The Repression of the HMGB1-TLR4-NF-κB Signaling Pathway by Safflower Yellow May Improve Spinal Cord Injury

Systemic Inflammation and the Breakdown of Intestinal Homeostasis Are Key Events in Chronic Spinal Cord Injury Patients

(2021) David Diaz et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Microglial inflammation after chronic spinal cord injury is enhanced by reactive astrocytes via the fibronectin/β1 integrin pathway

(2021) Shingo Yoshizaki et al.   Journal of Neuroinflammation

A novel CX3CR1 inhibitor AZD8797 facilitates early recovery of rat acute spinal cord injury by inhibiting inflammation and apoptosis

(2020) Guozhao Chen et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Multi-target approaches to CNS repair: olfactory mucosa-derived cells and heparan sulfates

(2020) Susan L. Lindsay et al.   Nature Reviews Neurology

Safflower Yellow Improves Synaptic Plasticity in APP/PS1 Mice by Regulating Microglia Activation Phenotypes and BDNF/TrkB/ERK Signaling Pathway

(2020) Jie Pang et al.   NEUROMOLECULAR MEDICINE

Restoring the Sense of Touch Using a Sensorimotor Demultiplexing Neural Interface

(2020) Patrick D. Ganzer et al.   CELL

Safflower Yellow Improves Insulin Sensitivity in High Fat Diet‐induced Obese Mice by Promoting PPARγ2 Expression in Subcutaneous Adipose Tissue

(2020) Kemin Yan et al.   Journal of Diabetes Investigation

Role of the Hippo signaling pathway in safflower yellow pigment treatment of paraquat-induced pulmonary fibrosis

(2020) Hai Li et al.   JOURNAL OF INTERNATIONAL MEDICAL RESEARCH

Deficiency of the microglial Hv1 proton channel attenuates neuronal pyroptosis and inhibits inflammatory reaction after spinal cord injury

(2020) Xuefei Li et al.   Journal of Neuroinflammation

Inhibiting HMGB1-RAGE axis prevents pro-inflammatory macrophages/microglia polarization and affords neuroprotection after spinal cord injury

(2020) Hong Fan et al.   Journal of Neuroinflammation

Enolase inhibition alters metabolic hormones and inflammatory factors to promote neuroprotection in spinal cord injury

(2020) Rachel Polcyn et al.   NEUROCHEMISTRY INTERNATIONAL

Microenvironment-responsive immunoregulatory electrospun fibers for promoting nerve function recovery

(2020) Kun Xi et al.   Nature Communications

Neuroprotective Effect of Ketone Metabolism on Inhibiting Inflammatory Response by Regulating Macrophage Polarization After Acute Cervical Spinal Cord Injury in Rats

(2020) Junyu Lin et al.   Frontiers in Neuroscience

Role of MK2 signaling pathway mediating microglia/macrophages polarization in chronic compression injury of cervical spinal cord

(2020) Lei Yu et al.   Annals of Palliative Medicine

Parthenolide promotes the repair of spinal cord injury by modulating M1/M2 polarization via the NF-κB and STAT 1/3 signaling pathway

(2020) Tao Gaojian et al.   Cell Death Discovery

Two new quinochalcone glycosides from the safflower yellow pigments

(2020) Hao Zhang et al.   JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH

Intensive Locomotor Training Provides Sustained Alleviation of Chronic Spinal Cord Injury-Associated Neuropathic Pain: A Two-Year Pre-Clinical Study

(2020) Elizabeth A. Dugan et al.   JOURNAL OF NEUROTRAUMA

Transplantation of neural precursors generated from spinal progenitor cells reduces inflammation in spinal cord injury via NF-κB pathway inhibition

(2019) Kristyna Karova et al.   Journal of Neuroinflammation

Traumatic Spinal Cord Injury: An Overview of Pathophysiology, Models and Acute Injury Mechanisms

(2019) Arsalan Alizadeh et al.   Frontiers in Neurology

Biomarkers in Spinal Cord Injury: Prognostic Insights and Future Potentials

(2019) Ahmed A. Albayar et al.   Frontiers in Neurology

Safflower Yellow B Protects Brain against Cerebral Ischemia Reperfusion Injury through AMPK/NF-kB Pathway

(2019) Shibin Du et al.   Evidence-based Complementary and Alternative Medicine

The origin, fate, and contribution of macrophages to spinal cord injury pathology

(2019) Lindsay M. Milich et al.   ACTA NEUROPATHOLOGICA

Cellular Inflammatory Response of the Spleen After Acute Spinal Cord Injury in Rat

(2019) Feng Wu et al.   INFLAMMATION

Acute Spinal Cord Injury: A Systematic Review Investigating miRNA Families Involved

(2019) Pinchi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Bassoon proteinopathy drives neurodegeneration in multiple sclerosis

(2019) Benjamin Schattling et al.   NATURE NEUROSCIENCE

Carthamin yellow protects heart against ischemia/reperfusion injury with reduced ROS release and inflammatory response

(2019) Qi yu Lu et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

High mobility group box-1 (HMGB1) antagonist BoxA suppresses status epilepticus-induced neuroinflammatory responses associated with Toll-like receptor 2/4 down-regulation in rats

