-dependent antiinflammatory effect of ursodeoxycholic acid in experimental colitis

(2012) Patricia Martínez-Moya et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Diversity, stability and resilience of the human gut microbiota

(2012) Catherine A. Lozupone et al.   NATURE

Activation of bile salt nuclear receptor FXR is repressed by pro-inflammatory cytokines activating NF-κB signaling in the intestine

(2011) Raffaella M. Gadaleta et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Inhibition of NF-κB by a PXR-dependent pathway mediates counter-regulatory activities of rifaximin on innate immunity in intestinal epithelial cells

(2011) Andrea Mencarelli et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Rifaximin-Extended Intestinal Release Induces Remission in Patients With Moderately Active Crohn's Disease

(2011) Cosimo Prantera et al.   GASTROENTEROLOGY

Farnesoid X receptor activation inhibits inflammation and preserves the intestinal barrier in inflammatory bowel disease

(2011) R. M. Gadaleta et al.   GUT

RORγt+ innate lymphoid cells regulate intestinal homeostasis by integrating negative signals from the symbiotic microbiota

(2011) Shinichiro Sawa et al.   NATURE IMMUNOLOGY

Farnesoid X Receptor (FXR) Activation and FXR Genetic Variation in Inflammatory Bowel Disease

(2011) Rian M. Nijmeijer et al.   PLoS One

Probiotics Modulate Intestinal Expression of Nuclear Receptor and Provide Counter-Regulatory Signals to Inflammation-Driven Adipose Tissue Activation

(2011) Andrea Mencarelli et al.   PLoS One

The Bile Acid Receptor GPBAR-1 (TGR5) Modulates Integrity of Intestinal Barrier and Immune Response to Experimental Colitis

(2011) Sabrina Cipriani et al.   PLoS One

Clinical trial: vitamin D3 treatment in Crohn’s disease - a randomized double-blind placebo-controlled study

(2010) S. P. Jørgensen et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Pregnane-X-receptor mediates the anti-inflammatory activities of rifaximin on detoxification pathways in intestinal epithelial cells

(2010) Andrea Mencarelli et al.   BIOCHEMICAL PHARMACOLOGY

A human gut microbial gene catalogue established by metagenomic sequencing

(2010) Junjie Qin et al.   NATURE

Expression and function of the bile acid receptor GpBAR1 (TGR5) in the murine enteric nervous system

(2010) D. P. Poole et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Gut Microbiota in Health and Disease

(2010) Inna Sekirov et al.   PHYSIOLOGICAL REVIEWS

Mutational Characterization of the Bile Acid Receptor TGR5 in Primary Sclerosing Cholangitis

(2010) Johannes R. Hov et al.   PLoS One

IL-17 and Th17 Cells

(2009) Thomas Korn et al.   Annual Review of Immunology

1α,25-Dihydroxyvitamin D3 inhibits CD40L-induced pro-inflammatory and immunomodulatory activity in Human Monocytes

(2009) Cristiana Almerighi et al.   CYTOKINE

Towards the human intestinal microbiota phylogenetic core

(2009) Julien Tap et al.   ENVIRONMENTAL MICROBIOLOGY

ErbB Signaling Is Required for the Proliferative Actions of GLP-2 in the Murine Gut

(2009) Bernardo Yusta et al.   GASTROENTEROLOGY

Crohn's disease: Th1, Th17 or both? The change of a paradigm: new immunological and genetic insights implicate Th17 cells in the pathogenesis of Crohn's disease

(2009) S. Brand   GUT

1,25-Dihydroxyvitamin D3 Is an Autonomous Regulator of the Transcriptional Changes Leading to a Tolerogenic Dendritic Cell Phenotype

(2009) L. Szeles et al.   JOURNAL OF IMMUNOLOGY

The Bile Acid Receptor FXR Is a Modulator of Intestinal Innate Immunity

(2009) P. Vavassori et al.   JOURNAL OF IMMUNOLOGY

Calcitriol Suppresses Antiretinal Autoimmunity through Inhibitory Effects on the Th17 Effector Response

(2009) J. Tang et al.   JOURNAL OF IMMUNOLOGY

Bile acids: regulation of synthesis

(2009) John Y. L. Chiang   JOURNAL OF LIPID RESEARCH

Vitamin D and Human Health: Lessons from Vitamin D Receptor Null Mice

(2008) Roger Bouillon et al.   ENDOCRINE REVIEWS

Nonclassic Actions of Vitamin D

(2008) Daniel Bikle   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Functional and comparative metagenomic analysis of bile salt hydrolase activity in the human gut microbiome

(2008) B. V. Jones et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Novel role of the vitamin D receptor in maintaining the integrity of the intestinal mucosal barrier

(2007) Juan Kong et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY