C1q/TNF-Related Protein 9 Attenuates Atherosclerosis by Inhibiting Hyperglycemia-Induced Endothelial Cell Senescence Through the AMPKα/KLF4 Signaling Pathway

Identification of a CTRP9 C-Terminal polypeptide capable of enhancing bone-derived mesenchymal stem cell cardioprotection through promoting angiogenic exosome production

(2021) Demin Liu et al.   Redox Biology

Bradykinin Protects Human Endothelial Progenitor Cells from High-Glucose-Induced Senescence through B2 Receptor-Mediated Activation of the Akt/eNOS Signalling Pathway

(2021) Yuehuan Wu et al.   Journal of Diabetes Research

C1q/Tumor Necrosis Factor-Related Protein-9 Attenuates Diabetic Nephropathy and Kidney Fibrosis in db/db Mice

(2020) Hongyao Hu et al.   DNA AND CELL BIOLOGY

CTRP9: An emerging potential anti-aging molecule in brain

(2020) Aysa Rezabakhsh et al.   CELLULAR SIGNALLING

KLF4 sensitizes the colon cancer cell HCT-15 to cisplatin by altering the expression of HMGB1 and hTERT

(2019) Suresh Singh Yadav et al.   LIFE SCIENCES

C1q/TNF-related protein-9 attenuates retinal inflammation and protects blood–retinal barrier in db/db mice

(2019) Wei Li et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Real-world risk of cardiovascular outcomes associated with hypertriglyceridaemia among individuals with atherosclerotic cardiovascular disease and potential eligibility for emerging therapies

(2019) Patrick R Lawler et al.   EUROPEAN HEART JOURNAL

Senescence-induced inflammation: an important player and key therapeutic target in atherosclerosis

(2019) Stevan D Stojanović et al.   EUROPEAN HEART JOURNAL

C1q/TNF-related protein-9 attenuates atherosclerosis through AMPK-NLRP3 inflammasome singling pathway

(2019) Hui Zhang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Cellular senescence links aging and diabetes in cardiovascular disease

(2018) Hadis Shakeri et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

C1q tumor necrosis factor-related protein 9 in atherosclerosis: Mechanistic insights and therapeutic potential

(2018) Xiao-Hua Yu et al.   ATHEROSCLEROSIS

Prevalence of cardiovascular disease in type 2 diabetes: a systematic literature review of scientific evidence from across the world in 2007–2017

(2018) Thomas R. Einarson et al.   Cardiovascular Diabetology

CTRP9 ameliorates cellular senescence via PGC‑1α/AMPK signaling in mesenchymal stem cells

(2018) Qun Li et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Mechanisms of Diabetes-Induced Endothelial Cell Senescence: Role of Arginase 1

(2018) Esraa Shosha et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

C1q/TNF-Related Protein 9 Inhibits THP-1 Macrophage Foam Cell Formation by Enhancing Autophagy

(2018) Lu Zhang et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Senescent cells: a therapeutic target for cardiovascular disease

(2018) Bennett G. Childs et al.   JOURNAL OF CLINICAL INVESTIGATION

APTO-253 Stabilizes G-quadruplex DNA, Inhibits MYC Expression, and Induces DNA Damage in Acute Myeloid Leukemia Cells

(2018) Andrea Local et al.   MOLECULAR CANCER THERAPEUTICS

Vasa Vasorum Angiogenesis: Key Player in the Initiation and Progression of Atherosclerosis and Potential Target for the Treatment of Cardiovascular Disease

(2018) Daniel G. Sedding et al.   Frontiers in Immunology

Obesity and type-2 diabetes as inducers of premature cellular senescence and ageing

(2018) Dominick G. A. Burton et al.   BIOGERONTOLOGY

Overexpression of CTRP9 attenuates the development of atherosclerosis in apolipoprotein E-deficient mice

(2018) Chengmin Huang et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

C1q/TNF-Related Protein-9 Ameliorates Ox-LDL-Induced Endothelial Dysfunction via PGC-1α/AMPK-Mediated Antioxidant Enzyme Induction

(2017) Haijian Sun et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

C1q/TNF-related protein 9 inhibits the cholesterol-induced Vascular smooth muscle cell phenotype switch and cell dysfunction by activating AMP-dependent kinase