(2019) Shi Yu et al.   BRAIN RESEARCH

Selective Modulation of A1 Astrocytes by Drug-Loaded Nano-Structured Gel in Spinal Cord Injury

(2019) Irma Vismara et al.   ACS Nano

Neuroinflammation induced by secretion of acetylated HMGB1 from activated microglia in hippocampi of mice following chronic cold exposure

(2019) Bin Xu et al.   BRAIN RESEARCH

Protective effect of Oxymatrine against acute spinal cord injury in rats via modulating oxidative stress, inflammation and apoptosis

(2019) Binggang Guan et al.   METABOLIC BRAIN DISEASE

Effects of safflower yellow on beta-amyloid deposition and activation of astrocytes in the brain of APP/PS1 transgenic mice

(2018) Xiao-meng Shi et al.   BIOMEDICINE & PHARMACOTHERAPY

Microenvironment Imbalance of Spinal Cord Injury

(2018) Baoyou Fan et al.   CELL TRANSPLANTATION

Multilayer polyion complex nanoformulations of superoxide dismutase 1 for acute spinal cord injury

(2018) N.V. Nukolova et al.   JOURNAL OF CONTROLLED RELEASE

Valproic acid attenuates traumatic spinal cord injury-induced inflammation via STAT1 and NF-κB pathway dependent of HDAC3

(2018) Shoubo Chen et al.   Journal of Neuroinflammation

Persons with Chronic Spinal Cord Injury Have Decreased Natural Killer Cell and Increased Toll-Like Receptor/Inflammatory Gene Expression

(2018) Paige Herman et al.   JOURNAL OF NEUROTRAUMA

Reactive oxygen species regulate axonal regeneration through the release of exosomal NADPH oxidase 2 complexes into injured axons

(2018) Arnau Hervera et al.   NATURE CELL BIOLOGY

A brainstem bypass for spinal cord injury

(2018) Brett J Hilton et al.   NATURE NEUROSCIENCE

Astrocyte reactivity and astrogliosis after spinal cord injury

(2018) Seiji Okada et al.   NEUROSCIENCE RESEARCH

Glial Cells Shape Pathology and Repair After Spinal Cord Injury

(2018) Andrew D. Gaudet et al.   Neurotherapeutics

Spinal Cord Injury Scarring and Inflammation: Therapies Targeting Glial and Inflammatory Responses

(2018) Michael B. Orr et al.   Neurotherapeutics

The Biology of Regeneration Failure and Success After Spinal Cord Injury

(2018) Amanda Phuong Tran et al.   PHYSIOLOGICAL REVIEWS

Safflower yellow promotes angiogenesis through p-VHL/ HIF-1α/VEGF signaling pathway in the process of osteogenic differentiation

(2018) Zhi Tang et al.   BIOMEDICINE & PHARMACOTHERAPY

Effect of hyperbaric oxygen therapy on HMGB1/NF-κB expression and prognosis of acute spinal cord injury: A randomized clinical trial

(2018) Lei Sun et al.   NEUROSCIENCE LETTERS

Reactive Astrocytes: Production, Function, and Therapeutic Potential

(2017) Shane A. Liddelow et al.   IMMUNITY

Myelin as an inflammatory mediator: Myelin interactions with complement, macrophages, and microglia in spinal cord injury

(2017) Timothy J. Kopper et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Assessment and management of acute spinal cord injury: From point of injury to rehabilitation

(2017) Laureen D. Hachem et al.   JOURNAL OF SPINAL CORD MEDICINE

Neurotoxic reactive astrocytes are induced by activated microglia

(2017) Shane A. Liddelow et al.   NATURE

Interaction of reactive astrocytes with type I collagen induces astrocytic scar formation through the integrin–N-cadherin pathway after spinal cord injury

(2017) Masamitsu Hara et al.   NATURE MEDICINE

Traumatic Spinal Cord Injury—Repair and Regeneration

(2017) Christopher S. Ahuja et al.   NEUROSURGERY

The effect of hydroxy safflower yellow A on coronary heart disease through Bcl‑2/Bax and PPAR‑γ

(2017) Dayan Zhou et al.   Experimental and Therapeutic Medicine

Electroacupuncture Suppresses the NF-κB Signaling Pathway by Upregulating Cylindromatosis to Alleviate Inflammatory Injury in Cerebral Ischemia/Reperfusion Rats

(2017) Jin Jiang et al.   Frontiers in Molecular Neuroscience

Oleoylethanolamide prevents neuroimmune HMGB1/TLR4/NF-kB danger signaling in rat frontal cortex and depressive-like behavior induced by ethanol binge administration

(2016) María Antón et al.   ADDICTION BIOLOGY

Heightened TWEAK-NF-κB signaling and inflammation-associated fibrosis in paralyzed muscles of men with chronic spinal cord injury

(2016) Ceren Yarar-Fisher et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Macrophage migration inhibitory factor promotes breast cancer metastasis via activation of HMGB1/TLR4/NF kappa B axis

(2016) Wei Lv et al.   CANCER LETTERS

Effects of Safflower Yellow on the Treatment of Severe Sepsis and Septic Shock: A Randomized Controlled Clinical Trial

(2016) Xiao-jin Li et al.   Evidence-based Complementary and Alternative Medicine

Neuroinflammation: the devil is in the details

(2016) Damon J. DiSabato et al.   JOURNAL OF NEUROCHEMISTRY

Effect of acute intermittent hypoxia on motor function in individuals with chronic spinal cord injury following ibuprofen pretreatment: A pilot study

(2016) Meaghan Lynch et al.   JOURNAL OF SPINAL CORD MEDICINE

A polarizing question: do M1 and M2 microglia exist?

