Dual CCR5/CCR2 targeting: opportunities for the cure of complex disorders
Published 2019 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Dual CCR5/CCR2 targeting: opportunities for the cure of complex disorders
Authors
Keywords
AIDS, Autoimmunity, Liver disease, Neuroinflammation, Therapeutic antibody, Chemokine receptor antagonist
Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume -, Issue -, Pages -
Publisher
Springer Science and Business Media LLC
Online
2019-08-03
DOI
10.1007/s00018-019-03255-6
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- HIV-1 remission following CCR5Δ32/Δ32 haematopoietic stem-cell transplantation
- (2019) Ravindra K. Gupta et al. NATURE
- Transcriptional down-regulation of ccr5 in a subset of HIV+ controllers and their family members
- (2019) Elena Gonzalo-Gil et al. eLife
- Cenicriviroc for the treatment of non-alcoholic steatohepatitis and liver fibrosis
- (2018) Frank Tacke EXPERT OPINION ON INVESTIGATIONAL DRUGS
- CCR5Δ32 – A piece of protection in the inflammatory puzzle of multiple sclerosis susceptibility
- (2018) Lian Lopes Troncoso et al. HUMAN IMMUNOLOGY
- Improved Cognitive Performance and Reduced Monocyte Activation in Virally Suppressed Chronic HIV Following Dual CCR2 and CCR5 Antagonism
- (2018) Michelle L. D’Antoni et al. JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
- Mechanisms regulating expansion of CD8+ T cells during HIV-1 infection
- (2018) A. Nasi et al. JOURNAL OF INTERNAL MEDICINE
- CCR5 Revisited: How Mechanisms of HIV Entry Govern AIDS Pathogenesis
- (2018) Anne Brelot et al. JOURNAL OF MOLECULAR BIOLOGY
- CCR2 on Peripheral Blood CD14+CD16+ Monocytes Correlates with Neuronal Damage, HIV-Associated Neurocognitive Disorders, and Peripheral HIV DNA: reseeding of CNS reservoirs?
- (2018) Mike Veenstra et al. Journal of Neuroimmune Pharmacology
- To the Brain and Back: Migratory Paths of Dendritic Cells in Multiple Sclerosis
- (2018) Maxime De Laere et al. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
- Maraviroc Is Associated with Latent HIV-1 Reactivation through NF-κB Activation in Resting CD4+ T Cells from HIV-Infected Individuals on Suppressive Antiretroviral Therapy
- (2018) Nadia Madrid-Elena et al. JOURNAL OF VIROLOGY
- Hepatocellular carcinoma
- (2018) Alejandro Forner et al. LANCET
- Mechanisms of NAFLD development and therapeutic strategies
- (2018) Scott L. Friedman et al. NATURE MEDICINE
- Multiple Sclerosis: Mechanisms and Immunotherapy
- (2018) Clare Baecher-Allan et al. NEURON
- Advances in Biomarker-Guided Therapy for Pediatric- and Adult-Onset Neuroinflammatory Disorders: Targeting Chemokines/Cytokines
- (2018) Michael R. Pranzatelli Frontiers in Immunology
- The Expanding Therapeutic Perspective of CCR5 Blockade
- (2018) Luca Vangelista et al. Frontiers in Immunology
- Pharmacological inhibition of CCR2/5 signaling prevents and reverses alcohol-induced liver damage, steatosis and inflammation in mice
- (2018) Aditya Ambade et al. HEPATOLOGY
- Molecular Pathogenesis of Nonalcoholic Steatohepatitis- (NASH-) Related Hepatocellular Carcinoma
- (2018) Ozlem Kutlu et al. Canadian Journal of Gastroenterology and Hepatology
- APOBEC3G/3A Expression in Human Immunodeficiency Virus Type 1-Infected Individuals Following Initiation of Antiretroviral Therapy Containing Cenicriviroc or Efavirenz
- (2018) Daniela A. Covino et al. Frontiers in Immunology
- Potentiating cancer vaccine efficacy in liver cancer
- (2018) Maria Tagliamonte et al. OncoImmunology
- Transforming Growth Factor-β-Induced Cell Plasticity in Liver Fibrosis and Hepatocarcinogenesis
- (2018) Isabel Fabregat et al. Frontiers in Oncology
- Multiple sclerosis - a review
- (2018) R. Dobson et al. EUROPEAN JOURNAL OF NEUROLOGY
- Characterization of the Genital Mucosa Immune Profile to Distinguish Phases of the Menstrual Cycle: Implications for HIV Susceptibility
- (2018) Geneviève Boily-Larouche et al. JOURNAL OF INFECTIOUS DISEASES
- Gene Editing of HIV-1 Co-receptors to Prevent and/or Cure Virus Infection
- (2018) Alexander G. Allen et al. Frontiers in Microbiology
- Host genetic variation and HIV disease: from mapping to mechanism
- (2017) Vivek Naranbhai et al. IMMUNOGENETICS
- Mechanisms of Regulation of the Chemokine-Receptor Network
- (2017) Martin Stone et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Targeting hepatic macrophages to treat liver diseases
- (2017) Frank Tacke JOURNAL OF HEPATOLOGY
- Is maraviroc useful in multiple sclerosis patients with natalizumab-related progressive multifocal leukoencephalopathy?
