Hybrid Models for the simulation and prediction of chromatographic processes for protein capture

Model based strategies towards protein A resin lifetime optimization and supervision

(2020) Fabian Feidl et al.   JOURNAL OF CHROMATOGRAPHY A

Mechanistic Modeling of Preparative Column Chromatography for Biotherapeutics

(2020) Vijesh Kumar et al.   Annual Review of Chemical and Biomolecular Engineering

Reinforcement learning based optimization of process chromatography for continuous processing of biopharmaceuticals

(2020) Saxena Nikita et al.   CHEMICAL ENGINEERING SCIENCE

Relations between kinetic parameters of different column models for liquid chromatography applying core-shell particles

(2019) Shamsul Qamar et al.   JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES

An overview of mechanistic modeling of liquid chromatography

(2019) Lalita K. Shekhawat et al.   PREPARATIVE BIOCHEMISTRY & BIOTECHNOLOGY

A new generation of predictive models: The added value of hybrid models for manufacturing processes of therapeutic proteins

(2019) Harini Narayanan et al.   BIOTECHNOLOGY AND BIOENGINEERING

Optimization of integrated chromatography sequences for purification of biopharmaceuticals

(2019) Anton Löfgren et al.   BIOTECHNOLOGY PROGRESS

Combining Mechanistic Modeling and Raman Spectroscopy for Monitoring Antibody Chromatographic Purification

(2019) Feidl et al.   Processes

Optimal Antibody Purification Strategies Using Data-Driven Models

(2019) Songsong Liu et al.   Engineering

Chromatography Analysis and Design Toolkit (CADET)

(2018) Samuel Leweke et al.   COMPUTERS & CHEMICAL ENGINEERING

Model-assisted process characterization and validation for a continuous two-column protein A capture process

(2018) Daniel Baur et al.   BIOTECHNOLOGY AND BIOENGINEERING

Estimation of adsorption isotherm and mass transfer parameters in protein chromatography using artificial neural networks

(2017) Gang Wang et al.   JOURNAL OF CHROMATOGRAPHY A

Root cause investigation of deviations in protein chromatography based on mechanistic models and artificial neural networks

(2017) Gang Wang et al.   JOURNAL OF CHROMATOGRAPHY A

Designing affinity chromatographic processes for the capture of antibodies. Part I: A simplified approach

(2017) D. Pfister et al.   JOURNAL OF CHROMATOGRAPHY A

Comparison of batch and continuous multi-column protein A capture processes by optimal design

(2016) Daniel Baur et al.   Biotechnology Journal

The role of more than 40 years of improvement in protein A chromatography in the growth of the therapeutic antibody industry

(2016) Glen R. Bolton et al.   BIOTECHNOLOGY PROGRESS

Downstream process development strategies for effective bioprocesses: Trends, progress, and combinatorial approaches

(2016) Pascal Baumann et al.   ENGINEERING IN LIFE SCIENCES

Model based adaptive control of a continuous capture process for monoclonal antibodies production

(2016) Fabian Steinebach et al.   JOURNAL OF CHROMATOGRAPHY A

Comparison of batch and continuous multi-column protein A capture processes by optimal design

(2016) Daniel Baur et al.   Biotechnology Journal

Optimal model-based design of the twin-column CaptureSMB process improves capacity utilization and productivity in protein A affinity capture

(2015) Daniel Baur et al.   Biotechnology Journal

Systematic interpolation method predicts protein chromatographic elution from batch isotherm data without a detailed mechanistic isotherm model

(2015) Arch Creasy et al.   Biotechnology Journal

Development of Gradient Retention Model in Ion Chromatography. Part III: Fuzzy Logic QSRR Approach

(2015) Šime Ukić et al.   CHROMATOGRAPHIA

Optimal model-based design of the twin-column CaptureSMB process improves capacity utilization and productivity in protein A affinity capture

(2015) Daniel Baur et al.   Biotechnology Journal

Systematic interpolation method predicts protein chromatographic elution from batch isotherm data without a detailed mechanistic isotherm model

(2015) Arch Creasy et al.   Biotechnology Journal

Purifying biopharmaceuticals: knowledge-based chromatographic process development

(2014) Alexander T. Hanke et al.   TRENDS IN BIOTECHNOLOGY

Optimizing a chromatographic three component separation: A comparison of mechanistic and empiric modeling approaches

(2012) A. Osberghaus et al.   JOURNAL OF CHROMATOGRAPHY A

Design of high productivity antibody capture by protein A chromatography using an integrated experimental and modeling approach

(2012) Candy K.S. Ng et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Designing new monoclonal antibody purification processes using mixed-mode chromatography sorbents

(2011) Magali Toueille et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Integration of scale-down experimentation and general rate modelling to predict manufacturing scale chromatographic separations

(2010) Spyridon Gerontas et al.   JOURNAL OF CHROMATOGRAPHY A

Optimizing model predictive control of the chromatographic multi-column solvent gradient purification (MCSGP) process

(2010) Cristian Grossmann et al.   JOURNAL OF PROCESS CONTROL

Recovery and purification process development for monoclonal antibody production

(2010) Hui F. Liu et al.   mAbs

High Throughput Screening for the Design and Optimization of Chromatographic Processes: Automated Optimization of Chromatographic Phase Systems

(2008) A. Susanto et al.   CHEMICAL ENGINEERING & TECHNOLOGY

A Hybrid Model Framework for the Optimization of Preparative Chromatographic Processes

(2004) Deepak Nagrath et al.   BIOTECHNOLOGY PROGRESS