(2016) Richard M Ransohoff   NATURE NEUROSCIENCE

Inflammogenesis of Secondary Spinal Cord Injury

(2016) M. Akhtar Anwar et al.   Frontiers in Cellular Neuroscience

Concise Review: Bridging the Gap: Novel Neuroregenerative and Neuroprotective Strategies in Spinal Cord Injury

(2016) Christopher S. Ahuja et al.   Stem Cells Translational Medicine

The Mechanism by Which Safflower Yellow Decreases Body Fat Mass and Improves Insulin Sensitivity in HFD-Induced Obese Mice

(2016) Huijuan Zhu et al.   Frontiers in Pharmacology

Crosstalk between Wnt/β-Catenin and NF-κB Signaling Pathway during Inflammation

(2016) Bin Ma et al.   Frontiers in Immunology

Heparin inhibits the inflammatory response induced by LPS and HMGB1 by blocking the binding of HMGB1 to the surface of macrophages

(2015) Li Li et al.   CYTOKINE

Circulating T cell subsets are altered in individuals with chronic spinal cord injury

(2015) Rachel Monahan et al.   IMMUNOLOGIC RESEARCH

Safflower Yellow regulates microglial polarization and inhibits inflammatory response in LPS-stimulated Bv2 cells

(2015) Xing-Wang Yang et al.   INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY

Cross-sectional associations of pulmonary function with systemic inflammation and oxidative stress in individuals with chronic spinal cord injury

(2015) Jaime E. Hart et al.   JOURNAL OF SPINAL CORD MEDICINE

Safflower Yellow Inhibits Angiotensin II–Induced Adventitial Fibroblast Proliferation and Migration

(2014) Yueqiang Liu et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Inhibitory effects of hydroxysafflor yellow A on PDGF-BB-induced proliferation and migration of vascular smooth muscle cells via mediating Akt signaling

(2014) YANMIN SONG et al.   Molecular Medicine Reports

NF-κB in Cellular Senescence and Cancer Treatment

(2014) Hua Jing et al.   MOLECULES AND CELLS

Hydroxy-safflor yellow A inhibits neuroinflammation mediated by Aβ1–42 in BV-2 cells

(2014) Zuohui Zhang et al.   NEUROSCIENCE LETTERS

Phytochemistry, pharmacology and medicinal properties of Carthamus tinctorius L.

(2013) Jinous Asgarpanah et al.   Chinese Journal of Integrative Medicine

Hydroxysafflor yellow A suppresses inflammatory responses of BV2 microglia after oxygen–glucose deprivation

(2013) Jie Li et al.   NEUROSCIENCE LETTERS

The Effect of Safflower Yellow on Spinal Cord Ischemia Reperfusion Injury in Rabbits

(2013) Daiwei Zhou et al.   Oxidative Medicine and Cellular Longevity

Safflor yellow B suppresses angiotensin II-mediated human umbilical vein cell injury via regulation of Bcl-2/p22phox expression

(2013) Chaoyun Wang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Protective effects of Batroxobin on spinal cord injury in rats

(2013) Hong Fan et al.   Neuroscience Bulletin

Management strategies for acute spinal cord injury

(2012) Philip F. Stahel et al.   Current Opinion in Critical Care

Inhibitory Effect of Safflor Yellow on Pulmonary Fibrosis

(2011) Lin Wang et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Hydroxysafflor Yellow A suppresses thrombin generation and inflammatory responses following focal cerebral ischemia–reperfusion in rats

(2010) Xia Sun et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Macrophages Promote Axon Regeneration with Concurrent Neurotoxicity

(2009) J. C. Gensel et al.   JOURNAL OF NEUROSCIENCE

Identification of Two Distinct Macrophage Subsets with Divergent Effects Causing either Neurotoxicity or Regeneration in the Injured Mouse Spinal Cord

(2009) K. A. Kigerl et al.   JOURNAL OF NEUROSCIENCE

ROLE OF TOLL-LIKE RECEPTORS 2 AND 4, AND THE RECEPTOR FOR ADVANCED GLYCATION END PRODUCTS IN HIGH-MOBILITY GROUP BOX 1-INDUCED INFLAMMATION IN VIVO

(2009) Marieke A.D. van Zoelen et al.   SHOCK

Dynamics of the inflammatory response after murine spinal cord injury revealed by flow cytometry

(2008) David P. Stirling et al.   JOURNAL OF NEUROSCIENCE RESEARCH