- (2017) Cristina Scarpazza et al. JOURNAL OF THE NEUROLOGICAL SCIENCES
- The Abrogation of Phosphorylation Plays a Relevant Role in the CCR5 Signalosome Formation with Natural Antibodies to CCR5
- (2017) Assunta Venuti et al. Viruses-Basel
- Mechanisms of CNS Viral Seeding by HIV + CD14 + CD16 + Monocytes: Establishment and Reseeding of Viral Reservoirs Contributing to HIV-Associated Neurocognitive Disorders
- (2017) Mike Veenstra et al. mBio
- Driving HIV-1 into a Vulnerable Corner by Taking Advantage of Viral Adaptation and Evolution
- (2017) Shigeyoshi Harada et al. Frontiers in Microbiology
- Neurological Complications of HIV Infection
- (2017) Shelli Farhadian et al. Current Infectious Disease Reports
- The Role of Natural Antibodies to CC Chemokine Receptor 5 in HIV Infection
- (2017) Assunta Venuti et al. Frontiers in Immunology
- CCL5–Glutamate Cross-Talk in Astrocyte-Neuron Communication in Multiple Sclerosis
- (2017) Anna Pittaluga Frontiers in Immunology
- A Natural CCR2 Antagonist Relieves Tumor-associated Macrophage-mediated Immunosuppression to Produce a Therapeutic Effect for Liver Cancer
- (2017) Wenbo Yao et al. EBioMedicine
- A 48-week randomized phase 2b study evaluating cenicriviroc versus efavirenz in treatment-naive HIV-infected adults with C-C chemokine receptor type 5-tropic virus
- (2016) Melanie Thompson et al. AIDS
- Role of chemokine pathways in hepatobiliary cancer
- (2016) Josef Ehling et al. CANCER LETTERS
- Efficacy and safety study of cenicriviroc for the treatment of non-alcoholic steatohepatitis in adult subjects with liver fibrosis: CENTAUR Phase 2b study design
- (2016) Scott Friedman et al. Contemporary Clinical Trials
- Combinatorial immunotherapy strategies for hepatocellular carcinoma
- (2016) Maria Tagliamonte et al. CURRENT OPINION IN IMMUNOLOGY
- Structural studies of G protein-coupled receptors
- (2016) Mengjie Lu et al. IUBMB LIFE
- The macrophage activation marker sCD163 is associated with morphological disease stages in patients with non-alcoholic fatty liver disease
- (2016) Konstantin Kazankov et al. LIVER INTERNATIONAL
- Epidemiology and natural history of non-alcoholic fatty liver disease
- (2016) Yousef Fazel et al. METABOLISM-CLINICAL AND EXPERIMENTAL
- Blocking the CCL2–CCR2 Axis Using CCL2-Neutralizing Antibody Is an Effective Therapy for Hepatocellular Cancer in a Mouse Model
- (2016) Kun-Yu Teng et al. MOLECULAR CANCER THERAPEUTICS
- RANTES correlates with inflammatory activity and synaptic excitability in multiple sclerosis
- (2016) Francesco Mori et al. Multiple Sclerosis Journal
- CCR5 blockade for neuroinflammatory diseases — beyond control of HIV
- (2016) Guillaume Martin-Blondel et al. Nature Reviews Neurology
- Class B β-arrestin2-dependent CCR5 signalosome retention with natural antibodies to CCR5
- (2016) Assunta Venuti et al. Scientific Reports
- RANTES correlates with inflammatory activity and synaptic excitability in multiple sclerosis
- (2016) Francesco Mori et al. Multiple Sclerosis Journal
- The role of chemokine C-C motif ligand 2 genotype and cerebrospinal fluid chemokine C-C motif ligand 2 in neurocognition among HIV-infected patients
- (2015) April D. Thames et al. AIDS
- The CCL2/CCR2 Axis in the Pathogenesis of HIV-1 Infection: A New Cellular Target for Therapy?
