The Main Alkaloids in Uncaria rhynchophylla and Their Anti-Alzheimer’s Disease Mechanism Determined by a Network Pharmacology Approach

Design, Synthesis, and Evaluation of Acetylcholinesterase and Butyrylcholinesterase Dual-Target Inhibitors against Alzheimer’s Diseases

(2020) Yan Guo et al.   MOLECULES

Brain Insulin Signaling, Alzheimer Disease Pathology, and Cognitive Function

(2020) Zoe Arvanitakis et al.   ANNALS OF NEUROLOGY

Herbal medicine treatment for Alzheimer disease

(2020) JiEun Lee et al.   MEDICINE

Antitumor Activity and Mechanism of Robustic Acid from Dalbergia benthami Prain via Computational Target Fishing

(2020) Juanjuan Huang et al.   MOLECULES

New therapeutics beyond amyloid-β and tau for the treatment of Alzheimer’s disease

(2020) Feng Zhang et al.   ACTA PHARMACOLOGICA SINICA

Alkaloids extracted from Uncaria rhynchophylla demonstrate neuroprotective effects in MPTP-induced experimental parkinsonism by regulating the PI3K/Akt/mTOR signaling pathway

(2020) Meizhu Zheng et al.   JOURNAL OF ETHNOPHARMACOLOGY

SwissTargetPrediction: updated data and new features for efficient prediction of protein targets of small molecules

(2019) Antoine Daina et al.   NUCLEIC ACIDS RESEARCH

Metascape provides a biologist-oriented resource for the analysis of systems-level datasets

(2019) Yingyao Zhou et al.   Nature Communications

Isorhynchophylline ameliorates cognitive impairment via modulating amyloid pathology, tau hyperphosphorylation and neuroinflammation: Studies in a transgenic mouse model of Alzheimer’s disease

(2019) Hui-Qin Li et al.   BRAIN BEHAVIOR AND IMMUNITY

Entanglement of CCR5 and Alzheimer’s Disease

(2019) Tianwen Li et al.   Frontiers in Aging Neuroscience

Altered Insulin Signaling in Alzheimer’s Disease Brain – Special Emphasis on PI3K-Akt Pathway

(2019) Sami Gabbouj et al.   Frontiers in Neuroscience

Therapeutic target database 2020: enriched resource for facilitating research and early development of targeted therapeutics

(2019) Yunxia Wang et al.   NUCLEIC ACIDS RESEARCH

A systematic integrated analysis of brain expression profiles reveals YAP1 and other prioritized hub genes as important upstream regulators in Alzheimer's disease

(2018) Min Xu et al.   Alzheimers & Dementia

The cholinergic system in the pathophysiology and treatment of Alzheimer’s disease

(2018) Harald Hampel et al.   BRAIN

A guide to using functional magnetic resonance imaging to study Alzheimer's disease in animal models

(2018) Mazen Asaad et al.   Disease Models & Mechanisms

Rhynchophylline suppresses soluble Aβ 1-42 -induced impairment of spatial cognition function via inhibiting excessive activation of extrasynaptic NR2B-containing NMDA receptors

(2018) Yang Yang et al.   NEUROPHARMACOLOGY

Isorhynchophylline Treatment Improves the Amyloid-β-Induced Cognitive Impairment in Rats via Inhibition of Neuronal Apoptosis and Tau Protein Hyperphosphorylation

(2018) Yan-Fang Xian et al.   JOURNAL OF ALZHEIMERS DISEASE

Uncaria rhynchophylla ameliorates amyloid beta deposition and amyloid beta-mediated pathology in 5XFAD mice

(2018) Soo Jung Shin et al.   NEUROCHEMISTRY INTERNATIONAL

STRING v11: protein–protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets

(2018) Damian Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

Why do trials for Alzheimer’s disease drugs keep failing? A discontinued drug perspective for 2010-2015

(2017) Dev Mehta et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

The Blood-Brain Barrier Permeability of Six Indole Alkaloids from Uncariae Ramulus Cum Uncis in the MDCK-pHaMDR Cell Monolayer Model

(2017) Yi-Nan Zhang et al.   MOLECULES

BACE1 Function and Inhibition: Implications of Intervention in the Amyloid Pathway of Alzheimer’s Disease Pathology

(2017) Gerald Koelsch   MOLECULES

Neurons derived from sporadic Alzheimer’s disease iPSCs reveal elevated TAU hyperphosphorylation, increased amyloid levels, and GSK3B activation

(2017) Anna Ochalek et al.   Alzheimers Research & Therapy

SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules

(2017) Antoine Daina et al.   Scientific Reports

Alzheimer's disease

(2016) Philip Scheltens et al.   LANCET

Clinical phenotype and genetic associations in autosomal dominant familial Alzheimer’s disease: a case series

(2016) Natalie S Ryan et al.   LANCET NEUROLOGY

Literature information in PubChem: associations between PubChem records and scientific articles

(2016) Sunghwan Kim et al.   Journal of Cheminformatics

The Distinct Role of ADAM17 in APP Proteolysis and Microglial Activation Related to Alzheimer’s Disease

(2015) Meng Qian et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Corynoxine, a Natural Autophagy Enhancer, Promotes the Clearance of Alpha-Synuclein via Akt/mTOR Pathway

(2014) Lei-Lei Chen et al.   Journal of Neuroimmune Pharmacology

Isorhynchophylline improves learning and memory impairments induced by D-galactose in mice

(2014) Yan-Fang Xian et al.   NEUROCHEMISTRY INTERNATIONAL

Bioassay-Guided Isolation of Neuroprotective Compounds fromUncaria rhynchophyllaagainst Beta-Amyloid-Induced Neurotoxicity

(2012) Yan-Fang Xian et al.   Evidence-based Complementary and Alternative Medicine

Inhibition of GSK3β-mediated BACE1 expression reduces Alzheimer-associated phenotypes

(2012) Philip T.T. Ly et al.   JOURNAL OF CLINICAL INVESTIGATION

SwissDock, a protein-small molecule docking web service based on EADock DSS

(2011) A. Grosdidier et al.   NUCLEIC ACIDS RESEARCH

What can we learn from study of Alzheimer's disease in patients with Down syndrome for early-onset Alzheimer's disease in the general population?

(2011) Robyn A Wallace et al.   Alzheimers Research & Therapy

Antihypertensive and neuroprotective activities of rhynchophylline: The role of rhynchophylline in neurotransmission and ion channel activity

(2010) Jiyin Zhou et al.   JOURNAL OF ETHNOPHARMACOLOGY

Anti-inflammatory effects of rhynchophylline and isorhynchophylline in mouse N9 microglial cells and the molecular mechanism

(2009) Dan Yuan et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Network pharmacology: the next paradigm in drug discovery

(2008) Andrew L Hopkins   Nature Chemical Biology