(2017) Qi Liu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Molecular identification and functional analysis of Ctrp9 inEpinephelus coioides

(2017) Guokun Yang et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

PARP1 controls KLF4-mediated telomerase expression in stem cells and cancer cells

(2017) Meng-Hsun Hsieh et al.   NUCLEIC ACIDS RESEARCH

Targeting vasa vasorum dysfunction to prevent atherosclerosis

(2017) Erin C. Boyle et al.   VASCULAR PHARMACOLOGY

CTRP9 induces mitochondrial biogenesis and protects high glucose-induced endothelial oxidative damage via AdipoR1 -SIRT1- PGC-1α activation

(2016) Liang Cheng et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Pathways of aging: comparative analysis of gene signatures in replicative senescence and stress induced premature senescence

(2016) Kamil C. Kural et al.   BMC GENOMICS

Cellular Senescence and Vascular Disease: Novel Routes to Better Understanding and Therapy

(2016) Hao Yin et al.   CANADIAN JOURNAL OF CARDIOLOGY

AMP-Activated Protein Kinase Alpha 2 Deletion Induces VSMC Phenotypic Switching and Reduces Features of Atherosclerotic Plaque StabilityNovelty and Significance

(2016) Ye Ding et al.   CIRCULATION RESEARCH

C1q-TNF-Related Protein-9 Promotes Cardiac Hypertrophy and FailureNovelty and Significance

(2016) Mahesh Appari et al.   CIRCULATION RESEARCH

C1q/TNF-related protein-9 inhibits cytokine-induced vascular inflammation and leukocyte adhesiveness via AMP-activated protein kinase activation in endothelial cells

(2016) Chang Hee Jung et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Senescent intimal foam cells are deleterious at all stages of atherosclerosis

(2016) B. G. Childs et al.   SCIENCE

Attenuation of atherosclerotic lesions in diabetic apolipoprotein E-deficient mice using gene silencing of macrophage migration inhibitory factor

(2015) Hui Sun et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Metformin and Resveratrol Inhibited High Glucose-Induced Metabolic Memory of Endothelial Senescence through SIRT1/p300/p53/p21 Pathway

(2015) Erli Zhang et al.   PLoS One

Endothelial Cell Senescence and Age-Related Vascular Diseases

(2014) Xiao-Li Tian et al.   Journal of Genetics and Genomics

Metformin modulates hyperglycaemia-induced endothelial senescence and apoptosis through SIRT1

(2013) Gnanapragasam Arunachalam et al.   BRITISH JOURNAL OF PHARMACOLOGY

Adiponectin Receptor as a Key Player in Healthy Longevity and Obesity-Related Diseases

(2013) Toshimasa Yamauchi et al.   Cell Metabolism

Inhibition of CTRP9, a novel and cardiac-abundantly expressed cell survival molecule, by TNFα-initiated oxidative signaling contributes to exacerbated cardiac injury in diabetic mice

(2012) Hui Su et al.   BASIC RESEARCH IN CARDIOLOGY

Effects of Aging on Angiogenesis

(2012) Johanna Lähteenvuo et al.   CIRCULATION RESEARCH

Krüppel-like factor 4 (KLF4) suppresses neuroblastoma cell growth and determines non-tumorigenic lineage differentiation

(2012) C K Y Shum et al.   ONCOGENE

C1q/TNF-Related Proteins, A Family of Novel Adipokines, Induce Vascular Relaxation Through the Adiponectin Receptor-1/AMPK/eNOS/Nitric Oxide Signaling Pathway

(2011) Qijun Zheng et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Insulin Resistance, Hyperglycemia, and Atherosclerosis

(2011) Karin E. Bornfeldt et al.   Cell Metabolism

Protein Kinase C (PKC) δ Suppresses Keratinocyte Proliferation by Increasing p21Cip1Level by a KLF4 Transcription Factor-dependent Mechanism

(2011) Yap Ching Chew et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Krüppel-Like Transcription Factor 4 Contributes to Maintenance of Telomerase Activity in Stem Cells

(2010) Chui-Wei Wong et al.   STEM CELLS

Identification and characterization of CTRP9, a novel secreted glycoprotein, from adipose tissue that reduces serum glucose in mice and forms heterotrimers with adiponectin

(2008) G. William Wong et al.   FASEB JOURNAL