- (2015) Daniela Angela Covino et al. CURRENT DRUG TARGETS
- Association of Adipose Tissue Inflammation With Histologic Severity of Nonalcoholic Fatty Liver Disease
- (2015) Johannie du Plessis et al. GASTROENTEROLOGY
- Targeting of tumour-infiltrating macrophages via CCL2/CCR2 signalling as a therapeutic strategy against hepatocellular carcinoma
- (2015) Xiaoguang Li et al. GUT
- Pathobiology of liver fibrosis: a translational success story
- (2015) Youngmin A Lee et al. GUT
- ERK1-Based Pathway as a New Selective Mechanism To Modulate CCR5 with Natural Antibodies
- (2015) Assunta Venuti et al. JOURNAL OF IMMUNOLOGY
- CCR5 susceptibility to ligand-mediated down-modulation differs between human T lymphocytes and myeloid cells
- (2015) James M. Fox et al. JOURNAL OF LEUKOCYTE BIOLOGY
- Demyelination Causes Adult CNS Progenitors to Revert to an Immature State and Express Immune Cues That Support Their Migration
- (2015) S. Moyon et al. JOURNAL OF NEUROSCIENCE
- Endogenous CCL2 neutralization restricts HIV-1 replication in primary human macrophages by inhibiting viral DNA accumulation
- (2015) Michela Sabbatucci et al. Retrovirology
- CCL2-CCR2 Signaling in Disease Pathogenesis
- (2015) Tracy O’Connor et al. Endocrine Metabolic & Immune Disorders-Drug Targets
- Chemokines and Chemokine Receptors: Positioning Cells for Host Defense and Immunity
- (2014) Jason W. Griffith et al. Annual Review of Immunology
- The clinical management of hepatocellular carcinoma in the United States, Europe, and Asia: A comprehensive and evidence-based comparison and review
- (2014) Zhi Ven Fong et al. CANCER
- Intratumoral Immunization: A New Paradigm for Cancer Therapy
- (2014) A. Marabelle et al. CLINICAL CANCER RESEARCH
- Monocytes Mediate HIV Neuropathogenesis: Mechanisms that Contribute to HIV Associated Neurocognitive Disorders
- (2014) Dionna Williams et al. CURRENT HIV RESEARCH
- Roles for Chemokines in Liver Disease
- (2014) Fabio Marra et al. GASTROENTEROLOGY
- CCL2-dependent infiltrating macrophages promote angiogenesis in progressive liver fibrosis
- (2014) Josef Ehling et al. GUT
- Endothelial progenitors promote hepatocarcinoma intrahepatic metastasis through monocyte chemotactic protein-1 induction of microRNA-21
- (2014) Yu-Tsung Shih et al. GUT
- Discrepancy in CCL2 and CCR2 expression in white versus grey matter hippocampal lesions of Multiple Sclerosis patients
- (2014) Marloes Prins et al. Acta Neuropathologica Communications
- Clinical development of monoclonal antibody-based drugs in HIV and HCV diseases
- (2013) Michela Flego et al. BMC Medicine
- Genetic diversity and linkage disequilibrium in the chemokine receptor CCR2-CCR5 region among individuals and populations
- (2013) Collene Lawhorn et al. CYTOKINE
- Inflammation-induced hepatocellular carcinoma is dependent on CCR5 in mice
- (2013) Neta Barashi et al. HEPATOLOGY
- Challenges in cancer vaccine development for hepatocellular carcinoma
- (2013) Luigi Buonaguro et al. JOURNAL OF HEPATOLOGY
- CCL2 induction by 1,25(OH)2D3 in dendritic cells from healthy donors and multiple sclerosis patients
- (2013) Isabella Sanseverino et al. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
- Nuclear Phosphoinositide-Specific Phospholipase C β1 Controls Cytoplasmic CCL2 mRNA Levels in HIV-1 gp120-Stimulated Primary Human Macrophages
- (2013) Francesca Spadaro et al. PLoS One
- Maraviroc, a CCR5 Antagonist, Prevents Development of Hepatocellular Carcinoma in a Mouse Model
- (2013) Laura Ochoa-Callejero et al. PLoS One
- HIV-1 exploits CCR5 conformational heterogeneity to escape inhibition by chemokines
- (2013) Philippe Colin et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Genital Tract Viral Load in HIV Type 1-Positive Women Correlates with Specific Cytokine Levels in Cervical-Vaginal Secretions But Is Not a Determinant of Infectious Virus or Anti-HIV Activity
- (2012) Lucy R. Mukura et al. AIDS RESEARCH AND HUMAN RETROVIRUSES
- Genital immunology and HIV susceptibility in young women
- (2012) Tae Joon Yi et al. AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
- Function, diversity and therapeutic potential of the N-terminal domain of human chemokine receptors
- (2012) Martyna Szpakowska et al. BIOCHEMICAL PHARMACOLOGY
- Cancer-associated fibroblasts up-regulate CCL2, CCL26, IL6 and LOXL2 genes related to promotion of cancer progression in hepatocellular carcinoma cells
- (2012) Zu-Yau Lin et al. BIOMEDICINE & PHARMACOTHERAPY
- Monocyte Activation Markers in Cerebrospinal Fluid Associated With Impaired Neurocognitive Testing in Advanced HIV Infection
- (2012) Anupa Kamat et al. JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
- Follicular helper T cells serve as the major CD4 T cell compartment for HIV-1 infection, replication, and production
- (2012) Matthieu Perreau et al. JOURNAL OF EXPERIMENTAL MEDICINE
- CCR2+CCR5+ T Cells Produce Matrix Metalloproteinase-9 and Osteopontin in the Pathogenesis of Multiple Sclerosis
- (2012) W. Sato et al. JOURNAL OF IMMUNOLOGY
- Chemokine Receptor Antagonists
- (2012) James Pease et al. JOURNAL OF MEDICINAL CHEMISTRY
- Chemokine-driven lymphocyte infiltration: an early intratumoural event determining long-term survival in resectable hepatocellular carcinoma
- (2011) Valerie Chew et al. GUT
- Selective transmission of R5 HIV-1 variants: where is the gatekeeper?
