Therapeutic Mechanism and Key Alkaloids of Uncaria rhynchophylla in Alzheimer’s Disease From the Perspective of Pathophysiological Processes
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Title
Therapeutic Mechanism and Key Alkaloids of Uncaria rhynchophylla in Alzheimer’s Disease From the Perspective of Pathophysiological Processes
Authors
Keywords
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Journal
Frontiers in Pharmacology
Volume 12, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2021-12-15
DOI
10.3389/fphar.2021.806984
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- (2021) Leslie A. Sandusky-Beltran et al. JOURNAL OF CLINICAL INVESTIGATION
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- (2021) Giovanna Lalli et al. EMBO Molecular Medicine
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- Drug Development for Psychotropic, Cognitive-Enhancing, and Disease-Modifying Treatments for Alzheimer’s Disease
- (2020) Jeffrey Cummings JOURNAL OF NEUROPSYCHIATRY AND CLINICAL NEUROSCIENCES
- HERB: a high-throughput experiment- and reference-guided database of traditional Chinese medicine
- (2020) ShuangSang Fang et al. NUCLEIC ACIDS RESEARCH
- The STRING database in 2021: customizable protein–protein networks, and functional characterization of user-uploaded gene/measurement sets
- (2020) Damian Szklarczyk et al. NUCLEIC ACIDS RESEARCH
- Alkaloids extracted from Uncaria rhynchophylla demonstrate neuroprotective effects in MPTP-induced experimental parkinsonism by regulating the PI3K/Akt/mTOR signaling pathway
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- SwissTargetPrediction: updated data and new features for efficient prediction of protein targets of small molecules
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- (2019) Sneham Tiwari et al. International Journal of Nanomedicine
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- (2018) Min Xu et al. Alzheimers & Dementia
- A guide to using functional magnetic resonance imaging to study Alzheimer's disease in animal models
- (2018) Mazen Asaad et al. Disease Models & Mechanisms
- ProTox-II: a webserver for the prediction of toxicity of chemicals
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- (2018) Shengquan Hu et al. Frontiers in Pharmacology
- Isorhynchophylline Treatment Improves the Amyloid-β-Induced Cognitive Impairment in Rats via Inhibition of Neuronal Apoptosis and Tau Protein Hyperphosphorylation
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- (2018) Soo Jung Shin et al. NEUROCHEMISTRY INTERNATIONAL
- ETCM: an encyclopaedia of traditional Chinese medicine
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- (2017) Yi-Nan Zhang et al. MOLECULES
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- (2017) Miren Ettcheto et al. Redox Biology
- SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules
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