- (2011) Jean-Charles Grivel et al. Journal of Translational Medicine
- Enhanced HIV-1 replication in ex vivo ectocervical tissues from post-menopausal women correlates with increased inflammatory responses
- (2011) C Rollenhagen et al. Mucosal Immunology
- Local-Regional Treatment of Hepatocellular Carcinoma
- (2011) Riccardo Lencioni et al. RADIOLOGY
- HIV-1 predisposed to acquiring resistance to maraviroc (MVC) and other CCR5 antagonists in vitro has an inherent, low-level ability to utilize MVC-bound CCR5 for entry
- (2011) Michael Roche et al. Retrovirology
- CCR2 Antagonists
- (2010) Mary Struthers et al. CURRENT TOPICS IN MEDICINAL CHEMISTRY
- Sorafenib: Where do we go from here?
- (2010) Abby B. Siegel et al. HEPATOLOGY
- Chemokine CCL2 modulation of neuronal excitability and synaptic transmission in rat hippocampal slices
- (2010) Yan Zhou et al. JOURNAL OF NEUROCHEMISTRY
- Genetic polymorphism of CCR2-64I increased the susceptibility of hepatocellular carcinoma
- (2010) Chao-Bin Yeh et al. JOURNAL OF SURGICAL ONCOLOGY
- Apigenin inhibits hepatoma cell growth through alteration of gene expression patterns
- (2010) Jing Cai et al. PHYTOMEDICINE
- Functional Contribution of Elevated Circulating and Hepatic Non-Classical CD14+CD16+ Monocytes to Inflammation and Human Liver Fibrosis
- (2010) Henning W. Zimmermann et al. PLoS One
- Association of HIV viral load with monocyte chemoattractant protein-1 and atherosclerosis burden measured by magnetic resonance imaging
- (2009) Michelle Floris-Moore et al. AIDS
- Enhancement of Chemokine Expression by Interferon Beta Therapy in Patients With Multiple Sclerosis
- (2009) Sabine Cepok ARCHIVES OF NEUROLOGY
- Identification of new sensitive biomarkers for thein vivoresponse to interferon-β treatment in multiple sclerosis using DNA-array evaluation
- (2009) F. Sellebjerg et al. EUROPEAN JOURNAL OF NEUROLOGY
- gp120 modulates the biology of human hepatic stellate cells: a link between HIV infection and liver fibrogenesis
- (2009) R. Bruno et al. GUT
- CCR2 promotes hepatic fibrosis in mice
- (2009) Ekihiro Seki et al. HEPATOLOGY
- Long-Term Control of HIV byCCR5Delta32/Delta32 Stem-Cell Transplantation
- (2009) Gero Hütter et al. NEW ENGLAND JOURNAL OF MEDICINE
- CCR5 monoclonal antibodies for HIV-1 therapy
- (2009) William C Olson et al. Current Opinion in HIV and AIDS
- Phosphatidylcholine-specific phospholipase C activation is required for CCR5-dependent, NF-kB-driven CCL2 secretion elicited in response to HIV-1 gp120 in human primary macrophages
- (2008) L. Fantuzzi et al. BLOOD
- CCL2 Increases X4-tropic HIV-1 Entry into Resting CD4+T Cells
- (2008) Grant R. Campbell et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- CCR5 expression on macrophages/microglia is associated with early remyelination in multiple sclerosis lesions
- (2008) C Trebst et al. Multiple Sclerosis Journal
- Chemokine receptor antagonists: overcoming developmental hurdles
- (2008) Richard Horuk NATURE REVIEWS DRUG DISCOVERY
- Highly potent, fully recombinant anti-HIV chemokines: Reengineering a low-cost microbicide
- (2008) H. Gaertner et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Targeting Chemokine Receptors in HIV: A Status Report
- (2007) Shawn E. Kuhmann et al. Annual Review of Pharmacology and Toxicology
Find the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
SearchCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now